Analytical Chemistry (Washington)
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- Gale, Acm, ACS, CSA, Ebscoatoz, Ebsconet, Proquest, and Ebsco
Ratiometric fluorescence probe for monitoring hydroxyl radical in live cells based on gold nanoclusters.
Determination of hydroxyl radical ((•)OH) with high sensitivity and accuracy in live cells is a challenge for evaluating the role that (•)OH plays in the physiological and pathological processes. In this work, a ratiometric fluorescence biosensor for (•)OH was developed, in which gold nanocluster (A...
Quantification of Peptide m/z Distributions from (13)C-Labeled Cultures with High-Resolution Mass Spectrometry.
Isotopic labeling studies of primary metabolism frequently utilize GC/MS to quantify (13)C in protein-hydrolyzed amino acids. During processing some amino acids are degraded, which reduces the size of the measurement set. The advent of high-resolution mass spectrometers provides a tool to assess mol...
Identification and Quantification of Aqueous Aromatic Hydrocarbons Using SH-Surface Acoustic Wave Sensors.
A need exists for compact sensor systems capable of in situ monitoring of groundwater for accidental releases of fuel and oil. The work reported here addresses this need, using shear horizontal surface acoustic wave (SH-SAW) sensors, which function effectively in liquid environments. To achieve enha...
Protein-conjugated quantum dots interface: binding kinetics and label-free lipid detection.
We propose a label-free biosensor platform to investigate the binding kinetics using antigen-antibody interaction via electrochemical and surface plasmon resonance (SPR) techniques. The l-cysteine in situ capped cadmium sulfide (CdS; size < 7 nm) quantum dots (QDs) self-assembled on gold (Au) coated...
Chemical generation of arsane and methylarsanes with amine boranes. Potentialities for nonchromatographic speciation of arsenic.
The efficiency of chemical generation of arsanes from inorganic arsenic, monomethylarsonic acid (MMAA) and dimethylarsinic acid (DMAA), to arsane, AsH3, monomethylarsane, CH3AsH2 (MMA), and dimethylarsane, (CH3)2AsH (DMA), has been investigated in different reaction media with the aim to better eluc...
Monitoring Phosphatidic Acid Formation in Intact Phosphatidylcholine Bilayers upon Phospholipase D Catalysis.
We have monitored the production of the negatively charged lipid, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphatidic acid acid (POPA), in supported lipid bilayers via the enzymatic hydrolysis of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (PC), a zwitterionic lipid. Experiments were performed with...
High-throughput solvent assisted ionization inlet for use in mass spectrometry.
We developed a multiplexed analysis platform providing a simple high-throughput means to characterize solutions. Automated analyses, requiring less than 5 s per sample without carryover and 1 s per sample, accepting minor cross contamination, was achieved using multiplexed solvent assisted ionizatio...
Investigation of Gender-Specific Exhaled Breath Volatome in Humans by GCxGC-TOF-MS.
We profiled the exhaled breath (∼450 mL) volatile organic compounds (VOCs) of 47 healthy volunteers (age: 19-47; 23 male (M) and 24 female (F)) using a multidimensional gas chromatography and mass spectrometry and employed chemometric analysis to identify gender-specific VOCs. Eleven exhaled breath...
Highly Flexible UV-Vis Radiation Sources and Novel Detection Schemes for Spectrophotometric HPLC Detection.
The concept and performance of the first multiwavelength deep UV light-emitting-diode-based high-performance liquid chromatography (HPLC) absorbance detector are presented. In single-wavelength mode and with optical reference, the limit of detection (LOD) is comparable to conventional state-of-the-a...