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Biochimica et Biophysica Acta

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  1. The Carbon Monoxide Dehydrogenase from Desulfovibrio vulgaris.

    Biochimica et Biophysica Acta 1847(12):1574 (2015) PMID 26255854

    Ni-containing Carbon Monoxide Dehydrogenases (CODHs) catalyze the reversible conversion between CO and CO2 and are involved in energy conservation and carbon fixation. These homodimeric enzymes house two NiFeS active sites (C-clusters) and three accessory [4Fe-4S] clusters. The Desulfovibrio vul...
  2. A new group of eubacterial light-driven retinal-binding proton pumps with an unusual cytoplasmic proton donor.

    Biochimica et Biophysica Acta 1847(12):1518 (2015) PMID 26260121

    One of the main functions of microbial rhodopsins is outward-directed light-driven proton transport across the plasma membrane, which can provide sources of energy alternative to respiration and chlorophyll photosynthesis. Proton-pumping rhodopsins are found in Archaea (Halobacteria), multiple g...
  3. Selection of specific interactors from phage display library based on sea lamprey variable lymphocyte receptor sequences.

    Biochimica et Biophysica Acta 1854(12):1833 (2015) PMID 26391289

    Variable lymphocyte receptors (VLRs) are non-immunoglobulin components of adaptive immunity in jawless vertebrates. These proteins composed of leucine-rich repeat modules offer some advantages over antibodies in target binding and therefore are attractive candidates for biotechnologica...
  4. Effects of nucleotide binding to LmrA: A combined MAS-NMR and solution NMR study.

    Biochimica et Biophysica Acta 1848(12):3158 (2015) PMID 26449340

    ABC transporters are fascinating examples of fine-tuned molecular machines that use the energy from ATP hydrolysis to translocate a multitude of substrates across biological membranes. While structural details have emerged on many members of this large protein superfamily, a number of ...
  5. Preparing giant unilamellar vesicles (GUVs) of complex lipid mixtures on demand: Mixing small unilamellar vesicles of compositionally heterogeneous mixtures.

    Biochimica et Biophysica Acta 1848(12):3175 (2015) PMID 26417657

    Giant unilamellar vesicles (GUVs) are simple model membrane systems of cell-size, which are instrumental to study the function of more complex biological membranes involving heterogeneities in lipid composition, shape, mechanical properties, and chemical properties. We have devised a method that...
  6. Secondary structure and membrane topology of dengue virus NS4B N-terminal 125 amino acids.

    Biochimica et Biophysica Acta 1848(12):3150 (2015) PMID 26403837

    The transmembrane NS4B protein of dengue virus (DENV) is a validated antiviral target that plays important roles in viral replication and invasion of innate immune response. The first 125 amino acids of DENV NS4B are sufficient for inhibition of alpha/beta interferon signaling. Resistance mutati...
  7. trans-2-Aminocyclohexanol-based amphiphiles as highly efficient helper lipids for gene delivery by lipoplexes.

    Biochimica et Biophysica Acta 1848(12):3113 (2015) PMID 26386397

    Lipidic amphiphiles equipped with the trans-2-aminocyclohexanol (TACH) moiety are promising pH-sensitive conformational switches ("flipids") that can trigger a lipid bilayer perturbation in response to increased acidity. Because pH-sensitivity was shown to improve the efficiency of several gene ...
  8. Scaffolded multimers of hIAPP20-29 peptide fragments fibrillate faster and lead to different fibrils compared to the free hIAPP20-29 peptide fragment.

    Biochimica et Biophysica Acta 1854(12):1890 (2015) PMID 26284878

    Applying fibril-forming peptides in nanomaterial design is still challenged by the difficulties in understanding and controlling how fibrils form. The present work investigates the influence of motional restriction on peptide fibrillation. We use cyclotriphosphazene and cyclodextrin as templates...
  9. Surface (S)-layer proteins of Deinococcus radiodurans and their utility as vehicles for surface localization of functional proteins.

    Biochimica et Biophysica Acta 1848(12):3181 (2015) PMID 26450150

    The radiation resistant bacterium, Deinococcus radiodurans contains two major surface (S)-layer proteins, Hpi and SlpA. The Hpi protein was shown to (a) undergo specific in vivo cleavage, and (b) closely associate with the SlpA protein. Using a non-specific acid phosphatase from Salmonella enter...
  10. Probing the gel to liquid-crystalline phase transition and relevant conformation changes in liposomes by (13)C magic-angle spinning NMR spectroscopy.

    Biochimica et Biophysica Acta 1848(12):3134 (2015) PMID 26375416

    A straightforward way to visualize gel to liquid-crystalline phase transition in phospholipid membranes is presented by using 13C magic-angle spinning NMR. The changes in the 13C isotropic chemical shifts with increasing temperature are shown to be a sensitive probe of the main thermot...