Journal of Cell Science

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  1. Phosphorylation of histone H3 at Thr3 is part of a combinatorial pattern that marks and configures mitotic chromatin.

    Journal of Cell Science 122(Pt 16):2809 (2009) PMID 19622635

    We have previously shown that histone H3 is transiently phosphorylated at Thr3 during mitosis. Extending these studies, we now report that phosphorylated Thr3 is always in cis to trimethylated Lys4 and dimethylated Arg8, forming a new type of combinatorial modification, which we have termed PMM....
  2. Regulation of VDR by deltaNp63alpha is associated with inhibition of cell invasion.

    Journal of Cell Science 122(Pt 16):2828 (2009) PMID 19622632 PMCID PMC2724606

    The p63 transcription factor has a pivotal role in epithelial morphogenesis. Multiple transcripts of the TP63 gene are generated because of alternative promoter usage and splicing. DeltaNp63alpha is the predominant isoform of p63 observed during epithelial morphogenesis and in human cancers. Los...
  3. KDP-1 is a nuclear envelope KASH protein required for cell-cycle progression.

    Journal of Cell Science 122(Pt 16):2895 (2009) PMID 19638405 PMCID PMC2724607

    Klarsicht, ANC-1 and Syne homology (KASH) proteins localize to the outer nuclear membrane where they connect the nucleus to the cytoskeleton. KASH proteins interact with Sad1-UNC-84 (SUN) proteins to transfer forces across the nuclear envelope to position nuclei or move chromosomes. A new KASH p...
  4. Y RNA functions at the initiation step of mammalian chromosomal DNA replication.

    Journal of Cell Science 122(Pt 16):2836 (2009) PMID 19657016

    Non-coding Y RNAs have recently been identified as essential novel factors for chromosomal DNA replication in mammalian cell nuclei, but mechanistic details of their function have not been defined. Here, we identify the execution point for Y RNA function during chromosomal DNA replication in a m...
  5. Organisation of human ER-exit sites: requirements for the localisation of Sec16 to transitional ER.

    Journal of Cell Science 122(Pt 16):2924 (2009) PMID 19638414 PMCID PMC2724609

    The COPII complex mediates the selective incorporation of secretory cargo and relevant machinery into budding vesicles at specialised sites on the endoplasmic reticulum membrane called transitional ER (tER). Here, we show using confocal microscopy, immunogold labelling of ultrathin cryosections ...
  6. Identification of a novel mouse P4-ATPase family member highly expressed during spermatogenesis.

    Journal of Cell Science 122(Pt 16):2866 (2009) PMID 19657017

    P4-ATPases are transmembrane proteins unique to eukaryotes that play a fundamental role in vesicular transport. They have been proposed to act as phospholipid flippases thereby regulating lipid topology in cellular membranes. We cloned and characterized a novel murine P4-ATPase that is specifica...
  7. G2 histone methylation is required for the proper segregation of chromosomes.

    Journal of Cell Science 122(Pt 16):2957 (2009) PMID 19638412

    Trimethylation of lysine 9 on histone H3 (H3K9me3) is known both to be necessary for proper chromosome segregation and to increase in late G2. We investigated the role of late G2 methylation, specifically in mitotic progression, by inhibiting methylation for 2 hours prior to mitosis using the ge...
  8. Transient assembly of F-actin by phagosomes delays phagosome fusion with lysosomes in cargo-overloaded macrophages.

    Journal of Cell Science 122(Pt 16):2935 (2009) PMID 19638408

    Dynamic remodelling of the cortical actin cytoskeleton is required for phagocytic uptake of pathogens and other particles by macrophages. Actin can also be nucleated de novo on membranes of nascent phagosomes, a process that can stimulate or inhibit phagosome fusion with lysosomes. Recently, pha...
  9. Unconventional splicing of XBP1 mRNA occurs in the cytoplasm during the mammalian unfolded protein response.

    Journal of Cell Science 122(Pt 16):2877 (2009) PMID 19622636

    XBP1 is a key transcription factor that regulates the mammalian unfolded protein response. Its expression is regulated by unconventional mRNA splicing that is carried out by endonuclease IRE1 and a specific, as yet unknown, RNA ligase in response to the accumulation of unfolded proteins in the E...
  10. SPOC1: a novel PHD-containing protein modulating chromatin structure and mitotic chromosome condensation.

