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Journal of Pharmaceutical Sciences

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Proquest, Rcgp, Ingenta, Wiley, and CSA

  1. Solvent diversity in polymorph screening.

    Journal of Pharmaceutical Sciences 97(6):2145 (2008) PMID 17847073

    Selecting a diverse set of solvents to be included in polymorph screening assignments can be a challenging task. As an aid to decision making, a database of 218 organic solvents with 24 property descriptors was explored and visualized using multivariate tools. The descriptors included, among oth...
  2. Modifications in low-density lipoprotein receptor expression affects Cyclosporin A cellular uptake and cytotoxicity.

    Journal of Pharmaceutical Sciences 97(6):2350 (2008) PMID 17823952

    The purpose of this study was to test the effect of modulating the expression of the human low-density lipoprotein receptor (LDLr) in human embryonic kidney (293T) cells on Cyclosporin A (CsA) cellular uptake and CsA-mediated cytotoxicity. LDLr expression was modulated using RNA interference (RN...
  3. Combination particles containing salmeterol xinafoate and fluticasone propionate: Formulation and aerodynamic assessment.

    Journal of Pharmaceutical Sciences 97(6):2299 (2008) PMID 17879293

    A precipitation process is used to produce combined particles consisting of two antiasthmatic drugs: salmeterol xinafoate and fluticasone propionate. To control the crystallisation of these particles, a micromixer is used to mix solvent and antisolvent flow. To produce particles in the respirabl...
  4. Effect of structural relaxation on the preparation and drug release behavior of poly(lactic-co-glycolic)acid microparticle drug delivery systems.

    Journal of Pharmaceutical Sciences 97(6):2022 (2008) PMID 17828755

    Control of burst release is a major challenge in the development of poly(lactide-co-glycolide) (PLGA) microparticle drug delivery systems. It has been well-documented in previous literature that formulation and processing variables determine particle morphology, which in turn, governs drug diffu...
  5. ABCB1 G1199A polymorphism and ovarian cancer response to paclitaxel.

    Journal of Pharmaceutical Sciences 97(6):2045 (2008) PMID 17828752

    P-glycoprotein (P-gp), encoded by the ABCB1 gene, confers multi-drug resistance to a variety of antineoplastic agents, for example, paclitaxel. Recently, the G1199T/A polymorphism in the ABCB1 gene was shown to be important for the function of P-gp as well as for the resistance to several chemot...
  6. Evaluating computational predictions of the relative stabilities of polymorphic pharmaceuticals.

    Journal of Pharmaceutical Sciences 97(6):2121 (2008) PMID 17828731

    The ability of computational methods to describe the relative energies of polymorphic pharmaceuticals is investigated for a diverse array of compounds. The initial molecular geometries were taken from crystal structures, and energy differences between polymorphic pairs were calculated with vario...
  7. Echogenic liposome compositions for increased retention of ultrasound reflectivity at physiologic temperature.

    Journal of Pharmaceutical Sciences 97(6):2242 (2008) PMID 17894368 PMCID PMC3119526

    Targetable echogenic liposomes (ELIP) for ultrasound enhancement of atheroma have recently been developed; however, their retention of echogenicity at physiological temperature is less than desirable. The purpose of this study was to improve ELIP stability and increase clinical potential. The ap...
  8. Stable-form screening: overcoming trace impurities that inhibit solution-mediated phase transformation to the stable polymorph of sulfamerazine.

    Journal of Pharmaceutical Sciences 97(6):2130 (2008) PMID 17879974

    Solution-mediated phase transformation (SMPT) has been used as a focused technique to rapidly identify the stable polymorph of a given substance. Despite ample precedence for acetonitrile being a good solvent for SMPT of sulfamerazine (SMZ), samples from specific lots of SMZ failed to convert fr...
  9. Rapid throughput screening of apparent KSP values for weakly basic drugs using 96-well format.

    Journal of Pharmaceutical Sciences 97(6):2080 (2008) PMID 17879292

    A rapid-throughput screening assay was developed to estimate the salt solubility parameter, K(SP), with a minimal quantity of drug. This assay allows for early evaluation of salt limited solubility with a large number of counter-ions and biologically promising drug leads. Drugs dissolved (typica...
  10. Inhibition of aggregation of aluminum hydroxide adjuvant during freezing and drying.

    Journal of Pharmaceutical Sciences 97(6):2049 (2008) PMID 17879291

    Aluminum-salt adjuvants are widely used to increase immunogenicity of recombinant protein vaccines. However, when vaccines formulated with these adjuvants are frozen or lyophilized, losses of efficacy are often reported. This loss of potency is usually attributed to the aggregation of adjuvant p...