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Analytical chemistry

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  1. Detection of fluoroquinolone antibiotics in milk via a labeless immunoassay based upon an alternating current impedance protocol.

    Analytical chemistry 80(23):9233 (2008) PMID 19551988

    This paper describes the construction of a labeless immunosensor for the antibiotic ciprofloxacin in milk and its interrogation using an ac impedance protocol. Commercial screen-printed carbon electrodes were used as the basis for the sensor. Polyaniline was electrodeposited onto the sensors and...
  2. Evaluating low-intensity unknown signals in quantitative proton NMR mixture analysis.

    Analytical chemistry 80(23):8956 (2008) PMID 19551928

    Analytical analyses of highly complex mixtures, such as biofluids or liquid food products, often give rise to signals for unknown compounds, particularly for compounds at low concentration. Here we compare two conventional chemometric approaches for NMR spectral analysis ("spectral binning" and ...
  3. Identification of viruses using microfluidic protein profiling and Bayesian classification.

    Analytical chemistry 80(23):9005 (2008) PMID 19551975

    We present a rapid method for the identification of viruses using microfluidic chip gel electrophoresis (CGE) of high-copy number proteins to generate unique protein profiles. Viral proteins are solubilized by heating at 95 degrees C in borate buffer containing detergent (5 min), then labeled wi...
  4. Profiling and imaging of lipids on brain and liver tissue by matrix-assisted laser desorption/ ionization mass spectrometry using 2-mercaptobenzothiazole as a matrix.

    Analytical chemistry 80(23):9105 (2008) PMID 18959430

    2-Mercaptobenzothiazole (MBT) is employed for the first time as a matrix for the analysis of lipids from tissue extracts using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. We demonstrate that the performance of MBT is superior to that of the matrixes commonly emp...
  5. Electrochemical DNA biosensor based on nanoporous gold electrode and multifunctional encoded DNA-Au bio bar codes.

    Analytical chemistry 80(23):9124 (2008) PMID 19551936

    A sensitive electrochemical DNA sensor based on nanoporous gold (NPG) electrode and multifunctional encoded Au nanoparticle (AuNP) was developed. The NPG electrode was prepared with a simple dealloying strategy, by which silver was dissoluted from silver/gold alloys in nitric acid, making the ac...
  6. Oligopeptides as mimic of acetylcholinesterase: from the rational design to the application in solid-phase extraction for pesticides.

    Analytical chemistry 80(23):9150 (2008) PMID 19551938

    Three different peptides (His-Glu-Pro-Ser, His-Gly-Ser-Ala and Glu-Pro-Ser-Ala) were selected and tested to be used as affinity binding receptors for organophosphate and carbamate pesticides. The peptides were rationally designed by mimicking acetylcholinesterase active site. The simulated bindi...
  7. Nitroavidin as a ligand for the surface capture and release of biotinylated proteins.

    Analytical chemistry 80(23):9336 (2008) PMID 19551994

    Discussed here is the preparation, detailed purification, and evaluation of nitroavidin as a ligand for surface capture and release of biotinylated proteins. Avidin from chicken egg white was nitrated using dilute tetranitromethane solutions. UV-vis spectroscopy was used to show decreased bindin...
  8. Instance based algorithm for posterior probability calculation by target-decoy strategy to improve protein identifications.

    Analytical chemistry 80(23):9326 (2008) PMID 19551949

    The target-decoy database search strategy is often applied to determine the global false-discovery rate (FDR) of peptide identifications in proteome research. However, the confidence of individual peptide identification is typically not determined. In this study, we introduced an approach for th...
  9. Single-cell chemical lysis method for analyses of intracellular molecules using an array of picoliter-scale microwells.

    Analytical chemistry 80(23):9141 (2008) PMID 19551983

    Analyzing the intracellular contents and enzymatic activities of single cells is important for studying the physiological and pathological activities at the cellular level. For this purpose, we developed a simple single-cell lysis method by using a dense array of microwells of 10-30-pL volume fa...
  10. Microwave-induced combustion coupled to flame furnace atomic absorption spectrometry for determination of cadmium and lead in botanical samples.

    Analytical chemistry 80(23):9369 (2008) PMID 19551997

    A procedure based on microwave-induced combustion coupled to flame furnace (FF) atomic absorption spectrometry (FF-AAS) was used for analysis of solid samples. Botanical samples were prepared as pellets and introduced into a quartz holder device. This device was fitted to a glass chamber that wa...