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Journal Of Cellular Physiology

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  1. Insulin receptor substrate (IRS)-1 regulates murine embryonic stem (mES) cells self-renewal.

    Journal Of Cellular Physiology 213(2):445 (2007) PMID 17620314 PMCID PMC3760688

    Mouse embryonic stem (mES) cells are pluripotent cells that can be propagated in vitro with leukemia inhibitory factor (LIF) and serum. Intracellular signaling by LIF is principally mediated by activation of STAT-3, although additional pathways for self-renewal have been described. Here, we iden...
  2. Seeing the light: new insights into the molecular pathogenesis of retinal diseases.

    Journal Of Cellular Physiology 213(2):348 (2007) PMID 17654481

    In the past, most treatments for retinal diseases have been empirical. Steroids and/or laser photocoagulation and/or surgery have been tried for almost every condition with little or no understanding of the underlying disease. Over the past several years vision researchers have uncovered molecul...
  3. Sp3-mediated VEGF regulation is dependent on phosphorylation by extra-cellular signals regulated kinases (Erk).

    Journal Of Cellular Physiology 213(2):454 (2007) PMID 17685427

    We have previously demonstrated that phosphorylation by Erk of Sp1 was essential for its full activity in the context of the VEGF promoter. Here, we show that Sp3, which, as Sp1, belongs to the GC-rich binding transcription factor family, is also phosphorylated by Erk in vitro on serine 73. We h...
  4. Increased Ca2+ storage capacity of the skeletal muscle sarcoplasmic reticulum of transgenic mice over-expressing membrane bound calcium binding protein junctate.

    Journal Of Cellular Physiology 213(2):464 (2007) PMID 17516551

    Junctate is an integral sarco(endo)plasmic reticulum protein expressed in many tissues including heart and skeletal muscle. Because of its localization and biochemical characteristics, junctate is deemed to participate in the regulation of the intracellular Ca2+ concentration. However, its physi...
  5. The PVT-1 oncogene is a Myc protein target that is overexpressed in transformed cells.

    Journal Of Cellular Physiology 213(2):511 (2007) PMID 17503467

    The human PVT-1 gene is located on chromosome 8 telomeric to the c-Myc gene and it is frequently involved in the translocations occurring in variant Burkitt's lymphomas and murine plasmacytomas. It has been proposed that PVT-1 regulates c-Myc gene transcription over a long distance. To get new i...
  6. Interplay between chromatin remodelers and protein arginine methyltransferases.

    Journal Of Cellular Physiology 213(2):306 (2007) PMID 17708529

    Chromatin modifying enzymes have emerged as key regulators of all DNA based processes, which control cell growth, development, and differentiation. Recently, it has become clear that different chromatin remodeling and histone-modifying activities are involved in transcriptional activation and re...
  7. Key factors in the regulation of fetal and postnatal Leydig cell development.

    Journal Of Cellular Physiology 213(2):429 (2007) PMID 17674364

    The primary function of testicular Leydig cells is the production of androgens to promote sexual differentiation in the fetus, secondary sexual maturation at puberty, and spermatogenesis in the adult. The fetal and postnatal (adult) populations of Leydig cells differ morphologically and have dis...
  8. Linkage studies for T2D in Chop and C/EBPbeta chromosomal regions in Italians.

    Journal Of Cellular Physiology 213(2):552 (2007) PMID 17620318

    The genes causing type 2 diabetes (T2D), a complex heterogeneous disorder, differ and/or overlap in various populations. Among others there are two loci in linkage to T2D, the chromosomes 20q12-13.1 and 12q15. These two regions harbor two genes, C/EBPbeta and CHOP, which are excellent candidate ...
  9. Fibrillin-rich microfibrils: Structural determinants of morphogenetic and homeostatic events.

    Journal Of Cellular Physiology 213(2):326 (2007) PMID 17708531

    Fibrillin-rich microfibrils are specialized extracellular matrix assemblies that endow connective tissues with mechanical stability and elastic properties, and that participate in the regulation of organ formation, growth and homeostasis. Their physiological importance is underscored by the comp...
  10. Impact of the non-cellular tumor microenvironment on metastasis: potential therapeutic and imaging opportunities.

    Journal Of Cellular Physiology 213(2):391 (2007) PMID 17657728

    Evidence is accumulating that the malignant phenotype of a given tumor is dependent not only on the intrinsic characteristics of tumor cells, but also on the cooperative interactions of non-neoplastic cells, soluble secreted factors and the non-cellular solid-state ECM network that comprise the ...