Seminars in Nuclear Medicine
- Print ISSN
- Electronic ISSN
- Impact factor
- Usage rank
- Article count
- Free count
- Free percentage
- PDFs via platforms
- Gale, Sciencedirect from 1971, Proquest, and CSA
There is an important and strong, but complex influence of the tumor microenvironment on tumor cells’ phenotype, aggressiveness and treatment sensitivity. One of the most frequent and best studied aspects of the tumor microenvironment is hypoxia. Low oxygen tension often occurs in tumo...
Imaging of hypoxia is important in many diseases states in oncology, cardiology and neurology. The radiopharmaceutical, copper labelled diacetyl-bis(N-methylthiosemicarbazone) (Cu-ATSM), has been used to assess hypoxia in many studies. In particular, Cu-ATSM has been used in oncologic ...
Hypoxia is present to some extent in most solid malignant human cancers because of an imbalance between the limited oxygen delivery capacity of the abnormal vasculature and the high oxygen consumption of tumor cells. This drives a complex and dynamic compensatory response to enable con...
Clinical studies using Eppendorf® needle sensors have invariably documented the resistance of hypoxic human tumors to therapy. These studies first documented the need for individual patient measurement of hypoxia, since hypoxia varied from tumor-to-tumor. Furthermore, hypoxia in sarcom...
Hypoxia is prevalent in many solid tumors. Hypoxic tumors tend to exhibit rapid growth and aberrant vasculature, which lead to oxygen (O2) depletion and impaired drug delivery. The reductive environment in hypoxic tumors alters cellular metabolism, which can trigger transcriptional res...
Hypoxia in solid tumors is one of the seminal mechanisms for developing aggressive trait and treatment resistsance in solid tumors. This evolutionarily conserved biological mechanism along with de-repression of cellular functions in cancer, although resulting in many challenges, provid...
There is significant interest in the development of improved image-guided therapy for neuro-oncology applications. Glioblastomas in particular present a considerable challenge because of their pervasive nature, propensity for recurrence and resistance to conventional therapies. MRI is ...