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Annals of Clinical Biochemistry

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  1. Salivary steroid assays - research or routine?

    Annals of Clinical Biochemistry 46(Pt 3):183 (2009) PMID 19176642

    Salivary concentrations of unconjugated steroids reflect those for free steroids in serum although concentrations may differ because of salivary gland metabolism. Samples for salivary steroid analysis are stable for up to 7 days at room temperature, one month or more at 4 degrees C and three mon...
  2. A monoclonal protein identified by an anomalous lipaemia index.

    Annals of Clinical Biochemistry 46(Pt 3):250 (2009) PMID 19261678

    We describe a patient being investigated for anaemia where the lipaemia index on a Beckman Coulter DxC800 analyser was markedly elevated and out of keeping with the visual appearance of the serum. Subsequent investigation revealed a monoclonal IgM kappa immunoglobulin with type I cryoglobulin be...
  3. Two cases of antiruthenium antibody interference in Modular free thyroxine assay.

    Annals of Clinical Biochemistry 46(Pt 3):263 (2009) PMID 19261677

  4. A worldwide multicentre comparison of assays for cerebrospinal fluid biomarkers in Alzheimer's disease.

    Annals of Clinical Biochemistry 46(Pt 3):235 (2009) PMID 19342441

    Different cerebrospinal fluid (CSF) amyloid-beta 1-42 (Abeta(1-42)), total Tau (Tau) and Tau phosphorylated at threonine 181 (P-Tau) levels are reported, but currently there is a lack of quality control programmes. The aim of this study was to compare the measurements of these CSF biomarkers, be...
  5. A prospective study of causes of haemolysis during venepuncture: tourniquet time should be kept to a minimum.

    Annals of Clinical Biochemistry 46(Pt 3):244 (2009) PMID 19389888

    Haemolysis is defined as the release of cellular components of erythrocytes and other blood cells into the extracellular space of blood. These cellular components can cause interference in laboratory measurements, potassium being a commonly measured analyte to be affected. A number of factors ha...
  6. Detection of haemolysis and reporting of potassium results in samples from neonates.

    Annals of Clinical Biochemistry 46(Pt 3):222 (2009) PMID 19261676

    In vitro haemolysis is a common occurrence in clinical laboratories and causes a spurious increase in potassium. In the past, haemolysis was sought by visual inspection but is now commonly detected by automated measurement of the haemolytic index (HI). This study compared detection of haemolysis...
  7. Ischaemia-modified albumin in dilated cardiomyopathy.

    Annals of Clinical Biochemistry 46(Pt 3):241 (2009) PMID 19389887

    Biomarkers of myocardial necrosis may be increased in patients with chronic heart failure. We investigated whether ischaemia-modified albumin (IMA), a marker of ischaemia, is also elevated in patients with compensated heart failure, due to dilated cardiomyopathy (DCM). We studied 42 patients wit...
  8. Reference change values: the way forward in monitoring.

    Annals of Clinical Biochemistry 46(Pt 3):264 (2009) PMID 19264828

  9. Stress cardiomyopathy - a unique presentation of diabetic ketoacidosis.

    Annals of Clinical Biochemistry 46(Pt 3):257 (2009) PMID 19307252

    We have documented a unique instance of diabetic ketoacidosis (DKA)-induced stress-related cardiomyopathy (CMP) in a 46-yr-old Caucasian female with type I diabetes mellitus. In times of stress, tissues with high capacity for aerobic metabolism, like myocardium, can preferentially change their m...
  10. Salivary steroid assays: still awaiting a killer application.

    Annals of Clinical Biochemistry 46(Pt 3):181 (2009) PMID 19389883