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Biochimica et Biophysica Acta

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  1. HDAC6 inhibition induces mitochondrial fusion, autophagic flux and reduces diffuse mutant huntingtin in striatal neurons.

    Biochimica et Biophysica Acta 1852(11):2484 (2015) PMID 26300485

    Striatal neurons are vulnerable to Huntington's disease (HD). Decreased levels of acetylated alpha-tubulin and impaired mitochondrial dynamics, such as reduced motility and excessive fission, are associated with HD; however, it remains unclear whether and how these factors might contribute to th...
  2. Eps15 homology domain containing protein of Plasmodium falciparum (PfEHD) associates with endocytosis and vesicular trafficking towards neutral lipid storage site.

    Biochimica et Biophysica Acta 1853(11 Pt A):2856 (2015) PMID 26284889

    The human malaria parasite, Plasmodium falciparum, takes up numerous host cytosolic components and exogenous nutrients through endocytosis during the intra-erythrocytic stages. Eps15 homology domain-containing proteins (EHDs) are conserved NTPases, which are implicated in membrane remodeling and...
  3. Fe65 negatively regulates Jagged1 signaling by decreasing Jagged1 protein stability through the E3 ligase Neuralized-like 1.

    Biochimica et Biophysica Acta 1853(11 Pt A):2918 (2015) PMID 26276215

    Fe65 is a highly conserved adaptor protein that interacts with several binding partners. Fe65 binds proteins to mediate various cellular processes. But the interacting partner and the regulatory mechanisms controlled by Fe65 are largely unknown. In this study, we found that Fe65 interacts with t...
  4. Nicotinamide ameliorates palmitate-induced ER stress in hepatocytes via cAMP/PKA/CREB pathway-dependent Sirt1 upregulation.

    Biochimica et Biophysica Acta 1853(11 Pt A):2929 (2015) PMID 26352206

  5. An automated phenotype-based microscopy screen to identify pro-longevity interventions acting through mitochondria in C. elegans.

    Biochimica et Biophysica Acta 1847(11):1469 (2015) PMID 25979236

    Mitochondria are multifunctional organelles that play a central role in cellular homeostasis. Severe mitochondrial dysfunction leads to life-threatening diseases in humans and accelerates the aging process. Surprisingly, moderate reduction of mitochondrial function in different species has anti-...
  6. Mitochondria, autophagy and age-associated neurodegenerative diseases: New insights into a complex interplay.

    Biochimica et Biophysica Acta 1847(11):1412 (2015) PMID 25917894

    Mitochondria represent the major bioenergetic hub coordinating cellular and organismal homeostasis. The underlying causes of many pathologies tormenting humans converge on impaired mitochondrial maintenance. Mitochondria-specific autophagy (mitophagy), a cellular catabolic process targeting mito...
  7. Is mitochondrial free radical theory of aging getting old?

    Biochimica et Biophysica Acta 1847(11):1345 (2015) PMID 26282072

  8. Mitochondrial DNA has a pro-inflammatory role in AMD.

    Biochimica et Biophysica Acta 1853(11 Pt A):2897 (2015) PMID 26305120

    Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in the elderly of industrialized nations, and there is increasing evidence to support a role for chronic inflammation in its pathogenesis. Mitochondrial DNA (mtDNA) has been recently reported to be pro-inflamma...
  9. Using an in vitro model to study oxidised protein accumulation in ageing fibroblasts.

    Biochimica et Biophysica Acta 1850(11):2177 (2015) PMID 26187876

    The accumulation of oxidised proteins in ageing cells and tissues results from an increase in oxidant damage coupled with impaired degradation of the damaged proteins. Heat Shock Proteins (HSP) and other chaperones are required to recognise damaged proteins and transport them to the lysosomal an...
  10. (13)C NMR based profiling unveils different α-ketoglutarate pools involved into glutamate and lysine synthesis in the milk yeast Kluyveromyces lactis.

    Biochimica et Biophysica Acta 1850(11):2222 (2015) PMID 26232531

    The construction of efficient cell factories for the production of metabolites requires the rational improvement/engineering of the metabolism of microorganisms. The subject of this paper is directed towards the quantitative understanding of the respiratory/fermentative Kluyveromyces lactis yeas...