Journal of Investigative Dermatology
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The Aryl Hydrocarbon Receptor Is Involved in UVR-Induced Immunosuppression.
We studied whether the AhR is involved in UVR-induced local immunosuppression and whether similar effects can be induced by AhR agonists. The AhR antagonist 3-methoxy-4-nitroflavone reduced UVR-mediated immunosuppression and the induction of Tregs in murine contact hypersensitivity (CHS). Conversely...
A mutation-independent therapeutic strategy for dominant dystrophic epidermolysis bullosa.
Gastrin-releasing peptide-expressing nerves comprise subsets of human cutaneous Aδ and C fibers that may sense pruritus.
Deformation gradients imprint the direction and speed of en masse fibroblast migration for fast healing.
We found that when fibroblasts migrated en masse over a hydrogel, they established a well-defined deformation field by traction forces and migrated along a trajectory defined by field gradients. The mechanics of the hydrogel determined the magnitude of the gradient. For materials stiff enough to wit...
Nuclear topology, epigenetics, and keratinocyte differentiation.
We are now able to gain new knowledge about these changes at the genomic level....
Skin-specific drug delivery: a rapid solution to skin diseases?
In this issue of The Journal of Investigative Dermatology, Kouno et al. achieve skin-specific drug delivery using an antibody to deliver substances in a highly specific manner to nontransformed cells. They make use of a nonpathogenic anti-desmoglein 3 autoantibody that had been derived from a patien...
First international symposium "epigenetic control of skin development and regeneration": how chromatin regulators orchestrate skin functions...
A Toll-like receptor 7, 8, and 9 antagonist inhibits Th1 and Th17 responses and inflammasome activation in a model of IL-23-induced psoriasi...
We have evaluated an antagonist of TLR7, 8, and 9 as a therapeutic agent in an IL-23-induced psoriasis model in mice. Psoriasis-like skin lesions were induced in C57BL/6 mice by intradermal injection of IL-23 in the ear or dorsum. IL-23-induced increase in ear thickness was inhibited in a dose-depen...