Journal of Biological Chemistry

Print ISSN
0021-9258
Electronic ISSN
1083-351X
Impact factor
5.328
Publisher
highwire
URL
http://www.jbc.org
Usage rank
3
Article count
163289
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147136
Free percentage
0.901077
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Aacr, CSA, American Society for Biochemistry and Molecular Biology, Ama, Nephrology, Endocrine, Aaas, Rupress, Highwire, Csh, and Proquest

  1. Functional interactions between the G' subdomain of bacterial translation factor EF-G and ribosomal protein L7/L12.

    Journal of Biological Chemistry 282(51):36998 (2007) PMID 17932030

    Protein L7/L12 of the bacterial ribosome plays an important role in activating the GTP hydrolytic activity of elongation factor G (EF-G), which promotes ribosomal translocation during protein synthesis. Previously, we cross-linked L7/L12 from two residues (209 and 231) flanking alpha-helix AG' i...
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  2. The lipid droplet binding domain of hepatitis C virus core protein is a major determinant for efficient virus assembly.

    Journal of Biological Chemistry 282(51):37158 (2007) PMID 17942391

    Hepatitis C virus core protein forms the viral capsid and is targeted to lipid droplets (LDs) by its domain 2 (D2). By using a comparative analysis of two hepatitis C virus genomes (JFH1 and Jc1) differing in their level of virus production in cultured human hepatoma cells, we demonstrate that t...
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  3. Solution structure of selenoprotein W and NMR analysis of its interaction with 14-3-3 proteins.

    Journal of Biological Chemistry 282(51):37036 (2007) PMID 17928294

    Selenium is a trace element with significant biomedical potential. It is essential in mammals due to its occurrence in several proteins in the form of selenocysteine (Sec). One of the most abundant mammalian Sec-containing proteins is selenoprotein W (SelW). This protein of unknown function has ...
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  4. Znt7 (Slc30a7)-deficient mice display reduced body zinc status and body fat accumulation.

    Journal of Biological Chemistry 282(51):37053 (2007) PMID 17954933

    In vitro studies have demonstrated that ZNT7 is involved in transporting the cytoplasmic zinc into the Golgi apparatus of the cell for zinc storage or to be incorporated into newly synthesized zinc-requiring enzymes/proteins. To evaluate the physiological role of ZNT7, we created a mouse model o...
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  5. Dissecting the facilitator and inhibitor allosteric metal sites of the P2X4 receptor channel: critical roles of CYS132 for zinc potentiation and ASP138 for copper inhibition.

    Journal of Biological Chemistry 282(51):36879 (2007) PMID 17962187

    Zinc and copper are atypical modulators of ligand-gated ionic channels in the central nervous system. We sought to identify the amino acids of the rat P2X4 receptor involved in trace metal interaction, specifically in the immediate linear vicinity of His140, a residue previously identified as be...
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  6. Novel conantokins from Conus parius venom are specific antagonists of N-methyl-D-aspartate receptors.

    Journal of Biological Chemistry 282(51):36905 (2007) PMID 17962189

    We report the discovery and characterization of three conantokin peptides from the venom of Conus parius. Each peptide (conantokin-Pr1, -Pr2, and -Pr3) contains 19 amino acids with three gamma-carboxyglutamate (Gla) residues, a post-translationally modified amino acid characteristic of conantoki...
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  7. BAG-1 associates with Hsc70.Tau complex and regulates the proteasomal degradation of Tau protein.

    Journal of Biological Chemistry 282(51):37276 (2007) PMID 17954934

    Intraneuronal accumulation of phosphorylated Tau protein is a molecular pathology found in many forms of dementia, including Alzheimer disease. Research into possible mechanisms leading to the accumulation of modified Tau protein and the possibility of removing Tau protein from the system have r...
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  8. Characterization of the NuoM (ND4) subunit in Escherichia coli NDH-1: conserved charged residues essential for energy-coupled activities.

    Journal of Biological Chemistry 282(51):36914 (2007) PMID 17977822

    The proton-translocating NADH-quinone (Q) oxidoreductase (NDH-1) from Escherichia coli is composed of two segments: a peripheral arm and a membrane arm. The membrane arm contains 7 hydrophobic subunits. Of these subunits, NuoM, a homolog of the mitochondrial ND4 subunit, is proposed to be involv...
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  9. Binding of Rac1, Rnd1, and RhoD to a novel Rho GTPase interaction motif destabilizes dimerization of the plexin-B1 effector domain.

    Journal of Biological Chemistry 282(51):37215 (2007) PMID 17916560 PMCID PMC2655321

    Plexins are the first known transmembrane receptors that interact directly with small GTPases. On binding to certain Rho family GTPases, the receptor regulates the remodeling of the actin cytoskeleton and alters cell movement in response to semaphorin guidance cues. In a joint solution NMR spect...
  10. Negative regulation of inducible nitric-oxide synthase expression mediated through transforming growth factor-beta-dependent modulation of transcription factor TCF11.

