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Biochimica et Biophysica Acta

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  1. Participation of thioredoxin in the V(V)-reduction reaction by Vanabin2.

    Biochimica et Biophysica Acta 1840(11):3238 (2014) PMID 25108063

    It is well-understood that ascidians accumulate high levels of vanadium, a reduced form of V(III), in an extremely acidic vacuole in their blood cells. Vanabins are small cysteine-rich proteins that have been identified only from vanadium-rich ascidians. A previous study revealed that Vanabin2 can a...
  2. Regulation of cytokinesis in the milk yeast Kluyveromyces lactis.

    Biochimica et Biophysica Acta 1843(11):2685 (2014) PMID 25110348

    We investigated the effects of various deletion mutants on cytokinesis in the milk yeast Kluyveromyces lactis. To determine the spatiotemporal parameters of cytokinesis components, live-cell imaging of fluorophor-tagged KlMyo1 and a new Lifeact probe for KlAct1 was employed. In contrast to Saccharom...
  3. D2N: Distance to the native.

    Biochimica et Biophysica Acta 1844(10):1798 (2014) PMID 25062912

    We report the development of a metric "D2N" (distance to the native) - that predicts the "RMSD" of any structure without actually knowing the native structure. By combining physico-chemical properties and known universalities in spatial organization of soluble proteins to develop D2N, we demonstrate...
  4. Efficiency of light harvesting in a photosynthetic bacterium adapted to different levels of light.

    Biochimica et Biophysica Acta 1837(10):1835 (2014) PMID 24984074

    We use the photosynthetic purple bacterium Rhodobacter sphaeroides to find out how the acclimation of photosynthetic apparatus to growth conditions influences the rates of energy migration toward the reaction center traps and the efficiency of charge separation at the reaction centers. To answer the...
  5. Loss of HuR leads to senescence-like cytokine induction in rodent fibroblasts by activating NF-κB.

    Biochimica et Biophysica Acta 1840(10):3079 (2014) PMID 25018007

    HuR (human antigen R) is a ubiquitously expressed member of the Hu/ELAV family of proteins that is involved in diverse biological processes. HuR has also been shown to play an important role in cell cycle arrest during replicative senescence in both human and mouse cells. Senescent cells not only ha...
  6. Preventing α-synuclein aggregation: the role of the small heat-shock molecular chaperone proteins.

    Biochimica et Biophysica Acta 1842(9):1830 (2014) PMID 24973551

    Protein homeostasis, or proteostasis, is the process of maintaining the conformational and functional integrity of the proteome. The failure of proteostasis can result in the accumulation of non-native proteins leading to their aggregation and deposition in cells and in tissues. The amyloid fibrilla...
  7. pH sensitivity of chlorophyll fluorescence quenching is determined by the detergent/protein ratio and the state of LHCII aggregation.

    Biochimica et Biophysica Acta 1837(9):1533 (2014) PMID 24321504

    We show how the protein environment in terms of detergent concentration/protein aggregation state, affects the sensitivity to pH of isolated, native LHCII, in terms of chlorophyll fluorescence quenching. Three detergent concentrations (200, 20 and 6μM n-dodecyl β-d-maltoside) have been tested. It wa...
  8. The "bacterial heterodisulfide" DsrC is a key protein in dissimilatory sulfur metabolism.

    Biochimica et Biophysica Acta 1837(7):1148 (2014) PMID 24662917

    We review the information on DsrC and its possible physiological partners, and discuss the idea that this protein may serve as a redox hub linking oxidation of several substrates to dissimilative sulfur metabolism. In addition, we analyze the distribution of proteins of the DsrC superfamily, includi...
  9. Exon 9 skipping of apoptotic caspase-2 pre-mRNA is promoted by SRSF3 through interaction with exon 8.

    Biochimica et Biophysica Acta 1839(1):25 (2014) PMID 24321384

    We show that knockdown of SRSF3 (also known as SRp20) with siRNA induced significant increase of endogenous exon 9 inclusion. In addition, overexpression of SRSF3 promoted exon 9 skipping. Thus we conclude that SRSF3 promotes exon 9 skipping. In order to understand the functional target of SRSF3 on...
  10. Targeting epigenetic mediators of gene expression in thoracic malignancies.

    Biochimica et Biophysica Acta (BBA) - Bioenerge... 1819(7):836 (2012) PMID 22507242

    Lung and esophageal cancer and malignant pleural mesotheliomas are highly lethal neoplasms that are leading causes of cancer-related deaths worldwide. Presently, limited information is available pertaining to epigenetic mechanisms mediating initiation and progression of these neoplas...