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Journal of Antibiotics

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  1. Endophytic fungal compounds active against Cryptococcus neoformans and C. gattii.

    Journal of Antibiotics 68(7):436 (2015) PMID 25712396

    Infections with Cryptococcus are invasive mycoses associated with significant morbidity and mortality, mainly in immunosuppressed patients. Several drugs have been introduced to combat these opportunistic infections. However, resistance of this organism to antifungal drugs has increased, causing...
  2. Study of efflux pump gene expression in rifampicin-monoresistant Mycobacterium tuberculosis clinical isolates.

    Journal of Antibiotics 68(7):431 (2015) PMID 25690361

    Rifampicin (RIF) resistance is a risk factor for poor outcome in tuberculosis (TB). In Mycobacterium tuberculosis, both target gene mutation and efflux pumps have major roles in the resistance to anti-TB drugs. This study aimed to determine whether RIF induces efflux pump activation in RIF-monor...
  3. Identification of novel endophenaside antibiotics produced by Kitasatospora sp. MBT66.

    Journal of Antibiotics 68(7):445 (2015) PMID 25690357

    Actinomycetes are a major source of bioactive secondary metabolites and are a focal point in the search for novel antimicrobial compounds that are needed to combat multidrug-resistant pathogens. Here, we report the discovery of several novel phenazine-type antibiotics produced by Kitasatospora s...
  4. Dandamycin and chandrananimycin E, benzoxazines from Streptomyces griseus.

    Journal of Antibiotics 68(7):463 (2015) PMID 25690358

    Two new benzoxazines were isolated from Streptomyces griseus (HKI 0545) and assigned as chandrananimycin E (1) and dandamycin (2). Although a number of phenoxazinone-type compounds have been reported from nature, phenoxazines are rarer, and carbon substitution at N-10 such as in 1 is unprecedent...
  5. Antimalarial activity of kinase inhibitor, nilotinib, in vitro and in vivo.

    Journal of Antibiotics 68(7):469 (2015) PMID 25690362

  6. Two herbimycin analogs, 4,5-dihydro-(4S)-4-hydroxyherbimycin B and (15S)-15-hydroxyherbimycin B, from Streptomyces sp. CPCC 200291.

    Journal of Antibiotics 68(7):476 (2015) PMID 25690359

  7. Cystodienoic acid: a new diterpene isolated from the myxobacterium Cystobacter sp.

    Journal of Antibiotics 68(7):473 (2015) PMID 25690355

  8. Streptosporangium terrae sp. nov., a novel actinomycete isolated from the rhizosphere of Callistemon citrinus (Curtis), India.

    Journal of Antibiotics 68(7):425 (2015) PMID 25690360

    A novel actinomycete strain, designated VRC21(T), was isolated from the rhizosphere of Callistemon citrinus collected from Hyderabad, India. The morphological and chemotaxonomic properties of strain VRC21(T) was consistent with the characteristics of members of the genus Streptosporangium, that ...
  9. Structure and biosynthetic implication of 5R-(N-acetyl-L-cysteinyl)-14S-hydroxy-dihydrokalafungin from a mutant of the actVA-ORF4 gene for actinorhodin biosynthesis in Streptomyces coelicolor A3(2).

    Journal of Antibiotics 68(7):481 (2015) PMID 25690356

  10. A new antibiotic with potent activity targets MscL.

    Journal of Antibiotics 68(7):453 (2015) PMID 25649856 PMCID PMC4430313

    The growing problem of antibiotic-resistant bacteria is a major threat to human health. Paradoxically, new antibiotic discovery is declining, with most of the recently approved antibiotics corresponding to new uses for old antibiotics or structurally similar derivatives of known antibiotics. We ...