Journal of Antibiotics

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  1. In vitro activity of dalbavancin and five comparator agents against common and uncommon Gram-positive organisms isolated from cancer patients.

    Journal of Antibiotics 69(5):381 (2016) PMID 26626876

    Dalbavancin is a long acting, bactericidal lipoglycopeptide. Its in vitro activity was compared with that of vancomycin, daptomycin, linezolid, trimethoprim/sulfamethoxazole (TMP/SMX) and levofloxacin against 241 Gram-positive organisms isolated from cancer patients. The rank order of potency fo...
  2. Synthesis and structure-activity relationships of novel lincomycin derivatives. Part 1. Newly generated antibacterial activities against Gram-positive bacteria with erm gene by C-7 modification.

    Journal of Antibiotics 69(5):368 (2016) PMID 26669755

    We synthesized 7(S)-7-deoxy-7-arylthiolincomycin derivatives possessing a heterocyclic ring at the C-7 position via sulfur atom by either Mitsunobu reaction of 2,3,4-tris-O-(trimethylsiliyl)lincomycin or SN2 reaction of 7-O-methanesulfonyl-2,3,4-tri-O-trimethylsiliyllincomycin. As a result, 7(S)...
  3. Biosynthetic origin of anthracimycin: a tricyclic macrolide from Streptomyces sp.

    Journal of Antibiotics 69(5):403 (2016) PMID 26626875

  4. Improvement of the productivity of ecumicin, a novel anti-tuberculosis agent, from new Nonomuraea sp. MJM5123.

    Journal of Antibiotics 69(5):362 (2016) PMID 26648116

    Ecumicin is a novel anti-tuberculosis agent produced by Nonomuraea sp. MJM5123 as a new strain of actinomycetes. First, in order to increase the cell mass of Nonomuraea sp. MJM5123, we optimized the culture conditions with regard to carbon and nitrogen sources. The cell mass of Nonomuraea sp. MJ...
  5. PM100117 and PM100118, new antitumor macrolides produced by a marine Streptomyces caniferus GUA-06-05-006A.

    Journal of Antibiotics 69(5):388 (2016) PMID 26648119

    Two new bioactive polyhydroxyl macrolide lactones PM100117 (1) and PM100118 (2) were isolated from the culture broth of the marine-derived Streptomyces caniferus GUA-06-05-006A. Their structures were elucidated by a combination of spectroscopic methods, mainly one-dimensional and 2D NMR and HRES...
  6. Maniwamycins: new quorum-sensing inhibitors against Chromobacterium violaceum CV026 were isolated from Streptomyces sp. TOHO-M025.

    Journal of Antibiotics 69(5):395 (2016) PMID 26648117

    Quorum sensing is an important microbial signaling system that controls the expression of many virulence genes. Maniwamycins C-F, new compounds and quorum-sensing inhibitors, were isolated from the culture broth of Streptomyces sp. TOHO-M025 using a silica gel column and preparative HPLC. The st...
  7. New p-terphenyls from the fruiting bodies of Pseudomerulius curtisii and their antioxidant activity.

    Journal of Antibiotics 69(5):400 (2016) PMID 26601684

  8. Application of bacterial cytological profiling to crude natural product extracts reveals the antibacterial arsenal of Bacillus subtilis.

    Journal of Antibiotics 69(5):353 (2016) PMID 26648120

    Although most clinically used antibiotics are derived from natural products, identifying new antibacterial molecules from natural product extracts is difficult due to the complexity of these extracts and the limited tools to correlate biological activity with specific molecules. Here, we show th...
  9. Improved antibiotic production and silent gene activation in Streptomyces diastatochromogenes by ribosome engineering.

    Journal of Antibiotics 69(5):406 (2016) PMID 26648118

  10. Strategies for construction of the all-carbon macrocyclic skeleton of the ansamycin antibiotic-kendomycin.

    Journal of Antibiotics 69(4):203 (2016) PMID 26860467

    Kendomycin, an ansamycin-type natural product first reported in 1996, possesses a series of attractive bioactivities and a unique all-carbon macrocyclic skeleton. To the date, seven total syntheses, two formal total syntheses and a number of synthetic studies on this hot molecule have been repor...
  11. Syntheses of methylated catechins and theaflavins using 2-nitrobenzenesulfonyl group to protect and deactivate phenol.

    Journal of Antibiotics 69(4):299 (2016) PMID 26905756

    An efficient and versatile synthetic method for labile polyphenols was established using 2-nitrobenzenesulfonate (Ns) as a protecting group for phenol. This methodology provides regio- and stereoselective access to a range of methylated catechins, such as methylated epigallocatechin gallates, th...
  12. The first total synthesis and the second- or third-generation approach.

    Journal of Antibiotics 69(4):191 (2016) PMID 27118326

  13. Anti-obesity activities of the yoshinone A and the related marine γ-pyrone compounds.

    Journal of Antibiotics 69(4):348 (2016) PMID 26932409 PMCID PMC4892692

  14. The Petasis-Ferrier rearrangement: developments and applications.

    Journal of Antibiotics 69(4):213 (2016) PMID 26732258

    In the mid-1990s, Petasis reexamined a promising but infrequently used rearrangement strategy, the so-called Ferrier-type-II reaction, and provided it with a modern update. Previously, Ferrier had developed a strategy where carbohydrate derivatives would undergo a fragmentation/aldol-type recomb...
  15. Professor Amos B Smith, III.

    Journal of Antibiotics 69(4):190 (2016) PMID 27118325

  16. The use of fluorescently-tagged apoptolidins in cellular uptake and response studies.

    Journal of Antibiotics 69(4):327 (2016) PMID 26956792

    The apoptolidins are glycomacrolide microbial metabolites reported to be selectively cytotoxic against tumor cells. Using fluorescently tagged active derivatives we demonstrate selective uptake of these four tagged glycomacrolides in cancer cells over healthy human blood cells. We also demonstra...
  17. Total synthesis of ent-(+)-cinanthrenol A.

    Journal of Antibiotics 69(4):280 (2016) PMID 26555362

    The first total synthesis of ent-(+)-cinanthrenol A of potent estrogenic activity was achieved with 10.9% overall yield in 13 steps from commercially available materials. Our synthesis features a photo-promoted oxidative 6π-electron electrocyclization/aromatization for construction of the cyclop...
  18. Natural product-derived quaternary ammonium compounds with potent antimicrobial activity.

    Journal of Antibiotics 69(4):344 (2016) PMID 26577453

  19. Stereoselective access to tubuphenylalanine and tubuvaline: improved Mn-mediated radical additions and assembly of a tubulysin tetrapeptide analog.

    Journal of Antibiotics 69(4):294 (2016) PMID 26883395

    Synthesis of tubuphenylalanine and tubuvaline (Tuv), α-substituted γ-amino acid building blocks for tubulysin family of antimitotic compounds, has been improved using a radical addition reaction in the presence of unprotected hydroxyl functionality. The key carbon-carbon bond construction entail...
  20. Practical synthesis of the C-ring precursor of paclitaxel from 3-methoxytoluene.

    Journal of Antibiotics 69(4):273 (2016) PMID 26860468

    The practical synthesis of the C-ring precursor of paclitaxel starting from 3-methoxytoluene is described. Lipase-catalyzed kinetic resolution of a substituted cyclohexane-1,2-diol, derived from 3-methoxytoluene in three steps, successfully afforded a desired enantiomer with >99% ee, which was t...