Biochimica et Biophysica Acta

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  1. Mass spectrometric analysis of host cell proteins interacting with dengue virus nonstructural protein 1 in dengue virus-infected HepG2 cells.

    Biochimica et Biophysica Acta 1864(9):1270 (2016) PMID 27108190

    Dengue virus (DENV) infection is a leading cause of the mosquito-borne infectious diseases that affect humans worldwide. Virus-host interactions appear to play significant roles in DENV replication and the pathogenesis of DENV infection. Nonstructural protein 1 (NS1) of DENV is likely involved i...
  2. Reduced and mutant lysozyme refolding with lipid vesicles. Model study of disulfide impact on equilibria and dynamics.

    Biochimica et Biophysica Acta 1864(9):1083 (2016) PMID 27240304

    The recovery of secondary structure in disordered, disulfide-reduced hen egg white lysozyme (HEWL) upon interaction with lipid vesicles was studied using circular dichroism (CD), fluorescence and infrared (IR) spectroscopic techniques. Lipid vesicles having negative head groups, such as DMPG, in...
  3. Prediction of change in protein unfolding rates upon point mutations in two state proteins.

    Biochimica et Biophysica Acta 1864(9):1104 (2016) PMID 27264959

    Studies on protein unfolding rates are limited and challenging due to the complexity of unfolding mechanism and the larger dynamic range of the experimental data. Though attempts have been made to predict unfolding rates using protein sequence-structure information there is no available method f...
  4. Integrin-mediated transactivation of P2X7R via hemichannel-dependent ATP release stimulates astrocyte migration.

    Biochimica et Biophysica Acta 1863(9):2175 (2016) PMID 27235833

    Our previous reports indicate that ligand-induced αVβ3 integrin and Syndecan-4 engagement increases focal adhesion formation and migration of astrocytes. Additionally, ligated integrins trigger ATP release through unknown mechanisms, activating P2X7 receptors (P2X7R), and the uptake of Ca(2+) to...
  5. Prostaglandin EP2 receptor signaling protects human trabecular meshwork cells from apoptosis induced by ER stress through down-regulation of p53.

    Biochimica et Biophysica Acta 1863(9):2322 (2016) PMID 27321910

    E-prostanoid receptor subtype 2 (EP2) agonists are currently under clinical development as hypotensive agents for the treatment of ocular hypertension. However, the effects of EP2 receptor agonists on trabecular meshwork (TM) alterations leading to primary open-angle glaucoma (POAG) are still un...
  6. Effects of G6PD activity inhibition on the viability, ROS generation and mechanical properties of cervical cancer cells.

    Biochimica et Biophysica Acta 1863(9):2245 (2016) PMID 27217331

    Glucose-6-phosphate dehydrogenase (G6PD) deficiency has been revealed to be involved in the efficacy to anti-cancer therapy but the mechanism remains unclear. We aimed to investigate the anti-cancer mechanism of G6PD deficiency. In our study, dehydroepiandrosterone (DHEA) and shRNA technology we...
  7. The glucagon-like peptide-1 analogue exendin-4 reverses impaired intracellular Ca(2+) signalling in steatotic hepatocytes.

    Biochimica et Biophysica Acta 1863(9):2135 (2016) PMID 27178543

    The release of Ca(2+) from the endoplasmic reticulum (ER) and subsequent replenishment of ER Ca(2+) by Ca(2+) entry through store-operated Ca(2+) channels (SOCE) play critical roles in the regulation of liver metabolism by adrenaline, glucagon and other hormones. Both ER Ca(2+) release and Ca(2+...
  8. Insert, remove or replace: A highly advanced genome editing system using CRISPR/Cas9.

    Biochimica et Biophysica Acta 1863(9):2333 (2016) PMID 27350235

    The clustered, regularly interspaced, short palindromic repeat (CRISPR) and CRISPR associated protein 9 (Cas9) system discovered as an adaptive immunity mechanism in prokaryotes has emerged as the most popular tool for the precise alterations of the genomes of diverse species. CRISPR/Cas9 system...
  9. Terminal regions of β-catenin are critical for regulating its adhesion and transcription functions.

    Biochimica et Biophysica Acta 1863(9):2345 (2016) PMID 27368802

    β-Catenin, the central molecule of canonical Wnt signaling pathway, has multiple binding partners and performs many roles in the cell. Apart from being a transcriptional activator, β-catenin acts as a crucial effector component of cadherin/catenin complex to physically interact with actin cytosk...
  10. Tetracycline-loaded calcium phosphate nanoparticle (Tet-CPNP): Rejuvenation of an obsolete antibiotic to further action.

    Biochimica et Biophysica Acta 1860(9):1929 (2016) PMID 27288585

    Increasing resistance in bacteria towards antibiotics has made it imperative to research on their revitalization to combat infectious diseases. This study dealt with synthesis of a nano-form of the antibiotic tetracycline, its characterization and potency of killing different multi-drug resistan...
  11. Disruption of the human COQ5-containing protein complex is associated with diminished coenzyme Q10 levels under two different conditions of mitochondrial energy deficiency.

