Biochimica et Biophysica Acta

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  1. Coordinated regulation of IFITM1, 2 and 3 genes by an IFN-responsive enhancer through long-range chromatin interactions.

    Biochimica et Biophysica Acta (2017) PMID 28511927

    Interferon-induced transmembrane protein (IFITM) 1, 2 and 3 are a family of interferon (IFN)-induced transmembrane proteins that block entry of a broad spectrum of pathogens. However, the transcriptional regulation of these genes, especially whether there exists any enhancers and their roles duri...
  2. An insight into the orphan nucleotide sugar transporter SLC35A4.

    Biochimica et Biophysica Acta (2017) PMID 28167211

    SLC35A4 has been classified in the SLC35A subfamily based on amino acid sequence homology. Most of the proteins belonging to the SLC35 family act as transporters of nucleotide sugars. In this study, the subcellular localization of endogenous SLC35A4 was determined via immunofluorescence staining,...
  3. Fragmentation of the CRISPR-Cas Type I-B signature protein Cas8b.

    Biochimica et Biophysica Acta (2017) PMID 28238733

    CRISPR arrays are transcribed into long precursor RNA species, which are further processed into mature CRISPR RNAs (crRNAs). Cas proteins utilize these crRNAs, which contain spacer sequences that can be derived from mobile genetic elements, to mediate immunity during a reoccurring virus infection...
  4. Histone methyltransferase Setd2 is critical for the proliferation and differentiation of myoblasts.

    Biochimica et Biophysica Acta 1864(4):697 (2017) PMID 28130125

    Skeletal muscle cell proliferation and differentiation are tightly regulated. Epigenetic regulation is a major component of the regulatory mechanism governing these processes. Histone modification is part of the epigenetic code used for transcriptional regulation of chromatin through the establis...
  5. microRNAs in the pathophysiology of CKD-MBD: Biomarkers and innovative drugs.

    Biochimica et Biophysica Acta 1863(1):337 (2016) PMID 27806914

    microRNAs comprise a novel class of endogenous small non-coding RNAs that have been shown to be implicated in both vascular damage and bone pathophysiology. Chronic kidney disease-mineral bone disorder (CKD-MBD) is characterized by vessel and bone damage secondary to progressive loss of kidney fu...
  6. Glycosylation-dependent binding of galectin-8 to activated leukocyte cell adhesion molecule (ALCAM/CD166) promotes its surface segregation on breast cancer cells.

    Biochimica et Biophysica Acta 1860(10):2255 (2016) PMID 27130882

    We previously demonstrated that the activated leukocyte cell adhesion molecule (ALCAM/CD166) can interact with galectin-8 (Gal-8) in endothelial cells. ALCAM is a member of the immunoglobulin superfamily that promotes homophilic and heterophilic cell-cell interactions. Gal-8 is a "tandem-repeat"...
  7. Tat PTD-Endostatin-RGD: A novel protein with anti-angiogenesis effect in retina via eye drops.

    Biochimica et Biophysica Acta 1860(10):2137 (2016) PMID 27233450

    Diabetic retinopathy is a leading cause of blindness. The objective was to design a novel fusion protein, Tat PTD-Endostatin-RGD, to treat retinal neovascularization via eye drops instead of traditional intravitreal injection trepapeutical methods. The anti-angiogenesis ability was evaluated in ...
  8. T-2 toxin induces the expression of porcine CYP3A22 via the upregulation of the transcription factor, NF-Y.

    Biochimica et Biophysica Acta 1860(10):2191 (2016) PMID 27156487

    T-2 toxin is one of the major pollutants in crops and feedstuffs. CYP3A22, one of hCYP3A4 homologs, detoxifies T-2 toxin in pigs. We investigated the mechanisms of expression activation of CYP3A22 under basal and induced conditions. Based on MatInspector analysis, several mutations in the CYP3A2...
  9. Galectin-related protein: An integral member of the network of chicken galectins: 2. From expression profiling to its immunocyto- and histochemical localization and application as tool for ligand detection.

    Biochimica et Biophysica Acta 1860(10):2298 (2016) PMID 27283907

    Galectin-related protein (GRP), present in vertebrates, is special within this family of adhesion/growth-regulatory proteins due to its strong positive selection and loss of canonical lectin activity. RT-PCR and Western blotting together with flow cytofluorimetry and immunocyto- and histochemist...
  10. Yeast trehalases: Two enzymes, one catalytic mission.

