Journal of Antibiotics
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Identification, synthesis and characterization of a novel antimicrobial peptide HKPLP derived from Hippocampus kuda Bleeker
A novel gene encoding 55 amino-acid residues has been identified from the brooding pouch cDNA library of Hippocampus kuda Bleeker. The deduced amino-acid sequence is highly homologous to several pleurocidin-like peptides from the winter flounder and comprises a signal peptide, a pro-...
Lanostane-type triterpenes from the sporoderm-broken spores of Ganoderma lucidum.
The Journal of Antibiotics advance online publication, 11 January 2012; doi:10.1038/ja.2011.135.
Spread of cfr gene among staphylococci conferring resistance to linezolid in a patient under treatment
Ganodermycin, a novel inhibitor of CXCL10 expression from Ganoderma applanatum
CXCL10 (inducible protein-10) is a highly inducible chemoattractant, which contributes to the recruitment of inflammatory cells, such as macrophages and T-lymphocytes, and thereby has important roles in chronic inflammatory conditions. In a search for new inhibitors of CXCL10 express...
In vitro and in vivo antitrypanosomal activities of three peptide antibiotics: leucinostatin A and B, alamethicin I and tsushimycin.
Evaluation of nisin-β-lactam antibiotics against clinical strains of Salmonella enterica serovar Typhi.
We had earlier confirmed that nisin has the potential to act in conjunction with β-lactams against murine salmonellosis using standard strain. However, evaluation of efficacy of these combinations against clinical isolates of Salmonella could be the next key step to confirm the value added potential...
Methyl 5-glucosyl-5,6-dihydro-apo-4,4'-lycopenoate, a novel antioxidative glyco-C30-carotenoic acid produced by a marine bacterium Planococc...
Mechanisms of β-lactam killing and resistance in the context of Mycobacterium tuberculosis.
We discuss possible mechanisms for β-lactam activity in M. tuberculosis and the means by which it may acquire resistance, within the context of what is known in other bacterial species....
Isolation, structural elucidation and biosynthesis of 3-hydroxy-6-dimethylallylindolin-2-one, a novel prenylated indole derivative from Acti...
We isolated a novel prenylated indole derivative, 3-hydroxy-6-dimethylallylindolin (DMAIN)-2-one, based on systematic purification of metabolites from a rare actinomycete, Actinoplanes missouriensis NBRC 102363. The structure of 3-hydroxy-6-DMAIN-2-one was determined by HR-MS and NMR analyses. We fo...