Journal of Dental Research
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- Highwire, Aaas, Nephrology, Rupress, Aacr, Csh, Proquest, Ama, International and American Associations for Dental Research, Sage, Endocrine, CSA, and Highwire
A missense mutation in DUSP6 is associated with Class III malocclusion.
We performed whole-exome sequencing on five siblings from an Estonian family affected by Class III malocclusion. We identified a rare heterozygous missense mutation, c.545C>T (p.Ser182Phe), in the DUSP6 gene, a likely causal variant. This variant co-segregated with the disease following an autosomal...
Fluoride concentration from dental sealants: a randomized clinical trial.
A randomized clinical trial was performed in schoolchildren (6-7 yrs) to evaluate fluoride concentration in interproximal fluid after the placement of 3 different sealants. The sample consisted of 2,776 children randomly divided: 926 in the high-viscosity Glass-ionomer Cement group (GIC group), 923...
Expanding the foundation for personalized medicine: implications and challenges for dentistry.
We present an overview of the opportunities and challenges that influence the oral health community's full participation in personalized medicine. We highlight selected research advances that are solidifying the foundation of personalized oral health care, elaborate on their impact on dentistry, and...
Sleep Apnea Symptoms and Risk of Temporomandibular Disorder: OPPERA Cohort.
The authors tested the hypothesis that obstructive sleep apnea (OSA) signs/symptoms are associated with the occurrence of temporomandibular disorder (TMD), using the OPPERA prospective cohort study of adults aged 18 to 44 years at enrollment (n = 2,604) and the OPPERA case-control study of chronic T...
Decreased jaw bone density and osteoblastic insulin signaling in a model of obesity.
We hypothesized that 12-week HFD rats exhibited not only peripheral insulin resistance but also osteoblastic insulin resistance, which leads to decreased jawbone quality. We found that the jawbones of rats fed a 12-week HFD exhibited increased osteoporosis. The osteoblastic cells isolated from HFD-f...
Periodontal disease and rheumatoid arthritis: a systematic review.
These results provide moderate evidence based on biochemical markers and stronger evidence with regard to clinical parameters that common risk factors or common pathologic processes may be responsible for an association between rheumatoid arthritis and periodontal disease. Further studies are requir...
Type I Interferon Receptor Deficiency Prevents Murine Sjogren's Syndrome.
We introduced a deficiency of interferon alpha receptor 1 (Ifnar1) into B6.Aec1Aec2 mice, which are known to have the genetic loci necessary for developing a SS-like disorder. This new mouse strain, B6.Aec1Aec2Ifnar1 (-/-), lacking type I IFN-mediated signaling, was characterized for pilocarpine-ind...
Odontoblastic syncytium through electrical coupling in the human dental pulp.
We have previously reported a dye-coupling network between odontoblasts (OBs). However, it is still unclear how the information detected by the odontoblasts is transmitted. The aim of this study was to characterize the odontoblastic syncytium electrophysiologically in the human dental pulp. Pulpal c...
Effects of initial stresses and time on orthodontic external root resorption.
We compared the effects of initial periodontal ligament (PDL) stresses over time in orthodontic external root resorption (OERR), necrosis, and the TRAP+ cell population. Forty-two rats (Fischer CDF) were treated with 10 cN of force for 5 different time periods. Finite element (FE) models of the firs...
Inhibiting Periapical Lesions through AAV-RNAi Silencing of Cathepsin K.
We applied a novel gene therapeutic approach using recombinant adeno-associated virus (AAV)-mediated RNAi knockdown of Cathepsin K (Ctsk) gene expression, to target osteoclasts and periapical bone resorption in a mouse model. We found that AAV-sh-Cathepsin K (AAV-sh-Ctsk) impaired osteoclast functio...