Biochimica et Biophysica Acta

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  1. Mass spectrometry-based identification of allergens from Curvularia pallescens, a prevalent aerospore in India.

    Biochimica et Biophysica Acta 1864(7):869 (2016) PMID 27003473

    The worldwide prevalence of fungal allergy in recent years has augmented mining allergens from yet unexplored ones. Curvularia pallescens (CP) being a dominant aerospore in India and a major sensitiser on a wide range of allergic population, pose a serious threat to human health. Therefore, we a...
  2. Quantitative proteomic analysis of mice corneal tissues reveals angiogenesis-related proteins involved in corneal neovascularization.

    Biochimica et Biophysica Acta 1864(7):787 (2016) PMID 27049463

    Corneal neovascularization (CNV) was induced in Balb/c mice by alkali burns in the central area of the cornea with a diameter of 2.5mm. After fourteen days, the cornea from one eye was collected for histological staining for CNV examination, while the cornea from the other eye of the same mouse ...
  3. Liprotides made of α-lactalbumin and cis fatty acids form core-shell and multi-layer structures with a common membrane-targeting mechanism.

    Biochimica et Biophysica Acta 1864(7):847 (2016) PMID 27068540

    α-Lactalbumin (aLA) has been shown to form complexes with oleic acid (OA), which may target cancer cells. We recently showed that aLA and several other proteins all form protein-OA complexes called liprotides with a generic structure consisting of a micellar OA core surrounded by a shell of part...
  4. The promiscuous phosphomonoestearase activity of Archaeoglobus fulgidus CopA, a thermophilic Cu(+) transport ATPase.

    Biochimica et Biophysica Acta 1858(7 Pt A):1471 (2016) PMID 27086711

    Membrane transport P-type ATPases display two characteristic enzymatic activities: a principal ATPase activity provides the driving force for ion transport across biological membranes, whereas a promiscuous secondary activity catalyzes the hydrolysis of phosphate monoesters. This last activity i...
  5. Relating structure and internalization for ROMP-based protein mimics.

    Biochimica et Biophysica Acta 1858(7 Pt A):1443 (2016) PMID 27039278

    Elucidating the predominant cellular entry mechanism for protein transduction domains (PTDs) and their synthetic mimics (PTDMs) is a complicated problem that continues to be a significant source of debate in the literature. The PTDMs reported here provide a well-controlled platform to vary molec...
  6. VDAC electronics: 3. VDAC-Creatine kinase-dependent generation of the outer membrane potential in respiring mitochondria.

    Biochimica et Biophysica Acta 1858(7 Pt A):1411 (2016) PMID 27085978

    Mitochondrial energy in cardiac cells has been reported to be channeled into the cytosol through the intermembrane contact sites formed by the adenine nucleotide translocator, creatine kinase and VDAC. Computational analysis performed in this study showed a high probability of the outer membrane...
  7. Cross-talk between macrophages and smooth muscle cells impairs collagen and metalloprotease synthesis and promotes angiogenesis.

    Biochimica et Biophysica Acta 1863(7 Pt A):1568 (2016) PMID 27060293

    Coronary atherosclerosis complicated by plaque disruption and thrombosis is a critical event in myocardial infarction and stroke, the major causes of cardiovascular death. In atherogenesis, macrophages (MAC) and smooth muscle cells (SMC) are key actors; they synthesize matrix components and nume...
  8. Phosphatidylethanolamine binding protein 4 (PEBP4) is a secreted protein and has multiple functions.

    Biochimica et Biophysica Acta 1863(7 Pt A):1682 (2016) PMID 27033522

    Phosphatidylethanolamine binding proteins (PEBP) represent a superfamily of proteins that are conserved from bacteria to humans. In mammals, four members have been identified, PEBP1-4. To determine the functional differences among PEBP1-4 and the underlying mechanism for their actions, we perfor...
  9. Adenosine A2A receptor signaling attenuates LPS-induced pro-inflammatory cytokine formation of mouse macrophages by inducing the expression of DUSP1.

    Biochimica et Biophysica Acta 1863(7 Pt A):1461 (2016) PMID 27066978

    Adenosine is known to reduce inflammation by suppressing the activity of most immune cells. Previous studies have shown that lipopolysaccharide (LPS) stimulated mouse macrophages produce adenosine, and the adenosine A2A receptor (A2AR) signaling activated in an autocrine manner attenuates LPS-in...
  10. PCGF2 negatively regulates arsenic trioxide-induced PML-RARA protein degradation via UBE2I inhibition in NB4 cells.