    Biochimica et Biophysica Acta 1860(10):2249 (2016) PMID 27133444

  11. Organization of the native ribosome-translocon complex at the mammalian endoplasmic reticulum membrane.

    Biochimica et Biophysica Acta 1860(10):2122 (2016) PMID 27373685

    In eukaryotic cells, many proteins have to be transported across or inserted into the endoplasmic reticulum membrane during their biogenesis on the ribosome. This process is facilitated by the protein translocon, a highly dynamic multi-subunit membrane protein complex. The aim of this review is ...
  12. Regulation of the subcellular trafficking of CD36, a major determinant of cardiac fatty acid utilization.

    Biochimica et Biophysica Acta 1860(10):1461 (2016) PMID 27090938

    Myocardial uptake of long-chain fatty acids largely occurs by facilitated diffusion, involving primarily the membrane-associated protein CD36. Other putative fatty acid transporters, such as FABPpm, FATP1 and FATP4, also play a role, but their quantitative contribution is much smaller or their i...
  13. Cardiac mitochondrial energy metabolism in heart failure: Role of cardiolipin and sirtuins.

    Biochimica et Biophysica Acta 1860(10):1544 (2016) PMID 26972373

    Mitochondrial oxidation of fatty acids accounts for the majority of cardiac ATP production in the heart. Fatty acid utilization by cardiac mitochondria is controlled at the level of fatty acid uptake, lipid synthesis, mobilization and mitochondrial import and oxidation. Consequently defective mi...
  14. Fat in the heart: The enzymatic machinery regulating cardiac triacylglycerol metabolism.

    Biochimica et Biophysica Acta 1860(10):1500 (2016) PMID 26924251

    The heart predominantly utilizes fatty acids (FAs) as energy substrate. FAs that enter cardiomyocytes can be activated and directly oxidized within mitochondria (and peroxisomes) or they can be esterified and intracellularly deposited as triacylglycerol (TAG) often simply referred to as fat. An ...
  15. CD36 actions in the heart: Lipids, calcium, inflammation, repair and more?

    Biochimica et Biophysica Acta 1860(10):1442 (2016) PMID 27004753 PMCID PMC4983248

    CD36 is a multifunctional immuno-metabolic receptor with many ligands. One of its physiological functions in the heart is the high-affinity uptake of long-chain fatty acids (FAs) from albumin and triglyceride rich lipoproteins. CD36 deletion markedly reduces myocardial FA uptake in rodents and h...
  16. Imaging of myocardial fatty acid oxidation.

    Biochimica et Biophysica Acta 1860(10):1535 (2016) PMID 26923433

    Myocardial fuel selection is a key feature of the health and function of the heart, with clear links between myocardial function and fuel selection and important impacts of fuel selection on ischemia tolerance. Radiopharmaceuticals provide uniquely valuable tools for in vivo, non-invasive assess...
  17. Monocarboxylate transporters in the brain and in cancer.

    Biochimica et Biophysica Acta 1863(10):2481 (2016) PMID 26993058

    Monocarboxylate transporters (MCTs) constitute a family of 14 members among which MCT1-4 facilitate the passive transport of monocarboxylates such as lactate, pyruvate and ketone bodies together with protons across cell membranes. Their anchorage and activity at the plasma membrane requires inte...
  18. UCPs, at the interface between bioenergetics and metabolism.

    Biochimica et Biophysica Acta 1863(10):2443 (2016) PMID 27091404

    The first member of the uncoupling protein (UCP) family, brown adipose tissue uncoupling protein 1 (UCP1), was identified in 1976. Twenty years later, two closely related proteins, UCP2 and UCP3, were described in mammals. Homologs of these proteins exist in other organisms, including plants. Un...
  19. Beta-cell mitochondrial carriers and the diabetogenic stress response.

    Biochimica et Biophysica Acta 1863(10):2540 (2016) PMID 26979549

    Mitochondria play a central role in pancreatic beta-cells by coupling metabolism of the secretagogue glucose to distal events of regulated insulin exocytosis. This process requires transports of both metabolites and nucleotides in and out of the mitochondria. The molecular identification of mito...
  20. Closing the gap: The approach of optical and computational microscopy to uncover biomembrane organization.

    Biochimica et Biophysica Acta 1858(10):2558 (2016) PMID 27039279

    Biological membranes are complex composites of lipids, proteins and sugars, which catalyze a myriad of vital cellular reactions in a spatiotemporal tightly controlled manner. Our understanding of the organization principles of biomembranes is limited mainly by the challenge to measure distributi...