    Journal of Biological Chemistry 282(51):36837 (2007) PMID 17928287

    Inducible nitric-oxide synthase (iNOS) plays a central role in the regulation of vascular function and response to injury. A central mediator controlling iNOS expression is transforming growth factor-beta (TGF-beta), which represses its expression through a mechanism that is poorly understood. W...
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  11. Cell type-specific functions of the lysosomal protease cathepsin L in the heart.

    Journal of Biological Chemistry 282(51):37045 (2007) PMID 17942402

    Deficiency of the lysosomal cysteine protease cathepsin L (Ctsl) in mice results in a phenotype affecting multiple tissues, including thymus, epidermis, and hair follicles, and in the heart develops as a progressive dilated cardiomyopathy (DCM). To understand the role of Ctsl in the maintenance ...
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  12. Crystal structures of blasticidin S deaminase (BSD): implications for dynamic properties of catalytic zinc.

    Journal of Biological Chemistry 282(51):37103 (2007) PMID 17959604

    The set of blasticidin S (BS) and blasticidin S deaminase (BSD) is a widely used selectable marker for gene transfer experiments. BSD is a member of the cytidine deaminase (CDA) family; it is a zinc-dependent enzyme with three cysteines and one water molecule as zinc ligands. The crystal structu...
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  13. Precursor protein is readily degraded in mitochondrial matrix space if the leader is not processed by mitochondrial processing peptidase.

    Journal of Biological Chemistry 282(51):37266 (2007) PMID 17959599

    It is not known why leader peptides are removed by the mitochondrial processing peptidase after import into the matrix space. The leaders of yeast aldehyde dehydrogenase (pALDH) and malate dehydrogenase were mutated so that they would not be processed after import. The recombinant nonprocessed p...
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  14. A novel structural fold in polysaccharide lyases: Bacillus subtilis family 11 rhamnogalacturonan lyase YesW with an eight-bladed beta-propeller.

    Journal of Biological Chemistry 282(51):37134 (2007) PMID 17947240

    Rhamnogalacturonan (RG) lyase produced by plant pathogenic and saprophytic microbes plays an important role in degrading plant cell walls. An extracellular RG lyase YesW from saprophytic Bacillus subtilis is a member of polysaccharide lyase family 11 and cleaves glycoside bonds in polygalacturon...
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  15. Evidence for nifU and nifS participation in the biosynthesis of the iron-molybdenum cofactor of nitrogenase.

    Journal of Biological Chemistry 282(51):37016 (2007) PMID 17959596

    The nifU and nifS genes encode the components of a cellular machinery dedicated to the assembly of [2Fe-2S] and [4Fe-4S] clusters required for growth under nitrogen-fixing conditions. The NifU and NifS proteins are involved in the production of active forms of the nitrogenase component proteins,...
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  16. Peroxisome proliferator-activated receptor gamma up-regulates the Bcl-2 anti-apoptotic protein in neurons and induces mitochondrial stabilization and protection against oxidative stress and apoptosis.

    Journal of Biological Chemistry 282(51):37006 (2007) PMID 17965419

    Peroxisome proliferator-activated receptor gamma (PPARgamma) has been proposed as a therapeutic target for neurodegenerative diseases because of its anti-inflammatory action in glial cells. However, PPARgamma agonists preventbeta-amyloid (Abeta)-induced neurodegeneration in hippocampal neurons, ...
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  17. Saccharomyces cerevisiae MutLalpha is a mismatch repair endonuclease.

    Journal of Biological Chemistry 282(51):37181 (2007) PMID 17951253 PMCID PMC2302834

    MutL homologs are crucial for mismatch repair and genetic stability, but their function is not well understood. Human MutLalpha (MLH1-PMS2 heterodimer) harbors a latent endonuclease that is dependent on the integrity of a PMS2 DQHA(X)2E(X)4E motif (Kadyrov, F. A., Dzantiev, L., Constantin, N., a...
  18. Crystal Structure of the interleukin-15.interleukin-15 receptor alpha complex: insights into trans and cis presentation.

    Journal of Biological Chemistry 282(51):37191 (2007) PMID 17947230

    Interleukin (IL)-15 is a pleiotropic cytokine that plays a pivotal role in both innate and adaptive immunity. IL-15 is unique among cytokines due to its participation in a trans signaling mechanism in which IL-15 receptor alpha (IL-15Ralpha) from one subset of cells presents IL-15 to neighboring...
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  19. Signaling by Toll-like receptors 8 and 9 requires Bruton's tyrosine kinase.

    Journal of Biological Chemistry 282(51):36953 (2007) PMID 17932028

    Toll-like receptors (TLRs) are a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense. TLR7 and TLR8 sense single-stranded RNA from viruses or host ribonucleoproteins and synthetic imidazoquinolines such as R848, whereas TLR9 senses unmethy...
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  20. Major house dust mite allergens Dermatophagoides pteronyssinus 1 and Dermatophagoides farinae 1 degrade and inactivate lung surfactant proteins A and D.

    Journal of Biological Chemistry 282(51):36808 (2007) PMID 17848554

    Lung surfactant proteins (SP) A and D are calcium-dependent carbohydrate-binding proteins. In addition to playing multiple roles in innate immune defense such as bacterial aggregation and modulation of leukocyte function, SP-A and SP-D have also been implicated in the allergic response. They int...
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