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- Proquest, Rcgp, CSA, Ingenta, Wiley from 1948, Gale, and Ovid from 2005
The overexpression of 14-3-3ζ and Hsp27 promotes non–small cell lung cancer progression.
The 14-3-3ζ protein has been identified as a putative oncoprotein in several cancers, including non–small cell lung cancer (NSCLC). However, the mechanisms underlying its functions have not been well defined. Proteins that interact with 14-3-3ζ were identified through coimmunoprecipitation and mass...
Consensus statement released for treating melanoma patients with immunotherapy.
Epigenetic silencing of Id4 identifies a glioblastoma subgroup with a better prognosis as a consequence of an inhibition of angiogenesis.
The promoter of Id4 was methylated in 23 of 62 (37%) GBMs. In methylated GBMs, Id4 mRNA was significantly reduced, compared with unmethylated GBMs (P = .0002). A significant reduction of protein expression was detected in all hypermethylated cases. GBMs with methylated Id4 showed a significant reduc...
Dramatic rise in skin cancer seen in young adults.
Validation of the Royal Marsden Hospital prognostic score in patients treated in the Phase I Clinical Trials Program at the MD Anderson Canc...
For patients with lung, pancreatic, and head and neck tumors who were treated on phase 1 trials, survival was predicted accurately by the RMH prognostic score. Cancer 2011;. © 2011 American Cancer Society. Copyright © 2011 American Cancer Society....
International field testing of the reliability and validity of the EORTC QLQ-BM22 module to assess health-related quality of life in patient...
The final QLQ-BM22 module contains 22 items and 4 scales assessing Painful Sites, Painful Characteristics, Functional Interference, and Psychosocial Aspects. Results confirmed the validity, reliability, cross-cultural applicability, and sensitivity of the 22-item EORTC QLQ-BM22. It is therefore reco...
Clinical outcomes of oncologic gastrointestinal resections in patients with cirrhosis.
Resection of GI malignancy in cirrhotics is associated with poor early postoperative and transitional outcomes, with severity of liver disease being the primary determinant of postoperative mortality. These data suggest that GI cancer operations can be performed safely in well-selected cirrhotic pat...
Researchers report discoveries in cancer progression and rare skin and pancreatic cancers.
Prostate cancer in the elderly: frequency of advanced disease at presentation and disease-specific mortality.
Compared with younger patients (aged <75 years), older patients were more likely to present with very advanced disease, had a greater risk of death from PC despite higher death rates from competing causes, and contributed more than half of all PC deaths. Awareness of this issue may improve future ou...