Advanced search×

Biochimica et Biophysica Acta

Print ISSN
Usage rank
Article count
Free count
Free percentage
PDFs via platforms

  1. Inositol-phosphodihydroceramides in the periodontal pathogen Tannerella forsythia: Structural analysis and incorporation of exogenous myo-inositol.

    Biochimica et Biophysica Acta 1851(11):1417 (2015) PMID 26277409 PMCID PMC4587543

    Unique phosphodihydroceramides containing phosphoethanolamine and glycerol have been previously described in Porphyromonas gingivalis. Importantly, they were shown to possess pro-inflammatory properties. Other common human bacteria were screened for the presence of these lipids, and they were fo...
  2. Electronegative LDL induces priming and inflammasome activation leading to IL-1β release in human monocytes and macrophages.

    Biochimica et Biophysica Acta 1851(11):1442 (2015) PMID 26327597

  3. Seipin is involved in the regulation of phosphatidic acid metabolism at a subdomain of the nuclear envelope in yeast.

    Biochimica et Biophysica Acta 1851(11):1450 (2015) PMID 26275961

    Yeast Fld1 and Ldb16 resemble mammalian seipin, implicated in neutral lipid storage. Both proteins form a complex at the endoplasmic reticulum-lipid droplet (LD) interface. Malfunction of this complex either leads to LD clustering or to the generation of supersized LD (SLD) in close vicinity to ...
  4. Molecular mechanism of dietary phospholipid requirement of Atlantic salmon, Salmo salar, fry.

    Biochimica et Biophysica Acta 1851(11):1428 (2015) PMID 26303578

    The phospholipid (PL) requirement in fish is revealed by enhanced performance when larvae are provided PL-enriched diets. To elucidate the molecular mechanism underlying PL requirement in Atlantic salmon, Salmo salar, were fed a minimal PL diet and tissue samples from major lipid metabolic sites...
  5. Mitochondrial autophagy: Origins, significance, and role of BNIP3 and NIX.

    Biochimica et Biophysica Acta 1853(10 Pt B):2775 (2015) PMID 25753537

    Mitochondrial autophagy (mitophagy) is a core cellular activity. In this review, we consider mitophagy and related cellular processes and discuss their significance for human disease. Strong parallels exist between mitophagy and xenophagy employed in host defense. These mechanisms converge on re...
  6. Rare disease policies to improve care for patients in Europe.

    Biochimica et Biophysica Acta 1852(10 Pt B):2329 (2015) PMID 25725454

    Rare diseases are those with a particularly low prevalence; in Europe, diseases are considered to be rare when they affect not more than 5 in 10000 persons in the European Union. The specificities of rare diseases make the area a veritable public health challenge: the limited number of patients ...
  7. The relevance of the storage of subunit c of ATP synthase in different forms and models of Batten disease (NCLs).

    Biochimica et Biophysica Acta 1852(10 Pt B):2287 (2015) PMID 26093153

    The discoveries of specific protein storage in the NCLs, particularly of subunit c of ATP synthase in most, and the sphingolipid activator proteins, SAPs or saposins A and D in CLN1, CLN10 and an unassigned form are reviewed. The subunit c stored in the relevant NCLs is the complete mature molec...
  8. Plant immunophilins: a review of their structure-function relationship.

    Biochimica et Biophysica Acta 1850(10):2145 (2015) PMID 25529299

    Originally discovered as receptors for immunosuppressive drugs, immunophilins consist of two major groups, FK506 binding proteins (FKBPs) and cyclosporin A binding proteins (cyclophilins, CYPs). Many members in both FKBP and CYP families are peptidyl prolyl isomerases that are involved in protei...
  9. Control of protein function by prolyl isomerization.

    Biochimica et Biophysica Acta 1850(10):1973 (2015) PMID 25542300

    Prolyl cis/trans isomerizations have long been known as critical and rate-limiting steps in protein folding. Now it is clear that they are also used as slow conformational switches and molecular timers in the regulation of protein activity. Here we describe several such proline switches and how ...
  10. TRIB3 enhances cell viability during glucose deprivation in HEK293-derived cells by upregulating IGFBP2, a novel nutrient deficiency survival factor.

    Biochimica et Biophysica Acta 1853(10 Pt A):2492 (2015) PMID 26094770

    Glucose deprivation occurs in several human diseases, including infarctions and solid tumors, and leads to cell death. In this article, we investigate the role of the pseudokinase Tribbles homolog 3 (TRIB3) in the cellular stress response to glucose starvation using cell lines derived from HEK29...