Journal of Antibiotics

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  1. Endophytic fungal compounds active against Cryptococcus neoformans and C. gattii.

    Journal of Antibiotics 68(7):436 (2015) PMID 25712396

    Infections with Cryptococcus are invasive mycoses associated with significant morbidity and mortality, mainly in immunosuppressed patients. Several drugs have been introduced to combat these opportunistic infections. However, resistance of this organism to antifungal drugs has increased, causing...
  2. Study of efflux pump gene expression in rifampicin-monoresistant Mycobacterium tuberculosis clinical isolates.

    Journal of Antibiotics 68(7):431 (2015) PMID 25690361

    Rifampicin (RIF) resistance is a risk factor for poor outcome in tuberculosis (TB). In Mycobacterium tuberculosis, both target gene mutation and efflux pumps have major roles in the resistance to anti-TB drugs. This study aimed to determine whether RIF induces efflux pump activation in RIF-monor...
  3. Identification of novel endophenaside antibiotics produced by Kitasatospora sp. MBT66.

    Journal of Antibiotics 68(7):445 (2015) PMID 25690357

    Actinomycetes are a major source of bioactive secondary metabolites and are a focal point in the search for novel antimicrobial compounds that are needed to combat multidrug-resistant pathogens. Here, we report the discovery of several novel phenazine-type antibiotics produced by Kitasatospora s...
  4. Dandamycin and chandrananimycin E, benzoxazines from Streptomyces griseus.

    Journal of Antibiotics 68(7):463 (2015) PMID 25690358

    Two new benzoxazines were isolated from Streptomyces griseus (HKI 0545) and assigned as chandrananimycin E (1) and dandamycin (2). Although a number of phenoxazinone-type compounds have been reported from nature, phenoxazines are rarer, and carbon substitution at N-10 such as in 1 is unprecedent...
  5. Antimalarial activity of kinase inhibitor, nilotinib, in vitro and in vivo.

    Journal of Antibiotics 68(7):469 (2015) PMID 25690362

  6. Two herbimycin analogs, 4,5-dihydro-(4S)-4-hydroxyherbimycin B and (15S)-15-hydroxyherbimycin B, from Streptomyces sp. CPCC 200291.

    Journal of Antibiotics 68(7):476 (2015) PMID 25690359

  7. Cystodienoic acid: a new diterpene isolated from the myxobacterium Cystobacter sp.

    Journal of Antibiotics 68(7):473 (2015) PMID 25690355

  8. Streptosporangium terrae sp. nov., a novel actinomycete isolated from the rhizosphere of Callistemon citrinus (Curtis), India.

    Journal of Antibiotics 68(7):425 (2015) PMID 25690360

    A novel actinomycete strain, designated VRC21(T), was isolated from the rhizosphere of Callistemon citrinus collected from Hyderabad, India. The morphological and chemotaxonomic properties of strain VRC21(T) was consistent with the characteristics of members of the genus Streptosporangium, that ...
  9. Structure and biosynthetic implication of 5R-(N-acetyl-L-cysteinyl)-14S-hydroxy-dihydrokalafungin from a mutant of the actVA-ORF4 gene for actinorhodin biosynthesis in Streptomyces coelicolor A3(2).

    Journal of Antibiotics 68(7):481 (2015) PMID 25690356

  10. A new antibiotic with potent activity targets MscL.

    Journal of Antibiotics 68(7):453 (2015) PMID 25649856 PMCID PMC4430313

    The growing problem of antibiotic-resistant bacteria is a major threat to human health. Paradoxically, new antibiotic discovery is declining, with most of the recently approved antibiotics corresponding to new uses for old antibiotics or structurally similar derivatives of known antibiotics. We ...
  11. Streptomyces oryzae sp. nov., an endophytic actinomycete isolated from stems of rice plant.

    Journal of Antibiotics 68(6):368 (2015) PMID 25586021

    An actinomycete strain S16-07(T), isolated from surface-sterilized stems of rice plant (Oryza sativa L.), was characterized using a polyphasic approach. Phylogenetic analysis of 16S rRNA gene sequences indicated affiliation of the strain belonged to the genus Streptomyces. The highest levels of ...
  12. Irciniastatin A, a pederin-type translation inhibitor, promotes ectodomain shedding of cell-surface tumor necrosis factor receptor 1.

    Journal of Antibiotics 68(6):417 (2015) PMID 25627015

  13. Additional congeners of the macrolide neaumycin: structure revision and biological activity.

    Journal of Antibiotics 68(6):406 (2015) PMID 25586025

  14. Tolypoalbin, a new tetramic acid from Tolypocladium album TAMA 479.

    Journal of Antibiotics 68(6):399 (2015) PMID 25627017

  15. Dactylosporangium sucinum sp. nov., isolated from Thai peat swamp forest soil.

    Journal of Antibiotics 68(6):379 (2015) PMID 25605042

    The actinomycete strain RY35-23(T) was isolated from peat swamp forest soil in Thailand. The taxonomic position of this strain was determined using polyphasic approach. Strain RY35-23(T) showed typical morphology and chemical properties similar to the members in the genus Dactylosporangium. On t...
  16. In vitro evaluation of ciclopirox as an adjuvant for polymyxin B against gram-negative bacteria.

    Journal of Antibiotics 68(6):395 (2015) PMID 25586022

  17. Trichoderamides A and B, a pair of stereoisomers from the plant endophytic fungus Trichoderma gamsii.

    Journal of Antibiotics 68(6):409 (2015) PMID 25649855

  18. Discovery and characterization of a novel class of pyrazolopyrimidinedione tRNA synthesis inhibitors.

    Journal of Antibiotics 68(6):361 (2015) PMID 25464974

    A high-throughput phenotypic screen for novel antibacterial agents led to the discovery of a novel pyrazolopyrimidinedione, PPD-1, with preferential activity against methicillin-resistant Staphylococcus aureus (MRSA). Resistance mapping revealed the likely target of inhibition to be lysyl tRNA s...
  19. Novel terpenes generated by heterologous expression of bacterial terpene synthase genes in an engineered Streptomyces host.

    Journal of Antibiotics 68(6):385 (2015) PMID 25605043

    Mining of bacterial genome data has revealed numerous presumptive terpene synthases. Heterologous expression of several putative terpene synthase genes in an engineered Streptomyces host has revealed 13 newly discovered terpenes whose GC-MS and NMR data did not match with any known compounds in ...
  20. Natural lipopeptide antibiotic tripropeptin C revitalizes and synergistically potentiates the activity of beta-lactams against methicillin-resistant Staphylococcus aureus.

    Journal of Antibiotics 68(6):373 (2015) PMID 25586024

    Tripropeptin C (TPPC) is a natural calcium-ion-dependent lipopeptide antibiotic that inhibits peptidoglycan biosynthesis by binding to prenyl pyrophosphate. It displays very potent antimicrobial activity both in vitro and in a mouse model of methicillin-resistant Staphylococcus aureus (MRSA) sep...