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Journal of Antibiotics

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  1. Micromonospora endophytica sp. nov., an endophytic actinobacteria of Thai upland rice (Oryza sativa).

    Journal of Antibiotics 68(11):680 (2015) PMID 25966850

    An actinobacterial strain, DCWR9-8-2(T), was isolated from a leaf of Thai upland rice (Oryza sativa) collected in Chumporn province, Thailand. Strain DCWR9-8-2(T) is Gram-stain-positive aerobic bacteria that produce single spores directly on the vegetative hypha. Cell wall peptidoglycan of this ...
  2. Structure-activity relationships of the plasminogen modulator SMTP with respect to the inhibition of soluble epoxide hydrolase.

    Journal of Antibiotics 68(11):685 (2015) PMID 25966853

    A family of fungal metabolites, SMTP, is a small-molecule plasminogen modulator that enhances plasminogen activation, leading to thrombolysis. We recently demonstrated that SMTP-7 effectively treats ischemic stroke due to its thrombolytic activity as well as anti-inflammatory action, which is at...
  3. Sydoxanthone C and acremolin B produced by deep-sea-derived fungus Aspergillus sp. SCSIO Ind09F01.

    Journal of Antibiotics 68(11):703 (2015) PMID 25944530

    A new xanthone named sydoxanthone C (1) and a new alkaloid named acremolin B (2), together with 10 known compounds (3-12) were isolated from a deep-sea-derived fungus Aspergillus sp. SCSIO Ind09F01. The structures of compounds (1-12) were determined by the extensive 1D, 2D-NMR, High resolution m...
  4. 13-Deoxytetrodecamycin, a new tetronate ring-containing antibiotic that is active against multidrug-resistant Staphylococcus aureus.

    Journal of Antibiotics 68(11):698 (2015) PMID 26014719

    WAC04657 is a wild-isolate Streptomyces that has antibiotic activities against multidrug-resistant Gram-negative and Gram-positive pathogens. From a solid-agar culture of this organism we isolated 13-deoxytetrodecamycin, a novel antibacterial molecule. It is one of at least three distinct antimi...
  5. Avellanin C, an inhibitor of quorum-sensing signaling in Staphylococcus aureus, from Hamigera ingelheimensis.

    Journal of Antibiotics 68(11):707 (2015) PMID 25944536

  6. Identification of small-molecule inhibitors against SecA by structure-based virtual ligand screening.

    Journal of Antibiotics 68(11):666 (2015) PMID 25990955

    The rapid rise of antibiotic-resistant bacteria is one of the major concerns in modern medicine. Therefore, to treat bacterial infections, there is an urgent need for new antibacterials-preferably directed against alternative bacterial targets. One such potential target is the preprotein translo...
  7. Cycloexpansamines A and B: spiroindolinone alkaloids from a marine isolate of Penicillium sp. (SF-5292).

    Journal of Antibiotics 68(11):715 (2015) PMID 25966848

  8. Activity of lipophilic and hydrophilic drugs against dormant and replicating Mycobacterium tuberculosis.

    Journal of Antibiotics 68(11):711 (2015) PMID 25944535

  9. Discovery of secondary metabolites in an extractive liquid-surface immobilization system and its application to high-throughput interfacial screening of antibiotic-producing fungi.

    Journal of Antibiotics 68(11):691 (2015) PMID 25966852

    An extractive liquid-surface immobilization (Ext-LSI) system, which consists of a hydrophobic organic solvent (an upper phase), a fungal cell-ballooned microsphere layer (a middle phase) and a liquid medium (a lower phase), is a unique interfacial cultivation system for fungi. The fungal cells g...
  10. Inhibitory activities of the marine streptomycete-derived compound SF2446A2 against Chlamydia trachomatis and Schistosoma mansoni.

    Journal of Antibiotics 68(11):674 (2015) PMID 25990954

    Infectious diseases caused by chlamydia or schistosomes are a major health problem worldwide, and particularly so in developing countries. The lack of appropriate vaccines renders the search for potent natural products against these disease-causing agents an urgent endeavor. Sponge-associated ac...