Biochimica et Biophysica Acta

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  1. Glycosylation-dependent binding of galectin-8 to activated leukocyte cell adhesion molecule (ALCAM/CD166) promotes its surface segregation on breast cancer cells.

    Biochimica et Biophysica Acta 1860(10):2255 (2016) PMID 27130882

    We previously demonstrated that the activated leukocyte cell adhesion molecule (ALCAM/CD166) can interact with galectin-8 (Gal-8) in endothelial cells. ALCAM is a member of the immunoglobulin superfamily that promotes homophilic and heterophilic cell-cell interactions. Gal-8 is a "tandem-repeat"...
  2. Tat PTD-Endostatin-RGD: A novel protein with anti-angiogenesis effect in retina via eye drops.

    Biochimica et Biophysica Acta 1860(10):2137 (2016) PMID 27233450

    Diabetic retinopathy is a leading cause of blindness. The objective was to design a novel fusion protein, Tat PTD-Endostatin-RGD, to treat retinal neovascularization via eye drops instead of traditional intravitreal injection trepapeutical methods. The anti-angiogenesis ability was evaluated in ...
  3. T-2 toxin induces the expression of porcine CYP3A22 via the upregulation of the transcription factor, NF-Y.

    Biochimica et Biophysica Acta 1860(10):2191 (2016) PMID 27156487

    T-2 toxin is one of the major pollutants in crops and feedstuffs. CYP3A22, one of hCYP3A4 homologs, detoxifies T-2 toxin in pigs. We investigated the mechanisms of expression activation of CYP3A22 under basal and induced conditions. Based on MatInspector analysis, several mutations in the CYP3A2...
  4. Galectin-related protein: An integral member of the network of chicken galectins: 2. From expression profiling to its immunocyto- and histochemical localization and application as tool for ligand detection.

    Biochimica et Biophysica Acta 1860(10):2298 (2016) PMID 27283907

    Galectin-related protein (GRP), present in vertebrates, is special within this family of adhesion/growth-regulatory proteins due to its strong positive selection and loss of canonical lectin activity. RT-PCR and Western blotting together with flow cytofluorimetry and immunocyto- and histochemist...
  5. Yeast trehalases: Two enzymes, one catalytic mission.

    Biochimica et Biophysica Acta 1860(10):2249 (2016) PMID 27133444

  6. Organization of the native ribosome-translocon complex at the mammalian endoplasmic reticulum membrane.

    Biochimica et Biophysica Acta 1860(10):2122 (2016) PMID 27373685

    In eukaryotic cells, many proteins have to be transported across or inserted into the endoplasmic reticulum membrane during their biogenesis on the ribosome. This process is facilitated by the protein translocon, a highly dynamic multi-subunit membrane protein complex. The aim of this review is ...
  7. Polyphenol compounds and PKC signaling.

    Biochimica et Biophysica Acta 1860(10):2107 (2016) PMID 27369735

    Naturally occurring polyphenols found in food sources provide huge health benefits. Several polyphenolic compounds are implicated in the prevention of disease states, such as cancer. One of the mechanisms by which polyphenols exert their biological actions is by interfering in the protein kinase...
  8. Effect of DNA bending on transcriptional interference in the systems of closely spaced convergent promoters.

    Biochimica et Biophysica Acta 1860(10):2086 (2016) PMID 27373731

    Over the past years there are increasing evidences that the interplay between two molecules of RNA polymerases, initiating transcription from promoters, oriented in opposite (convergent) directions, can serve as a regulatory factor of gene expression. The data concerning the molecular mechanisms...
  9. Lid dynamics of porcine pancreatic lipase in non-aqueous solvents.

    Biochimica et Biophysica Acta 1860(10):2326 (2016) PMID 27155580

    Understanding the dynamics of enzymes in organic solvents has wider implications on their industrial applications. Pancreatic lipases, which show activity in their lid open-state, demonstrate enhanced activity in organic solvents at higher temperatures. However, the lid dynamics of pancreatic li...
  10. Lid closure dynamics of porcine pancreatic lipase in aqueous solution.

    Biochimica et Biophysica Acta 1860(10):2313 (2016) PMID 27155582

    Pancreatic lipases hydrolyze fatty acids in dietary pathway. The activity of porcine pancreatic lipase (PPL) is controlled by lid domain along with a coenzyme, colipase. The active open-state conformation of the protein could be induced by detergents or bile salts which would be further stabiliz...
  11. Relationship between the magnitude of IgE production in mice and conformational stability of the house dust mite allergen, Der p 2.

