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Biochimica et Biophysica Acta

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  1. A hydrogen peroxide safety valve: The reversible phosphorylation of catalase from the freeze-tolerant North American wood frog, Rana sylvatica.

    Biochimica et Biophysica Acta 1860(3):476 (2016) PMID 26691137

    The North American wood frog, Rana sylvatica, endures whole body freezing while wintering on land and has developed multiple biochemical adaptations to elude cell/tissue damage and optimize its freeze tolerance. Blood flow is halted in the frozen state, imparting both ischemic and oxidative stre...
  2. Fluoroquinolones stimulate the DNA cleavage activity of topoisomerase IV by promoting the binding of Mg(2+) to the second metal binding site.

    Biochimica et Biophysica Acta 1860(3):569 (2016) PMID 26723176 PMCID PMC4720527

    Fluoroquinolones target bacterial type IIA topoisomerases, DNA gyrase and topoisomerase IV (Topo IV). Fluoroquinolones trap a topoisomerase-DNA covalent complex as a topoisomerase-fluoroquinolone-DNA ternary complex and ternary complex formation is critical for their cytotoxicity. A divalent met...
  3. Biochemical and biophysical characterization of a plant calmodulin: Role of the N- and C-lobes in calcium binding, conformational change, and target interaction.

    Biochimica et Biophysica Acta 1864(3):297 (2016) PMID 26708477

    In plants, transient elevation of intracellular Ca(2+) concentration in response to abiotic stress is responsible for glutamate decarboxylase (GAD) activation via association with calmodulin (CaM), an EF-hand protein consisting of two homologous domains (N and C). An unusual 1:2 binding mode of ...
  4. Galectin 3 as a guardian of the tumor microenvironment.

    Biochimica et Biophysica Acta 1863(3):427 (2016) PMID 26264495

    Galectin 3 is a member of a family of ╬▓-galactoside binding proteins and has emerged as an important regulator of diverse functions critical in cancer biology including apoptosis, metastasis, immune surveillance, molecular trafficking, mRNA splicing, gene expression, and inflammation. Galectin 3...
  5. The endocannabinoid 2-arachidonoylglycerol dysregulates the synthesis of proteins by the human syncytiotrophoblast.

    Biochimica et Biophysica Acta 1861(3):205 (2016) PMID 26698196

    In recent years, endocannabinoids emerged as new players in various reproductive events. Recently, we demonstrated the involvement of 2-arachidonoylglycerol (2-AG) in human cytotrophoblast apoptosis and syncytialization. However, 2-AG impact in hormone production by the syncytiotrophoblast (hST)...
  6. Hemolysin of uropathogenic Escherichia coli: A cloak or a dagger?

    Biochimica et Biophysica Acta 1858(3):538 (2016) PMID 26299820

    Hemolysin from uropathogenic Escherichia coli (UPEC) is a hemolytic and cytotoxic protein active against a broad range of species and cell types. Expression of hemolysin correlates with severity of infection, as up to 78% of UPEC isolates from pyelonephritis cases express hemolysin. Despite deca...
  7. Analytical applications for pore-forming proteins.

    Biochimica et Biophysica Acta 1858(3):593 (2016) PMID 26431785

    Proteinaceous nanometer-scale pores are ubiquitous in biology. The canonical ionic channels (e.g., those that transport Na(+), K(+), Ca(2+), and Cl(-) across cell membranes) play key roles in many cellular processes, including nerve and muscle activity. Another class of channels includes bacteri...
  8. Distribution and dynamics of OXPHOS complexes in the bacterial cytoplasmic membrane.

    Biochimica et Biophysica Acta 1857(3):198 (2016) PMID 26545610

    Oxidative phosphorylation (OXPHOS) is an essential process for most living organisms mostly sustained by protein complexes embedded in the cell membrane. In order to thrive, cells need to quickly respond to changes in the metabolic demand or in their environment. An overview of the strategies th...
  9. Protein translocation and thylakoid biogenesis in cyanobacteria.

    Biochimica et Biophysica Acta 1857(3):266 (2016) PMID 26341016

    Cyanobacteria exhibit a complex form of membrane differentiation that sets them apart from most bacteria. Many processes take place in the plasma membrane, but photosynthetic light capture, electron transport and ATP synthesis take place in an abundant internal thylakoid membrane. This review co...
  10. Preface to BBA special issue: "Organisation and dynamics of bioenergetic systems in bacteria".

    Biochimica et Biophysica Acta 1857(3):189 (2016) PMID 26777587