Clinica Chimica Acta
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Utilization management in the core laboratory.
The need for appropriate utilization management of diagnostic testing is increasingly important. The majority of laboratory tests are performed in highly automated core laboratories that combine chemistry, immunoassays, hematology, coagulation and esoteric assays. These core laboratories are designe...
Measurement of ganciclovir concentration in human plasma by ultra-performance liquid chromatography-tandem mass spectrometry.
We developed and validated a simple chromatographic method by ultra-performance liquid chromatography tandem mass spectrometry to measure plasma concentration of ganciclovir in human plasma. Chromatographic separation was achieved using an Acquity(®) UPLC(®) BEH™ (2.1×50mm id, 1.7μm) reverse-phase C...
Improvement for identification of heterophile antibody interference and AFP hook effect in immunoassays with multiplex suspension bead array...
We modified protocols with two newly-developed solutions that can identify heterophile antibody interference and AFP hook effect. Effectiveness of the two solutions was assessed in serum samples from patients. Concentrations of 9 tumor markers in heterophile antibody positive samples assayed with So...
Reference intervals of D-dimer during the pregnancy and puerperium period on the STA-R evolution coagulation analyzer.
We established gestational age-specific reference intervals for D-dimer, and estimate the role of D-dimer test in ruling out VTE and DIC in pregnant women. We followed 1343 healthy pregnant women and 1042 uncomplicated postpartum women to establish gestational age-specific reference intervals of D-d...
Analytical characterization and clinical evaluation of an enzyme-linked immunosorbent assay for measurement of afamin in human plasma.
We evaluated precision, linearity, and detection limit of the assay, analyte stability and biological variability, determined reference values and quantified afamin concentrations in various diseases. Within-run and total coefficients of variation were <10%. The method was linear across the tested m...
CD4(+) immune response as a potential biomarker of patient reported inflammatory bowel disease (IBD) activity.
Crohn's disease (CD) and ulcerative colitis (UC) are inflammatory bowel diseases (IBDs) which are characterized by dysfunctional regulation of the immune system. A number of immune modifying drugs are used to treat CD and UC. Therapy is adjusted largely on the bases of subjective reports of disease...
A rapid and reliable method for the quantitation of hydroxychloroquine in serum using turbulent flow liquid chromatography-tandem mass spect...
We report a turbulent flow LC-MS/MS method we developed for this purpose. After protein precipitation from serum with 0.33mol/l perchloric acid, hydroxychloroquine and its deuterated analog were injected onto a Cyclone turbulent flow column for sample cleanup. Analytical separation was accomplished...
Simultaneous detection of diagnostic biomarkers of alkaptonuria, ornithine carbamoyltransferase deficiency, and neuroblastoma disease by hig...
We quantified the level of creatinine in urine in one LC-MS run. The limits of detection were 10μg/l for HGA, 25μg/l for HVA/VMA, and 50μg/l for OA with a single-to-noise ratio of 3; the limits of quantification were 50μg/l for HVA and HGA, 100μg/l for VMA, and 250μg/l for OA. The linear dynamic ran...
Overweight modulates APOE and APOA5 alleles on the risk of severe hypertriglyceridemia.
This study aimed to investigate whether the body mass index (BMI) in combination with genetic variations in APOE and APOA5_'T' alleles modulates the risk of sHTG. There were 255 moderate HTG (TG ≥2.26 and <2.26mmol/L) were recruited. AP...
Ethylene glycol poisoning: Quintessential clinical toxicology; analytical conundrum.