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Seminars in Nuclear Medicine

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  1. Erratum to “Evaluation of Osseous Metastasis in Bone Scintigraphy”

    Seminars in Nuclear Medicine 45(3) (2015)

  2. Guest Editorial

    Seminars in Nuclear Medicine 45(2):98 (2015) PMID 25704382

  3. Biology of Hypoxia

    Seminars in Nuclear Medicine 45(2) (2015) PMID 25704383

    There is an important and strong, but complex influence of the tumor microenvironment on tumor cells’ phenotype, aggressiveness and treatment sensitivity. One of the most frequent and best studied aspects of the tumor microenvironment is hypoxia. Low oxygen tension often occurs in tumo...
  4. Editorial: Hypoxia Imaging in Nuclear Medicine

    Seminars in Nuclear Medicine 45(2):97 (2015) PMID 25704381

  5. Evaluation of Hypoxia with Cu-ATSM

    Seminars in Nuclear Medicine 45(2) (2015) PMID 25704389 PMCID PMC4339100

    Imaging of hypoxia is important in many diseases states in oncology, cardiology and neurology. The radiopharmaceutical, copper labelled diacetyl-bis(N-methylthiosemicarbazone) (Cu-ATSM), has been used to assess hypoxia in many studies. In particular, Cu-ATSM has been used in oncologic ...
  6. The Clinical Significance of Hypoxia in Human Cancers

    Seminars in Nuclear Medicine 45(2):110 (2015) PMID 25704384

    Hypoxia is present to some extent in most solid malignant human cancers because of an imbalance between the limited oxygen delivery capacity of the abnormal vasculature and the high oxygen consumption of tumor cells. This drives a complex and dynamic compensatory response to enable con...
  7. Optimizing Hypoxia Detection and Treatment Strategies

    Seminars in Nuclear Medicine 45(2) (2015) PMID 25704388 PMCID PMC4365940

    Clinical studies using Eppendorf® needle sensors have invariably documented the resistance of hypoxic human tumors to therapy. These studies first documented the need for individual patient measurement of hypoxia, since hypoxia varied from tumor-to-tumor. Furthermore, hypoxia in sarcom...
  8. The Chemistry and Radiochemistry of Hypoxia-Specific, Radiohalogenated Nitroaromatic Imaging Probes

    Seminars in Nuclear Medicine 45(2) (2015) PMID 25704385

    Hypoxia is prevalent in many solid tumors. Hypoxic tumors tend to exhibit rapid growth and aberrant vasculature, which lead to oxygen (O2) depletion and impaired drug delivery. The reductive environment in hypoxic tumors alters cellular metabolism, which can trigger transcriptional res...
  9. F18 fluoromisonidazole for imaging tumor hypoxia: Imaging the microenvironment for personalized Cancer therapy

    Seminars in Nuclear Medicine 45(2) (2015) PMID 25704387 PMCID PMC4339212

    Hypoxia in solid tumors is one of the seminal mechanisms for developing aggressive trait and treatment resistsance in solid tumors. This evolutionarily conserved biological mechanism along with de-repression of cellular functions in cancer, although resulting in many challenges, provid...
  10. Hypoxia imaging in gliomas with 18F-Fluoromisonidazole PET: Towards clinical translation

    Seminars in Nuclear Medicine 45(2) (2015)

    There is significant interest in the development of improved image-guided therapy for neuro-oncology applications. Glioblastomas in particular present a considerable challenge because of their pervasive nature, propensity for recurrence and resistance to conventional therapies. MRI is ...