Advanced search×

Journal of Pharmaceutical Sciences

Print ISSN
Electronic ISSN
Impact factor
Usage rank
Article count
Free count
Free percentage
PDFs via platforms
Proquest, Rcgp, Ingenta, Wiley, and CSA

  1. Prolonged circulation half-life of interferon γ activity by gene delivery of interferon γ-serum albumin fusion protein in mice.

    Journal of Pharmaceutical Sciences 100(6):2350 (2011) PMID 21246562

    We tried to increase the circulation half-life of IFNγ after its gene delivery by designing a novel fusion protein of IFNγ with mouse serum albumin (MSA). Western blot analysis confirmed that IFNγ-MSA was expressed as a fusion protein, but hardly formed dimer as IFNγ did. The biological activity...
  2. Usefulness of a nanoparticle formulation to investigate some hemodynamic parameters of a poorly soluble compound.

    Journal of Pharmaceutical Sciences 100(6):2194 (2011) PMID 21491443

    Drug solubility is an important issue when progressing investigational compounds into clinical candidates. The present paper describes the development and characterization of a nanosuspension that was formulated to overcome problems with poor water solubility and possible adverse events caused by cos...
  3. Lengthening of cardiac repolarization in isolated guinea pigs hearts by sequential or concomitant administration of two IKr blockers.

    Journal of Pharmaceutical Sciences 100(6):2469 (2011) PMID 21491454

    Block of I(Kr) is of major concern in drug safety. The objective of this study was to assess prolongation of cardiac repolarization during the combined use of two I(Kr) blockers when administered concomitantly or sequentially. (1) When isolated hearts from male guinea pigs were perfused concomitantly...
  4. Expect the unexpected-screen your screens

    Journal of Pharmaceutical Sciences 100(5):1996 (2011) PMID 21154629

  5. Polyamidoamine dendrimers can improve the pulmonary absorption of insulin and calcitonin in rats.

    Journal of Pharmaceutical Sciences 100(5):1866 (2011) PMID 21374620

    The absorption-enhancing effects of polyamidoamine (PAMAM) dendrimers with various generations (G0-G3) and concentrations [0.1%-1.0% (w/v)] on the pulmonary absorption of peptide and protein drugs were studied in rats. Insulin and calcitonin were chosen as models of peptide and prote...
  6. The corrected traditional equations for calculation of hepatic clearance that account for the difference in drug ionization in extracellular...

    Journal of Pharmaceutical Sciences 100(3):1167 (2011) PMID 21355107

    The estimation of hepatic clearance, Clh, using in vitro data on metabolic stability of compound, its protein binding and blood–plasma equilibrium concentration ratio is commonly performed using well-stirred, parallel tube or dispersion models. It appears that for ionizable drugs t...
  7. A two-stage strategy for sterilization of poly(lactide-co-glycolide) particles by γ-irradiation does not impair their potency for vaccine de...

    Journal of Pharmaceutical Sciences 100(2):646 (2011) PMID 20665902

    This study evaluated the feasibility of using gamma-irradiation for preparing sterile poly(lactide-co-glycolide) (PLG) formulations for vaccines. PLG microparticles were prepared by water-in-oil-in-water double-emulsion technique and lyophilized. The vials were gamma-irradiated for s...
  8. Alteration in the pharmacokinetics of hemoglobin-vesicles in a rat model of chronic liver cirrhosis is associated with Kupffer cell phagocyt...

    Journal of Pharmaceutical Sciences 100(2):775 (2011) PMID 20799362

    Our previous pharmacokinetic studies demonstrated that the liver is strongly associated with the metabolism and excretion of HbV. The aim of this study was to evaluate the pharmacokinetics of HbV in a chronic cirrhosis rat (CCR) model induced by carbon tetrachloride (CCl(4)) and explore whether live...
  9. Transmembrane delivery and biological effect of human growth hormone via a phage displayed peptide in vivo and in vitro

    Journal of Pharmaceutical Sciences 99(12):4880 (2010) PMID 20821386

    We show that a synthetic peptide, TD (ACSSSPSKHCG) was efficient in transferring human growth hormone (GH) across various kinds of membranes and the blood-brain barrier (BBB) in vivo via rectal administration, resulting in elevation of GH level in serum, acetylcholine and O-choline acetyltransferase...
  10. Comparative effects of pH and ionic strength on protein-protein interactions, unfolding, and aggregation for IgG1 antibodies

    Journal of Pharmaceutical Sciences 99(12):4830 (2010) PMID 20821389

    I on aggregation kinetics and pathways. These correlated strongly with whether aggregates of a given antibody bound ThT, suggesting possible differences with respect to conformational changes and/or regions of the proteins that are structurally involved in stabilizing the aggregates. (c) 2010 Wiley-...