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Seminars in Nuclear Medicine

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  1. Erratum to “Evaluation of Osseous Metastasis in Bone Scintigraphy”[Seminars in Nuclear Medicine (2015) 3–15]

    Seminars in Nuclear Medicine 45(3):266 (2015)

  2. Biology of Hypoxia

    Seminars in Nuclear Medicine 45(2) (2015) PMID 25704383

    There is an important and strong, but complex influence of the tumor microenvironment on tumor cells’ phenotype, aggressiveness and treatment sensitivity. One of the most frequent and best studied aspects of the tumor microenvironment is hypoxia. Low oxygen tension often occurs in tumo...
  3. The Clinical Significance of Hypoxia in Human Cancers

    Seminars in Nuclear Medicine 45(2) (2015) PMID 25704384

    Hypoxia is present to some extent in most solid malignant human cancers because of an imbalance between the limited oxygen delivery capacity of the abnormal vasculature and the high oxygen consumption of tumor cells. This drives a complex and dynamic compensatory response to enable con...
  4. The Chemistry and Radiochemistry of Hypoxia-Specific, Radiohalogenated Nitroaromatic Imaging Probes

    Seminars in Nuclear Medicine 45(2) (2015) PMID 25704385

    Hypoxia is prevalent in many solid tumors. Hypoxic tumors tend to exhibit rapid growth and aberrant vasculature, which lead to oxygen (O2) depletion and impaired drug delivery. The reductive environment in hypoxic tumors alters cellular metabolism, which can trigger transcriptional res...
  5. Evaluation of Hypoxia With Copper-Labeled Diacetyl-bis(N-Methylthiosemicarbazone)

    Seminars in Nuclear Medicine 45(2):177 (2015) PMID 25704389 PMCID PMC4339100

    Imaging of hypoxia is important in many diseases states in oncology, cardiology, and neurology. The radiopharmaceutical, copper-labeled diacetyl-bis(N-methylthiosemicarbazone), has been used to assess hypoxia in many studies. In particular, copper-labeled diacetyl-bis(N-methylthiosemic...
  6. Subject Index
    Author(s) unavailable

    Seminars in Nuclear Medicine 44(6):e3 (2014)

  7. Table of Contents
    Author(s) unavailable

    Seminars in Nuclear Medicine 44(6):i (2014)

  8. Quantitative Assessment of Myocardial Blood Flow - Clinical and Research Applications

    Seminars in Nuclear Medicine 44(4) (2014) PMID 24948151

    Myocardial perfusion imaging with SPECT/CT or with PET/CT is a mainstay in clinical practice for the diagnostic assessment of downstream, flow-limiting effects of epicardial lesions during hyperemic flows and for risk stratification of patients with known or suspected coronary artery d...
  9. Left Ventricular Dyssynchrony Assessment Using Myocardial Single-Photon Emission CT

    Seminars in Nuclear Medicine 44(4):314 (2014) PMID 24948153

    Myocardial SPECT using standard procedure for perfusion imaging and phase analysis is a novel approach to left ventricular dyssynchrony assessment. Preliminary data suggest excellent repeatability and potential utility for guiding cardiac resynchronization therapy and elucidating mecha...
  10. New Cardiac Cameras: Single-Photon Emission CT and PET

    Seminars in Nuclear Medicine 44(4):232 (2014) PMID 24948149

    Nuclear cardiology instrumentation has evolved significantly in the recent years. Concerns about radiation dose and long acquisition times have propelled developments of dedicated high-efficiency cardiac SPECT scanners. Novel collimator designs, such as multipinhole or locally focusing...