Journal of Biological Chemistry

Print ISSN
0021-9258
Electronic ISSN
1083-351X
Impact factor
5.328
Publisher
highwire
URL
http://www.jbc.org
Usage rank
3
Article count
163289
Free count
147136
Free percentage
0.901077
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Aacr, CSA, American Society for Biochemistry and Molecular Biology, Ama, Nephrology, Endocrine, Aaas, Rupress, Highwire, Csh, and Proquest

  1. Functional interactions between the G' subdomain of bacterial translation factor EF-G and ribosomal protein L7/L12.

    Journal of Biological Chemistry 282(51):36998 (2007) PMID 17932030

    Protein L7/L12 of the bacterial ribosome plays an important role in activating the GTP hydrolytic activity of elongation factor G (EF-G), which promotes ribosomal translocation during protein synthesis. Previously, we cross-linked L7/L12 from two residues (209 and 231) flanking alpha-helix AG' i...
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  2. Signal peptide peptidase and gamma-secretase share equivalent inhibitor binding pharmacology.

    Journal of Biological Chemistry 282(51):36829 (2007) PMID 17932033

    The enzyme gamma-secretase has long been considered a potential pharmaceutical target for Alzheimer disease. Presenilin (the catalytic subunit of gamma-secretase) and signal peptide peptidase (SPP) are related transmembrane aspartyl proteases that cleave transmembrane substrates. SPP and gamma-s...
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  3. The active site of an algal prolyl 4-hydroxylase has a large structural plasticity.

    Journal of Biological Chemistry 282(51):37112 (2007) PMID 17940281

    Prolyl 4-hydroxylases (P4Hs) are 2-oxoglutarate dioxygenases that catalyze the hydroxylation of peptidyl prolines. They play an important role in collagen synthesis, oxygen homeostasis, and plant cell wall formation. We describe four structures of a P4H from the green alga Chlamydomonas reinhard...
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  4. Dissecting the facilitator and inhibitor allosteric metal sites of the P2X4 receptor channel: critical roles of CYS132 for zinc potentiation and ASP138 for copper inhibition.

    Journal of Biological Chemistry 282(51):36879 (2007) PMID 17962187

    Zinc and copper are atypical modulators of ligand-gated ionic channels in the central nervous system. We sought to identify the amino acids of the rat P2X4 receptor involved in trace metal interaction, specifically in the immediate linear vicinity of His140, a residue previously identified as be...
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  5. Heat shock transcription factor 1 is required for maintenance of ciliary beating in mice.

    Journal of Biological Chemistry 282(51):37285 (2007) PMID 17965413

    Heat shock transcription factors (HSFs) maintain protein homeostasis through regulating expression of heat shock proteins, especially in stressed conditions. In addition, HSFs are involved in cellular differentiation and development by regulating development-related genes, as well as heat shock ...
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  6. Control of phenotypic plasticity of smooth muscle cells by bone morphogenetic protein signaling through the myocardin-related transcription factors.

    Journal of Biological Chemistry 282(51):37244 (2007) PMID 17947237 PMCID PMC3405982

    Vascular smooth muscle cells (VSMCs), unlike other muscle cells, do not terminally differentiate. In response to injury, VSMCs change phenotype, proliferate, and migrate as part of the repair process. Dysregulation of this plasticity program contributes to the pathogenesis of several vascular di...
  7. A novel structural fold in polysaccharide lyases: Bacillus subtilis family 11 rhamnogalacturonan lyase YesW with an eight-bladed beta-propeller.

    Journal of Biological Chemistry 282(51):37134 (2007) PMID 17947240

    Rhamnogalacturonan (RG) lyase produced by plant pathogenic and saprophytic microbes plays an important role in degrading plant cell walls. An extracellular RG lyase YesW from saprophytic Bacillus subtilis is a member of polysaccharide lyase family 11 and cleaves glycoside bonds in polygalacturon...
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  8. Three-dimensional reconstruction using transmission electron microscopy reveals a swollen, bell-shaped structure of transient receptor potential melastatin type 2 cation channel.

    Journal of Biological Chemistry 282(51):36961 (2007) PMID 17940282

    Transient receptor potential melastatin type 2 (TRPM2) is a redox-sensitive, calcium-permeable cation channel activated by various signals, such as adenosine diphosphate ribose (ADPR) acting on the ADPR pyrophosphatase (ADPRase) domain, and cyclic ADPR. Here, we purified the FLAG-tagged tetramer...
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  9. Functional interactions between the G' subdomain of bacterial translation factor EF-G and ribosomal protein L7/L12.

    Journal of Biological Chemistry 282(51):36998 (2007) PMID 17932030

    Protein L7/L12 of the bacterial ribosome plays an important role in activating the GTP hydrolytic activity of elongation factor G (EF-G), which promotes ribosomal translocation during protein synthesis. Previously, we cross-linked L7/L12 from two residues (209 and 231) flanking alpha-helix AG' i...
    PDF not found
  10. The lipid droplet binding domain of hepatitis C virus core protein is a major determinant for efficient virus assembly.

