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Seminars in Nuclear Medicine

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  1. Erratum to “Evaluation of Osseous Metastasis in Bone Scintigraphy”[Seminars in Nuclear Medicine (2015) 3–15]

    Seminars in Nuclear Medicine 45(3):266 (2015)

  2. Biology of Hypoxia

    Seminars in Nuclear Medicine 45(2) (2015) PMID 25704383

    There is an important and strong, but complex influence of the tumor microenvironment on tumor cells’ phenotype, aggressiveness and treatment sensitivity. One of the most frequent and best studied aspects of the tumor microenvironment is hypoxia. Low oxygen tension often occurs in tumo...
  3. The Clinical Significance of Hypoxia in Human Cancers

    Seminars in Nuclear Medicine 45(2) (2015) PMID 25704384

    Hypoxia is present to some extent in most solid malignant human cancers because of an imbalance between the limited oxygen delivery capacity of the abnormal vasculature and the high oxygen consumption of tumor cells. This drives a complex and dynamic compensatory response to enable con...
  4. The Chemistry and Radiochemistry of Hypoxia-Specific, Radiohalogenated Nitroaromatic Imaging Probes

    Seminars in Nuclear Medicine 45(2) (2015) PMID 25704385

    Hypoxia is prevalent in many solid tumors. Hypoxic tumors tend to exhibit rapid growth and aberrant vasculature, which lead to oxygen (O2) depletion and impaired drug delivery. The reductive environment in hypoxic tumors alters cellular metabolism, which can trigger transcriptional res...
  5. Evaluation of Hypoxia With Copper-Labeled Diacetyl-bis(N-Methylthiosemicarbazone)

    Seminars in Nuclear Medicine 45(2):177 (2015) PMID 25704389 PMCID PMC4339100

    Imaging of hypoxia is important in many diseases states in oncology, cardiology, and neurology. The radiopharmaceutical, copper-labeled diacetyl-bis(N-methylthiosemicarbazone), has been used to assess hypoxia in many studies. In particular, copper-labeled diacetyl-bis(N-methylthiosemic...
  6. Altered biodistribution of bone seeking radiopharmaceuticals (Jan 2015 Seminars in Nuclear Medicine)

    Seminars in Nuclear Medicine 45(1) (2015) PMID 25475381

    Bone scintigraphy has remained a mainstay of clinical nuclear medicine for over 4 decades. An extensive medical literature has developed surrounding the etiology and significance of alterations in distribution of bone radiopharmaceuticals. Altered biodistribution may be of a global nat...
  7. Radionuclide Therapy for Osseous Metastases in Prostate Cancer

    Seminars in Nuclear Medicine 45(1):66 (2015) PMID 25475380

    Bone metastases are associated with increased morbidity and poor prognosis in castration-resistant prostate cancer. Since 2010, 5 systemic therapies for metastatic castration-resistant prostate cancer have been approved by the US Food and Drug Administration based on an improvement in ...
  8. Editorial

    Seminars in Nuclear Medicine (2015)

  9. Radiation Dose Concerns for the Pregnant or Lactating Patient

    Seminars in Nuclear Medicine 44(6):479 (2014) PMID 25362237

    This article discusses issues regarding administration of radiopharmaceuticals to pregnant women or nursing mothers. Uncertainties in calculated dose estimates and possible biological effects on the unborn child are presented. Models and dose estimates for pregnant women at several sta...
  10. Subject Index
    Author(s) unavailable

    Seminars in Nuclear Medicine 44(6):e3 (2014)