Analytical chemistry

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  1. Oligopeptides as mimic of acetylcholinesterase: from the rational design to the application in solid-phase extraction for pesticides.

    Analytical chemistry 80(23):9150 (2008) PMID 19551938

    Three different peptides (His-Glu-Pro-Ser, His-Gly-Ser-Ala and Glu-Pro-Ser-Ala) were selected and tested to be used as affinity binding receptors for organophosphate and carbamate pesticides. The peptides were rationally designed by mimicking acetylcholinesterase active site. The simulated bindi...
  2. Integration of microdialysis sampling and microchip electrophoresis with electrochemical detection.

    Analytical chemistry 80(23):9257 (2008) PMID 19551945 PMCID PMC2771943

    Here we describe the fabrication, optimization, and application of a microfluidic device that integrates microdialysis (MD) sampling, microchip electrophoresis (ME), and electrochemical detection (EC). The manner in which the chip is produced is reproducible and enables the fixed alignment of th...
  3. Single-cell chemical lysis method for analyses of intracellular molecules using an array of picoliter-scale microwells.

    Analytical chemistry 80(23):9141 (2008) PMID 19551983

    Analyzing the intracellular contents and enzymatic activities of single cells is important for studying the physiological and pathological activities at the cellular level. For this purpose, we developed a simple single-cell lysis method by using a dense array of microwells of 10-30-pL volume fa...
  4. Obtaining Nernstian response of a Ca(2+)-selective electrode in a broad concentration range by tuned galvanostatic polarization.

    Analytical chemistry 80(23):9181 (2008) PMID 19551940

    Linear Nernstian response is obtained for a neutral ionophore-based Ca(2+)-selective electrode down to 10(-10) M CaCl2 by means of galvanostatic polarization. The densities of the applied cathodic current were tuned for particular concentrations of Ca2+. The procedure included recording the pote...
  5. Impedance biosensor for peanut protein Ara h 1.

    Analytical chemistry 80(23):9157 (2008) PMID 19551984

    A reagentless electrochemical impedance biosensor for detection of peanut protein Ara h 1, one of the allergenic proteins found in peanuts, has been demonstrated using an Au substrate onto which an antibody film has been immobilized. Following initial stabilization of the self-assembled monolaye...
  6. Analysis of hybrid silica materials with the aid of conventional NMR and GC/MS.

    Analytical chemistry 80(23):9355 (2008) PMID 19551951

    Two simple and straightforward procedures for determining the organic content of hybrid silica materials by means of conventional NMR and GC/MS techniques are described. The methods involve dissolving the hybrid material either in a concentrated solution of sodium hydroxide in deuterated water c...
  7. Determination of pesticide residues in fruit-based soft drinks.

    Analytical chemistry 80(23):8966 (2008) PMID 19551973

    Here we report the first worldwide reconnaissance study of the presence and occurrence of pesticides in fruit-based soft drinks. While there are strict regulations and exhaustive controls for pesticides in fruits, vegetables, and drinking water, scarce attention has been paid to highly consumed ...
  8. Development of a selective ESI-MS derivatization reagent: synthesis and optimization for the analysis of aldehydes in biological mixtures.

    Analytical chemistry 80(23):9042 (2008) PMID 19551932

    In LC-MS, derivatization is primarily used to improve ionization characteristics, especially for analytes that are not (efficiently) ionized by ESI or APCI such as aldehydes, sugars, and steroids. Derivatization strategies are then directed at the incorporation of a group with a permanent charge...
  9. Effect of sample heterogeneity on the interpretation of QCM(-D) data: comparison of combined quartz crystal microbalance/atomic force microscopy measurements with finite element method modeling.

    Analytical chemistry 80(23):8891 (2008) PMID 18954085

    A quartz crystal microbalance was integrated into an AFM in order to monitor the adsorption of biomolecules to the resonator surface with both atomic force microscopy and microgravimetry. The comparison between the two techniques allows the fractional coverage of the surface, theta, to be correl...
  10. Identification of viruses using microfluidic protein profiling and Bayesian classification.

    Analytical chemistry 80(23):9005 (2008) PMID 19551975

    We present a rapid method for the identification of viruses using microfluidic chip gel electrophoresis (CGE) of high-copy number proteins to generate unique protein profiles. Viral proteins are solubilized by heating at 95 degrees C in borate buffer containing detergent (5 min), then labeled wi...
  11. Application of photonic crystal enhanced fluorescence to a cytokine immunoassay.

