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Biochimica et Biophysica Acta

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  1. Hepatocystin contributes to interferon-mediated antiviral response to hepatitis B virus by regulating hepatocyte nuclear factor 4α.

    Biochimica et Biophysica Acta 1842(9):1648 (2014) PMID 24769044

    We investigated the role of hepatocystin on the cytokine-mediated antiviral response against hepatitis B virus infection. We investigated the antiviral effect and mechanism of hepatocystin by ectopic expression and RNAi knockdown in cell culture and mouse livers. Hepatocystin suppressed the replicat...
  2. Therapeutic angiogenesis in a murine model of limb ischemia by recombinant periostin and its fasciclin I domain.

    Biochimica et Biophysica Acta 1842(9):1324 (2014) PMID 24834847

    We examined the effect of periostin in angiogenic potentials of human endothelial colony forming cells (ECFCs) in vitro and in an ischemic limb animal model. Recombinant periostin protein stimulated the migration and tube formation of ECFCs. To identify the functional domains of periostin implicated...
  3. Changes in glutathione-dependent redox status and mitochondrial energetic strategies are part of the adaptive response during the filamentat...

    Biochimica et Biophysica Acta 1842(9):1855 (2014) PMID 25018088

    We investigated the role of glutathione during the transition between the yeast and hyphal forms of the pathogen, in relation to possible changes in mitochondrial bioenergetic pathways. Using various growth media and selective mutations affecting the filamentation process, we showed that C. albicans...
  4. The role of spontaneous lipid curvature in the interaction of interfacially active peptides with membranes.

    Biochimica et Biophysica Acta 1838(9):2250 (2014) PMID 24853655

    We discuss different parameters such as H-bonding, electrostatic repulsion, changes in monolayer surface area and lateral pressure that affect induction of membrane curvature, but also vice versa how membrane curvature triggers peptide response. In addition, the impact of membrane lipid composition...
  5. Self-recognition behavior of a helix-loop-helix domain by a fragment scan.

    Biochimica et Biophysica Acta 1844(9):1675 (2014) PMID 24981796

    We evaluated the ability of the Id-protein HLH domain to recognize itself in form of short sequences extracted from the helical and loop regions. We performed a peptide scan of the Id1 HLH domain 64-106 based on three-residue overlapping octapeptides. Interaction of each octapeptide with the nativel...
  6. Orai1 and STIM1 mediate SOCE and contribute to apoptotic resistance of pancreatic adenocarcinoma.

    Biochimica et Biophysica Acta 1843(10):2263 (2014) PMID 24583265

    We demonstrate that ORAI1 and STIM1 mediate store-operated calcium entry (SOCE) in pancreatic adenocarcinoma cell lines. We show that both ORAI1 and STIM1 play pro-survival anti-apoptotic role in pancreatic adenocarcinoma cell lines, as siRNA-mediated knockdown of ORAI1 and/or STIM1 increases apopto...
  7. Quantitative evaluation of the cell penetrating properties of an iodinated Tyr-l-maurocalcine analog.

    Biochimica et Biophysica Acta 1843(10):2356 (2014) PMID 24667409

    L-Maurocalcine (L-MCa) is the first reported animal cell-penetrating toxin. Characterizing its cell penetration properties is crucial considering its potential as a vector for the intracellular delivery of drugs. Radiolabeling is a sensitive and quantitative method to follow the cell accumulation of...
  8. The "bacterial heterodisulfide" DsrC is a key protein in dissimilatory sulfur metabolism.

    Biochimica et Biophysica Acta 1837(7):1148 (2014) PMID 24662917

    We review the information on DsrC and its possible physiological partners, and discuss the idea that this protein may serve as a redox hub linking oxidation of several substrates to dissimilative sulfur metabolism. In addition, we analyze the distribution of proteins of the DsrC superfamily, includi...
  9. Exon 9 skipping of apoptotic caspase-2 pre-mRNA is promoted by SRSF3 through interaction with exon 8.

    Biochimica et Biophysica Acta 1839(1):25 (2014) PMID 24321384

    We show that knockdown of SRSF3 (also known as SRp20) with siRNA induced significant increase of endogenous exon 9 inclusion. In addition, overexpression of SRSF3 promoted exon 9 skipping. Thus we conclude that SRSF3 promotes exon 9 skipping. In order to understand the functional target of SRSF3 on...
  10. Targeting epigenetic mediators of gene expression in thoracic malignancies.

    Biochimica et Biophysica Acta (BBA) - Bioenerge... 1819(7):836 (2012) PMID 22507242

    Lung and esophageal cancer and malignant pleural mesotheliomas are highly lethal neoplasms that are leading causes of cancer-related deaths worldwide. Presently, limited information is available pertaining to epigenetic mechanisms mediating initiation and progression of these neoplas...