Journal Of Cellular Physiology

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  1. CRISPR-Cas Assisted Multiplexing (CAM): Simple Same-Day Multi-Locus Engineering in Yeast.

    Journal Of Cellular Physiology (2016) PMID 26991244

    Demands on the industrial and academic yeast strain engineer have increased significantly in the era of synthetic biology. Installing complex biosynthetic pathways and combining point mutations are tedious and time-consuming using traditional methods. With multiplex engineering tools, these tasks...
  2. Insulin receptor substrate (IRS)-1 regulates murine embryonic stem (mES) cells self-renewal.

    Journal Of Cellular Physiology 213(2):445 (2007) PMID 17620314 PMCID PMC3760688

    Mouse embryonic stem (mES) cells are pluripotent cells that can be propagated in vitro with leukemia inhibitory factor (LIF) and serum. Intracellular signaling by LIF is principally mediated by activation of STAT-3, although additional pathways for self-renewal have been described. Here, we iden...
  3. Seeing the light: new insights into the molecular pathogenesis of retinal diseases.

    Journal Of Cellular Physiology 213(2):348 (2007) PMID 17654481

    In the past, most treatments for retinal diseases have been empirical. Steroids and/or laser photocoagulation and/or surgery have been tried for almost every condition with little or no understanding of the underlying disease. Over the past several years vision researchers have uncovered molecul...
  4. Sp3-mediated VEGF regulation is dependent on phosphorylation by extra-cellular signals regulated kinases (Erk).

    Journal Of Cellular Physiology 213(2):454 (2007) PMID 17685427

    We have previously demonstrated that phosphorylation by Erk of Sp1 was essential for its full activity in the context of the VEGF promoter. Here, we show that Sp3, which, as Sp1, belongs to the GC-rich binding transcription factor family, is also phosphorylated by Erk in vitro on serine 73. We h...
  5. Increased Ca2+ storage capacity of the skeletal muscle sarcoplasmic reticulum of transgenic mice over-expressing membrane bound calcium binding protein junctate.

    Journal Of Cellular Physiology 213(2):464 (2007) PMID 17516551

    Junctate is an integral sarco(endo)plasmic reticulum protein expressed in many tissues including heart and skeletal muscle. Because of its localization and biochemical characteristics, junctate is deemed to participate in the regulation of the intracellular Ca2+ concentration. However, its physi...
  6. The PVT-1 oncogene is a Myc protein target that is overexpressed in transformed cells.

    Journal Of Cellular Physiology 213(2):511 (2007) PMID 17503467

    The human PVT-1 gene is located on chromosome 8 telomeric to the c-Myc gene and it is frequently involved in the translocations occurring in variant Burkitt's lymphomas and murine plasmacytomas. It has been proposed that PVT-1 regulates c-Myc gene transcription over a long distance. To get new i...
  7. Interplay between chromatin remodelers and protein arginine methyltransferases.

    Journal Of Cellular Physiology 213(2):306 (2007) PMID 17708529

    Chromatin modifying enzymes have emerged as key regulators of all DNA based processes, which control cell growth, development, and differentiation. Recently, it has become clear that different chromatin remodeling and histone-modifying activities are involved in transcriptional activation and re...
  8. Key factors in the regulation of fetal and postnatal Leydig cell development.

    Journal Of Cellular Physiology 213(2):429 (2007) PMID 17674364

    The primary function of testicular Leydig cells is the production of androgens to promote sexual differentiation in the fetus, secondary sexual maturation at puberty, and spermatogenesis in the adult. The fetal and postnatal (adult) populations of Leydig cells differ morphologically and have dis...
  9. Linkage studies for T2D in Chop and C/EBPbeta chromosomal regions in Italians.

    Journal Of Cellular Physiology 213(2):552 (2007) PMID 17620318

    The genes causing type 2 diabetes (T2D), a complex heterogeneous disorder, differ and/or overlap in various populations. Among others there are two loci in linkage to T2D, the chromosomes 20q12-13.1 and 12q15. These two regions harbor two genes, C/EBPbeta and CHOP, which are excellent candidate ...
  10. Fibrillin-rich microfibrils: Structural determinants of morphogenetic and homeostatic events.

