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Developmental Biology

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  1. Utilizing the chicken as an animal model for human craniofacial ciliopathies.

    Developmental Biology (2015) PMID 26597494

    The chicken has been a particularly useful model for the study of craniofacial development and disease for over a century due to their relatively large size, accessibility, and amenability for classical bead implantation and transplant experiments. Several naturally occurring mutant lines with cr...
  2. Lineage-associated tracts defining the anatomy of the Drosophila first instar larval brain

    Developmental Biology 406(1):14 (2015) PMID 26141956

    Fixed lineages derived from unique, genetically specified neuroblasts form the anatomical building blocks of the Drosophila brain. Neurons belonging to the same lineage project their axons in a common tract, which is labeled by neuronal markers. In this paper, we present a detailed atl...
  3. Editorial Board
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    Developmental Biology 406(1):IFC (2015)

  4. Rap1 GTPase is required for mouse lens epithelial maintenance and morphogenesis

    Developmental Biology 406(1):74 (2015) PMID 26212757 PMCID PMC4587029

    Rap1, a Ras-like small GTPase, plays a crucial role in cell−matrix adhesive interactions, cell−cell junction formation, cell polarity and migration. The role of Rap1 in vertebrate organ development and tissue architecture, however, remains elusive. We addressed this question in a mouse...
  5. Fertilization stimulates 8-hydroxy-2′-deoxyguanosine repair and antioxidant activity to prevent mutagenesis in the embryo

    Developmental Biology 406(1):1 (2015) PMID 26234752

    Oxidative DNA damage harbored by both spermatozoa and oocytes at the time of fertilization must be repaired prior to S-phase of the first mitotic division to reduce the risk of transversion mutations occurring in the zygote and subverting the normal patterns of cell differentiation and...
  6. Negative Fgf8-Bmp2 feed-back is regulated by miR-130 during early cardiac specification

    Developmental Biology 406(1):63 (2015) PMID 26165600

    It is known that secreted proteins from the anterior lateral endoderm, FGF8 and BMP2, are involved in mesodermal cardiac differentiation, which determines the first cardiac field, defined by the expression of the earliest specific cardiac markers Nkx-2.5 and Gata4. However, the molecul...
  7. Spatiotemporal regulation of GLI target genes in the mammalian limb bud

    Developmental Biology 406(1):92 (2015) PMID 26238476 PMCID PMC4587286

    GLI proteins convert Sonic hedgehog (Shh) signaling into a transcriptional output in a tissue-specific fashion. The Shh pathway has been extensively studied in the limb bud, where it helps regulate growth through a SHH–FGF feedback loop. However, the transcriptional response is still p...
  8. Vascular endothelial growth factor signaling affects both angiogenesis and osteogenesis during the development of scleral ossicles

    Developmental Biology 406(1):52 (2015) PMID 26210172

    Intramembranous ossification is a complex multi-step process which relies on extensive interactions among bone cells and surrounding tissues. The embryonic vasculature is essential in regulating endochondral ossification; however, its role during intramembranous ossification remains po...
  9. Integration of vascular systems between the brain and spinal cord in zebrafish

    Developmental Biology 406(1):40 (2015) PMID 26234750

    Cerebral and spinal vascular systems are organized individually, and they then conjugate at their border, through the integration of basilar artery and vertebral arteries. Zebrafish (Danio rerio) is an ideal organism for studying early vascular development, and the precise procedure of...
  10. SDB 2015 Meeting Dates & Times
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    Developmental Biology 402(1):2 (2015)