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Biochimica et Biophysica Acta

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  1. Characterization of the cell-free DNA released by cultured cancer cells.

    Biochimica et Biophysica Acta 1863(1):157 (2016) PMID 26529550

    The most prominent factor that delays the translation of cell-free DNA (cfDNA) analyses to clinical practice is the lack of knowledge regarding its origin and composition. The elucidation of the former is complicated by the seemingly random fluctuation of quantitative and qualitative characteris...
  2. FoxO1 mediates TGF-beta1-dependent cardiac myofibroblast differentiation.

    Biochimica et Biophysica Acta 1863(1):128 (2016) PMID 26518453

    Cardiac fibroblast differentiation to myofibroblast is a crucial process in the development of cardiac fibrosis and is tightly dependent on transforming growth factor beta-1 (TGF-β1). The transcription factor forkhead box O1 (FoxO1) regulates many cell functions, including cell death by apoptosi...
  3. Structural and biochemical characterization of two heme binding sites on α1-microglobulin using site directed mutagenesis and molecular simulation.

    Biochimica et Biophysica Acta 1864(1):29 (2016) PMID 26497278

    α1-Microglobulin (A1M) is a reductase and radical scavenger involved in physiological protection against oxidative damage. These functions were previously shown to be dependent upon cysteinyl-, C34, and lysyl side-chains, K(92, 118,130). A1M binds heme and the crystal structure suggests that C34...
  4. Transient protein-protein interactions visualized by solution NMR.

    Biochimica et Biophysica Acta 1864(1):115 (2016) PMID 25896389

    Proteins interact with each other to establish their identities in cell. The affinities for the interactions span more than ten orders of magnitude, and KD values in μM-mM regimen are considered transient and are important in cell signaling. Solution NMR including diamagnetic and paramagnetic te...
  5. Subcellular functions of proteins under fluorescence single-cell microscopy.

    Biochimica et Biophysica Acta 1864(1):77 (2016) PMID 26025769

    A cell is a highly organized, dynamic, and intricate biological entity orchestrated by a myriad of proteins and their self-assemblies. Because a protein's actions depend on its coordination in both space and time, our curiosity about protein functions has extended from the test tube into the int...
  6. Measuring specificity in multi-substrate/product systems as a tool to investigate selectivity in vivo.

    Biochimica et Biophysica Acta 1864(1):70 (2016) PMID 26321598

    Multiple substrate enzymes present a particular challenge when it comes to understanding their activity in a complex system. Although a single target may be easy to model, it does not always present an accurate representation of what that enzyme will do in the presence of multiple substrates sim...
  7. Coordinate regulation of microenvironmental stimuli and role of methylation in bone metastasis from breast carcinoma.

    Biochimica et Biophysica Acta 1863(1):64 (2016) PMID 26481505

    The pathogenesis of bone metastasis is unclear, and much focus in metastatic biology and therapy relays on epigenetic alterations. Since DNA-methyltransferase blockade with 5-aza-2'-deoxycytidine (dAza) counteracts tumour growth, here we utilized dAza to clarify whether molecular events undergoi...
  8. Identification of a new oat β-amylase by functional proteomics.

    Biochimica et Biophysica Acta 1864(1):52 (2016) PMID 26455400

    Oat (Avena sativa L.) seed extracts exhibited a high degree of catalytic activity including amylase activities. Proteins in the oat seed extracts were optimized for their amylolytic activities. Oat extract with amylolytic activity was separated by SDS-PAGE and a major protein band with...
  9. Trypanosoma cruzi mitochondrial tryparedoxin peroxidase is located throughout the cell and its pull down provides one step towards the understanding of its mechanism of action.

    Biochimica et Biophysica Acta 1864(1):1 (2016) PMID 26527457

    Trypanosoma cruzi depends on the effectiveness of redox metabolism to survive and ensure infection in the host. Homeostasis of redox metabolism in T. cruzi is achieved by the actions of several proteins that differ in many aspects from host proteins. Although extensive research has been performe...
  10. The catalytic function of renalase: A decade of phantoms.

    Biochimica et Biophysica Acta 1864(1):177 (2016) PMID 25900362

    Ten years after the initial identification of human renalase the first genuinely catalytic substrates have been identified. Throughout the prior decade a consensus belief that renalase is produced predominantly by the kidney and catalytically oxidizes catecholamines in order to lower blood press...