Seminars in Nuclear Medicine
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The Clinical Significance of Hypoxia in Human Cancers
Hypoxia is present to some extent in most solid malignant human cancers because of an imbalance between the limited oxygen delivery capacity of the abnormal vasculature and the high oxygen consumption of tumor cells. This drives a complex and dynamic compensatory response to enable continu...
Perspectives in molecular imaging through translational research, human medicine, and veterinary medicine.
The concept of molecular imaging has taken off over the past 15 years to the point of the renaming of the Society of Nuclear Medicine (Society of Nuclear Medicine and Molecular Imaging) and Journals (European Journal of Nuclear Medicine and Molecular Imaging) and offering of medical fellowships spec...
PET/CT imaging of inflammatory bowel disease.
PET/CT imaging has become an important part of the evaluation of patients with many types of cancer. This imaging modality can also be used to image areas of active inflammation, such as those occurring in patients with active inflammatory bowel disease (IBD) (Crohn's disease and ulcerative colitis)...
Letter from the editors.
Letter from the editors: positron emission tomography radiopharmaceuticals-current status.
In Memoriam: Alexander Gottschalk, MD (1932-2010)
V/Q SPECT: utility for investigation of pulmonary physiology.
Single-photon emission computed tomography (SPECT) is being increasingly used as a tool in respiratory research, in particular ventilation SPECT. Much of the basic understanding of pulmonary physiology has been derived from inhaled radioactive inert gases because, as the lung behaves in an asymmetri...
Introduction to clinical decision making.
We need better "thinking tools" to help us handle the flow of information. The term "clinical decision making" is used to describe a systematic way to handle data and algorithms to decide on a best course of action. This introductory article discusses some of the problems in establishing a decision...
Physiology and pathophysiology of incidental findings detected on FDG-PET scintigraphy.
A routine feature of positron emission tomography/computed tomography (PET/CT) imaging is whole-body acquisition that results in many unexpected findings identified outside of the primary region of abnormality. Furthermore, (18)F-fluorodeoxyglucose (FDG) is a marker of glycolysis and does not specif...
Dose intensified molecular targeted radiotherapy for cancer-lymphoma as a paradigm.
Although most patients with locoregional cancer are cured by surgery, radiotherapy, chemotherapy, and combinations thereof, those with distant metastases are not despite systemic chemotherapy. These patients respond to local radiotherapy but generally need systemic therapy. Non-Hodgkin's lymphoma (N...