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Analytical chemistry

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  1. Single-cell copy number analysis of prostate cancer cells captured with geometrically enhanced differential immunocapture microdevices.

    Analytical chemistry 86(22):11013 (2014) PMID 25363873

    We present a one-step controllable chemical extraction of whole nuclei from prostate cancer cells captured using geometrically enhanced differential immunocapture (GEDI) microdevices. We have successfully used copy number profile analysis to differentiate between two unique cancer cell line populati...
  2. Template-oriented genetic algorithm feature selection of analyte wavelets in the Raman spectrum of a complex mixture.

    Analytical chemistry 86(21):10591 (2014) PMID 25260090

    We introduce a fast computational method for feature selection that facilitates the accurate spectral analysis of a chemical species of interest in the presence of overlapping uncorrelated variance. Using a genetic algorithm in a data-driven approach, our method assigns predictors according to a tem...
  3. Creation of libraries of recurring mass spectra from large data sets assisted by a dual-column workflow.

    Analytical chemistry 86(20):10231 (2014) PMID 25233296

    An analytical methodology has been developed for extracting recurrent unidentified spectra (RUS) from large GC/MS data sets. Spectra were first extracted from original data files by the Automated Mass Spectral Deconvolution and Identification System (AMDIS; Stein, S. E. J. Am. Soc. Mass Spectrom. 19...
  4. 1,5-diaminonaphthalene hydrochloride assisted laser desorption/ionization mass spectrometry imaging of small molecules in tissues following ...

    Analytical chemistry 86(20):10114 (2014) PMID 25247713

    Our results suggested that the newly prepared matrix possessed brilliant features including low cost, strong ultraviolet absorption, high salt tolerance capacity, and fewer background signals especially in the low mass range (typically m/z < 500), which permitted us to visualize the spatial distribu...
  5. Ratiometric Two-Photon Fluorescent Probe for Quantitative Detection of β-Galactosidase Activity in Senescent Cells.

    Analytical chemistry 86(20):10001 (2014) PMID 25293957

    We reported a ratiometric two-photon fluorescent probe (SG1) for β-galactosidase (β-gal) and its application to quantitative detection of β-gal activity during cellular senescence in live cells and in aged tissues. This probe is characterized by a significant two-photon excited fluorescence, a marke...
  6. Depth Profiling of Element Concentrations in Stratified Materials by Confocal Microbeam X-ray Fluorescence Spectrometry with Polychromatic E...

    Analytical chemistry 86(22):11275 (2014) PMID 25307861

    The confocal microbeam X-ray fluorescence technique is a well-established analytical tool that is widely used for qualitative and quantitative analysis of stratified materials. There are several different reconstruction methods dedicated to this type of samples. However, these methods are applicable...
  7. LipidBlast Templates As Flexible Tools for Creating New in-Silico Tandem Mass Spectral Libraries.

    Analytical chemistry 86(22):11024 (2014) PMID 25340521

    We here show the versatility of in-silico or computer generated tandem mass spectra that are directly obtained from compound structures. We use the freely available LipidBlast development software to generate 15 000 MS/MS spectra of the glucuronosyldiacylglycerol (GlcADG) lipid class, recently disco...
  8. Poly β-Cyclodextrin/TPdye Nanomicelle-based Two-Photon Nanoprobe for Caspase-3 Activation Imaging in Live Cells and Tissues.

    Analytical chemistry 86(22):11440 (2014) PMID 25347212

    We have designed a TPdye/βCDP nanomicelle-based TPA fluorescent nanoconjugate for enzymatic activity assay in biological fluids, live cells and tissues. This sensing system is composed of a trans-4-[p-(N,N-diethylamino)styryl]-N-methylpyridinium iodide (DEASPI)/βCDP nanomicelle as TPA fluorophore an...
  9. Characterization of small protein aggregates and oligomers using size exclusion chromatography with online detection by native electrospray ...

    Analytical chemistry 86(21):10692 (2014) PMID 25310183

    Self-association of proteins is important in a variety of processes ranging from acquisition of native quaternary structure (where the association is tightly controlled and proceeds in a highly ordered fashion) to aggregation and amyloidosis. The latter is frequently accompanied (or indeed triggered...
  10. Credentialing features: a platform to benchmark and optimize untargeted metabolomic methods.

    Analytical chemistry 86(19):9583 (2014) PMID 25160088 PMCID PMC4188275

    We introduce an alternative approach to benchmarking metabolome coverage which relies on mixed Escherichia coli extracts from cells cultured in regular and (13)C-enriched media. After mass spectrometry-based metabolomic analysis of these extracts, we "credential" features arising from E. coli metabo...