    Biochimica et Biophysica Acta 1863(7 Pt A):1499 (2016) PMID 27030546

    Arsenic trioxide (ATO) is a therapeutic agent for acute promyelocytic leukemia (APL) which induces PML-RARA protein degradation via enhanced UBE2I-mediated sumoylation. PCGF2, a Polycomb group protein, has been suggested as an anti-SUMO E3 protein by inhibiting the sumoylation of UBE2I substrate...
  11. Retinoic acid regulates Schwann cell migration via NEDD9 induction by transcriptional and post-translational mechanisms.

    Biochimica et Biophysica Acta 1863(7 Pt A):1510 (2016) PMID 27085739

    Schwann cell migration is essential during the regenerative response to nerve injury, however, the factors that regulate this phenomenon are not yet clear. Here we describe that retinoic acid (RA), whose production and signaling activity are greatly enhanced during nerve regeneration, increases ...
  12. Compression regulates gene expression of chondrocytes through HDAC4 nuclear relocation via PP2A-dependent HDAC4 dephosphorylation.

    Biochimica et Biophysica Acta 1863(7 Pt A):1633 (2016) PMID 27106144 PMCID PMC4871159

    Biomechanics plays a critical role in the modulation of chondrocyte function. The mechanisms by which mechanical loading is transduced into intracellular signals that regulate chondrocyte gene expression remain largely unknown. Histone deacetylase 4 (HDAC4) is specifically expressed in chondrocy...
  13. Peripheral membrane proteins: Tying the knot between experiment and computation.

    Biochimica et Biophysica Acta 1858(7 Pt B):1584 (2016) PMID 26903211

    Experimental biology has contributed to answer questions about the morphology of a system and how molecules organize themselves to maintain a healthy functional cell. Single-molecule techniques, optical and magnetic experiments, and fluorescence microscopy have come a long way to probe structura...
  14. Computational and experimental approaches for investigating nanoparticle-based drug delivery systems.

    Biochimica et Biophysica Acta 1858(7 Pt B):1688 (2016) PMID 26930298

    Most therapeutic agents suffer from poor solubility, rapid clearance from the blood stream, a lack of targeting, and often poor translocation ability across cell membranes. Drug/gene delivery systems (DDSs) are capable of overcoming some of these barriers to enhance delivery of drugs to their ri...
  15. Viral channel forming proteins - How to assemble and depolarize lipid membranes in silico.

    Biochimica et Biophysica Acta 1858(7 Pt B):1710 (2016) PMID 26806161

    Viral channel forming proteins (VCPs) have been discovered in the late 70s and are found in many viruses to date. Usually they are small and have to assemble to form channels which depolarize the lipid membrane of the host cells. Structural information is just about to emerge for just some of th...
  16. Decrypting protein insertion through the translocon with free-energy calculations.

    Biochimica et Biophysica Acta 1858(7 Pt B):1663 (2016) PMID 26896694

    Protein insertion into a membrane is a complex process involving numerous players. The most prominent of these players is the Sec translocon complex, a conserved protein-conducting channel present in the cytoplasmic membrane of bacteria and the membrane of the endoplasmic reticulum in eukaryotes...
  17. Developmental proteome dynamics of silk glands in the 5th instar larval stage of Bombyx mori L (CSR2×CSR4).

    Biochimica et Biophysica Acta 1864(7):860 (2016) PMID 27032299

    Bivoltine breed of Bombyx mori (B. mori), CSR2×CSR4 is an Indian high yielding silkworm strain. Silk gland proteome of this strain was not studied till now. Methods of improving silk production by chemical approaches have reached saturation and transgenic methods are needed in further to boost s...
  18. Cold-active alkaline phosphatase is irreversibly transformed into an inactive dimer by low urea concentrations.

    Biochimica et Biophysica Acta 1864(7):755 (2016) PMID 27043172

    Alkaline phosphatase is a homodimeric metallo-hydrolase where both Zn(2+) and Mg(2+) are important for catalysis and stability. Cold-adapted alkaline phosphatase variants have high activity at low temperatures and lower thermal stability compared with variants from mesophilic hosts. The instabil...
  19. MBPpred: Proteome-wide detection of membrane lipid-binding proteins using profile Hidden Markov Models.

    Biochimica et Biophysica Acta 1864(7):747 (2016) PMID 27048983

    A large number of modular domains that exhibit specific lipid binding properties are present in many membrane proteins involved in trafficking and signal transduction. These domains are present in either eukaryotic peripheral membrane or transmembrane proteins and are responsible for the non-cov...
  20. Cellular cholesterol accumulation modulates high fat high sucrose (HFHS) diet-induced ER stress and hepatic inflammasome activation in the development of non-alcoholic steatohepatitis.

    Biochimica et Biophysica Acta 1861(7):594 (2016) PMID 27090939

    Non-alcoholic steatohepatitis (NASH), is the form of non-alcoholic fatty liver disease posing risk to progress into serious long term complications. Human and pre-clinical models implicate cellular cholesterol dysregulation playing important role in its development. Mouse model studies suggest s...