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Infant's bilobar thyroid agenesis and mother's I-131 accidental administration.
We reported a case of female hospital staff who received I-131 accidently during (10-12th gestational weeks) and after her pregnancy. The absorbed dose to fetus was higher than 30mGy. At birth, the infant was found to have no thyroid. It was speculated that the fetal thyroid agenesis may be related...
Clinical audit concerning the quality of management in patients with classic form of congenital adrenal hyperplasia.
We had tested our professional practices. All patients aged more than 18 years with classic CAH of the adult endocrine units in the Nancy's University Hospital Center. We have made a clinical audit. We checked all medical records to see whether the recommendation were applied or not between the last...
Pituitary endocrine cell networks - 10 years and beyond.
We have shown that endocrine cells are homotypically organized into three-dimensional networks. In addition, using multicellular calcium imaging combined with online/real-time measures of hormone secretion, we have demonstrated that these networks play a crucial role in hormone release by integratin...
[Abstracts of the 28th Congress of the French Endocrinology Society. Clermont-Ferrand, France. October 10-13, 2011].
Primary bilateral adrenal lymphoma revealed by hemophagocytic syndrome.
We report a case of a 69-year-old woman who had a diffuse large B-cell lymphoma associated with hemophagocytic syndrome. The abdominal imaging reveals the existence of bilateral adrenal hypertrophy. A CT scan-guided biopsy concluded to a diffuse large B-cell lymphoma CD 20-positive associated EBV. T...
HLA-DRB1/DQB1 susceptibility for autoimmune polyglandular syndrome type II and III in south of Tunisia.
The aim of our study was to investigate the association of HLA-DRB1 and HLA-DQB1 alleles with autoimmune polyglandular syndromes (APS) type II and III in a southern Tunisian population. Sixty-two unrelated patients with APSII (n=20) and APSIII (n=42) and 146 healthy controls were genotyped for HLA c...
Lethal acute demyelinization with encephalo-myelitis as a complication of cured Cushing's disease.
We report for the first time a 34-year old woman with a psychiatric background, who developed four months after the surgical cure of Cushing's disease an acute disseminated encephalomyelitis (ADEM) presenting initially as a psychiatric illness. We hypothesize that the recent correction of hypercorti...
[Place of pelvic ultrasonography using transabdominal technique in the investigation of premature ovarian failure].
The detection of the two ovaries by ultrasound was positive in 33 patients; only one ovary was identified in seven patients; none was noted in 40 patients. The surface of the ovaries ranged between 0.74 et 5.92cm(2) (2.2+/-1.13cm(2)). Ultrasonography identified follicles in 23 patients (28.75%). The...
Clinical genetics of Kallmann syndrome.
The Kallmann syndrome (KS) combines hypogonadotropic hypogonadism (HH) with anosmia. This is a clinically and genetically heterogeneous disease. KAL1, encoding the extracellular glycoprotein anosmin-1, is responsible for the X chromosome-linked recessive form of the disease (KAL1). Mutations in FGFR...