Journal of Biological Chemistry

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  1. The N-terminal region of the atypical chemokine receptor ACKR2 is a key determinant of ligand binding.

    Journal of Biological Chemistry 289(18):12330 (2014) PMID 24644289

    The atypical chemokine receptor, ACKR2 is a pivotal regulator of chemokine-driven inflammatory responses and works by binding, internalizing, and degrading inflammatory CC-chemokines. ACKR2 displays promiscuity of ligand binding and is capable of interacting with up to 14 different inflammatory C...
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  2. AP-1 activated by toll-like receptors regulates expression of IL-23 p19.

    Journal of Biological Chemistry 284(36):24006 (2009) PMID 19592489 PMCID PMC2781995

    Interleukin (IL)-23, a new member of the IL-12 family, plays a central role in the Th17 immune response and in autoimmune diseases. It is clear that activated macrophages and dendritic cells produce IL-23, but the molecular mechanisms whereby inflammatory signals stimulate IL-23 expression are n...
  3. Distinct structures of scrapie prion protein (PrPSc)-seeded versus spontaneous recombinant prion protein fibrils revealed by hydrogen/deuterium exchange.

    Journal of Biological Chemistry 284(36):24233 (2009) PMID 19596861 PMCID PMC2782017

    The detailed structures of prion disease-associated, partially protease-resistant forms of prion protein (e.g. PrP(Sc)) are largely unknown. PrP(Sc) appears to propagate itself by autocatalyzing the conformational conversion and oligomerization of normal prion protein (PrP(C)). One manifestation...
  4. Lysophosphatidic acid enhances pulmonary epithelial barrier integrity and protects endotoxin-induced epithelial barrier disruption and lung injury.

    Journal of Biological Chemistry 284(36):24123 (2009) PMID 19586906 PMCID PMC2782006

    Lysophosphatidic acid (LPA), a bioactive phospholipid, induces a wide range of cellular effects, including gene expression, cytoskeletal rearrangement, and cell survival. We have previously shown that LPA stimulates secretion of pro- and anti-inflammatory cytokines in bronchial epithelial cells....
  5. Role of intramembrane polar residues in the YgfO xanthine permease: HIS-31 and ASN-93 are crucial for affinity and specificity, and ASP-304 and GLU-272 are irreplaceable.

    Journal of Biological Chemistry 284(36):24257 (2009) PMID 19581302 PMCID PMC2782019

    Using the YgfO xanthine permease of Escherichia coli as a bacterial model for the study of the evolutionarily ubiquitous nucleobase-ascorbate transporter (NAT/NCS2) family, we performed a systematic Cys-scanning and site-directed mutagenesis of 14 putatively charged (Asp, Glu, His, Lys, or Arg) ...
  6. Distinct structural requirements for interleukin-4 (IL-4) and IL-13 binding to the shared IL-13 receptor facilitate cellular tuning of cytokine responsiveness.

    Journal of Biological Chemistry 284(36):24289 (2009) PMID 19586918 PMCID PMC2782022

    Both interleukin-4 (IL-4) and IL-13 can bind to the shared receptor composed of the IL-4 receptor alpha chain and the IL-13 receptor alpha1 chain (IL-13Ralpha1); however, the mechanisms by which these ligands bind to the receptor chains are different, enabling the principal functions of these li...
  7. A monomeric chicken IgY receptor binds IgY with 2:1 stoichiometry.

    Journal of Biological Chemistry 284(36):24168 (2009) PMID 19592496 PMCID PMC2782010

    IgY is the principal serum antibody in birds and reptiles, and an IgY-like molecule was the evolutionary precursor of both mammalian IgG and IgE. A receptor for IgY on chicken monocytes, chicken leukocyte receptor AB1 (CHIR-AB1), lies in the avian leukocyte receptor cluster rather than the class...
  8. The hexosamine biosynthesis pathway is essential for pancreatic beta cell development.

    Journal of Biological Chemistry 284(36):24583 (2009) PMID 19586915 PMCID PMC2782048

    Pancreatic exocrine and endocrine cells develop during embryonic life from endodermal progenitors. This process depends on activation of a hierarchy of transcription factors. Although information is available regarding the mesodermal signals controlling pancreas development, little is known abou...
  9. The role of nitric-oxide synthase in the regulation of UVB light-induced phosphorylation of the alpha subunit of eukaryotic initiation factor 2.

    Journal of Biological Chemistry 284(36):24281 (2009) PMID 19586904 PMCID PMC2782021

    UV light induces phosphorylation of the alpha subunit of the eukaryotic initiation factor 2 (eIF2alpha) and inhibits global protein synthesis. Both eIF2 kinases, protein kinase-like endoplasmic reticulum kinase (PERK) and general control of nonderepressible protein kinase 2 (GCN2), have been sho...
  10. Interaction of Akt-phosphorylated SRPK2 with 14-3-3 mediates cell cycle and cell death in neurons.

