Advanced search×
×

Biochimica et Biophysica Acta

Print ISSN
0006-3002
Publisher
Sciencedirect
URL
http://www.sciencedirect.com/science/journal/00063002
Usage rank
5494
Article count
89807
Free count
396
Free percentage
0.00440946
PDFs via platforms
Sciencedirect

  1. Four Cys residues in heterodimeric 2-oxoacid:ferredoxin oxidoreductase are required for CoA-dependent oxidative decarboxylation but not for ...

    Biochimica et Biophysica Acta 1844(4):736 (2014) PMID 24491525

    Heterodimeric 2-oxoacid:ferredoxin oxidoreductase (OFOR) from Sulfolobus tokodaii (StOFOR) has only one [4Fe-4S](2+) cluster, ligated by 4 Cys residues, C12, C15, C46, and C197. The enzyme has no other Cys. To elucidate the role of these Cys residues in holding of the iron-sulfur cluster in the cour...
  2. Crystal structure of a "loopless" GH19 chitinase in complex with chitin tetrasaccharide spanning the catalytic center.

    Biochimica et Biophysica Acta 1844(4):793 (2014) PMID 24582745

    The structure of a GH19 chitinase from the moss Bryum coronatum (BcChi-A) in complex with the substrate was examined by X-ray crystallography and NMR spectroscopy in solution. The X-ray crystal structure of the inactive mutant of BcChi-A (BcChi-A-E61A) liganded with chitin tetramer (GlcNAc)4 reveale...
  3. TLR2/1 and sphingosine 1-phosphate modulate inflammation, myofibroblast differentiation and cell migration in fibroblasts.

    Biochimica et Biophysica Acta 1841(4):484 (2014) PMID 24440818

    We demonstrate that TLR2 ligation strongly enhances the production of the pro-inflammatory cytokines IL-6 and IL-8. S1P significantly induces pro-inflammatory cytokines time- and concentration-dependently via S1P receptor (S1PR)2 and S1PR3. The TLR2/1 agonist Pam3CSK4 and S1P (>1μM) or TGF-β markedl...
  4. Foreword to 2014 aquaporins special issue.

    Biochimica et Biophysica Acta 1840(5):1466 (2014) PMID 24607310

  5. Exon 9 skipping of apoptotic caspase-2 pre-mRNA is promoted by SRSF3 through interaction with exon 8.

    Biochimica et Biophysica Acta 1839(1):25 (2014) PMID 24321384

    We show that knockdown of SRSF3 (also known as SRp20) with siRNA induced significant increase of endogenous exon 9 inclusion. In addition, overexpression of SRSF3 promoted exon 9 skipping. Thus we conclude that SRSF3 promotes exon 9 skipping. In order to understand the functional target of SRSF3 on...
  6. Targeting epigenetic mediators of gene expression in thoracic malignancies.

    Biochimica et Biophysica Acta (BBA) - Bioenerge... 1819(7):836 (2012) PMID 22507242

    Lung and esophageal cancer and malignant pleural mesotheliomas are highly lethal neoplasms that are leading causes of cancer-related deaths worldwide. Presently, limited information is available pertaining to epigenetic mechanisms mediating initiation and progression of these neoplas...
  7. Overexpression of insulin like growth factor binding protein 5 reduces liver fibrosis in chronic cholangiopathy.

    Biochimica et Biophysica Acta (BBA) - Bioenerge... 1822(6):996 (2012) PMID 22434064

    The ATP-binding cassette, sub-family B member 4 knock-out mouse (Abcb4(-/-)) is a relevant model for chronic cholangiopathy in man. Due to the lack of this P-glycoprotein in the canalicular membrane of hepatocytes, the secretion of phospholipids into bile is absent, resulting in incr...
  8. IQGAP2, A candidate tumour suppressor of prostate tumorigenesis.

    Biochimica et Biophysica Acta (BBA) - Bioenerge... 1822(6):875 (2012) PMID 22406297

    We report here that IQGAP2 is a candidate tumour suppressor of prostate cancer (PC). Elevated IQGAP2 was detected in prostatic intraepithelial neoplasia (PIN), early stages of PCs (Gleason score ≤3), and androgen-dependent LNCaP PC cells. However, IQGAP2 was expressed at substantially reduced leve...
  9. Regulation of SGLT expression and localization through Epac/PKA-dependent caveolin-1 and F-actin activation in renal proximal tubule cells.

    Biochimica et Biophysica Acta (BBA) - Bioenerge... 1823(4):971 (2012) PMID 22230192

    This study demonstrated that exchange proteins directly activated by cAMP (Epac) and protein kinase A (PKA) by 8-bromoadenosine (8-Br)-adenosine 3',5'-cyclic monophosphate (cAMP) stimulated [(14)C]-α-methyl-D-glucopyranoside (α-MG) uptake through increased sodium-glucose cotranspor...
  10. Proteasomal AAA-ATPases: structure and function.

    Biochimica et Biophysica Acta (BBA) - Bioenerge... 1823(1):67 (2012) PMID 21820014

    The 26S proteasome is a chambered protease in which the majority of selective cellular protein degradation takes place. Throughout evolution, access of protein substrates to chambered proteases is restricted and depends on AAA-ATPases. Mechanical force generated through cycles of ATP binding and hydr...