    Analytical chemistry 80(23):9013 (2008) PMID 19551930

    Photonic crystal surfaces are demonstrated as a means for enhancing the detection sensitivity and resolution for assays that use a fluorescent tag to quantify the concentration of an analyte protein molecule in a liquid test sample. Computer modeling of the spatial distribution of resonantly cou...
  12. Preparation of alkanethiolate-functionalized core/shell Fe3O4@Au nanoparticles and its interaction with several typical target molecules.

    Analytical chemistry 80(23):9091 (2008) PMID 19551935

    This paper reports the synthesis of alkanethiolate-functionalized core/shell Fe3O4/Au nanoparticles (Fe3O4@Au NPs) that combine the advantages of core/shell magnetic nanoparticles with self-assembled monolayers (SAMs). The alkanethiolates, having carboxylic acid (COOH) and methyl (CH3) terminal ...
  13. Electrochemical immunosensor for detection of celiac disease toxic gliadin in foodstuff.

    Analytical chemistry 80(23):9265 (2008) PMID 19551990

    Celiac disease is a gluten-sensitive enteropathy that affects as much as 1% of the population. Patients with celiac disease should maintain a lifelong gluten-free diet, in order to avoid serious complications and consequences. It is essential to have methods of analysis to reliably control the c...
  14. Biosensor-based screening method for the detection of aflatoxins B1-G1.

    Analytical chemistry 80(23):9250 (2008) PMID 19551989

    Aflatoxins are extremely toxic metabolites from Aspergillus species that can adulterate a wide range of human foodstuff. Herein, we propose a novel assay designed as an analytical test for aflatoxin B1 and G1 (AFB1 and AFG1, respectively) that could represent an alternative screening technique f...
  15. Microwave-induced combustion coupled to flame furnace atomic absorption spectrometry for determination of cadmium and lead in botanical samples.

    Analytical chemistry 80(23):9369 (2008) PMID 19551997

    A procedure based on microwave-induced combustion coupled to flame furnace (FF) atomic absorption spectrometry (FF-AAS) was used for analysis of solid samples. Botanical samples were prepared as pellets and introduced into a quartz holder device. This device was fitted to a glass chamber that wa...
  16. Reversed-phase LC/MS method for polyphosphoinositide analyses: changes in molecular species levels during epidermal growth factor activation in A431 cells.

    Analytical chemistry 80(23):9226 (2008) PMID 19551943

    In studies on lipid metabolomics, liquid chromatography/ mass spectrometry (LC/MS) is a robust and popular technique. Although effective reversed-phase (RP) LC/ MS methods enabling the separation of phospholipid molecular species have been developed, RPLC methods to analyze phosphatidylinositol ...
  17. Urinary metabolite quantification employing 2D NMR spectroscopy.

    Analytical chemistry 80(23):9288 (2008) PMID 19551947

    Two-dimensional (2D) nuclear magnetic resonance (NMR) spectroscopy is a fairly novel method for the quantification of metabolites in biological fluids and tissue extracts. We show in this contribution that, compared to 1D 1H spectra, superior quantification of human urinary metabolites is obtain...
  18. Multiple isotopic labels for quantitative mass spectrometry.

    Analytical chemistry 80(23):9298 (2008) PMID 19551992 PMCID PMC2771887

    Quantitative mass spectrometry is often performed using isotopically labeled samples. Although the 4-trimethylammoniumbutyryl (TMAB) labels have many advantages over other isotopic tags, only two forms have previously been synthesized (i.e., a heavy form containing nine deuteriums and a light fo...
  19. Shedding new light on the molecular architecture of oocytes using a combination of synchrotron Fourier transform-infrared and Raman spectroscopic mapping.

    Analytical chemistry 80(23):9065 (2008) PMID 18983174 PMCID PMC2761072

    Synchrotron Fourier transform-infrared (FT-IR) and Raman microspectroscopy were applied to investigate changes in the molecular architecture of mouse oocytes and demonstrate the overall morphology of the maturing oocyte. Here we show that differences were identified between immature mouse oocyte...
  20. A new dynamic in mass spectral imaging of single biological cells.

    Analytical chemistry 80(23):9058 (2008) PMID 19551933

    Time-of-flight secondary ion mass spectrometry (TOF-SIMS) has unique capabilities in the area of high-resolution mass spectrometric imaging of biological samples. The technique offers parallel detection of native and non-native molecules at physiological concentrations with potentially submicrom...