Journal of Comparative Neurology

Print ISSN
Electronic ISSN
Impact factor
Usage rank
Article count
Free count
Free percentage
PDFs via platforms
Wiley, CSA, and Proquest

  1. Lead exposure during development results in increased neurofilament phosphorylation, neuritic beading, and temporal processing deficits within the murine auditory brainstem.

    Journal of Comparative Neurology 506(6):1003 (2008) PMID 18085597

    Low-level lead (Pb) exposure is a risk factor for learning disabilities, attention deficit hyperactivity disorder (ADHD), and other neurological dysfunction. It is not known how Pb produces these behavioral deficits, but low-level exposure during development is associated with auditory temporal ...
  2. Bulbospinal neurons of the rat rostromedial medulla are highly collateralized.

    Journal of Comparative Neurology 506(6):960 (2008) PMID 18085592

    The rostromedial medulla participates in a large variety of sensory, motor, and autonomic functions. We asked whether individual bulbospinal neurons in this region have localized, target-specific terminal arbors or whether they collateralize broadly in the spinal cord. Collateralization was quan...
  3. Molecular characterization and comparative localization of the mRNAs encoding two glutamic acid decarboxylases (GAD65 and GAD67) in the brain of the African lungfish, Protopterus annectens.

    Journal of Comparative Neurology 506(6):979 (2008) PMID 18085593

    The existence of two distinct genes encoding two isoforms of glutamic acid decarboxylase (GAD65 and GAD67) has been demonstrated in most vertebrate classes, yet little is known about their differential distributions and functions in the central nervous system in nonmammalian vertebrates. In the ...
  4. Enkephalin co-expression with classic neurotransmitters in the amygdaloid complex of the rat.

    Journal of Comparative Neurology 506(6):943 (2008) PMID 18085591

    This study aimed at characterizing the neurotransmitter phenotype of enkephalin neurons in the rat amygdaloid complex. We first established the detailed distribution of vesicular glutamate transporters 1 and 2 (VGLUT1 and -2) and glutamate decarboxylase 65 (GAD65) in the amygdala by using in sit...
  5. PI3K signaling effects in hypothalamic neurons mediated by estrogen.

    Journal of Comparative Neurology 506(6):895 (2008) PMID 18085586

    Multiple mechanisms mediate the effects of estrogen in the central nervous system, including signal transduction pathways such as protein kinase A, protein kinase C, and phosphatidylinositol 3-kinase (PI3K) pathways. Previously we demonstrated that estrogen regulates a number of PI3K-related gen...
  6. Differential localization of GABAA receptor subunits within the substantia nigra of the human brain: an immunohistochemical study.

    Journal of Comparative Neurology 506(6):912 (2008) PMID 18085588

    Gamma-aminobutyric acid(A) (GABA(A)) receptors (GABA(A)R) are inhibitory heteropentameric chloride ion channels comprising a variety of subunits and are localized at postsynaptic sites within the central nervous system. In this study we present the first detailed immunohistochemical investigatio...
  7. Repopulation of cochlear macrophages in murine hematopoietic progenitor cell chimeras: the role of CX3CR1.

    Journal of Comparative Neurology 506(6):930 (2008) PMID 18085589

    Cochlear macrophages have been shown to accumulate in the murine cochlea following acoustic trauma. This investigation was performed to determine whether cochlear macrophages could be replaced by donor transplantation of bone marrow precursors. Lethally irradiated C57BL/6 mice were transplanted ...
  8. Expression of receptors for glial cell line-derived neurotrophic factor family ligands in sacral spinal cord reveals separate targets of pelvic afferent fibers.

    Journal of Comparative Neurology 506(6):989 (2008) PMID 18085594 PMCID PMC3049865

    Nerve growth factor has been proposed to mediate many structural and chemical changes in bladder sensory neurons after injury or inflammation. We have examined the expression of receptors for the glial cell line-derived neurotrophic factor (GDNF) family within sensory terminals located in the sa...
  9. Characterization of nitric oxidergic neurons in the alimentary tract of the snail Helix pomatia L.: histochemical and physiological study.

    Journal of Comparative Neurology 506(5):801 (2008) PMID 18076086

    By using NADPH-diaphorase (NADPH-d) histochemistry, nitric oxide synthase (NOS) immunohistochemistry, Western blotting, and NO pharmacology, we investigated the distribution and possible function of NOS-containing neurons in different units of the alimentary tract of the snail, Helix pomatia. Di...
  10. Cellular and subcellular localization of Kir2.1 subunits in neurons and glia in piriform cortex with implications for K+ spatial buffering.

