Annals of Clinical Biochemistry

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0004-5632
Electronic ISSN
1758-1001
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http://acb.rsmjournals.com
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Article count
4177
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6
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0.00143644
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  1. Salivary steroid assays - research or routine?

    Annals of Clinical Biochemistry 46(Pt 3):183 (2009) PMID 19176642

    Salivary concentrations of unconjugated steroids reflect those for free steroids in serum although concentrations may differ because of salivary gland metabolism. Samples for salivary steroid analysis are stable for up to 7 days at room temperature, one month or more at 4 degrees C and three mon...
  2. A monoclonal protein identified by an anomalous lipaemia index.

    Annals of Clinical Biochemistry 46(Pt 3):250 (2009) PMID 19261678

    We describe a patient being investigated for anaemia where the lipaemia index on a Beckman Coulter DxC800 analyser was markedly elevated and out of keeping with the visual appearance of the serum. Subsequent investigation revealed a monoclonal IgM kappa immunoglobulin with type I cryoglobulin be...
  3. Two cases of antiruthenium antibody interference in Modular free thyroxine assay.

    Annals of Clinical Biochemistry 46(Pt 3):263 (2009) PMID 19261677

  4. A worldwide multicentre comparison of assays for cerebrospinal fluid biomarkers in Alzheimer's disease.

    Annals of Clinical Biochemistry 46(Pt 3):235 (2009) PMID 19342441

    Different cerebrospinal fluid (CSF) amyloid-beta 1-42 (Abeta(1-42)), total Tau (Tau) and Tau phosphorylated at threonine 181 (P-Tau) levels are reported, but currently there is a lack of quality control programmes. The aim of this study was to compare the measurements of these CSF biomarkers, be...
  5. A prospective study of causes of haemolysis during venepuncture: tourniquet time should be kept to a minimum.

    Annals of Clinical Biochemistry 46(Pt 3):244 (2009) PMID 19389888

    Haemolysis is defined as the release of cellular components of erythrocytes and other blood cells into the extracellular space of blood. These cellular components can cause interference in laboratory measurements, potassium being a commonly measured analyte to be affected. A number of factors ha...
  6. Detection of haemolysis and reporting of potassium results in samples from neonates.

    Annals of Clinical Biochemistry 46(Pt 3):222 (2009) PMID 19261676

    In vitro haemolysis is a common occurrence in clinical laboratories and causes a spurious increase in potassium. In the past, haemolysis was sought by visual inspection but is now commonly detected by automated measurement of the haemolytic index (HI). This study compared detection of haemolysis...
  7. Ischaemia-modified albumin in dilated cardiomyopathy.

    Annals of Clinical Biochemistry 46(Pt 3):241 (2009) PMID 19389887

    Biomarkers of myocardial necrosis may be increased in patients with chronic heart failure. We investigated whether ischaemia-modified albumin (IMA), a marker of ischaemia, is also elevated in patients with compensated heart failure, due to dilated cardiomyopathy (DCM). We studied 42 patients wit...
  8. Reference change values: the way forward in monitoring.

    Annals of Clinical Biochemistry 46(Pt 3):264 (2009) PMID 19264828

  9. Stress cardiomyopathy - a unique presentation of diabetic ketoacidosis.

    Annals of Clinical Biochemistry 46(Pt 3):257 (2009) PMID 19307252

    We have documented a unique instance of diabetic ketoacidosis (DKA)-induced stress-related cardiomyopathy (CMP) in a 46-yr-old Caucasian female with type I diabetes mellitus. In times of stress, tissues with high capacity for aerobic metabolism, like myocardium, can preferentially change their m...
  10. Salivary steroid assays: still awaiting a killer application.

    Annals of Clinical Biochemistry 46(Pt 3):181 (2009) PMID 19389883

  11. A simple automated solid-phase extraction procedure for measurement of 25-hydroxyvitamin D3 and D2 by liquid chromatography-tandem mass spectrometry.

