Acta poloniae pharmaceutica
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Kinetics of degradation of imidapril hydrochloride in finished dosage formulations.
This study investigates the impact of relative air humidity and temperature on the stability of imidapril hydrochloride (IMD) tablets. For this purpose the forced degradation test was used and the following environmental conditions were employed: RH = 76.4% and the temperature range of 313 - 333 K....
Compounded preparations with nystatin for oral and oromucosal administration.
Therapy of oral, esophageal and gastrointestinal candidiasis is still a common problem that can be solved by an administration of antimycotics. Major disadvantage of registered commercial antifungal medicinal products is their price, so the health care system and its payers may profit from extempora...
The analysis of plant-based raw materials of unknown origin.
Chosen aspects of the safety of use of several herbs received from National Medicines Institute, which came from smuggling, have been examined. The analysis has been conducted in three different aspects: (1) Possibilities of contamination of plant-based raw materials by metals of heavy elements (As,...
Plant phenolics as drug leads -- what is missing?
We have selected and surveyed this particular class of secondary metabolites, which shares high chemical reactivity with intrinsic biocompatibility and affinity for variety of molecular targets gained through evolution, because their suitability as prospective lead compounds for medicinal chemistry...
Oseltamivir analog with boron cluster modulator.
Synthesis of novel neuraminidase inhibitor -- carborane ester of oseltamivir carboxylic acid is described, and its physicochemical and spectral characteristics is provided. Surprisingly, carborane analog of oseltamivir is of an order of magnitude less active than its precursor, the corresponding eth...
Individual medication management system (IMMS) as a proposition of obeying the doctor's recommendation with pharmacist cooperation.
The pharmacist is an expert with the knowledge of drugs, who has a possibility to follow the patient's individual pharmacotherapy, which is the basis of the pharmaceutical care programme. The implementation of the Individual Medication Management System (IMMS) may be one of the propo...
Monitoring of NSAIDs adverse effects based on spontaneous reports from Wrocław regional adverse drug reactions monitoring center.
The mechanism of action of non-steroidal anti-inflammatory drugs (NSAIDs) in majority of cases is responsible for adverse reactions of these therapeutic agents. Obtaining post-registration information on adverse drug reactions (ADRs) by means of the Yellow Card System is a significan...
An overview for various aspects of multifaceted, health care Tecomella undulata Seem. plant.
Quercetin ameliorates bisphenol A-induced toxicity in mice.
Self-emulsifying oils for ocular drug delivery. II. In vitro release of indomethacin and hydrocortisone.
The objective of this study was to compare the in vitro release of indomethacin and hydrocortisone from self-emulsifying drug delivery systems (SEDDS) and aqueous or oily suspensions. SEDDS carriers were obtained by dissolving Cremophor EL, Tween 20 or Span 80 in Miglyol oil. The rel...