Journal of Antibiotics
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LC-MS/MS determination of colistin in Mueller-Hinton broth for in vitro pharmacodynamic studies.
A rapid and simple method was developed and validated for the determination of colistin A and B in Mueller-Hinton broth using LC-tandem MS. Both analyte and internal standard (IS) (polymyxin B1) were determined using ESI. The MS data were obtained via the selected reaction monitoring in positive-ion...
Identification, synthesis and characterization of a novel antimicrobial peptide HKPLP derived from Hippocampus kuda Bleeker
A novel gene encoding 55 amino-acid residues has been identified from the brooding pouch cDNA library of Hippocampus kuda Bleeker. The deduced amino-acid sequence is highly homologous to several pleurocidin-like peptides from the winter flounder and comprises a signal peptide, a pro-...
Lanostane-type triterpenes from the sporoderm-broken spores of Ganoderma lucidum.
The Journal of Antibiotics advance online publication, 11 January 2012; doi:10.1038/ja.2011.135.
Spread of cfr gene among staphylococci conferring resistance to linezolid in a patient under treatment
Ganodermycin, a novel inhibitor of CXCL10 expression from Ganoderma applanatum
CXCL10 (inducible protein-10) is a highly inducible chemoattractant, which contributes to the recruitment of inflammatory cells, such as macrophages and T-lymphocytes, and thereby has important roles in chronic inflammatory conditions. In a search for new inhibitors of CXCL10 express...
In vitro and in vivo antitrypanosomal activities of three peptide antibiotics: leucinostatin A and B, alamethicin I and tsushimycin.
Substance index for volume 67.
In memory of Piero Sensi (1920-2013).
Mullinamides A and B, new cyclopeptides produced by the Ruth Mullins coal mine fire isolate Streptomyces sp. RM-27-46.
Two new cyclopeptides, mullinamides A [cyclo-(-L-Gly-L-Glu-L-Val-L-Ile-L-Pro-)] and B [cyclo-(-L-Glu-L-Met-L-Pro-)] were isolated from the crude extract of terrestrial Streptomyces sp. RM-27-46 along with the three known cyclopeptides surugamide A [cyclo-(-L-Ile-D-Ile-L-Lys-L-Ile-D-Phe-D-Leu-L-Ile-D...
New myxothiazols from the predatory bacterium Myxococcus fulvus.
Extracts of the predatory bacterium Myxococcus fulvus HKI 722 showed promising antimicrobial activities in the agar diffusion assay. A combined chemical and computational analysis led to the identification of five thiazole-containing antibiotics. Two of the isolated compounds represent previously un...