    Journal of Comparative Neurology 506(5):877 (2008) PMID 18076085

    Potassium channels of the Kir2 family are widely expressed in neurons and glia, where they form strong inwardly rectifying channels. Existing functional hypotheses for these channels in neurons are based on the weak outward conductance, whereas the leading hypothesis for glia, that they promote ...
  11. Regenerating motor bridge axons refine connections and synapse on lumbar motoneurons to bypass chronic spinal cord injury.

    Journal of Comparative Neurology 506(5):838 (2008) PMID 18076081

    To restore motor control after spinal cord injury requires reconnecting the brain with spinal motor circuits below the lesion. A bridge around the injury is an important alternative to promoting axon regeneration through the injury. Previously, we reported a novel motor bridge in rats. The thirt...
  12. Molecular dynamics of photoreceptor synapse formation in the developing chick retina.

    Journal of Comparative Neurology 506(5):822 (2008) PMID 18076030

    The cellular and molecular mechanisms underlying photoreceptor synaptogenesis are poorly understood. Furthermore, a detailed picture of the molecular composition of photoreceptor synapses, or their subtypes, is not yet available, nor do we know what differences, if any, exist among those subtype...
  13. Early afferent signaling in the outer plexiform layer regulates development of horizontal cell morphology.

    Journal of Comparative Neurology 506(5):745 (2008) PMID 18076080

    The dendritic patterning of retinal horizontal cells has been shown to be specified by the cone photoreceptor afferents. The present investigation has addressed whether this specification is due to visually dependent synaptic transmission in the outer plexiform layer or to some other early, pre-...
  14. Developmental changes of serotonin 4(a) receptor expression in the rat pre-Bötzinger complex.

    Journal of Comparative Neurology 506(5):775 (2008) PMID 18076058

    Serotonin receptors (5-HTRs) are known to be involved in the regulation of breathing behavior and to mediate neurotrophic actions that exert a significant function in network formation during development. We studied neuronal 5-HT(4(a))R-immunoreactivity (-IR) at developmental ages from E14 to P1...
  15. The fovea regulates symmetrical development of the visual cortex.

    Journal of Comparative Neurology 506(5):791 (2008) PMID 18076059

    The foveal region contains the highest cell density in the human retina; consequently a disproportionately large area of the visual cortex is dedicated to its representation. In aniridia and albinism the fovea does not develop, and the corresponding cortical representation shows a reduction in g...
  16. Sexual dimorphism in neuronal number of the posterodorsal medial amygdala is independent of circulating androgens and regional volume in adult rats.

    Journal of Comparative Neurology 506(5):851 (2008) PMID 18076082

    The posterodorsal medial amygdala (MePD) in rodents integrates olfactory and pheromonal information, which, coupled with the appropriate hormonal signals, may facilitate or repress reproductive behavior in adulthood. MePD volume and neuronal soma size are greater in male rats than in females, an...
  17. Anatomical and physiological definition of the motor cortex of the marmoset monkey.

    Journal of Comparative Neurology 506(5):860 (2008) PMID 18076083

    We used a combination of anatomical and physiological techniques to define the primary motor cortex (M1) of the marmoset monkey and its relationship to adjacent cortical fields. Area M1, defined as a region containing a representation of the entire body and showing the highest excitability to in...
  18. Identification, developmental expression, and functions of bursicon in the tobacco hawkmoth, Manduca sexta.

    Journal of Comparative Neurology 506(5):759 (2008) PMID 18076057

    During posteclosion, insects undergo sequential processes of wing expansion and cuticle tanning. Bursicon, a highly conserved neurohormone implicated in regulation of these processes, was characterized recently as a heterodimeric cystine knot protein in Drosophila melanogaster. Here we report th...
  19. Expression of P2X3 receptor in the trigeminal sensory nuclei of the rat.

    Journal of Comparative Neurology 506(4):627 (2008) PMID 18067147

    Trigeminal primary afferents expressing P2X(3) receptor are involved in the transmission of orofacial nociceptive information. However, little is known about their central projection pattern and ultrastructural features within the trigeminal brainstem sensory nuclei (TBSN). Here we use multiple ...
  20. N-cadherin expression in palisade nerve endings of rat vellus hairs.

    Journal of Comparative Neurology 506(4):525 (2008) PMID 18067145

    Palisade nerve endings (PNs) are mechanoreceptors around vellus hairs of mammals. Each lanceolate nerve ending (LN) of the PN is characterized by a sensory nerve ending symmetrically sandwiched by two processes of type II terminal Schwann cells (tSCIIs). However, the molecular mechanisms underly...