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Distal regulation of heme binding of heme oxygenase-1 mediated by conformational fluctuations.
We characterized conformational dynamics of HO-1 using NMR to elucidate the mechanism by which HO-1 recognizes heme. NMR relaxation experiments showed that the heme-binding site in heme-free HO-1 fluctuates in concert with a surface-exposed loop and transiently forms a partially unfolded structure....
Dynamic asymmetry and the role of the conserved active-site thiol in rabbit muscle creatine kinase.
Symmetric and asymmetric crystal structures of the apo and transition state analogue forms, respectively, of the dimeric rabbit muscle creatine kinase have invoked an "induced fit" explanation for asymmetry between the two subunits and their active sites. However, previously reported thiol reactivit...
The Cys-Tyr Cross-Link of Cysteine Dioxygenase Changes the Optimal pH of the Reaction without a Structural Change.
We have investigated its role in catalysis through a combined crystallographic and kinetic approach. The C93G variant lacks the cross-link and shows little change in structure from that of the wild type, suggesting that the cross-link does not stabilize an otherwise unfavorable conformation. A pH-de...
Molecular Basis of Peptide Recognition in Metallopeptidase Dug1p from Saccharomyces cerevisiae.
We report the crystal structure of Dug1p at 2.55 Å resolution in complex with a Gly-Cys dipeptide and two Zn(2+) ions. The dipeptide is trapped in the tunnel-like active site; its C-terminus is held by residues at the S1' binding pocket, whereas the S1 pocket coordinates Zn(2+) ions and the N-termin...
Avian synaptopodin 2 (fesselin) stabilizes myosin filaments and actomyosin in the presence of ATP.
These results support the view that one role of fesselin is to organize contractile units of myosin and actin....
Correction to Redox Potential and Peroxide Reactivity of Human Peroxiredoxin 3.
Crystal Structures of Human Δ4-3-Ketosteroid 5β-Reductase (AKR1D1) Reveal the Presence of an Alternative Binding Site Responsible for Substr...
Proteolytic activation of recombinant pro-memapsin 2 (Pro-beta-secretase) studied with new fluorogenic substrates
Characterization of the heme and pyridoxal phosphate cofactors of human cystathionine beta-synthase reveals nonequivalent active sites
The Molecular Biology of Hepatitis Delta Virus
Biochemistry (Washington) 64:259 (1995)