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Annals of Clinical Biochemistry

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  1. Salivary steroid assays - research or routine?

    Annals of Clinical Biochemistry 46(Pt 3):183 (2009) PMID 19176642

    Salivary concentrations of unconjugated steroids reflect those for free steroids in serum although concentrations may differ because of salivary gland metabolism. Samples for salivary steroid analysis are stable for up to 7 days at room temperature, one month or more at 4 degrees C and three mon...
  2. Two cases of antiruthenium antibody interference in Modular free thyroxine assay.

    Annals of Clinical Biochemistry 46(Pt 3):263 (2009) PMID 19261677

  3. Ischaemia-modified albumin in dilated cardiomyopathy.

    Annals of Clinical Biochemistry 46(Pt 3):241 (2009) PMID 19389887

    Biomarkers of myocardial necrosis may be increased in patients with chronic heart failure. We investigated whether ischaemia-modified albumin (IMA), a marker of ischaemia, is also elevated in patients with compensated heart failure, due to dilated cardiomyopathy (DCM). We studied 42 patients wit...
  4. How should proteinuria be detected and measured?

    Annals of Clinical Biochemistry 46(Pt 3):205 (2009) PMID 19389884

    Proteinuria is a classic sign of kidney disease and its presence carries powerful prognostic information. Although proteinuria testing is enshrined in clinical practice guidelines, there is surprising variation among such guidelines as to the definition of clinically significant proteinuria. The...
  5. A study of the relationship between albuminuria, proteinuria and urinary reagent strips.

    Annals of Clinical Biochemistry 46(Pt 3):247 (2009) PMID 19264826

    The aims of this study were to examine the relationship between proteinuria and albuminuria and to assess the equivalence between the albumin to creatinine ratio (ACR) and the protein to creatinine ratio (PCR) at the cut-offs recommended by the National Institute for Health and Clinical Excellen...
  6. A worldwide multicentre comparison of assays for cerebrospinal fluid biomarkers in Alzheimer's disease.

    Annals of Clinical Biochemistry 46(Pt 3):235 (2009) PMID 19342441

    Different cerebrospinal fluid (CSF) amyloid-beta 1-42 (Abeta(1-42)), total Tau (Tau) and Tau phosphorylated at threonine 181 (P-Tau) levels are reported, but currently there is a lack of quality control programmes. The aim of this study was to compare the measurements of these CSF biomarkers, be...
  7. The mean and the biological variation of insulin resistance does not differ between polycystic ovary syndrome and type 2 diabetes.

    Annals of Clinical Biochemistry 46(Pt 3):218 (2009) PMID 19389885

    There is an assumption that the mean and biological variation of insulin resistance (IR) is less in polycystic ovary syndrome (PCOS), and intuitively higher in type 2 diabetes (T2DM). To test this hypothesis we compared the mean and biological variation in IR in PCOS to that of T2DM and to age- ...
  8. A monoclonal protein identified by an anomalous lipaemia index.

    Annals of Clinical Biochemistry 46(Pt 3):250 (2009) PMID 19261678

    We describe a patient being investigated for anaemia where the lipaemia index on a Beckman Coulter DxC800 analyser was markedly elevated and out of keeping with the visual appearance of the serum. Subsequent investigation revealed a monoclonal IgM kappa immunoglobulin with type I cryoglobulin be...
  9. Salivary steroid assays: still awaiting a killer application.

    Annals of Clinical Biochemistry 46(Pt 3):181 (2009) PMID 19389883

  10. Stress cardiomyopathy - a unique presentation of diabetic ketoacidosis.

    Annals of Clinical Biochemistry 46(Pt 3):257 (2009) PMID 19307252

    We have documented a unique instance of diabetic ketoacidosis (DKA)-induced stress-related cardiomyopathy (CMP) in a 46-yr-old Caucasian female with type I diabetes mellitus. In times of stress, tissues with high capacity for aerobic metabolism, like myocardium, can preferentially change their m...