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Biochimica et Biophysica Acta

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  1. Deletion of sphingosine kinase 1 ameliorates hepatic steatosis in diet-induced obese mice: Role of PPARγ.

    Biochimica et Biophysica Acta 1861(2):138 (2016) PMID 26615875

    Sphingolipid metabolites have emerged playing important roles in the pathogenesis of nonalcoholic fatty liver disease, whereas the underlying mechanism remains largely unknown. In the present study, we provide both in vitro and in vivo evidence showing a pathogenic role of sphingosine kinase 1 (...
  2. Protective role against hydrogen peroxide and fibroblast stimulation via Ce-doped TiO2 nanostructured materials.

    Biochimica et Biophysica Acta 1860(2):452 (2016) PMID 26656883

    Cerium oxide (CeO2) and Ce-doped nanostructured materials (NMs) are being seen as innovative therapeutic tools due to their exceptional antioxidant effects; nevertheless their bio-applications are still in their infancy. TiO2, Ce-TiO2 and CeO2-TiO2 NMs were synthesized by a bottom-up microemulsi...
  3. Influence of a family 29 carbohydrate binding module on the activity of galactose oxidase from Fusarium graminearum.

    Biochimica et Biophysica Acta 1860(2):354 (2016) PMID 26518347

    Galactose oxidase (GaO) selectively oxidizes the primary hydroxyl of galactose to a carbonyl, facilitating targeted chemical derivatization of galactose-containing polysaccharides, leading to renewable polymers with tailored physical and chemical properties. Here we investigate the impact of a f...
  4. Preferential nitrite inhibition of the mitochondrial F1FO-ATPase activities when activated by Ca(2+) in replacement of the natural cofactor Mg(2.).

    Biochimica et Biophysica Acta 1860(2):345 (2016) PMID 26555906

  5. Tryptophan-containing lipopeptide antibiotics derived from polymyxin B with activity against Gram positive and Gram negative bacteria.

    Biochimica et Biophysica Acta 1858(2):333 (2016) PMID 26607008

    Resistance to all known antibiotics is a growing concern worldwide, and has renewed the interest in antimicrobial peptides, a structurally diverse class of amphipathic molecules that essentially act on the bacterial membrane. Propelled by the antimicrobial potential of this compound class, we ha...
  6. Complexation of phospholipids and cholesterol by triterpenic saponins in bulk and in monolayers.

    Biochimica et Biophysica Acta 1858(2):363 (2016) PMID 26654784

    The interactions between three triterpene saponins: α-hederin, hederacoside C and ammonium glycyrrhizate with model lipids: cholesterol and dipalmitoylphosphatidylcholine (DPPC) are described. The oleanolic acid-type saponins (α-hederin and hederacoside C) were shown to form 1:1 complexes with l...
  7. Translocation of 5' mRNA cap analogue - peptide conjugates across the membranes of giant unilamellar vesicles.

    Biochimica et Biophysica Acta 1858(2):311 (2016) PMID 26654783

    Cell-penetrating peptides (CPPs) have been extensively studied because of their ability to deliver various cargo molecules, which are often potential therapeutic agents. However, in most cases, the exact entry mechanism of CPPs is still unknown. In this study, we focused our attention on the mem...
  8. The importance of hydrogen bonding in sphingomyelin's membrane interactions with co-lipids.

    Biochimica et Biophysica Acta 1858(2):304 (2016) PMID 26656158

    Sphingomyelin is an important constituent of mammalian cell membranes. Its molecular structure is N-acyl-d-erythro-sphingosylphosphorylcholine. The N-acyls in sphingomyelin often contain 16-24 carbons that are mostly saturated chains; however, the monounsaturated 24:1(Δ15c) acyl chain is also co...
  9. Nuclear Overhauser effect as a probe of molecular structure, dynamics and order of axially reorienting molecules in membranes.

    Biochimica et Biophysica Acta 1858(2):295 (2016) PMID 26607012

    The location, orientation, order and dynamics of cholesterol in model membranes have been well characterized, therefore cholesterol is an ideal molecule for developing new methods for studying structured molecules undergoing rapid axially symmetric reorientation. The use of (13)C filtering via s...
  10. Assessment of liposome disruption to quantify drug delivery in vitro.

    Biochimica et Biophysica Acta 1858(2):163 (2016) PMID 26589183

    Efficient liposome disruption inside the cells is a key for success with any type of drug delivery system. The efficacy of drug delivery is currently evaluated by direct visualization of labeled liposomes internalized by cells, not addressing objectively the release and distribution of the drug....