    Journal of Biological Chemistry 282(51):37158 (2007) PMID 17942391

    Hepatitis C virus core protein forms the viral capsid and is targeted to lipid droplets (LDs) by its domain 2 (D2). By using a comparative analysis of two hepatitis C virus genomes (JFH1 and Jc1) differing in their level of virus production in cultured human hepatoma cells, we demonstrate that t...
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  11. Solution structure of selenoprotein W and NMR analysis of its interaction with 14-3-3 proteins.

    Journal of Biological Chemistry 282(51):37036 (2007) PMID 17928294

    Selenium is a trace element with significant biomedical potential. It is essential in mammals due to its occurrence in several proteins in the form of selenocysteine (Sec). One of the most abundant mammalian Sec-containing proteins is selenoprotein W (SelW). This protein of unknown function has ...
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  12. Znt7 (Slc30a7)-deficient mice display reduced body zinc status and body fat accumulation.

    Journal of Biological Chemistry 282(51):37053 (2007) PMID 17954933

    In vitro studies have demonstrated that ZNT7 is involved in transporting the cytoplasmic zinc into the Golgi apparatus of the cell for zinc storage or to be incorporated into newly synthesized zinc-requiring enzymes/proteins. To evaluate the physiological role of ZNT7, we created a mouse model o...
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  13. Dissecting the facilitator and inhibitor allosteric metal sites of the P2X4 receptor channel: critical roles of CYS132 for zinc potentiation and ASP138 for copper inhibition.

    Journal of Biological Chemistry 282(51):36879 (2007) PMID 17962187

    Zinc and copper are atypical modulators of ligand-gated ionic channels in the central nervous system. We sought to identify the amino acids of the rat P2X4 receptor involved in trace metal interaction, specifically in the immediate linear vicinity of His140, a residue previously identified as be...
    PDF not found
  14. Novel conantokins from Conus parius venom are specific antagonists of N-methyl-D-aspartate receptors.

    Journal of Biological Chemistry 282(51):36905 (2007) PMID 17962189

    We report the discovery and characterization of three conantokin peptides from the venom of Conus parius. Each peptide (conantokin-Pr1, -Pr2, and -Pr3) contains 19 amino acids with three gamma-carboxyglutamate (Gla) residues, a post-translationally modified amino acid characteristic of conantoki...
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  15. Binding of Rac1, Rnd1, and RhoD to a novel Rho GTPase interaction motif destabilizes dimerization of the plexin-B1 effector domain.

    Journal of Biological Chemistry 282(51):37215 (2007) PMID 17916560 PMCID PMC2655321

    Plexins are the first known transmembrane receptors that interact directly with small GTPases. On binding to certain Rho family GTPases, the receptor regulates the remodeling of the actin cytoskeleton and alters cell movement in response to semaphorin guidance cues. In a joint solution NMR spect...
  16. Abnormal taste perception in mice lacking the type 3 inositol 1,4,5-trisphosphate receptor.

    Journal of Biological Chemistry 282(51):37225 (2007) PMID 17925404

    Inositol 1,4,5-trisphosphate receptor (IP3R) is one of the important calcium channels expressed in the endoplasmic reticulum and has been shown to play crucial roles in various physiological phenomena. Type 3 IP3R is expressed in taste cells, but the physiological relevance of this receptor in t...
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  17. Asparatic acid 221 is critical in the calcium-induced modulation of the enzymatic activity of human aminopeptidase A.

    Journal of Biological Chemistry 282(51):37074 (2007) PMID 17932029

    Aminopeptidase A (APA) plays an important role in the regulation of blood pressure by mediating angiotensin II degradation in the renin-angiotensin system. The Ca2+-induced modulation of enzymatic activity is the most characteristic feature of APA among the M1 family of aminopeptidases. In this ...
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  18. Bone morphogenetic protein 2 opposes Shh-mediated proliferation in cerebellar granule cells through a TIEG-1-based regulation of Nmyc.

    Journal of Biological Chemistry 282(51):37170 (2007) PMID 17951258

    Nmyc is a potent regulator of cell cycle in cerebellar granular neuron precursors (CGNPs) and has been proposed to be the main effector of Shh (Sonic hedgehog) proliferative activity. Nmyc ectopic expression is sufficient to promote cell autonomous proliferation and can lead to tumorigenesis. Bo...
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  19. BAG-1 associates with Hsc70.Tau complex and regulates the proteasomal degradation of Tau protein.

    Journal of Biological Chemistry 282(51):37276 (2007) PMID 17954934

    Intraneuronal accumulation of phosphorylated Tau protein is a molecular pathology found in many forms of dementia, including Alzheimer disease. Research into possible mechanisms leading to the accumulation of modified Tau protein and the possibility of removing Tau protein from the system have r...
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  20. Modulation of F-actin rearrangement by the cyclic AMP/cAMP-dependent protein kinase (PKA) pathway is mediated by MAPK-activated protein kinase 5 and requires PKA-induced nuclear export of MK5.

    Journal of Biological Chemistry 282(51):37232 (2007) PMID 17947239

    The MAPK-activated protein kinases belong to the Ca2+/calmodulin-dependent protein kinases. Within this group, MK2, MK3, and MK5 constitute three structurally related enzymes with distinct functions. Few genuine substrates for MK5 have been identified, and the only known biological role is in ra...
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