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Ligand Recognition Specificity of Leukocyte Integrin αMβ2 (Mac-1, CD11b/CD18) and Its Functional Consequences.
We know little about how and why αMβ2 binds its multiple ligands. Within αMβ2, the αMI-domain is responsible for integrin's multiligand binding properties. To identify its recognition motif, we screened peptide libraries spanning sequences of many known protein ligands for αMI-domain binding and als...
Insights into the structure of intrastrand cross-link DNA lesion-containing oligonucleotides: g[8-5m]T and g[8-5]C from molecular dynamics s...
We propose the use of explicit solvent molecular dynamics simulations to build up damaged oligonucleotides containing two intrastrand cross-link defects, namely, the guanine-thymine and guanine-cytosine defects. Each of these lesions, G[8-5m]T and G[8-5]C, is placed in the middle of a dodecameric se...
Nucleotide contributions to the structural integrity and DNA replication initiation activity of noncoding y RNA.
We provide a structure-function analysis of this essential RNA domain under physiological conditions. Solution state nuclear magnetic resonance and far-ultraviolet circular dichroism spectroscopy show that the upper stem domain of human Y1 RNA adopts a locally destabilized A-form helical structure i...
Avian synaptopodin 2 (fesselin) stabilizes myosin filaments and actomyosin in the presence of ATP.
These results support the view that one role of fesselin is to organize contractile units of myosin and actin....
Correction to Redox Potential and Peroxide Reactivity of Human Peroxiredoxin 3.
Crystal Structures of Human Δ4-3-Ketosteroid 5β-Reductase (AKR1D1) Reveal the Presence of an Alternative Binding Site Responsible for Substr...
Proteolytic activation of recombinant pro-memapsin 2 (Pro-beta-secretase) studied with new fluorogenic substrates
Characterization of the heme and pyridoxal phosphate cofactors of human cystathionine beta-synthase reveals nonequivalent active sites
The Molecular Biology of Hepatitis Delta Virus
Biochemistry (Washington) 64:259 (1995)
Site-Directed Mutagenesis and Functional Analysis of the Active-Site Residues of the E2 Component of Bovine Branched-Chain .alpha.-Keto Acid...