Analytical Chemistry (Washington)
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- Gale, Acm, ACS, CSA, Ebscoatoz, Ebsconet, Proquest, and Ebsco
Dating human bone: is racemization dating species-specific?
Our recently developed dating technique based on the racemization rate of aspartic acid was applied to dating human bone, as well as that of other mammals, utilizing capillary electrophoresis mass spectrometry. First, several well-dated (mostly (14)C-dated and with strong archeological evidence) hum...
Multiplexed Target Detection Using DNA-Binding Dye Chemistry in Droplet Digital PCR.
We described the first droplet digital PCR (ddPCR) system aimed at empowering all researchers with a tool that removes the substantial uncertainties associated with using the analogue standard, quantitative real-time PCR (qPCR). This system enabled TaqMan hydrolysis probe-based assays for the absolu...
In Situ Synthesis of MIL-100(Fe) in the Capillary Column for Capillary Electrochromatographic Separation of Small Organic Molecules.
We report an in situ, layer-by-layer self-assembly approach to fabricate MIL-100(Fe) coated open tubular (OT) capillary columns for capillary electrochromatography. By a controllable manner, the OT capillary columns with a tailored MIL-100(Fe) coating have been successfully synthesized. The results...
Bioluminescent probes to analyze ligand-induced phosphatidylinositol 3,4,5-trisphosphate production with split luciferase complementation.
We describe a novel method for the analysis of relative PIP3 amount based on spontaneous complementation of split luciferase fragments. An N-terminal fragment of a luciferase was located on the plasma membrane (LucN-pm). A C-terminal fragment of a luciferase fused with PIP3 binding units, pleckstrin...
Hydrodynamic chromatography coupled with single particle-inductively coupled plasma mass spectrometry for investigating nanoparticles agglom...
We used online coupling of two promising complementary sizing techniques: hydrodynamic chromatography (HDC) and single-particle ICPMS analysis to analyze gold nanoparticles agglomerated under controlled conditions. We used the single-particle mode of the ICPMS detector to detect single particles elu...
Direct Quantitation of Methyl Phosphonate Adducts to Human Serum Butyrylcholinesterase by Immunomagnetic-UHPLC-MS/MS.
Hydrolysis of G- and V-series organophosphorus nerve agents (OPNAs) containing a phosphorus-methyl bond yields a methylphosphonic acid (MeP) product when adducted to human butyrylcholinesterase (BChE). The MeP adduct is considered a sign of "aging" and results in loss of the o-alkyl identifier speci...
Stable DNA aggregation by removal of counterions.
We investigated whether removal of counterions from the strongly bound counterion layer would elicit any novel DNA properties or behaviors. In order to remove the tightly bound counterions, we used dialysis against deionized water in the presence of a strong (0.6 kV/cm) electric field. The electric...
Microfluidic biosensor for monitoring temporal variations of hemorheological and hemodynamic properties using an extracorporeal rat bypass l...
We propose a novel microfluidic biosensor for monitoring hemorheological and hemodynamic properties using an extracorporeal rat bypass loop. To monitor temporal variations of biophysical properties including viscosity, flow rate, and pressure of rat blood, a complex fluidic network is established by...
Development of a pretreatment system for the analysis of atmospheric reduced sulfur compounds.
A new pretreatment system was used to evaluate a technology to analyze reduced sulfur compounds (RSCs). To conduct this research, a self-developed custom dryer (Desolvator) and a thermal desorber system (TDS) were installed in the front of GC/PFPD. The syringe pump inside the TDS was devised in such...
Novel analytical methods for flame retardants and plasticizers based on gas chromatography, comprehensive two-dimensional gas chromatography...
We assess the applicability of different analytical techniques, namely, direct probe (DP), gas chromatography (GC), and comprehensive two-dimensional gas chromatography (GC × GC) coupled to atmospheric pressure chemical ionization (APCI) with a high resolution (HR)-time-of-flight (TOF)-mass spectrom...