Seminars in Nuclear Medicine
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Novel methods and tracers for breast cancer imaging.
We review herein novel tracers in breast cancer including steroidal endocrine tracers, 16α-[(18)F]fluoro-17β-estradiol (FES) to measure tumor estrogen receptor density and function and 21-(18)F-fluoro-16α,17α-[(R)-(1'-α-furylmethylidene)dioxy]-19-norpregn-4-ene-3,20-dione (FFNP) to assay tumor proge...
The IAEA technical cooperation programme and nuclear medicine in the developing world: objectives, trends, and contributions.
The International Atomic Energy Agency's technical cooperation (TC) programme helps Member States in the developing world with limited infrastructure and human resource capacity to harness the potential of nuclear technologies in meeting socioeconomic development challenges. As a part of its human h...
Peptides and receptors in image-guided therapy: theranostics for neuroendocrine neoplasms.
We move toward personalized medicine, the diagnostic information obtained from PET/CT must be improved, that is, by fast routine quantification of lesions. PRRNT is highly effective for the treatment of NENs, even in very advanced cases, and lends a benefit in overall survival of several years. In a...
Thyroid Stunning: Fact or Fiction?
We present the data from both sides of the debate in an attempt to highlight the strengths and deficiencies in the investigations cited. Clinical, animal, and in vitro studies are included. There are considerable differences in clinical practice, such as the administered activity for diagnostic whol...
PET/CT Imaging and Radioimmunotherapy of Prostate Cancer.
Prostate cancer is a common cancer in men and continues to be a major health problem. Imaging plays an important role in the clinical management of patients with prostate cancer. An important goal for prostate cancer imaging is more accurate disease characterization through the synthesis of anatomic...
Genomic biomarkers for molecular imaging: predicting the future.
We and others have designed, synthesized, and evaluated some novel probes specific for those oncogenes and oncogene product biomarkers for PET and SPECT molecular imaging of certain types of cancers. This article briefly describes this approach and gives specific examples that depict the ability of...
Interventional Nuclear Brain Imaging
Interventional nuclear brain imaging incorporates a variety of radiopharmaceutical techniques to enhance the functional assessment of the central nervous system. Many interventional nuclear brain imaging techniques initially were used in research protocols. In recent years, however, these same chall...
The Role of Multidetector Computed Tomography Angiography for the Diagnosis of Pulmonary Embolism
We are likely to see further technical developments in CT technology in the near future. These advances will most likely further improve image quality. Several questions or issues remain, including strategies for further imaging when CT is inconclusive or contraindicated, issues regarding radiation...
State of the Art in Nuclear Medicine Dose Assessment
We show how to implement them in currently available dose calculational models. Current practice of the use of internal emitters in therapy also is briefly presented here. Some of the future challenges for dose assessment in nuclear medicine are discussed, including application of patient-specific d...
Single-Photon Emission Computed Tomography and Positron Emission Tomography Evaluations of Patients With Central Motor Disorders
Neuroimaging biomarkers in movement disorders during the past decade have served as diagnostic agents (Europe), tools for evaluation of novel therapeutics, and a powerful means for describing pathophysiology by revealing in vivo changes at different stages of disease and within the course of an indi...