Journal of Pharmacology and Experimental Therapeutics
- Print ISSN
- Electronic ISSN
- Impact factor
- Usage rank
- Article count
- Free count
- Free percentage
- PDFs via platforms
- Endocrine, Ama, Highwire, Aacr, Rupress, CSA, Proquest, Aaas, Nephrology, Csh, and American Society for Pharmacology and Experimental Therapeutics
Increased Blood Pressure and Hyperdynamic Cardiovascular Responses in Carriers of a Common Hyperfunctional Variant of Adenylyl Cyclase 6
We have recently identified a genetic variant (A674S) in ADCY isoform 6 (ADCY6). Subsequent studies demonstrated that the expression of this ADCY6 variant paralleled an increase in adenylyl cyclase-mediated functions. However, the impact of this hyperfunctional variant on cardiovascular function is...
Protection from doxorubicin-induced cardiomyopathy using the modified anthracycline N-benzyladriamycin-14-valerate (AD 198).
We investigated the possibility of in vivo protective effects of low dose AD 198 against Dox-induced cardiomyopathy. To do this, rats were divided into 4 groups: Vehicle, Dox (20 mg/kg; single injection Day 1), AD 198 (0.3 mg/kg per injection; injections on Day 1, 2 and 3), or a combination treatmen...
Diminished activity-dependent brain-derived neurotrophic factor expression underlies cortical neuron microcircuit hypoconnectivity resulting...
Reduced renal clearance of a zwitterionic substrate cephalexin in MATE1-deficient mice.
We carried out transport experiments of cephalexin via MATE1 and performed pharmacokinetic analyses of cephalexin in Mate1 knockout [Mate1(-/-)] mice. Cephalexin uptake by human MATE1-expressing human embryonic kidney 293 cells exhibited saturable kinetics (K(m) = 5.9 +/- 0.5 mM) and a bell-shaped p...
Inhibition or deletion of soluble epoxide hydrolase prevents hyperglycemia, promotes insulin secretion, and reduces islet apoptosis.
We used two separate approaches, targeted disruption of Ephx2 gene (sEH knockout (KO)) and a selective inhibitor of sEH (t-AUCB), to assess the role of sEH in glucose and insulin homeostasis in STZ mice. We also examined the effects of sEH KO or t-AUCB on glucose-stimulated insulin secretion (GSIS)...
Suppression of growth arrest and DNA damage-inducible 45alpha expression confers resistance to sulindac and indomethacin-induced gastric muc...
We investigated whether GADD45alpha, a stress signal response gene involved in regulation of DNA repair and induction of apoptosis, plays a part in NSAID-induced gastric mucosal injury and apoptosis in vivo in mice, and in vitro in cultured human AGS and rat RGM-1 gastric epithelial cells. Intraperi...
Human recombinant vascular endothelial growth factor reduces necrosis and enhances hepatocyte regeneration in a mouse model of acetaminophen...
We reported previously that vascular endothelial growth factor (VEGF) was increased in acetaminophen (APAP) toxicity in mice and treatment with a VEGF receptor inhibitor reduced hepatocyte regeneration. The effect of human recombinant VEGF (hrVEGF) on APAP toxicity in the mouse was examined. In earl...
TAK-348, Longer Lasting Inhibition of Gastric Acid Secretion through Potassium-Competitive Acid Blockage.
A claudin-targeting molecule as an inhibitor of tumor metastasis.
We previously prepared a claudin-4-targeting anti-tumor molecule that consisted of the C-terminal fragment of Clostridium perfringens enterotoxin (C-CPE) fused to protein synthesis inhibitory factor (PSIF) derived from Pseudomonas exotoxin. In the present study, we investigated whether claudin CPE r...
Pharmacodynamic and pharmacokinetic characterization of the aldosterone synthase inhibitor FAD286 in two rodent models of hyperaldosteronism...
We characterized the pharmacokinetic/pharmacodynamic relationships of a prototypical ASI, (+)-(5R)-4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl]benzonitrile hydrochloride (CGS020286A, FAD286, FAD) and compared these profiles to those of the 11beta-hydroxylase inhibitor metyrapone (MET) in two rod...