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Journal of Medicinal Chemistry

Print ISSN
0022-2623
Electronic ISSN
1520-4804
Impact factor
5.207
Publisher
ACS
URL
http://pubs.acs.org/journal/jmcmar
Usage rank
54
Article count
24373
Free count
319
Free percentage
0.0130883
PDFs via platforms
Acs, CSA, Proquest, and Acm

  1. Synthesis and structure-activity relationship studies of novel dual inhibitors of soluble epoxide hydrolase and 5-lipoxygenase.

    Journal of Medicinal Chemistry 56(4):1777 (2013) PMID 23356879

    We therefore designed and synthesized a library of hybrid molecules incorporating an imidazo[1,2-a]pyridine and an urea moiety as novel soluble epoxide hydrolase (sEH)/5-lipoxygenase (5-LO) dual inhibitors. Evaluation of the compounds was accomplished by in vitro testing using recombinant enzyme ass...
  2. Correction to Development of Indole Compounds as Small Molecule Fusion Inhibitors Targeting HIV-1 Glycoprotein-41.

    Journal of Medicinal Chemistry 54(24):8713 (2011) PMID 22122312

  3. Corrections to Heat Shock Protein 90: Inhibitors in Clinical Trials.

    Journal of Medicinal Chemistry (2010) PMID 20146424

  4. Annual Review of Biochemistry. Volume 78 Annual Review of Biochemistry. Volume 78 . Edited by Roger D. Kornberg , Christian R. H. Raetz , Ja...

    Journal of Medicinal Chemistry (2009) PMID 19938859

  5. Corrections to Multidentate Small-Molecule Inhibitors of Vaccinia H1-Related (VHR) Phosphatase Decrease Proliferation of Cervix Cancer Cells...

    Journal of Medicinal Chemistry (2009) PMID 19904931

  6. Book Review of Chemoinformatics Approaches to Virtual Screening Chemoinformatics Approaches to Virtual Screening . Edited by Alexander Varne...

    Journal of Medicinal Chemistry 52(10):3428 (2009)

  7. Modeling Binding Modes of α7 Nicotinic Acetylcholine Receptor with Ligands: The Roles of Gln117 and Other Residues of the Receptor in Agonis...

    Journal of Medicinal Chemistry 52(3):890 (2009)

  8. Hybrids of phenylsulfonylfuroxan and coumarin as potent antitumor agents.

    Journal of Medicinal Chemistry 57(22):9343 (2014) PMID 25350923

    Sixteen furoxan-based nitric oxide (NO) releasing coumarin derivatives (6a-c, 8a-g, 10a, 13a,b, 15, and 17a,b) were designed, synthesized, and evaluated against the A549, HeLa, A2780, A2780/CDDP, and HUVEC cell lines. Most derivatives displayed potent antiproliferation activities. Among them, 8b exh...
  9. Structural analysis of a novel small molecule ligand bound to the CXCL12 chemokine.

    Journal of Medicinal Chemistry 57(22):9693 (2014) PMID 25356720 PMCID PMC4255719

    We previously identified small molecule ligands that bind CXCL12 and block CXCR4-mediated chemotaxis. We now report a 1.9 Å resolution X-ray structure of CXCL12 bound by such a molecule at a site normally bound by sY21 of CXCR4. The complex structure reveals binding hot spots for future inhibitor de...
  10. Discovery of 1-[2-fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one (TAK-063), a highly potent, se...

    Journal of Medicinal Chemistry 57(22):9627 (2014) PMID 25384088

    Our optimization efforts using structure-based drug design (SBDD) techniques on the basis of the X-ray crystal structure of PDE10A in complex with hit compound 1 (IC50 = 23 nM; 110-fold selectivity over other PDEs) led to the identification of 1-[2-fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxy-3-(1-ph...