    Journal of Biological Chemistry 284(36):24512 (2009) PMID 19592491 PMCID PMC2782043

    Terminally differentiated neurons are unable to reenter the cell cycle. Aberrant cell cycle activation provokes neuronal cell death, whereas cell cycle inhibition elevates neuronal survival. However, the molecular mechanism regulating the cell cycle and cell death in mature neurons remains elusi...
  11. Structural and kinetic characterizations of the polysialic acid O-acetyltransferase OatWY from Neisseria meningitidis.

    Journal of Biological Chemistry 284(36):24501 (2009) PMID 19525232 PMCID PMC2782042

    The neuroinvasive pathogen Neisseria meningitidis has 13 capsular serogroups, but the majority of disease is caused by only 5 of these. Groups B, C, Y, and W-135 all display a polymeric sialic acid-containing capsule that provides a means for the bacteria to evade the immune response during infe...
  12. Identification of specific hemopexin-like domain residues that facilitate matrix metalloproteinase collagenolytic activity.

    Journal of Biological Chemistry 284(36):24017 (2009) PMID 19574232 PMCID PMC2781996

    Collagen serves as a structural scaffold and a barrier between tissues, and thus collagen catabolism (collagenolysis) is required to be a tightly regulated process in normal physiology. In turn, the destruction or damage of collagen during pathological states plays a role in tumor growth and inv...
  13. The thioxotriazole copper(II) complex A0 induces endoplasmic reticulum stress and paraptotic death in human cancer cells.

    Journal of Biological Chemistry 284(36):24306 (2009) PMID 19561079 PMCID PMC2782024

    The copper(II) complex A0 induces a type of non-apoptotic cell death also known as paraptosis. Paraptosis involves extensive endoplasmic reticulum vacuolization in the absence of caspase activation. A wide panel of human cancer cell lines was used to demonstrate differences in cytotoxicity by th...
  14. The small terminase, gp16, of bacteriophage T4 is a regulator of the DNA packaging motor.

    Journal of Biological Chemistry 284(36):24490 (2009) PMID 19561086 PMCID PMC2782041

    Tailed bacteriophages and herpes viruses use powerful molecular motors to translocate DNA into a preassembled prohead and compact the DNA to near crystalline density. The phage T4 motor, a pentamer of 70-kDa large terminase, gp17, is the fastest and most powerful motor reported to date. gp17 has...
  15. Detergent-activated BAX protein is a monomer.

    Journal of Biological Chemistry 284(36):23935 (2009) PMID 19564333 PMCID PMC2781987

    BAX is a pro-apoptotic member of the BCL-2 protein family. At the onset of apoptosis, monomeric, cytoplasmic BAX is activated and translocates to the outer mitochondrial membrane, where it forms an oligomeric pore. The chemical mechanism of BAX activation is controversial, and several in vitro a...
  16. FANCI protein binds to DNA and interacts with FANCD2 to recognize branched structures.

    Journal of Biological Chemistry 284(36):24443 (2009) PMID 19561358 PMCID PMC2782037

    In this study, we report that the purified wild-type FANCI (Fanconi anemia complementation group I) protein directly binds to a variety of DNA substrates. The DNA binding domain roughly encompasses residues 200-1000, as suggested by the truncation study. When co-expressed in insect cells, a smal...
  17. Crystal structure of Bacillus anthracis transpeptidase enzyme CapD.

    Journal of Biological Chemistry 284(36):24406 (2009) PMID 19535342 PMCID PMC2782033

    Bacillus anthracis elaborates a poly-gamma-d-glutamic acid capsule that protects bacilli from phagocytic killing during infection. The enzyme CapD generates amide bonds with peptidoglycan cross-bridges to anchor capsular material within the cell wall envelope of B. anthracis. The capsular biosyn...
  18. Structural investigation of the interaction between LolA and LolB using NMR.

    Journal of Biological Chemistry 284(36):24634 (2009) PMID 19546215 PMCID PMC2782052

    Lipoproteins that play critical roles in various cellular functions of Gram-negative bacteria are localized in the cells inner and outer membranes. Lol proteins (LolA, LolB, LolC, LolD, and LolE) are involved in the transportation of outer membrane-directed lipoproteins from the inner to the out...
  19. Biglycan, a danger signal that activates the NLRP3 inflammasome via toll-like and P2X receptors.

    Journal of Biological Chemistry 284(36):24035 (2009) PMID 19605353 PMCID PMC2781998

    The role of endogenous inducers of inflammation is poorly understood. To produce the proinflammatory master cytokine interleukin (IL)-1beta, macrophages need double stimulation with ligands to both Toll-like receptors (TLRs) for IL-1beta gene transcription and nucleotide-binding oligomerization ...
  20. A unitary anesthetic binding site at high resolution.

    Journal of Biological Chemistry 284(36):24176 (2009) PMID 19605349 PMCID PMC2782011

    Propofol is the most widely used injectable general anesthetic. Its targets include ligand-gated ion channels such as the GABA(A) receptor, but such receptor-channel complexes remain challenging to study at atomic resolution. Until structural biology methods advance to the point of being able to...