Journal Of Cellular Physiology
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P53 dependent mitochondrial permeability transition pore opening is required for dexamethasone-induced death of osteoblasts.
We studied the cellular mechanism of dexamethasone (Dex)-induce osteoblast cell death by focusing on the role of mitochondrial permeability transition pore (mPTP). In cultured osteoblastic MC3T3-E1 cells, Dex-induced mPTP opening, which was demonstrated by mitochondrial membrane potential (MPP) decr...
Calcineurin Regulates Progressive Motility Activation of Rhinella (Bufo) arenarum Sperm Through Dephosphorylation of PKC Substrates.
We have shown that the signal transduction pathway required for in situ motility activation involves a rise in intracellular cAMP through a transmembrane adenylyl cyclase and activation of PKA, mostly in the midpiece and in the sperm head. In this report, we demonstrate that activation of calcineuri...
Quantifying mitotic chromosome dynamics and positioning.
We will discuss analytical approaches to investigate the position-dependent control of mitotic chromosomes in cultured cells. These methods can be used to dissect the specific contributions of mitotic proteins to the molecular control of chromosome dynamics. J. Cell. Physiol. 229: 1301-1305, 2014. ©...
Journal of cellular physiology: volume 229, number 8, august 2014.
Cover: Diagram showing components of platelet biology important in cancer progression. See article by Sharma et al. on pages 1005-1015. © 2014 Wiley Periodicals, Inc.
Table of contents: volume 229, number 6.
Table of contents: volume 229, number 5.
VEGF inhibitor (Iressa) arrests histone deacetylase expression: single-cell cotransfection imaging cytometry for multi-target-multi-drug ana...
We report single-cell cotransfection imaging cytometry to quantitatively screen drug-induced off-target effects. Vascular endothelial growth factor (VEGF) and histone deacetylase (HDAC) genes amplified from the genomic DNA were cloned in fluorescently tagged gene constructs (RFP-HDAC/YFP-VEGF). Thes...
Expression of Notch receptors, ligands, and target genes during development of the mouse mammary gland
We have quantitatively determined the levels and mRNA expression patterns of the Notch receptor genes, their ligands and target genes in the postnatal mouse mammary gland. The steady state levels of Notch3 mRNA are the highest among receptor genes, Jagged1 and Dll3 mRNA levels are the highest among...
Numerous isoforms of Fgf8 reflect its multiple roles in the developing brain.
We review the roles of Fgf8 in vertebrate development and summarize the recent findings on the in vivo function of different Fgf8 splice variants. We propose that multiple Fgf8 isoform proteins act in concert to regulate the overall function of Fgf8 and account for the diverse and essential role of...
Decreased secretion of MMP by non-lesional late-stage scleroderma fibroblasts after selection via activation of the apoptotic Fas-pathway.
Our results show that resistance to apoptosis is an important characteristic of the late-stage lesional SSc fibroblast phenotype. We thus hypothesized that a selection of specific fibroblast subpopulations from late-stage non-lesional SSc skin areas could be at the origin of lesional populations. Th...