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Analytical Chemistry (Washington)

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  1. Behavior and Determination of Titanium Dioxide Nanoparticles in Nitric Acid and River Water by ICP Spectrometry.

    Analytical Chemistry (Washington) 86(7):3453 (2014) PMID 24575712

    ICP spectrometry (ICPMS, ICPOES) are classical techniques for the determination of solubilized or suspended elements. Unfortunately, their relevance for nanoparticles at low concentration (below 10 ppm) is rarely called into question, even if literature reports are not always coherent. This work is...
  2. Effects of Calibration Approaches on the Accuracy for LC-MS Targeted Quantification of Therapeutic Protein.

    Analytical Chemistry (Washington) 86(7):3575 (2014) PMID 24611550

    We performed a well-controlled and systematic comparative study using quantification of monoclonal-antibody in plasma as the model system. Method development utilized a high-throughput orthogonal-array-optimization, and two sensitive and stable signature-peptides (SP) from different domains were sel...
  3. Suppression of Apparent Fluid Flow in Capillary Isotachophoresis without Recourse to Capillary Coating.

    Analytical Chemistry (Washington) 86(7):3317 (2014) PMID 24624887

    This manuscript describes a new analytical methodology that allows one to stop the apparent fluid flow in uncoated fused silica capillaries. This method, which requires neither capillary coating nor buffer additive, is based on the use of a 22% polyethylene oxide gel which is placed at the anodic en...
  4. Turn-On Fluorescence Sensor for Intracellular Imaging of Glutathione Using g-C3N4 Nanosheet-MnO2 Sandwich Nanocomposite.

    Analytical Chemistry (Washington) 86(7):3426 (2014) PMID 24655132

    We demonstrate a facile one-step approach for the synthesis of a g-C3N4 nanosheet-MnO2 sandwich nanocomposite for the first time. The fluorescence of g-C3N4 nanosheet in this nanocomposite is quenched, which attributing to fluorescence resonance energy transfer (FRET) from a g-C3N4 nanosheet to the...
  5. Metabolic Analysis of Striatal Tissues from Parkinson's Disease-like Rats by Electrospray Ionization Ion Mobility Mass Spectrometry.

    Analytical Chemistry (Washington) 86(6):3075 (2014) PMID 24548008

    Electrospray ionization ion mobility mass spectrometry (ESI-IMMS) was used to study the striatal metabolomes in a Parkinson's like disease (PD-like) rat model. Striatal tissue samples from Berlin Druckrey IV (BD-IV) with PD-like disease 20 dpn-affected and 15 dpn-affected rats (dpn: days postnatal)...
  6. Site-Specific Characterization of d-Amino Acid Containing Peptide Epimers by Ion Mobility Spectrometry.

    Analytical Chemistry (Washington) 86(6):2972 (2014) PMID 24328107

    We developed a novel site-specific strategy to rapidly and precisely localize d-amino acids in peptides by ion mobility spectrometry (IMS) analysis of mass spectrometry (MS)-generated epimeric fragment ions. Briefly, the d/l-peptide epimers were separated by online reversed-phase liquid chromatograp...
  7. Mini 12, miniature mass spectrometer for clinical and other applications-introduction and characterization.

    Analytical Chemistry (Washington) 86(6):2909 (2014) PMID 24521423

    A benchtop miniature mass spectrometer system, Mini 12, with ambient ionization source and tandem mass spectrometry capabilities has been developed and characterized. This instrument was developed as a self-contained system to produce quantitative results for unprocessed samples of small volumes inc...
  8. Small molecule-initiated light-activated semiconducting polymer dots: an integrated nanoplatform for targeted photodynamic therapy and imagi...

    Analytical Chemistry (Washington) 86(6):3092 (2014) PMID 24552272

    We prepared an integrated nanoplatform for targeted PDT and imaging of cancer cells using folic acid and horseradish peroxidase (HRP)-bifunctionalized semiconducting polymer dots (FH-Pdots). In the FH-Pdots, meta-tetra(hydroxyphenyl)-chlorin (m-THPC) was used as photosensitizer to produce cytotoxic...
  9. Analysis of protein interactions with picomolar binding affinity by fluorescence-detected sedimentation velocity.

    Analytical Chemistry (Washington) 86(6):3181 (2014) PMID 24552356

    We present a new approach for the study of high-affinity interactions using fluorescence detected sedimentation velocity analytical ultracentrifugation (FDS-SV). Taking full advantage of the large data sets in FDS-SV by direct boundary modeling with sedimentation coefficient distributions c(s), we d...
  10. Digital Encoding of Cellular mRNAs Enabling Precise and Absolute Gene Expression Measurement by Single-Molecule Counting.

    Analytical Chemistry (Washington) 86(6):2867 (2014) PMID 24579851

    We present a new approach for the sensitive detection and accurate quantitation of messenger ribonucleic acid (mRNA) gene transcripts in single cells. First, the entire population of mRNAs is encoded with molecular barcodes during reverse transcription. After amplification of the gene targets of int...