Biochimica et Biophysica Acta

Print ISSN
0006-3002
Publisher
Sciencedirect
URL
http://www.sciencedirect.com/science/journal/00063002
Usage rank
5494
Article count
89807
Free count
396
Free percentage
0.00440946
PDFs via platforms
Sciencedirect

  1. Organization of the native ribosome-translocon complex at the mammalian endoplasmic reticulum membrane.

    Biochimica et Biophysica Acta 1860(10):2122 (2016) PMID 27373685

    In eukaryotic cells, many proteins have to be transported across or inserted into the endoplasmic reticulum membrane during their biogenesis on the ribosome. This process is facilitated by the protein translocon, a highly dynamic multi-subunit membrane protein complex. The aim of this review is ...
  2. Glycosylation-dependent binding of galectin-8 to activated leukocyte cell adhesion molecule (ALCAM/CD166) promotes its surface segregation on breast cancer cells.

    Biochimica et Biophysica Acta 1860(10):2255 (2016) PMID 27130882

    We previously demonstrated that the activated leukocyte cell adhesion molecule (ALCAM/CD166) can interact with galectin-8 (Gal-8) in endothelial cells. ALCAM is a member of the immunoglobulin superfamily that promotes homophilic and heterophilic cell-cell interactions. Gal-8 is a "tandem-repeat"...
  3. Tat PTD-Endostatin-RGD: A novel protein with anti-angiogenesis effect in retina via eye drops.

    Biochimica et Biophysica Acta 1860(10):2137 (2016) PMID 27233450

    Diabetic retinopathy is a leading cause of blindness. The objective was to design a novel fusion protein, Tat PTD-Endostatin-RGD, to treat retinal neovascularization via eye drops instead of traditional intravitreal injection trepapeutical methods. The anti-angiogenesis ability was evaluated in ...
  4. T-2 toxin induces the expression of porcine CYP3A22 via the upregulation of the transcription factor, NF-Y.

    Biochimica et Biophysica Acta 1860(10):2191 (2016) PMID 27156487

    T-2 toxin is one of the major pollutants in crops and feedstuffs. CYP3A22, one of hCYP3A4 homologs, detoxifies T-2 toxin in pigs. We investigated the mechanisms of expression activation of CYP3A22 under basal and induced conditions. Based on MatInspector analysis, several mutations in the CYP3A2...
  5. Galectin-related protein: An integral member of the network of chicken galectins: 2. From expression profiling to its immunocyto- and histochemical localization and application as tool for ligand detection.

    Biochimica et Biophysica Acta 1860(10):2298 (2016) PMID 27283907

    Galectin-related protein (GRP), present in vertebrates, is special within this family of adhesion/growth-regulatory proteins due to its strong positive selection and loss of canonical lectin activity. RT-PCR and Western blotting together with flow cytofluorimetry and immunocyto- and histochemist...
  6. Yeast trehalases: Two enzymes, one catalytic mission.

    Biochimica et Biophysica Acta 1860(10):2249 (2016) PMID 27133444

  7. Regulation of the subcellular trafficking of CD36, a major determinant of cardiac fatty acid utilization.

    Biochimica et Biophysica Acta 1860(10):1461 (2016) PMID 27090938

    Myocardial uptake of long-chain fatty acids largely occurs by facilitated diffusion, involving primarily the membrane-associated protein CD36. Other putative fatty acid transporters, such as FABPpm, FATP1 and FATP4, also play a role, but their quantitative contribution is much smaller or their i...
  8. Cardiac mitochondrial energy metabolism in heart failure: Role of cardiolipin and sirtuins.

    Biochimica et Biophysica Acta 1860(10):1544 (2016) PMID 26972373

    Mitochondrial oxidation of fatty acids accounts for the majority of cardiac ATP production in the heart. Fatty acid utilization by cardiac mitochondria is controlled at the level of fatty acid uptake, lipid synthesis, mobilization and mitochondrial import and oxidation. Consequently defective mi...
  9. Fat in the heart: The enzymatic machinery regulating cardiac triacylglycerol metabolism.

    Biochimica et Biophysica Acta 1860(10):1500 (2016) PMID 26924251

    The heart predominantly utilizes fatty acids (FAs) as energy substrate. FAs that enter cardiomyocytes can be activated and directly oxidized within mitochondria (and peroxisomes) or they can be esterified and intracellularly deposited as triacylglycerol (TAG) often simply referred to as fat. An ...
  10. Imaging of myocardial fatty acid oxidation.