    Biochimica et Biophysica Acta 1860(9):1864 (2016) PMID 27155576

    The Coq protein complex assembled from several Coq proteins is critical for coenzyme Q6 (CoQ6) biosynthesis in yeast. Secondary CoQ10 deficiency is associated with mitochondrial DNA (mtDNA) mutations in patients. We previously demonstrated that carbonyl cyanide-p-trifluoromethoxyphenylhydrazone ...
  12. Manganese ion concentration affects production of human core 3 O-glycan in Saccharomyces cerevisiae.

    Biochimica et Biophysica Acta 1860(9):1809 (2016) PMID 27259834

    Production of various mucin-like glycoproteins could be useful for development of antibodies specific to disease-related glycoproteins as well as for the biosynthesis of clinically useful glycoproteins. A Saccharomyces cerevisiae strain capable of in vivo production of mucin-type core 1 structur...
  13. Bacoside-A, an anti-amyloid natural substance, inhibits membrane disruption by the amyloidogenic determinant of prion protein through accelerating fibril formation.

    Biochimica et Biophysica Acta 1858(9):2208 (2016) PMID 27365272

    Bacosides, class of compounds extracted from the Bacopa monniera plant, exhibit interesting therapeutic properties, particularly enhancing cognitive functions and putative anti-amyloid activity. We show that bacoside-A exerted significant effects upon fibrillation and membrane interactions of th...
  14. Mechanisms and metabolic regulation of PPARα activation in Nile tilapia (Oreochromis niloticus).

    Biochimica et Biophysica Acta 1861(9 Pt A):1036 (2016) PMID 27320014

    Although the key metabolic regulatory functions of mammalian peroxisome proliferator-activated receptor α (PPARα) have been thoroughly studied, the molecular mechanisms and metabolic regulation of PPARα activation in fish are less known. In the first part of the present study, Nile tilapia (Nt)P...
  15. Effect of preduodenal lipase inhibition in suckling rats on dietary octanoic acid (C8:0) gastric absorption and plasma octanoylated ghrelin concentration.

    Biochimica et Biophysica Acta 1861(9 Pt A):1111 (2016) PMID 27317984

    Part of medium chain fatty acids (MCFAs) coming from dietary triglycerides (TGs) can be directly absorbed through the gastric mucosa after the action of preduodenal lipase (lingual lipase in the rat). MCFA gastric absorption, particularly that of octanoic acid (C8:0), may have a physiological im...
  16. Resolvin D1 protects the liver from ischemia/reperfusion injury by enhancing M2 macrophage polarization and efferocytosis.

    Biochimica et Biophysica Acta 1861(9 Pt A):1025 (2016) PMID 27317426

    Resolution of inflammation is an active process involving a novel category of lipid factors known as specialized pro-resolving lipid mediators, which includes Resolvin D1 (RvD1). While accumulating evidence suggests that RvD1 counteracts proinflammatory signaling and promotes resolution, the spe...
  17. Whole-body DHA synthesis-secretion kinetics from plasma eicosapentaenoic acid and alpha-linolenic acid in the free-living rat.

    Biochimica et Biophysica Acta 1861(9 Pt A):997 (2016) PMID 27263420

    Whole body docosahexaenoic acid (DHA, 22:6n-3) synthesis from α-linolenic acid (ALA, 18:3n-3) is considered to be very low, however, the daily synthesis-secretion of DHA may be sufficient to supply the adult brain. The current study aims to assess whether whole body DHA synthesis-secretion kinet...
  18. Inflammatory intracellular pathways activated by electronegative LDL in monocytes.

    Biochimica et Biophysica Acta 1861(9 Pt A):963 (2016) PMID 27235719

    Electronegative LDL (LDL(-)) is a plasma LDL subfraction that induces cytokine release in monocytes through toll-like receptor 4 (TLR4) activation. However, the intracellular pathways induced by LDL(-) downstream TLR4 activation are unknown. We aimed to identify the pathways activated by LDL(-) ...
  19. Does a methionine-to-norleucine substitution in PGLa influence peptide-membrane interactions?

    Biochimica et Biophysica Acta 1858(9):2019 (2016) PMID 27267703

    Yes. To understand the molecular mechanisms of amphiphilic membrane-active peptides, it is essential to study their interactions with lipid bilayers under near-native conditions. Amino acid composition largely determines the non-specific properties of peptides, on the basis of the physicochemica...
  20. Protein architecture and core residues in unwound α-helices provide insights to the transport function of plant AtCHX17.

    Biochimica et Biophysica Acta 1858(9):1983 (2016) PMID 27179641

    Using Arabidopsis thaliana AtCHX17 as an example, we combine structural modeling and mutagenesis to provide insights on its protein architecture and transport function which is poorly characterized. This approach is based on the observation that protein structures are significantly more conserve...