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Clinica Chimica Acta

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  1. Editorial Board
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    Clinica Chimica Acta 444:IFC (2015)

  2. Cardiac biomarker testing in the clinical laboratory: Where do we stand? General overview of the methodology with special emphasis on natriuretic peptides

    Clinica Chimica Acta 443:17 (2015)

    Diagnosis of heart failure (HF) is not based on a single test, but on a combination of history, physical examination and appropriate investigations. For these reasons, the accuracy of diagnosis by clinical means alone is often inadequate, especially in the early, asymptomatic stages of...
  3. Which biomarkers do clinicians need for diagnosis and management of heart failure with reduced ejection fraction?

    Clinica Chimica Acta 443:9 (2015) PMID 25447693

    While there have been significant recent advances in the medical management of chronic HF (including the use of beta-blockers, angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, and aldosterone blockers), the ability to characterize, monitor, and predict a pati...
  4. Personalized risk assessment of heart failure patients: More perspectives from transforming growth factor super-family members

    Clinica Chimica Acta 443:94 (2015)

    More personalized risk assessment of patients with heart failure (HF) is important to develop more tailored based care and for a better allocation of resources. The measurement of biomarkers is now part of the standards of care and is important for the sub-phenotyping of HF patients to...
  5. An unclassified viariant in the fibrillin-1 gene leading to exon skipping in a patient with Marfan syndrome: The use of minigene assay in splicing analysis

    Clinica Chimica Acta 442:84 (2015) PMID 25636182

  6. Autoreactivity to isoforms of glycoprotein 2 in inflammatory bowel disease

    Clinica Chimica Acta 442:82 (2015) PMID 25625482

  7. Relationship between carotid artery intima-media thickness and small dense low-density lipoprotein cholesterol concentrations measured by homogenous assay in Japanese subjects

    Clinica Chimica Acta 442:110 (2015) PMID 25603407

    Background Small dense low-density lipoprotein cholesterol (sdLDL-C) concentrations correlate more strongly with coronary heart disease than other LDL-C and large LDL particle concentrations. We investigated the association between carotid artery intima-media thickness (IMT) ...
  8. Novel Nanomonitor ultra-sensitive detection of troponin T

    Clinica Chimica Acta 442:96 (2015) PMID 25619774

    Background Troponin is the preferred biomarker for diagnosing myocardial infarction. Point of care devices have not matched the sensitivity of laboratory-based methods for measuring troponin. The Nanomonitor is a novel point-of-care device that uses the change in electrical i...
  9. Simultaneous gas-chromatographic urinary measurement of sugar probes to assess intestinal permeability: Use of time course analysis to optimize its use to assess regional gut permeability

    Clinica Chimica Acta 442:24 (2015) PMID 25591964 PMCID PMC4339548

    Background Measurement of intestinal permeability is important in several diseases but currently several methods are employed. We sought to: (1) develop a new GC based method to measure urinary mannitol, lactulose and sucralose to assess regional and total gut permeability; (...
  10. Increased serum sclerostin in postoperative biliary atresia

    Clinica Chimica Acta 442:136 (2015) PMID 25659290

    Background We determined the relationship between serum sclerostin and disease severity of biliary atresia (BA).