    Biochimica et Biophysica Acta 1860(10):1535 (2016) PMID 26923433

    Myocardial fuel selection is a key feature of the health and function of the heart, with clear links between myocardial function and fuel selection and important impacts of fuel selection on ischemia tolerance. Radiopharmaceuticals provide uniquely valuable tools for in vivo, non-invasive assess...
  11. CD36 actions in the heart: Lipids, calcium, inflammation, repair and more?

    Biochimica et Biophysica Acta 1860(10):1442 (2016) PMID 27004753 PMCID PMC4983248

    CD36 is a multifunctional immuno-metabolic receptor with many ligands. One of its physiological functions in the heart is the high-affinity uptake of long-chain fatty acids (FAs) from albumin and triglyceride rich lipoproteins. CD36 deletion markedly reduces myocardial FA uptake in rodents and h...
  12. Force Field Development for Lipid Membrane Simulations.

    Biochimica et Biophysica Acta 1858(10):2483 (2016) PMID 26766518

    With the rapid development of computer power and wide availability of modelling software computer simulations of realistic models of lipid membranes, including their interactions with various molecular species, polypeptides and membrane proteins have become feasible for many research groups. The...
  13. Monocarboxylate transporters in the brain and in cancer.

    Biochimica et Biophysica Acta 1863(10):2481 (2016) PMID 26993058

    Monocarboxylate transporters (MCTs) constitute a family of 14 members among which MCT1-4 facilitate the passive transport of monocarboxylates such as lactate, pyruvate and ketone bodies together with protons across cell membranes. Their anchorage and activity at the plasma membrane requires inte...
  14. UCPs, at the interface between bioenergetics and metabolism.

    Biochimica et Biophysica Acta 1863(10):2443 (2016) PMID 27091404

    The first member of the uncoupling protein (UCP) family, brown adipose tissue uncoupling protein 1 (UCP1), was identified in 1976. Twenty years later, two closely related proteins, UCP2 and UCP3, were described in mammals. Homologs of these proteins exist in other organisms, including plants. Un...
  15. Closing the gap: The approach of optical and computational microscopy to uncover biomembrane organization.

    Biochimica et Biophysica Acta 1858(10):2558 (2016) PMID 27039279

    Biological membranes are complex composites of lipids, proteins and sugars, which catalyze a myriad of vital cellular reactions in a spatiotemporal tightly controlled manner. Our understanding of the organization principles of biomembranes is limited mainly by the challenge to measure distributi...
  16. An overview of molecular dynamics simulations of oxidized lipid systems, with a comparison of ELBA and MARTINI force fields for coarse grained lipid simulations.

    Biochimica et Biophysica Acta 1858(10):2498 (2016) PMID 27058982

    Biological membranes and model lipid systems containing high amounts of unsaturated lipids and sterols are subject to chemical and/or photo-induced lipid oxidation, which leads to the creation of exotic oxidized lipid products (OxPLs). OxPLs are known to have significant physiological impact in ...
  17. Na(+)/H(+) antiporter (NHE1) and lactate/H(+) symporters (MCTs) in pH homeostasis and cancer metabolism.

    Biochimica et Biophysica Acta 1863(10):2465 (2016) PMID 26944480

    The Na(+)/H(+)-exchanger NHE1 and the monocarboxylate transporters MCT1 and MCT4 are crucial for intracellular pH regulation, particularly under active metabolism. NHE1, a reversible antiporter, uses the energy provided by the Na(+) gradient to expel H(+) ions generated in the cytosol. The rever...
  18. Beta-cell mitochondrial carriers and the diabetogenic stress response.

    Biochimica et Biophysica Acta 1863(10):2540 (2016) PMID 26979549

    Mitochondria play a central role in pancreatic beta-cells by coupling metabolism of the secretagogue glucose to distal events of regulated insulin exocytosis. This process requires transports of both metabolites and nucleotides in and out of the mitochondria. The molecular identification of mito...
  19. Low molecular weight protein tyrosine phosphatase: Multifaceted functions of an evolutionarily conserved enzyme.

    Biochimica et Biophysica Acta 1864(10):1339 (2016) PMID 27421795

    Originally identified as a low molecular weight acid phosphatase, LMW-PTP is actually a protein tyrosine phosphatase that acts on many phosphotyrosine-containing cellular proteins that are primarily involved in signal transduction. Differences in sequence, structure, and substrate recognition as...
  20. The effect of fluorescent labeling on α-synuclein fibril morphology.

    Biochimica et Biophysica Acta 1864(10):1419 (2016) PMID 27475048

    The misfolding and aggregation of a small, natively unfolded protein α-synuclein (α-syn) is presumably an important factor in the development of Parkinson's disease. However, the mechanism of α-syn aggregation into amyloid fibrils and their morphology are not well understood. To elucidate the ag...