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Journal of Antibiotics

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  1. Streptomyces lactacystinicus sp. nov. and Streptomyces cyslabdanicus sp. nov., producing lactacystin and cyslabdan, respectively.

    Journal of Antibiotics 68(5):322 (2015) PMID 25491896

    Actinomycete strains OM-6519(T) and K04-0144(T) produce the bioactive compounds lactacystin and cyslabdan, respectively. Here, the taxonomic positions of these two strains were determined. The morphological and chemical features of strains OM-6519(T) and K04-0144(T) indicated that they belonged ...
  2. Two butenolides with PPARα agonistic activity from a marine-derived Streptomyces.

    Journal of Antibiotics 68(5):345 (2015) PMID 25388602

  3. Mutant prevention concentrations of levofloxacin, pazufloxacin and ciprofloxacin for A. baumannii and mutations in gyrA and parC genes.

    Journal of Antibiotics 68(5):313 (2015) PMID 25351948

    Fluoroquinolones are antimicrobial agents that are widely used clinically, but the increasing resistance of Acinetobacter baumannii (A. baumannii) to these agents is a matter of concern. We investigated mutant prevention concentrations (MPCs) of three fluoroquinolones, levofloxacin (LVX), pazufl...
  4. Cytotoxic hydroanthraquinones from the mangrove-derived fungus Paradictyoarthrinium diffractum BCC 8704.

    Journal of Antibiotics 68(5):334 (2015) PMID 25407145

    Two new hydroanthraquinones, paradictyoarthrins A (1) and B (2), were isolated from the mangrove-derived fungus Paradictyoarthrinium diffractum BCC 8704. Structures of the new compounds were elucidated by analyses of the NMR spectroscopic and mass spectrometry data. The absolute configuration of...
  5. Sinomonas mesophila sp. nov., isolated from ancient fort soil.

    Journal of Antibiotics 68(5):318 (2015) PMID 25464972

    A moderate growing strain designated as MPKL 26(T) was isolated from a soil sample of Bidar Fort, Karnataka, India. The strain MPKL 26(T) was Gram positive, bent rod in shape. The optimum pH and temperature for growth was 7.0 and 30 °C, respectively. The 16S ribosomal RNA gene sequence analysis ...
  6. New steroidal compounds from an actinomycete strain, Lechevalieria aerocolonigenes K10-0216.

    Journal of Antibiotics 68(5):348 (2015) PMID 25491895

  7. Identification of the biosynthetic gene cluster for the herbicide phosphonothrixin in Saccharothrix sp. ST-888.

    Journal of Antibiotics 68(5):357 (2015) PMID 25351949

  8. Tackling vancomycin-resistant bacteria with 'lipophilic-vancomycin-carbohydrate conjugates'.

    Journal of Antibiotics 68(5):302 (2015) PMID 25351946

    Vancomycin, a glycopeptide antibiotic, has long been a drug of choice for life-threatening Gram-positive bacterial infections. Vancomycin confers its antibacterial activity by inhibiting bacterial cell wall biosynthesis. However, over the time, vancomycin has also been rendered ineffective by va...
  9. Inhibition of biofilm formation in Bacillus subtilis by new halogenated furanones.

    Journal of Antibiotics 68(5):297 (2015) PMID 25335695

    Gram-positive bacteria can cause various infections including hospital-acquired infections. While in the biofilm, the resistance of bacteria to both antibiotics and the human immune system is increased causing difficulties in the treatment. Bacillus subtilis, a non-pathogenic Gram-positive bacte...
  10. A new stachybotrin congener from a soil fungus Stachybotrys parvispora strain HS-FG-843.

    Journal of Antibiotics 68(5):339 (2015) PMID 25335693