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Biochimica et Biophysica Acta

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  1. Four Cys residues in heterodimeric 2-oxoacid:ferredoxin oxidoreductase are required for CoA-dependent oxidative decarboxylation but not for ...

    Biochimica et Biophysica Acta 1844(4):736 (2014) PMID 24491525

    Heterodimeric 2-oxoacid:ferredoxin oxidoreductase (OFOR) from Sulfolobus tokodaii (StOFOR) has only one [4Fe-4S](2+) cluster, ligated by 4 Cys residues, C12, C15, C46, and C197. The enzyme has no other Cys. To elucidate the role of these Cys residues in holding of the iron-sulfur cluster in the cour...
  2. Crystal structure of a "loopless" GH19 chitinase in complex with chitin tetrasaccharide spanning the catalytic center.

    Biochimica et Biophysica Acta 1844(4):793 (2014) PMID 24582745

    The structure of a GH19 chitinase from the moss Bryum coronatum (BcChi-A) in complex with the substrate was examined by X-ray crystallography and NMR spectroscopy in solution. The X-ray crystal structure of the inactive mutant of BcChi-A (BcChi-A-E61A) liganded with chitin tetramer (GlcNAc)4 reveale...
  3. TLR2/1 and sphingosine 1-phosphate modulate inflammation, myofibroblast differentiation and cell migration in fibroblasts.

    Biochimica et Biophysica Acta 1841(4):484 (2014) PMID 24440818

    We demonstrate that TLR2 ligation strongly enhances the production of the pro-inflammatory cytokines IL-6 and IL-8. S1P significantly induces pro-inflammatory cytokines time- and concentration-dependently via S1P receptor (S1PR)2 and S1PR3. The TLR2/1 agonist Pam3CSK4 and S1P (>1μM) or TGF-β markedl...
  4. Foreword to 2014 aquaporins special issue.

    Biochimica et Biophysica Acta 1840(5):1466 (2014) PMID 24607310

  5. An antimicrobial helix A-derived peptide of heparin cofactor II blocks endotoxin responses in vivo.

    Biochimica et Biophysica Acta 1838(5):1225 (2014) PMID 24522010

    We describe that the peptide GKS26 (GKSRIQRLNILNAKFAFNLYRVLKDQ), corresponding to the A domain of heparin cofactor II (HCII), ameliorates experimental septic shock. The peptide displays antimicrobial effects through direct membrane disruption, also at physiological salt concentration and in the pres...
  6. Insulin and IGF-I actions on IGF-I receptor in seminiferous tubules from immature rats.

    Biochimica et Biophysica Acta 1838(5):1332 (2014) PMID 24530896

    Insulin and insulin-like growth factor 1 (IGF-I) are capable of activating similar intracellular pathways. Insulin acts mainly through its own receptor, but can also activate the IGF-I receptor (IGF-IR). The aim of this study was to investigate the involvement of the IGF-IR in the effects of insulin...
  7. Exon 9 skipping of apoptotic caspase-2 pre-mRNA is promoted by SRSF3 through interaction with exon 8.

    Biochimica et Biophysica Acta 1839(1):25 (2014) PMID 24321384

    We show that knockdown of SRSF3 (also known as SRp20) with siRNA induced significant increase of endogenous exon 9 inclusion. In addition, overexpression of SRSF3 promoted exon 9 skipping. Thus we conclude that SRSF3 promotes exon 9 skipping. In order to understand the functional target of SRSF3 on...
  8. Targeting epigenetic mediators of gene expression in thoracic malignancies.

    Biochimica et Biophysica Acta (BBA) - Bioenerge... 1819(7):836 (2012) PMID 22507242

    Lung and esophageal cancer and malignant pleural mesotheliomas are highly lethal neoplasms that are leading causes of cancer-related deaths worldwide. Presently, limited information is available pertaining to epigenetic mechanisms mediating initiation and progression of these neoplas...
  9. Overexpression of insulin like growth factor binding protein 5 reduces liver fibrosis in chronic cholangiopathy.

    Biochimica et Biophysica Acta (BBA) - Bioenerge... 1822(6):996 (2012) PMID 22434064

    The ATP-binding cassette, sub-family B member 4 knock-out mouse (Abcb4(-/-)) is a relevant model for chronic cholangiopathy in man. Due to the lack of this P-glycoprotein in the canalicular membrane of hepatocytes, the secretion of phospholipids into bile is absent, resulting in incr...
  10. IQGAP2, A candidate tumour suppressor of prostate tumorigenesis.

    Biochimica et Biophysica Acta (BBA) - Bioenerge... 1822(6):875 (2012) PMID 22406297

    We report here that IQGAP2 is a candidate tumour suppressor of prostate cancer (PC). Elevated IQGAP2 was detected in prostatic intraepithelial neoplasia (PIN), early stages of PCs (Gleason score ≤3), and androgen-dependent LNCaP PC cells. However, IQGAP2 was expressed at substantially reduced leve...