    Journal Of Cellular Physiology 213(2):326 (2007) PMID 17708531

    Fibrillin-rich microfibrils are specialized extracellular matrix assemblies that endow connective tissues with mechanical stability and elastic properties, and that participate in the regulation of organ formation, growth and homeostasis. Their physiological importance is underscored by the comp...
  11. Impact of the non-cellular tumor microenvironment on metastasis: potential therapeutic and imaging opportunities.

    Journal Of Cellular Physiology 213(2):391 (2007) PMID 17657728

    Evidence is accumulating that the malignant phenotype of a given tumor is dependent not only on the intrinsic characteristics of tumor cells, but also on the cooperative interactions of non-neoplastic cells, soluble secreted factors and the non-cellular solid-state ECM network that comprise the ...
  12. A mechanistic view on the evolutionary origin for centrin-based control of centriole duplication.

    Journal Of Cellular Physiology 213(2):420 (2007) PMID 17694534

    Mounting evidence implicates the protein centrin as a key regulator of centriole duplication, yet it remains to be determined just how centrin functions in this process. Recent studies suggest that centrin exerts both spatial and temporal control over centriole duplication through its role as a ...
  13. The MET receptor tyrosine kinase in invasion and metastasis.

    Journal Of Cellular Physiology 213(2):316 (2007) PMID 17607709

    Various cytokines and soluble growth factors upon interaction with their membrane receptors are responsible for inducing cellular proliferation, differentiation, movement, and protection from anoikis (a planned suicide activated by normal cells in absence of attachment to neighboring cells or ex...
  14. Ca2+ signaling differentiation during oocyte maturation.

    Journal Of Cellular Physiology 213(2):331 (2007) PMID 17620315

    Oocyte maturation is an essential cellular differentiation pathway that prepares the egg for activation at fertilization leading to the initiation of embryogenesis. An integral attribute of oocyte maturation is the remodeling of Ca2+ signaling pathways endowing the egg with the capacity to produ...
  15. The chromatin of differentiating erythroblasts is cleaved into large size fragments independent of caspase activated DNase and apoptosis inducing factor.

    Journal Of Cellular Physiology 213(2):490 (2007) PMID 17492772

    Erythroblast cell differentiation involves self-controlled and limited nuclear proteolysis prior nucleus loss. Early evidence suggests that apoptotic-like pathways are activated during this process. The chromatin of developing erythroblasts becomes fragmented in vivo, however, the exact mechanis...
  16. Early replication and the apoptotic pathway.

    Journal Of Cellular Physiology 213(2):434 (2007) PMID 17520690

    In higher eukaryotes there is a link between time of replication and transcription. It is generally accepted that genes that are actively transcribed are replicated in the first half of S phase while inactive genes replicate in the second half of S phase. We have recently reported that in normal...
  17. Liver regeneration.

    Journal Of Cellular Physiology 213(2):286 (2007) PMID 17559071 PMCID PMC2701258

    Liver regeneration after partial hepatectomy is a very complex and well-orchestrated phenomenon. It is carried out by the participation of all mature liver cell types. The process is associated with signaling cascades involving growth factors, cytokines, matrix remodeling, and several feedbacks ...
  18. The participation of the Na+-Ca2+ exchanger in primary cardiac myofibroblast migration, contraction, and proliferation.

    Journal Of Cellular Physiology 213(2):540 (2007) PMID 17541957

    Cardiac ventricular myofibroblast motility, proliferation, and contraction contribute to post-myocardial infarct wound healing, infarct scar formation, and remodeling of the ventricle remote to the site of infarction. The Na+-Ca2+ exchanger (NCX1) is involved in altered calcium handling in cardi...
  19. Activin receptor-like kinase 1 inhibits human microvascular endothelial cell migration: potential roles for JNK and ERK.

    Journal Of Cellular Physiology 213(2):484 (2007) PMID 17620321

    Activin receptor-like kinase 1 (ALK1) is an endothelial-specific type I receptor of the TGFbeta receptor family that is implicated in angiogenesis and in the pathogenesis of the vascular disease, hereditary hemorrhagic telangiectasia (HHT). In the absence of a specific ligand, ALK1 cellular func...
  20. Insulin receptor substrate 1 (IRS-1) plays a unique role in normal epidermal physiology.

    Journal Of Cellular Physiology 213(2):519 (2007) PMID 17508357

    Insulin receptor substrate (IRS) proteins play a central role in insulin signaling. Previously we have demonstrated that insulin is essential for normal skin development and function. In the present study we investigated the involvement of the IRS-1 and IRS-2 proteins in skin physiology and in m...