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Journal of Immunological Methods

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  1. Modulation of hematopoietic progenitor cell fate in vitro by varying collagen oligomer matrix stiffness in the presence or absence of osteoblasts

    Journal of Immunological Methods 425:108 (2015) PMID 26159389

    To recreate the in vivo hematopoietic cell microenvironment or niche and to study the impact of extracellular matrix (ECM) biophysical properties on hematopoietic progenitor cell (HPC) proliferation and function, mouse bone-marrow derived HPC (Lin-Sca1+cKit+/(LSK) were cultured within ...
  2. A computational study of the interaction of the foot and mouth disease virus VP1 with monoclonal antibodies

    Journal of Immunological Methods 425:51 (2015) PMID 26093030

    Foot and mouth disease is caused by a non-enveloped virus (FMDV), which disposes several antigenic sites at the surface of their capsid proteins. The most relevant and immunodominant antigenic site of FMDV (site A or AnSA) includes a key virus–cell interaction element (RGD motif) locat...
  3. Enhancing efficiency and quality of statistical estimation of immunogenicity assay cut points through standardization and automation

    Journal of Immunological Methods 425:88 (2015) PMID 26130368

    Biotherapeutics can elicit immune responses, which can alter the exposure, safety, and efficacy of the therapeutics. A well-designed and robust bioanalytical method is critical for the detection and characterization of relevant anti-drug antibody (ADA) and the success of an immunogenic...
  4. The effects of age and gender on plasma levels of 63 cytokines

    Journal of Immunological Methods 425:58 (2015) PMID 26080062

    Cytokines play important roles as regulators of cell functions, and over the last decades a number of cytokine assays have been developed. The aim of the present study was to investigate the effects of age and gender on a large number of cytokines. Plasma samples were collected from 33...
  5. A rapid, accurate and robust particle-based assay for the simultaneous screening of plasma samples for the presence of five different anti-cytokine autoantibodies

    Journal of Immunological Methods 425:62 (2015) PMID 26080061

    Purpose To establish and validate a rapid, cost-effective and accurate screening assay for the simultaneous testing of human naturally occurring anti-cytokine autoantibodies (c-aAb) targeting interleukin-1α (IL-1α), interleukin-6 (IL-6), interleukin-10 (IL-10), granulocyte–ma...
  6. Unpredicted phenotypes of two mutants of the TcR DMF5

    Journal of Immunological Methods 425:37 (2015) PMID 26079729

    When a T-cell Receptor (TcR) interacts with its cognate peptide-MHC (pMHC), it triggers activation of a signaling cascade that results in the elicitation of a T cell effector function. Different models have been proposed to understand which parameters are needed to obtain an optimal ac...
  7. Editorial Board
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    Journal of Immunological Methods 425:ii (2015)

  8. Statistical approaches to developing a multiplex immunoassay for determining human exposure to environmental pathogens

    Journal of Immunological Methods 425:1 (2015) PMID 26070441

    There are numerous pathogens that can be transmitted through water. Identifying and understanding the routes and magnitude of exposure or infection to these microbial contaminants are critical to assessing and mitigating risk. Conventional approaches of studying immunological responses...
  9. Determination of lymph flow in murine oral mucosa using depot clearance of near-infrared-labeled albumin

    Journal of Immunological Methods 425:97 (2015) PMID 26141254

    The lymphatic vessels are playing an important role in inflammation since they return extravasated fluid, proteins, and cells back into the circulation and regulate immune cell trafficking. The oral mucosa, including gingiva, is well supplied with lymphatic vessels and is frequently ch...
  10. Repeated fine-needle aspiration of solid tumours in mice allows the identification of multiple infiltrating immune cell types

    Journal of Immunological Methods 425:102 (2015) PMID 26159390

    This paper describes a novel method for following the changes in mouse tumour-infiltrating immune cell populations by repeated sampling of tumours by fine needle aspiration (FNA), followed by flow cytometry. Using this technique we were able to collect samples from P815 mouse mastocyto...