Journal of Pharmaceutical Sciences
- Print ISSN
- Electronic ISSN
- Impact factor
- Usage rank
- Article count
- Free count
- Free percentage
- PDFs via platforms
- Proquest, Rcgp, Ingenta, Wiley, and CSA
Achieving continuous manufacturing for final dosage formation: challenges and how to meet them. May 20-21, 2014 continuous manufacturing sym...
We describe the key issues and possibilities for continuous final dosage formation, otherwise known as downstream processing or drug product manufacturing. A distinction is made between heterogeneous processing and homogeneous processing, the latter of which is expected to add more value to continuo...
Association efficiency of three ionic forms of oxytetracycline to cationic and anionic oil-in-water nanoemulsions analyzed by diafiltration.
The association efficiency of oxytetracycline (OTC) to pharmaceutical available, ionic oil-in-water nanoemulsions is studied. Theoretical mathematical developments allowed us to differentiate by diafiltration (DF) between thermodynamically and kinetically controlled binding of the drug to the nanoem...
Systematic screening of different surface modifiers for the production of physically stable nanosuspensions.
The role of a surface modifier is important in the formation of stable nanosuspensions. In this study, a simple and systematic screening method for selecting optimum surface modifiers was performed by utilizing a low-energy wet ball milling method. Nine surface modifiers from different classes with...
Mutation choice to eliminate buried free cysteines in protein therapeutics.
We report a comprehensive structure and stability study of Ala, Ser, Thr, and Val mutations at each of the three buried free-Cys positions (Cys16, Cys83, and Cys117) in fibroblast growth factor-1. Mutation was almost universally destabilizing, indicating a general optimization for the wild-type Cys,...
Lengthening of cardiac repolarization in isolated guinea pigs hearts by sequential or concomitant administration of two IKr blockers.
Block of I(Kr) is of major concern in drug safety. The objective of this study was to assess prolongation of cardiac repolarization during the combined use of two I(Kr) blockers when administered concomitantly or sequentially. (1) When isolated hearts from male guinea pigs were perfused concomitantly...
Expect the unexpected-screen your screens
Response to ldquocommercial aluminum hydroxidesrdquo
Progress in pharmaceutical research critical reports on applied chemistry, vol. 4. Edited by K. R. H. Wooldridge. Blackwell Scientific Publi...
Chemistry and biochemistry of the amino acids. Edited by G. C. Barrett. Chapman and Hall Ltd., New York, NY 10001. 1985. 684pp. 16 × 24.5 cm...