    Annals of Clinical Biochemistry 46(Pt 3):226 (2009) PMID 19389886

    Measurement of 25-hydroxyvitamin D(3) (25OHD(3)) and D(2) (25OHD(2)) is challenging. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods have been described but they are often complex and difficult to automate. We have developed a simplified procedure involving an automated solid-p...
  12. The mean and the biological variation of insulin resistance does not differ between polycystic ovary syndrome and type 2 diabetes.

    Annals of Clinical Biochemistry 46(Pt 3):218 (2009) PMID 19389885

    There is an assumption that the mean and biological variation of insulin resistance (IR) is less in polycystic ovary syndrome (PCOS), and intuitively higher in type 2 diabetes (T2DM). To test this hypothesis we compared the mean and biological variation in IR in PCOS to that of T2DM and to age- ...
  13. Incorrect use of ratios in commercial assay kit instructions.

    Annals of Clinical Biochemistry 46(Pt 3):262 (2009) PMID 19176645

  14. Clinical biochemistry of assisted conception.

    Annals of Clinical Biochemistry 46(Pt 3):197 (2009) PMID 19261675

    Assisted reproductive technology has shown rapid advancement since the birth of the first 'test-tube' baby in Oldham, UK, in 1978. Since April 2005, women between the ages of 23 and 39, who meet the described eligibility criteria, are able to get one free in vitro fertilization cycle funded by t...
  15. Controlled study on folate status following folic acid supplementation and discontinuation in women of child-bearing age.

    Annals of Clinical Biochemistry 46(Pt 3):231 (2009) PMID 19342442

    To decrease the incidence of neural tube defects, active efforts are currently undertaken to promote folic acid (FA) intake among women. In 2003, the Food and Drug Administration approved the proposal of introducing an oral contraceptive (OC) and FA combination pill. It is unknown whether these ...
  16. A study of the relationship between albuminuria, proteinuria and urinary reagent strips.

    Annals of Clinical Biochemistry 46(Pt 3):247 (2009) PMID 19264826

    The aims of this study were to examine the relationship between proteinuria and albuminuria and to assess the equivalence between the albumin to creatinine ratio (ACR) and the protein to creatinine ratio (PCR) at the cut-offs recommended by the National Institute for Health and Clinical Excellen...
  17. New onset of heterophilic antibody interference in prostate-specific antigen measurement occurring during the period of post-prostatectomy prostate-specific antigen monitoring.

    Annals of Clinical Biochemistry 46(Pt 3):253 (2009) PMID 19264827

    Laboratories evaluated whether an interference was causing a false-positive PSA for the Immulite 2000 immunoassay after a time course of increasing prostate-specific antigen (PSA) in a post-prostatectomy patient led to salvage therapy, which had no effect on the elevated PSA. Serial dilutions of...
  18. How should proteinuria be detected and measured?

    Annals of Clinical Biochemistry 46(Pt 3):205 (2009) PMID 19389884

    Proteinuria is a classic sign of kidney disease and its presence carries powerful prognostic information. Although proteinuria testing is enshrined in clinical practice guidelines, there is surprising variation among such guidelines as to the definition of clinically significant proteinuria. The...
  19. Measuring salivary cortisol with the Architect i2000 random access analyser.

    Annals of Clinical Biochemistry 46(Pt 3):261 (2009) PMID 19225025

  20. Evaluation of the particle gel diffusion technique for the detection of haemoglobin S in Sudanese patients.

    Annals of Clinical Biochemistry 46(Pt 2):114 (2009) PMID 19164340

    Sickle cell disease is a heterogenous disorder characterized by an abnormal haemoglobin and sickling phenomena of red cells. It is prevalent among certain nomadic tribes in Sudan. Painful, aplastic and haemolytic crises mark sickle cell anaemia. Haemoglobin S (HbS) is detected using haemoglobin ...