Journal of Pharmaceutical Sciences
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Surface effects on the crystallization of ritonavir glass.
In our previous study, initiation time of crystallization was shown to be basically expressed as a function of only the reduced temperature, which was a ratio of storage and glass transition temperatures. This conclusion was obtained using quenched glasses with minimized surface area stored under a...
Cocrystals of acyclovir with promising physicochemical properties.
Cocrystal forming ability of antiviral drug acyclovir (ACV) with different coformers was studied. Three cocrystals containing ACV with fumaric acid, malonic acid, and dl-tartaric acid were isolated. Methods of cocrystallization included grinding with dropwise solvent addition and solvent evaporation...
A novel combined micellar system of lapatinib and Paclitaxel with enhanced antineoplastic effect against human epidermal growth factor recep...
Lapatinib (LPT) could sensitize human epidermal growth factor receptor-2 (HER-2) positive breast cancer to paclitaxel (PTX) and induce synergetic action with PTX in preclinical test and phase II/III trial. In this study, LPT-conjugated poly (ethylene glycol) (PEG) and poly (lactic acid) (PLA) (LPT-P...
Lengthening of cardiac repolarization in isolated guinea pigs hearts by sequential or concomitant administration of two IKr blockers.
Block of I(Kr) is of major concern in drug safety. The objective of this study was to assess prolongation of cardiac repolarization during the combined use of two I(Kr) blockers when administered concomitantly or sequentially. (1) When isolated hearts from male guinea pigs were perfused concomitantly...
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Response to ldquocommercial aluminum hydroxidesrdquo
Progress in pharmaceutical research critical reports on applied chemistry, vol. 4. Edited by K. R. H. Wooldridge. Blackwell Scientific Publi...
Chemistry and biochemistry of the amino acids. Edited by G. C. Barrett. Chapman and Hall Ltd., New York, NY 10001. 1985. 684pp. 16 × 24.5 cm...
Medicinal chemistry: The role of organic chemistry in drug research. Edited by S. M. Roberts and B. J. Price. Academic Press Inc., London. 1...