Journal of Neurophysiology
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- Ama, Endocrine, Aacr, Proquest, Nephrology, Rupress, Aaas, Highwire from 1938, American Physiological Society, CSA, and Csh
Upregulation of D2-class signaling in dopamine-denervated striatum is in part mediated by D3 receptors acting on Ca V 2.1 channels via PIP2 ...
The loss of dopaminergic neurons in the substantia nigra compacta followed by striatal dopamine depletion is a hallmark of Parkinsons disease. After dopamine depletion, dopaminergic D(2)-receptor class (D(2)R-class) supersensitivity develops in striatal neurons. The supersensitivity...
Recall of spatial patterns stored in a hippocampal slice by long-term potentiation.
Nervous systems are thought to encode information as patterns of electrical activity distributed sparsely through networks of neurons. These networks then process information by transforming one pattern of electrical activity into another. To store information as a pattern, a neural network must str...
Optical imaging of cortical networks via intracortical microstimulation.
We examined whether the optical imaging of intrinsic signals (OIS) reveals the functional patterns of activity evoked by electrical cortical microstimulation. We examined the effects of current amplitude, train duration, and depth of cortical stimulation on the hemodynamic response to electrical mic...
Dendritic mechanisms contribute to stimulus-specific adaptation in an insect neuron.
We test the hypothesis that dendritic mechanisms underlie TN-1 response cessation to fast-pulse rate repeated signals. Electrically stimulating TN-1 with either high-rate or continuous-current pulses resulted in a decreased ability in TN-1 to generate action potentials but failed to elicit cessation...
Perceptual learning in sensorimotor adaptation.
We test the idea that perceptual learning alters somatosensory function and in so doing produces changes to human motor performance and sensorimotor adaptation. Subjects in these experiments undergo perceptual training in which a robotic device passively moves the subject's arm on one of a set of fa...
Network and neuronal membrane properties in hybrid networks reciprocally regulate selectivity to rapid thalamocortical inputs.
We investigate this transformation by creating a barrel-like hybrid network with whole-cell recordings of in vitro neurons from a cortical slice preparation, embedding the biological neuron in the simulated network by presenting virtual synaptic conductances via a conductance clamp. Utilizing the hy...
Incomplete spinal cord injury promotes durable functional changes within the spinal locomotor circuitry.
We raise the issue as to whether the CPG can adapt or reorganize in response to a chronic change of supraspinal inputs, as it is the case after spinal cord injury (SCI). Kinematic data obtained from 6 adult cats walking at different treadmill speeds were collected to calculate the cycle and sub-phas...
Short-interval intracortical inhibition blocks long-term potentiation induced by paired associative stimulation.
We hypothesized that evoking GABA(A) receptor-mediated short-interval intracortical inhibition (SICI) simultaneously with excitatory PAS would depress long-term potentiation plasticity in motor cortex. Four different PAS paradigms were tested, standard PAS (PAS25) and three conditioned PAS protocols...
Frequency-dependent effects of electrical stimulation in the globus pallidus of dystonia patients.
Deep brain stimulation (DBS) in the globus pallidus internus (GPi) has been shown to improve dystonia, a movement disorder of repetitive twisting movements and postures. DBS at frequencies above 60 Hz improves dystonia, but the mechanisms underlying this frequency dependence are uncl...