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Journal of Pharmaceutical Sciences

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  1. Sumatriptan succinate transdermal delivery systems for the treatment of migraine.

    Journal of Pharmaceutical Sciences 97(6):2102 (2008) PMID 17854062

    We have successfully obtained sumatriptan transdermal systems with different polymer compositions: methyl cellulose (MC), polyvinyl pyrrolidone (PVP) and a polyvinyl pyrrolidone (PVP)-polyvinyl alcohol (PVA) mixture. The systems contained 1,2-propylenglycol (MC) or sorbitol as a plasticizer (PVP...
  2. A framework to investigate drug release variability arising from hypromellose viscosity specifications in controlled release matrix tablets.

    Journal of Pharmaceutical Sciences 97(6):2277 (2008) PMID 17828741

    Substitution level, particle size, and molecular weight are key properties of hypromellose (HPMC) known to be important to its performance in pharmaceutical-controlled release applications. The hypromellose monographs indirectly specify acceptable ranges for the molecular weight of HPMC products...
  3. Quality control of protease inhibitors.

    Journal of Pharmaceutical Sciences 97(6):2012 (2008) PMID 17828738

    Protease inhibitors (PIs) are potent competitive inhibitors of the human immunodeficiency virus (HIV) widely used in the treatment of the acquired immune deficiency syndrome (AIDS) and prescribed in combination with other antiretroviral drugs. So far ten PIs were approved by the United States Fo...
  4. Oral and IV dosing: a method to determine the compartment of drug elimination for two-compartment models.

    Journal of Pharmaceutical Sciences 97(6):2036 (2008) PMID 17847075

    It has been shown previously that it is impossible to measure the volume of distribution at steady state conclusively for a multicompartment system from an iv bolus dose only. The problem lies in deciding from which compartment elimination of the drug occurs in the compartmental model. In this p...
  5. Effect of structural relaxation on the preparation and drug release behavior of poly(lactic-co-glycolic)acid microparticle drug delivery systems.

    Journal of Pharmaceutical Sciences 97(6):2022 (2008) PMID 17828755

    Control of burst release is a major challenge in the development of poly(lactide-co-glycolide) (PLGA) microparticle drug delivery systems. It has been well-documented in previous literature that formulation and processing variables determine particle morphology, which in turn, governs drug diffu...
  6. Endotoxin limits in formulations for preclinical research.

    Journal of Pharmaceutical Sciences 97(6):2041 (2008) PMID 17847072

    This brief commentary discusses a review of the current status on endotoxin limits, a critical parameter, for formulations to be administered to animals. The endotoxin units set by United States Pharmacopoeia (USP), and the techniques specified by USP for endotoxin testing are described. Endotox...
  7. Conformation and side chains environments of recombinant human interleukin-1 receptor antagonist (rh-IL-1ra) probed by raman, raman optical activity, and UV-resonance Raman spectroscopy.

    Journal of Pharmaceutical Sciences 97(6):2228 (2008) PMID 17914732

    The conformation and local environments of the side chains cysteines and aromatics of recombinant human interleukin-1 receptor antagonist (rh-IL-1ra) have been studied by visible Raman, Raman optical activity (ROA) and UVRR spectroscopy. The results reveal that the secondary structure of rh-IL-1...
  8. Formulation and statistical optimization of a novel crosslinked polymeric anti-tuberculosis drug delivery system.

    Journal of Pharmaceutical Sciences 97(6):2176 (2008) PMID 17879985

    The crux of this research was the pragmatic investigation into the formulation of a reconstitutable multiparticulate anti-tuberculosis drug delivery system for facilitated administration for the attainment of segregated gastrointestinal (GI) delivery of rifampicin (RIF) and isoniazid (INH) in or...
  9. Prediction of the possibility of the second peak of drug plasma concentration time curve after iv bolus administration from the standpoint of the traditional multi-compartmental linear pharmacokinetics.

    Journal of Pharmaceutical Sciences 97(6):2385 (2008) PMID 17828740

    It is shown that the existence of the second peak on the drug plasma concentration time curve C(p)(t) after iv bolus dosing can be explained by considering the traditional multi-compartmental linear pharmacokinetics. It was found that a direct solution of the general three-compartment model yiel...
  10. Data mining of fractured experimental data using neurofuzzy logic-discovering and integrating knowledge hidden in multiple formulation databases for a fluid-bed granulation process.

    Journal of Pharmaceutical Sciences 97(6):2091 (2008) PMID 17887121

    In the pharmaceutical field, current practice in gaining process understanding by data analysis or knowledge discovery has generally focused on dealing with single experimental databases. This limits the level of knowledge extracted in the situation where data from a number of sources, so called...