    Biochimica et Biophysica Acta 1860(10):2279 (2016) PMID 27108391

    Protein antigens are degraded by endosomal protease in antigen presentation cell. T cells recognize peptides derived from antigen proteins bound to class II major histocompatibility complex molecules. We previously reported that an increase in the conformational stability of an antigen depressed...
  12. Galectin-related protein: An integral member of the network of chicken galectins 1. From strong sequence conservation of the gene confined to vertebrates to biochemical characteristics of the chicken protein and its crystal structure.

    Biochimica et Biophysica Acta 1860(10):2285 (2016) PMID 27268118

  13. Limited versus total epithelial debridement ocular surface injury: Live fluorescence imaging of hemangiogenesis and lymphangiogenesis in Prox1-GFP/Flk1::Myr-mCherry mice.

    Biochimica et Biophysica Acta 1860(10):2148 (2016) PMID 27233452

    Immunohistochemical staining experiments have shown that both hemangiogenesis and lymphangiogenesis occur following severe corneal and conjunctival injury and that the neovascularization of the cornea often has severe visual consequences. To better understand how hemangiogenesis and lymphangioge...
  14. Is there a relationship between solubility and resorbability of different calcium phosphate phases in vitro?

    Biochimica et Biophysica Acta 1860(10):2157 (2016) PMID 27212690

    Does chemistry govern biology or it is the other way around - that is a broad connotation of the question that this study attempted to answer. Comparison was made between the solubility and osteoclastic resorbability of four fundamentally different monophasic calcium phosphate (CP) powders with ...
  15. Targeted delivery of quercetin loaded mesoporous silica nanoparticles to the breast cancer cells.

    Biochimica et Biophysica Acta 1860(10):2065 (2016) PMID 27392941

    Mesoporous silica nanoparticles (MSNs) have been promising vehicles for drug delivery. Quercetin (Q), a natural flavonoid, has been reported to have many useful effects. However, poor water solubility as well as less bioavailability has confined its use as a suitable anti-cancer drug. Therefore,...
  16. Interactions of GFAP with ceftriaxone and phenytoin: SRCD and molecular docking and dynamic simulation.

    Biochimica et Biophysica Acta 1860(10):2239 (2016) PMID 27133445

    GFAP is the major intermediate filament protein in mature astrocytes. Its increased expression and aggregation was firstly associated to Alexander's disease, and successively in different neurological diseases including scrapie, Alzheimer's and Creutzfeld-Jacob diseases. Recently, ceftriaxone a ...
  17. Restrictions in ATP diffusion within sarcomeres can provoke ATP-depleted zones impairing exercise capacity in chronic obstructive pulmonary disease.

    Biochimica et Biophysica Acta 1860(10):2269 (2016) PMID 27130881

    Chronic obstructive pulmonary disease (COPD) is characterized by the inability of patients to sustain a high level of ventilation resulting in perceived exertional discomfort and limited exercise capacity of leg muscles at average intracellular ATP levels sufficient to support contractility. Myo...
  18. Epidermal growth factor receptor inhibitor cancer drug gefitinib modulates cell growth and differentiation of acute myeloid leukemia cells via histamine receptors.

    Biochimica et Biophysica Acta 1860(10):2178 (2016) PMID 27180173

    Epidermal growth factor receptor (EGFR) inhibitor gefitinib (Iressa) is used for treating non-small cell lung cancer. Gefitinib also induces differentiation in acute myeloid leukemia (AML) cell lines and patient samples lacking EGFR by an unknown mechanism. Here we dissected the mechanism of gef...
  19. Mechanical stress regulates osteogenic differentiation and RANKL/OPG ratio in periodontal ligament stem cells by the Wnt/β-catenin pathway.

    Biochimica et Biophysica Acta 1860(10):2211 (2016) PMID 27154288

    The balance between osteoblastic and osteoclastic activity is critical in orthodontic tooth movement (OTM). Mesenchymal stem cells (MSCs) play an important role in maintaining bone homeostasis, and periodontal ligament stem cells (PDLSCs) are tissue-specific MSCs in the periodontal ligament. How...
  20. Enlightening mineral iron sensing in Pseudomonas fluorescens by surface active maghemite nanoparticles: Involvement of the OprF porin.

    Biochimica et Biophysica Acta 1860(10):2202 (2016) PMID 27155575

    Mineral iron(III) recognition by bacteria is considered a matter of debate. The peculiar surface chemistry of novel naked magnetic nanoparticles, called SAMNs (surface active maghemite nanoparticles) characterized by solvent exposed Fe(3+) sites on their surface, was exploited for studying miner...