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Journal Of Cellular Physiology

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  1. Low levels of DNA ligases III and IV sufficient for effective NHEJ.

    Journal Of Cellular Physiology 213(2):475 (2007) PMID 17492771

    Cells of higher eukaryotes rejoin double strand breaks (DSBs) in their DNA predominantly by a non-homologous DNA end joining (NHEJ) pathway that utilizes the products of DNA-PKcs, Ku, LIG4, XRCC4, XLF/Cernunnos, Artemis as well as DNA polymerase lambda (termed D-NHEJ). Mutants with defects in th...
  2. Gene therapy: the first two decades and the current state-of-the-art.

    Journal Of Cellular Physiology 213(2):301 (2007) PMID 17577203

    The concept of gene therapy was envisioned soon after the emergence of restriction endonucleases and subcloning of mammalian genes in phage and plasmids. Over the ensuing decades, vectors were developed, including nonviral methods, integrating virus vectors (gammaretrovirus and lentivirus), and ...
  3. Interplay between chromatin remodelers and protein arginine methyltransferases.

    Journal Of Cellular Physiology 213(2):306 (2007) PMID 17708529

    Chromatin modifying enzymes have emerged as key regulators of all DNA based processes, which control cell growth, development, and differentiation. Recently, it has become clear that different chromatin remodeling and histone-modifying activities are involved in transcriptional activation and re...
  4. Seeing the light: new insights into the molecular pathogenesis of retinal diseases.

    Journal Of Cellular Physiology 213(2):348 (2007) PMID 17654481

    In the past, most treatments for retinal diseases have been empirical. Steroids and/or laser photocoagulation and/or surgery have been tried for almost every condition with little or no understanding of the underlying disease. Over the past several years vision researchers have uncovered molecul...
  5. Insulin receptor substrate 1 (IRS-1) plays a unique role in normal epidermal physiology.

    Journal Of Cellular Physiology 213(2):519 (2007) PMID 17508357

    Insulin receptor substrate (IRS) proteins play a central role in insulin signaling. Previously we have demonstrated that insulin is essential for normal skin development and function. In the present study we investigated the involvement of the IRS-1 and IRS-2 proteins in skin physiology and in m...
  6. Fibrillin-rich microfibrils: Structural determinants of morphogenetic and homeostatic events.

    Journal Of Cellular Physiology 213(2):326 (2007) PMID 17708531

    Fibrillin-rich microfibrils are specialized extracellular matrix assemblies that endow connective tissues with mechanical stability and elastic properties, and that participate in the regulation of organ formation, growth and homeostasis. Their physiological importance is underscored by the comp...
  7. Impact of the non-cellular tumor microenvironment on metastasis: potential therapeutic and imaging opportunities.

    Journal Of Cellular Physiology 213(2):391 (2007) PMID 17657728

    Evidence is accumulating that the malignant phenotype of a given tumor is dependent not only on the intrinsic characteristics of tumor cells, but also on the cooperative interactions of non-neoplastic cells, soluble secreted factors and the non-cellular solid-state ECM network that comprise the ...
  8. Adult mesenchymal stem cells for tissue engineering versus regenerative medicine.

    Journal Of Cellular Physiology 213(2):341 (2007) PMID 17620285

    Adult mesenchymal stem cells (MSCs) can be isolated from bone marrow or marrow aspirates and because they are culture-dish adherent, they can be expanded in culture while maintaining their multipotency. The MSCs have been used in preclinical models for tissue engineering of bone, cartilage, musc...
  9. Linkage studies for T2D in Chop and C/EBPbeta chromosomal regions in Italians.

    Journal Of Cellular Physiology 213(2):552 (2007) PMID 17620318

    The genes causing type 2 diabetes (T2D), a complex heterogeneous disorder, differ and/or overlap in various populations. Among others there are two loci in linkage to T2D, the chromosomes 20q12-13.1 and 12q15. These two regions harbor two genes, C/EBPbeta and CHOP, which are excellent candidate ...
  10. Signal transduction and cell-type specific regulation of matrix metalloproteinase gene expression: can MMPs be good for you?

    Journal Of Cellular Physiology 213(2):355 (2007) PMID 17654499

    An abundance of literature over the past several years indicates a growing interest in the role of matrix metalloproteinases (MMPs) in normal physiology and in disease pathology. MMPs were originally defined by their ability to degrade the extracellular matrix, but it is now well documented that...