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  1. Cerebral glucose metabolism in adults with neurofibromatosis type 1

    Brain Research 1625:97 (2015)

    Previous studies with positron emission tomography (PET) and the glucose analog F-18-fluorodeoxyglucose (FDG) in patients with neurofibromatosis type 1 (NF1) suggest reduced cerebral glucose metabolism in NF1 specifically in the thalamus. The latter is distinguished by extensive neural...
  2. Stimulation of α7 nicotinic acetylcholine receptor regulates glutamate transporter GLAST via basic fibroblast growth factor production in cultured cortical microglia

    Brain Research 1625:111 (2015)

    The α7 nicotinic acetylcholine (nACh) receptor expressed in microglia has a crucial role in neuroprotection. Simulation of α7 nACh receptor leads to increased expression of glutamate/aspartate transporter (GLAST), which in turn decreases synaptic glutamate levels. However, the upregula...
  3. ERP evidence for hemispheric asymmetries in exemplar-specific explicit memory access

    Brain Research 1625:73 (2015)

    The right cerebral hemisphere (RH) appears to be more effective in representing visual objects as distinct exemplars than the left hemisphere (LH) which is presumably biased towards coding objects at the level of abstract prototypes. As of yet, relatively little is known about the role...
  4. NDUFV2 regulates neuronal migration in the developing cerebral cortex through modulation of the multipolar–bipolar transition

    Brain Research 1625:102 (2015)

    Abnormalities during brain development are tightly linked several psychiatric disorders. Mutations in NADH dehydrogenase ubiquinone flavoprotein 2 (NDUFV2) are responsible for schizophrenia, bipolar disorder and Parkinson׳s disease. However, the function of NDUFV2 during brain developm...
  5. Hippocampal signaling pathways are involved in stress-induced impairment of memory formation in rats

    Brain Research 1625:54 (2015)

    Stress is a potent modulator of hippocampal-dependent memory formation. The aim of the present study was to assess the role of hippocampal signaling pathways in stress-induced memory impairment in male Wistar rats. The animals were exposed to acute elevated platform (EP) stress and mem...
  6. CIH-induced neurocognitive impairments are associated with hippocampal Ca2+ overload, apoptosis, and dephosphorylation of ERK1/2 and CREB that are mediated by overactivation of NMDARs

    Brain Research 1625:64 (2015)

    Chronic intermittent hypoxia (CIH) is commonly seen in patients with obstructive sleep apnea, and has been hypothesized to underlie the neurocognitive dysfunction in these patients. However, its cellular and molecular mechanisms remain to be defined. The present study aimed to investig...
  7. Involvement of nitric oxide in the induction of interleukin-1 beta in microglia

    Brain Research 1625:121 (2015)

    In response to in vitro stimulation with lipopolysaccharide (LPS), microglia induce the production of the inflammatory cytokine interleukin-1 beta (IL-1β) together with nitric oxide (NO) and superoxide anion (O2−). Here we investigated the role of NO and O2− in the signaling mechanism ...
  8. Microinjection of orexin-A into the rat locus coeruleus nucleus induces analgesia via cannabinoid type-1 receptors

    Brain Research 1624:424 (2015)

    Locus coeruleus (LC) nucleus is involved in noradrenergic descending pain modulation. LC receives dense orexinergic projections from the lateral hypothalamus. Orexin-A and -B are hypothalamic peptides which modulate a variety of brain functions via orexin type-1 (OX1) and orexin type-2...
  9. Cerebral microvascular pericytes and neurogliovascular signaling in health and disease

    Brain Research 1623:3 (2015) PMID 25862573

    Increases in neuronal activity cause an enhanced blood flow to the active brain area. This neurovascular coupling is regulated by multiple mechanisms: Adenosine and lactate produced as metabolic end-products couple activity with flow by inducing vasodilation. As a specific mechanism to...
  10. Coupling of neurogenesis and angiogenesis after ischemic stroke

    Brain Research 1623:166 (2015) PMID 25736182 PMCID PMC4552615

    Stroke is a leading cause of mortality and severe long-term disability worldwide. Development of effective treatment or new therapeutic strategies for ischemic stroke patients is therefore crucial. Ischemic stroke promotes neurogenesis by several growth factors including FGF-2, IGF-1, ...