Journal of Neurochemistry
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- Wiley from 1956, Rcgp, CSA, Proquest, Ingenta, Gale, and Ovid from 2000
Acknowledgement of reviewers.
The antiretroviral protease inhibitors indinavir and nelfinavir stimulate Mrp1-mediated GSH export from cultured brain astrocytes.
We have exposed astrocyte-rich primary cultures to various antiretroviral compounds. Treatment of the cultures with the protease inhibitors indinavir or nelfinavir in low micromolar concentrations resulted in a time- and concentration-dependent depletion of cellular GSH from viable cells which was a...
Attenuation of scratch-induced reactive astrogliosis by novel EphA4 kinase inhibitors.
We have identified novel small molecule inhibitors of EphA4 kinase in specific enzymatic and cell-based assays. In addition, we have demonstrated in two in vitro models of scratch injury that EphA4 receptor kinase is activated through phosphorylation and is involved in the repopulation of the wound...
How important are Rho GTPases in neurosecretion?
We discuss data that highlight the importance of Rho GTPases and their regulators into the control of neurotransmitter and hormone release in neurons and neuroendocrine cells, respectively. © 2011 The Authors. Journal of Neurochemistry © 2011 International Society for Neurochemistry....
Abnormal exocytotic release of glutamate in a mouse model of amyotrophic lateral sclerosis.
We report our studies on the exocytotic release of glutamate as a possible source of excessive glutamate transmission. The basal glutamate efflux from spinal cord nerve terminals of mice expressing human SOD1 with the G93A mutation [SOD1/G93A(+)], a transgenic model of ALS, was elevated when compare...
Distribution of stomatin expressing in the central nervous system and its up-regulation in cerebral cortex of rat by hypoxia.
We examined distribution of stomatin in CNS of rat, and investigated the effects of hypoxia exposure and glucocorticoid on stomatin expression in cerebral cortex of rat. Immunofluorescence staining revealed a broad expression of stomatin protein in many areas of adult rat brain and spinal cord, incl...
Cellular prion protein is implicated in the regulation of local Ca2+ movements in cerebellar granule neurons.
We have compared local Ca(2+) movements in cerebellar granule neurons (CGN) derived from wild-type (WT), or PrP-knockout (KO), mice, by means of the Ca(2+) -sensitive photo-probe, aequorin, genetically targeted to specific intracellular domains and delivered to CGN by lentiviral vectors. The use of...
Functional characterization of putative cholesterol binding sequence (CRAC) in human type-1 cannabinoid receptor.
We identified in the transmembrane helix 7 of human CBRs a consensus sequence already known in other proteins as cholesterol recognition/interaction amino acid sequence and consensus pattern. As this motif is different in the two CBR subtypes, we mutated lysine 402 of CB(1) R into glycine, to obtain...
The deletion of the microtubule-associated STOP protein affects the serotonergic mouse brain network.
We characterized some features of the serotonergic neurotransmission in STOP KO mice. In the brainstem, mutant mice displayed higher tissue 5-HT levels and in vivo synthesis rate, together with marked increases in 5-HT transporter (SERT) densities and 5-HT1A autoreceptor levels and electrophysiologi...
Expression of Ttyh1, a member of the Tweety family in neurons in vitro and in vivo and its potential role in brain pathology.
We have previously shown that Ttyh1 mRNA is expressed in neurons and its expression is upregulated in the brain during epileptogenesis and epilepsy. In this study we aimed to elucidate the role of Ttyh1 in neurons. We found widespread expression of Ttyh1 protein in neurons in vivo and in vitro. Ttyh...