Journal of Antibiotics

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  1. New natural products isolated from Metarhizium robertsii ARSEF 23 by chemical screening and identification of the gene cluster through engineered biosynthesis in Aspergillus nidulans A1145.

    Journal of Antibiotics 69(7):561 (2016) PMID 27189118

    To rapidly identify novel natural products and their associated biosynthetic genes from underutilized and genetically difficult-to-manipulate microbes, we developed a method that uses (1) chemical screening to isolate novel microbial secondary metabolites, (2) bioinformatic analyses to identify ...
  2. Genome mining of the sordarin biosynthetic gene cluster from Sordaria araneosa Cain ATCC 36386: characterization of cycloaraneosene synthase and GDP-6-deoxyaltrose transferase.

    Journal of Antibiotics 69(7):541 (2016) PMID 27072286

    Sordarin is a glycoside antibiotic with a unique tetracyclic diterpene aglycone structure called sordaricin. To understand its intriguing biosynthetic pathway that may include a Diels-Alder-type [4+2]cycloaddition, genome mining of the gene cluster from the draft genome sequence of the producer ...
  3. Design and synthesis of 15-deoxyspergualin-biotin conjugates as novel binding probes for target protein screening.

    Journal of Antibiotics 69(7):574 (2016) PMID 27005555

  4. Exploring the diversification mechanism of skeletal construction in representative natural product families.

    Journal of Antibiotics 69(7):471 (2016) PMID 27460869

  5. Biosynthesis of the α-nitro-containing cyclic tripeptide psychrophilin.

    Journal of Antibiotics 69(7):571 (2016) PMID 26956794 PMCID PMC4963283

  6. Using quantum chemical computations of NMR chemical shifts to assign relative configurations of terpenes from an engineered Streptomyces host.

    Journal of Antibiotics 69(7):534 (2016) PMID 27189124

    Density functional theory calculations of (1)H and (13)C chemical shifts are used to assign the relative configurations of isohirsut-1-ene, isohirsut-4-ene and tsukubadiene, three terpenes previously isolated from an engineered Streptomyces.
  7. Actinoquinolines A and B, anti-inflammatory quinoline alkaloids from a marine-derived Streptomyces sp., strain CNP975.

    Journal of Antibiotics 69(7):511 (2016) PMID 27220408

    Actinomycete bacteria of the common genus Streptomyces can be routinely isolated from shallow and deep ocean sediments. Although commonly considered a terrestrial genus, and most abundantly found in soil, Streptomyces strains are found that have distinct requirements for seawater and routinely d...
  8. Recent advances of Diels-Alderases involved in natural product biosynthesis.

    Journal of Antibiotics 69(7):500 (2016) PMID 27301662

    Frequent occurrence of [4+2] adducts in the secondary metabolites suggested involvement of Diels-Alderases (DAases) in their biosynthesis. However, a limited number of DAases were reported before early 2000s. Advancements in whole-genome sequencing and searching tool of the biosynthetic gene clu...
  9. Nature as organic chemist.

    Journal of Antibiotics 69(7):473 (2016) PMID 27460870

  10. Methyltransferases excised from trans-AT polyketide synthases operate on N-acetylcysteamine-bound substrates.

    Journal of Antibiotics 69(7):567 (2016) PMID 27301661 PMCID PMC4963292

  11. Chemical diversity of labdane-type bicyclic diterpene biosynthesis in Actinomycetales microorganisms.

    Journal of Antibiotics 69(7):515 (2016) PMID 26814669

    Five pairs of bacterial type-A and type-B diterpene synthases have been characterized: BAD86798/BAD86797, AHK61133/AHK61132, BAB39207/BAB39206, CldD/CldB and RmnD/RmnB, and are involved in the formation of pimara-9(11),15-diene, terpente-3,13,15-triene and labda-8(17),12(E),14-triene. Mining of ...
  12. Biosynthetic potential of sesquiterpene synthases: product profiles of Egyptian Henbane premnaspirodiene synthase and related mutants.

    Journal of Antibiotics 69(7):524 (2016) PMID 27328867

    The plant terpene synthase (TPS) family is responsible for the biosynthesis of a variety of terpenoid natural products possessing diverse biological functions. TPSs catalyze the ionization and, most commonly, rearrangement and cyclization of prenyl diphosphate substrates, forming linear and cycl...
  13. Insights into polyketide biosynthesis gained from repurposing antibiotic-producing polyketide synthases to produce fuels and chemicals.

    Journal of Antibiotics 69(7):494 (2016) PMID 27245558

    Complex polyketides comprise a large number of natural products that have broad application in medicine and agriculture. They are produced in bacteria and fungi from enzyme complexes named type I polyketide synthases (PKSs) that are composed of multifunctional polypeptides containing discrete en...
  14. New conjugates of polyene macrolide amphotericin B with benzoxaboroles: synthesis and properties.

    Journal of Antibiotics 69(7):549 (2016) PMID 27005557

    A novel series of conjugates of the antifungal antibiotic amphotericin B (AmB) with benzoxaboroles was synthesized. Antifungal activity of new compounds was tested on yeastβ Candida albicans and Cryptococcus humicolus and filamentous fungi Aspergillus niger and Fusarium oxysporum using the broth...
  15. General base-general acid catalysis by terpenoid cyclases.

    Journal of Antibiotics 69(7):486 (2016) PMID 27072285 PMCID PMC4963284

    Terpenoid cyclases catalyze the most complex reactions in biology, in that more than half of the substrate carbon atoms often undergo changes in bonding during the course of a multistep cyclization cascade that proceeds through multiple carbocation intermediates. Many cyclization mechanisms requ...
  16. Recognition of acyl carrier proteins by ketoreductases in assembly line polyketide synthases.

    Journal of Antibiotics 69(7):507 (2016) PMID 27118242 PMCID PMC4963262

    Ketoreductases (KRs) are the most widespread tailoring domains found in individual modules of assembly line polyketide synthases (PKSs), and are responsible for controlling the configurations of both the α-methyl and β-hydroxyl stereogenic centers in the growing polyketide chain. Because they re...
  17. Amethysione and amethysamide, new metabolites from Streptosporangium amethystogenes BCC 27081.

    Journal of Antibiotics 69(6):459 (2016) PMID 26669754

  18. Structure and absolute configuration of drimentine I, an alkaloid from Streptomyces sp. CHQ-64.

    Journal of Antibiotics 69(6):467 (2016) PMID 26732256

  19. A small-molecule compound belonging to a class of 2,4-disubstituted 1,3,4-thiadiazine-5-ones suppresses Salmonella infection in vivo.

    Journal of Antibiotics 69(6):422 (2016) PMID 26732253

    Therapeutic strategies that target bacterial virulence have received considerable attention. The type III secretion system (T3SS) is important for bacterial virulence and represents an attractive therapeutic target. A novel compound with a predicted T3SS inhibitory activity named CL-55 (N-(2,4-d...
  20. Synthesis and antibacterial activity of novel lincomycin derivatives. I. Enhancement of antibacterial activities by introduction of substituted azetidines.

    Journal of Antibiotics 69(6):440 (2016) PMID 26758495

    The synthesis and antibacterial activity of (7S)-7-sulfur-azetidin-3-yl lincomycin derivatives are described. Modification was achieved by a simple reaction of (7R)-7-O-methanesulfonyllincomycin and the corresponding substituted azetidine-2-thiol. Several compounds first showed moderate antibact...