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Biochimica et Biophysica Acta

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  1. TRP channels interaction with lipids and its implications in disease.

    Biochimica et Biophysica Acta 1848(9):1818 (2015) PMID 25838124

    Transient receptor potential (TRP) proteins are a family of ion channels central for sensory signaling. These receptors and, in particular, those involved in thermal sensing are also involved in pain signaling. Noteworthy, thermosensory receptors are polymodal ion channels that respond to both p...
  2. How cholesterol interacts with proteins and lipids during its intracellular transport.

    Biochimica et Biophysica Acta 1848(9):1908 (2015) PMID 26004840

    Sterols, as cholesterol in mammalian cells and ergosterol in fungi, are indispensable molecules for proper functioning and nanoscale organization of the plasma membrane. Synthesis, uptake and efflux of cholesterol are regulated by a variety of protein-lipid and protein-protein interactions. Simi...
  3. Electrostatically driven lipid-protein interaction: Answers from FRET.

    Biochimica et Biophysica Acta 1848(9):1837 (2015) PMID 25769805

    Electrostatics govern the association of a large number of proteins with cellular membranes. In some cases, these proteins present specialized lipid-binding modules or membrane targeting domains while in other cases association is achieved through nonspecific interaction of unstructured clusters...
  4. Nicotinic acetylcholine receptor-lipid interactions: Mechanistic insight and biological function.

    Biochimica et Biophysica Acta 1848(9):1806 (2015) PMID 25791350

    Membrane lipids are potent modulators of the nicotinic acetylcholine receptor (nAChR) from Torpedo. Lipids influence nAChR function by both conformational selection and kinetic mechanisms, stabilizing varying proportions of activatable versus non-activatable conformations, as well as influencing...
  5. Redox meets protein trafficking.

    Biochimica et Biophysica Acta 1847(9):949 (2015) PMID 25626173

    After the engulfment of two prokaryotic organisms, the thus emerged eukaryotic cell needed to establish means of communication and signaling to properly integrate the acquired organelles into its metabolism. Regulatory mechanisms had to evolve to ensure that chloroplasts and mitochondria smoothl...
  6. The role of active site tyrosine 58 in Citrobacter freundii methionine γ-lyase.

    Biochimica et Biophysica Acta 1854(9):1220 (2015) PMID 25584856

    In the spatial structure of methionine γ-lyase (MGL, EC from Citrobacter freundii, Tyr58 is located at H-bonding distance to the oxygen atom of the phosphate "handle" of pyridoxal 5'-phosphate (PLP). It was replaced for phenylalanine by site-directed mutagenesis. The X-ray structure of...
  7. Discovery of compounds that protect tyrosine hydroxylase activity through different mechanisms.

    Biochimica et Biophysica Acta 1854(9):1078 (2015) PMID 25960279

    Pharmacological chaperones are small compounds that correct the folding of mutant proteins, and represent a promising therapeutic strategy for misfolding diseases. We have performed a screening of 10,000 compounds searching for pharmacological chaperones of tyrosine hydroxylase (TH), the tetrahy...
  8. Chemistry and diversity of pyridoxal-5'-phosphate dependent enzymes.

    Biochimica et Biophysica Acta 1854(9):1167 (2015) PMID 25615531

    Pyridoxal-5'-phosphate (PLP) is a versatile cofactor that enzymes use to catalyze a wide variety of reactions of amino acids, including transamination, decarboxylation, racemization, β- and γ-eliminations and substitutions, retro-aldol and Claisen reactions. These reactions depend on the ability...
  9. A comprehensive glycome profiling of Huntington's disease transgenic mice.

    Biochimica et Biophysica Acta 1850(9):1704 (2015) PMID 25907331

    Huntington's disease (HD) is an autosomal, dominantly inherited and progressive neurodegenerative disease, nosologically classified as the presence of intranuclear inclusion bodies and the loss of GABA-containing neurons in the neostriatum and subsequently in the cerebellar cortex. Abnormal proc...
  10. Apocrine secretion: New insights into an old phenomenon.

    Biochimica et Biophysica Acta 1850(9):1740 (2015) PMID 25960390

    While apocrine secretion was among the earliest secretory mechanisms to be identified, its underlying basis remains poorly understood. This review reappraises our understanding of apocrine secretion using insights about apocrine secretion from the salivary glands of Drosophila, in which molecula...