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Brain Research 1629:1 (2015)In vitro assays offer a means of screening potential therapeutics and accelerating the drug development process. Here, we utilized neuronal cultures on planar microelectrode arrays (MEA) as a functional assay to assess the neurotoxicity of amyloid-β 1-42 (Aβ42), a biomolecule implicate...
Brain Research 1629:85 (2015)Glioblastoma is the most lethal brain tumor. Failure of conventional chemotherapies prompted the search for natural compounds for treatment of glioblastoma. Plant-derived flavonoids could be alternative medicine for inhibiting not only glioblastoma cells but also glioblastoma stem cell...
Brain Research 1629:63 (2015)Self-transcendence is an inherent human personality trait relating to the experience of spiritual aspects of the self. We examined the relationship between self-transcendence and serotonin transporter (SERT) availability in brainstem raphe nuclei, which are collections of five differen...
Brain Research 1629:38 (2015)The brain circuits underlying tics in Tourette׳s syndrome (TS) are unknown but thought to involve cortico/amygdalo-striato-thalamo-cortical (CSTC) loop hyperactivity. We previously engineered a transgenic mouse "circuit model" of TS by expressing an artificial neuropotentiating transge...
Brain Research 1629:26 (2015)Background Cortical oscillatory activity in the beta frequency band (13–30Hz) is associated with voluntary movement and may be altered in motor disorders such as stroke.
Brain Research 1629:126 (2015)Methamphetamine (METH) is a highly addictive psychostimulant that may cause long-lasting synaptic dysfunction and abnormal gene expression. We aimed to explore the differential expression of synaptic plasticity genes in chronic METH-treated mouse brain. We used the RT2 Profiler PCR Arr...
Brain Research 1629:10 (2015)A central component of Attention Deficit Hyperactivity Disorder (ADHD) is increased distractibility in response to visual and auditory stimuli, which is linked to the superior colliculus (SC). Furthermore, there is now mounting evidence of altered collicular functioning in ADHD and it ...
Brain Research 1629:72 (2015)The detection of unexpected or unfavorable events is crucial for successful behavioral adaptation. There is a family of ERP components, the so-called error negativities, that has been associated with these detection processes. In the current study, we explored the functional characteri...
Brain Research 1629:54 (2015)Objective To investigate whether high performance on college preparedness tests at 18 years of age can be predicted from brain activation patterns during narrative comprehension at 5–7 years of age.
Brain Research 1629:94 (2015)Purpose Apoptosis is implicated in mild-moderate ischemic injury. Cell death pathways in the severely ischemic brain are not characterized. We sought to determine the role of apoptosis in the severely ischemic immature brain.