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Genetic alterations explaining the clinical variability of prolactinomas still could not be clarified and dopamine D2 receptor (DRD2) polymorphism is a putative candidate for the variable response to dopaminergic treatment. The present study was conducted to investigate the influence of DRD2 Taq...
Studies based on Chinese populations reported that inconsistent results were found on the association of ApoE gene polymorphisms with type 2 diabetic nephropathy (T2DN). Therefore, we performed this meta-analysis to provide a reliable evaluation of the associations between ApoE gene polymorphism...
Growth hormone deficiency affects roughly between one in 3000 and one in 4000 children with most instances of growth hormone deficiency being idiopathic. Growth hormone deficiency can also be associated with genetic diseases or chromosome abnormalities. Association of growth hormone deficiency t...
Hypophysitis is a rare pathology. As clinical symptoms and radiologic signs are non-specific, the diagnostic is difficult. Hypophysitis's pathogenesis remains obscure but new histological and etiological variants have recently been reported. Primary hypophysitis is the main form. For the first t...
Over the last two decades, surgery for primary hyperparathyroidism has evolved to offer a panel of procedures based on improvements in imaging, new technology and, consequently, novel surgical techniques. Multiple courses of action are possible, consistent with varying degrees of complexity. Fro...
The aim of this study was to evaluate thyroid volume in women with prolactinoma and investigate the relationship between anabolic hormones [insulin, insulin like growth factor (IGF-1), estrogen] and thyroid volume in the patients. Sixty-three euthyroid women with prolactinoma and 60 healthy euth...
Aberrant circulating adipokines are considered to be related to the pathological mechanism of polycystic ovary syndrome (PCOS). This study aims to evaluate the relationship between plasma omentin-1 levels, metabolic and hormonal parameters in the setting of non-obese Chinese women with PCOS. Thi...
For at least 30 years, cancer has been defined as a genetic disease and explained by the so-called somatic mutation theory (SMT), which has dominated the carcinogenesis field. Criticism of the SMT has recently greatly increased, although still not enough to force all SMT supporters to ...
Parmi les familles de protéines des génomes d’invertébrés et de vertébrés, les récepteurs couplés aux protéines G (RCPGs) sont sans aucun doute les plus versatiles. Leur adaptation a permis la génération d’un grand nombre de récepteurs responsables de la reconnaissance et de l’action d...
Le diabète de type 2 (DT2) est une maladie métabolique associant une insulino-résistance et une sécrétion insuffisante d’insuline par les cellules bêta du pancréas. C’est une maladie multifactorielle dépendant à la fois d’une prédisposition génétique et environnementale. De façon surpr...