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European Journal of Pharmacology

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  1. Opposite role played by GABAAand GABABreceptors in the modulation of peristaltic activity in mouse distal colon

    European Journal of Pharmacology 731:93 (2014)

    We investigated the role of GABA on intestinal motility using as model the murine distal colon. Effects induced by GABA receptors recruitment were examined in whole colonic segments and isolated circular muscle preparations to analyze their influence on peristaltic reflex and on spontaneous and neur...
  2. The phosphorylation of endogenous Nedd4-2 In Na+—absorbing human airway epithelial cells

    European Journal of Pharmacology 732:32 (2014)

    Neural precursor cell expressed, developmentally down-regulated protein 4-2 (Nedd4-2) mediates the internalisation / degradation of epithelial Na+ channel subunits (α-, β- and γ-ENaC). Serum / glucocorticoid inducible kinase 1 (SGK1) and protein kinase A (PKA) both appear to inhibit this p...
  3. Prevention of aortic calcification by etidronate in the renal failure rat model.

    European Journal of Pharmacology 558(1-3):159 (2007) PMID 17270170

    Our recent clinical study indicated that etidronate may inhibit the progression of aortic calcification in hemodialysis patients. To determine whether etidronate inhibits aortic calcification in renal failure rats, renal failure was induced by subtotal nephrectomy, in which 5/6 of the kidneys were r...
  4. Mycophenolate mofetil prevents autoimmune glomerulonephritis and alterations of intrarenal adrenomedullin in rats

    European Journal of Pharmacology 489(1):127 (2004)

    We studied the effects of mycophenolate mofetil, a specific inhibitor of inosine monophosphate dehydrogenase, on the mercuric chloride induced autoimmune glomerulonephritis in Brown Norway rats and also on the renal contents of adrenomedullin. In the rats with autoimmune glomerulonephritis, plasma a...
  5. Physiological modulation of GABA(A) receptor plasticity by progesterone metabolites.

    European Journal of Pharmacology 375(1-3):225 (1999) PMID 10443579

    The possible functional relation between changes in brain and plasma concentrations of neurosteroids and the plasticity of gamma-aminobutyric acid type A (GABA(A)) receptors in the brain during pregnancy and after delivery was investigated in rats. The concentrations in the cerebral cortex and plasm...
  6. SB-236057, a selective 5-HT1B receptor inverse agonist, blocks the 5-HT human terminal autoreceptor.

    European Journal of Pharmacology 375(1-3):359 (1999) PMID 10443589

    A novel compound, SB-236057 (1'-ethyl-5-(2'-methyl-4'-(5-methyl-1,3,4-oxadiazol-2-yl)biphenyl- 4-carbonyl)-2,3,6,7-tetrahydrospiro[furo[2,3-f]indole-3,4'-piperid ine]) has been shown to have high affinity for human 5-hydroxytryptamine1B (5-HT1B) receptors (pKi = 8.2) and displays over 75 or more-fol...
  7. Effects of anticonvulsive drugs on pentylenetetrazol kindling and long-term potentiation in freely moving rats.

    European Journal of Pharmacology 356(2-3):179 (1998) PMID 9774247

    Drugs with anticonvulsive properties and different mechanisms of action were compared for their influence on long-term potentiation and pentylenetetrazol kindling in freely moving animals. Rats were chronically implanted with a stimulation electrode in the angular bundle and a recording electrode in...
  8. Inhibition of ligand-gated cation-selective channels by tamoxifen.

    European Journal of Pharmacology 354(2-3):261 (1998) PMID 9754928

    We have investigated the action of tamoxifen and the related derivative toremifene on ligand-gated cationic nicotinic acetylcholine and 5-HT3 receptor channels. Tamoxifen and toremifene both inhibited cationic currents of adult-type human muscle nicotinic acetylcholine receptors expressed in Xenopus...
  9. The response of rat colonic mucosa to 5-hydroxytryptamine in health and following restraint stress.

    European Journal of Pharmacology 353(2-3):289 (1998) PMID 9726659

    The present study characterized the rat colonic secretory response to 5-hydroxytryptamine (5-HT) and determined alterations in this response following stress. 5-HT stimulated rat colonic short-circuit current in a concentration-dependent fashion (pD2 = 5.19). This response was subject to desensitiza...
  10. Evaluation of PD 154075, a tachykinin NK1 receptor antagonist, in a rat model of postoperative pain.

    European Journal of Pharmacology 344(2-3):115 (1998) PMID 9600644

    PD 154075 ([(2-benzofuran)-CH2OCO]-(R)-alpha-MeTrp-(S)-NHCH(CH3) Ph) is a selective tachykinin NK1 receptor antagonist. Its effect on development and maintenance of thermal and mechanical hypersensitivity was examined in a rat model of surgical pain. When administered 30 min before surgery, PD 154075...