    Journal of Cell Science 122(Pt 16):2946 (2009) PMID 19638409

    In this study, we characterize the molecular and functional features of a novel protein called SPOC1. SPOC1 RNA expression was previously reported to be highest in highly proliferating tissues and increased in a subset of ovarian carcinoma patients, which statistically correlated with poor progn...
  11. Furrow-like invaginations of the yeast plasma membrane correspond to membrane compartment of Can1.

    Journal of Cell Science 122(Pt 16):2887 (2009) PMID 19638406

    Plasma membrane of the yeast Saccharomyces cerevisiae contains stable lateral domains. We have investigated the ultrastructure of one type of domain, the membrane compartment of Can1 (MCC). In two yeast strains (nce102Delta and pil1Delta) that are defective in segregation of MCC-specific protein...
  12. Mammalian cytosine methylation at a glance.

    Journal of Cell Science 122(Pt 16):2787 (2009) PMID 19657014 PMCID PMC2724605

  13. Neogenesis and maturation of transient Golgi-like cisternae in a simple eukaryote.

    Journal of Cell Science 122(Pt 16):2846 (2009) PMID 19622633

    The highly reduced protozoan parasite Giardia lamblia has minimal machinery for cellular processes such as protein trafficking. Giardia trophozoites maintain diverse and regulated secretory pathways but lack an identifiable Golgi complex. During differentiation to cysts, however, they produce sp...
  14. Opposing effects of Ndel1 and alpha1 or alpha2 on cytoplasmic dynein through competitive binding to Lis1.

    Journal of Cell Science 122(Pt 16):2820 (2009) PMID 19622634

    Lis1 is an essential protein whose insufficiency causes aberrant neuronal positioning during neocortical development. It is believed to regulate both cytoplasmic dynein, a microtubule minus-end-directed motor, through direct interaction, and platelet-activating factor acetylhydrolase (PAF-AH) Ib...
  15. Normal human mammary epithelial cells proliferate rapidly in the presence of elevated levels of the tumor suppressors p53 and p21(WAF1/CIP1).

    Journal of Cell Science 122(Pt 16):2989 (2009) PMID 19638413

    In normal cells, p53 protein is maintained at low levels, but the levels increase after stress or inappropriate growth signals to coordinate growth arrest or apoptosis. Human mammary epithelial cells (HMECs) are unusual in that they exhibit two phases of growth. The second growth phase, referred...
  16. Dynamic changes in Rap1 activity are required for cell retraction and spreading during mitosis.

    Journal of Cell Science 122(Pt 16):2996 (2009) PMID 19638416

    At the onset of mitosis, most adherent cells undergo cell retraction characterised by the disassembly of focal adhesions and actin stress fibres. Mitosis takes place in rounded cells, and the two daughter cells spread again after cytokinesis. Because of the well-documented ability of the small G...
  17. Mechanisms by which Bak and Bax permeabilise mitochondria during apoptosis.

    Journal of Cell Science 122(Pt 16):2801 (2009) PMID 19795525 PMCID PMC2736138

    Mitochondrial outer membrane permeabilisation (MOMP) is the point of no return in many forms of apoptotic cell death. The killing effect of MOMP is twofold; it both initiates a proteolytic cascade of pro-apoptotic enzymes and damages mitochondrial function. Accordingly, prevention of MOMP can re...
  18. The dynamic properties of intermediate filaments during organelle transport.

    Journal of Cell Science 122(Pt 16):2914 (2009) PMID 19638410 PMCID PMC2724608

    Intermediate filament (IF) dynamics during organelle transport and their role in organelle movement were studied using Xenopus laevis melanophores. In these cells, pigment granules (melanosomes) move along microtubules and microfilaments, toward and away from the cell periphery in response to al...
  19. The ADAMTS12 metalloprotease gene is epigenetically silenced in tumor cells and transcriptionally activated in the stroma during progression of colon cancer.

    Journal of Cell Science 122(Pt 16):2906 (2009) PMID 19638407

    Proteases have long been associated with tumor progression, given their ability to degrade extracellular matrix components and facilitate invasion and metastasis. However, recent findings indicate that different proteases can also act as tumor-suppressor enzymes. We have recently reported that l...
  20. Phosphorylation of CLASP2 by GSK-3beta regulates its interaction with IQGAP1, EB1 and microtubules.

    Journal of Cell Science 122(Pt 16):2969 (2009) PMID 19638411

    Polarised cell migration is required for various cell behaviours and functions. Actin and microtubules are coupled structurally and distributed asymmetrically along the front-rear axis of migrating cells. CLIP-associating proteins (CLASPs) accumulate near the ends of microtubules at the front of...