Advanced search×

Journal of Theoretical Biology

Print ISSN
Electronic ISSN
Impact factor
Usage rank
Article count
Free count
Free percentage
PDFs via platforms
Ingenta, Sciencedirect from 1961, CSA, Proquest, Gale, and Rcgp

  1. Siderophore production and the evolution of investment in a public good: An adaptive dynamics approach to kin selection

    Journal of Theoretical Biology 388:61 (2016)

    Like many other bacteria, Pseudomonas aeruginosa sequesters iron from the environment through the secretion, and subsequent uptake, of iron-binding molecules. As these molecules can be taken up by other bacteria in the population than those who secreted them, this is a form of cooperat...
  2. Alpha, delta and theta rhythms in a neural net model. Comparison with MEG data

    Journal of Theoretical Biology 388:11 (2016)

    The aim of this study is to provide information regarding the comparison of a neural model to MEG measurements. Our study population consisted of 10 epileptic patients and 10 normal subjects. The epileptic patients had high MEG amplitudes characterized with θ (4–7Hz) or δ (2–3Hz) rhyth...
  3. PDCD5 functions as a regulator of p53 dynamics in the DNA damage response

    Journal of Theoretical Biology 388:1 (2016)

    The tumor suppressor p53 plays a central role in cell fate decisions after DNA damage. Programmed Cell Death 5 (PDCD5) interacts with the p53 pathway to promote cell apoptosis. Recombinant human PDCD5 can significantly sensitize different cancers to chemotherapies. In the present paper...
  4. How direct competition shapes coexistence and vaccine effects in multi-strain pathogen systems

    Journal of Theoretical Biology 388:50 (2016)

    We describe an integrated modeling framework for understanding strain coexistence in polymorphic pathogen systems. Previous studies have debated the utility of neutral formulations and focused on cross-immunity between strains as a major stabilizing mechanism. Here we convey that direc...
  5. Homology modeling, functional annotation and comparative genomics of outer membrane protein H of Pasteurella multocida

    Journal of Theoretical Biology 386:18 (2015) PMID 26362105

    Pasteurella multocida is an important pathogen of animals and humans. Outer Membrane Protein (Omp) H is a major conserved protein in the envelope of P. multocida and has been commonly targeted as a protective antigen. However, not much is known about its structure and function due to t...
  6. Subcellular localization for Gram positive and Gram negative bacterial proteins using linear interpolation smoothing model

    Journal of Theoretical Biology 386:25 (2015) PMID 26386142

    Protein subcellular localization is an important topic in proteomics since it is related to a protein׳s overall function, helps in the understanding of metabolic pathways, and in drug design and discovery. In this paper, a basic approximation technique from natural language processing ...
  7. A multi-scale mathematical modeling framework to investigate anti-viral therapeutic opportunities in targeting HIV-1 accessory proteins

    Journal of Theoretical Biology 386:89 (2015) PMID 26385832

    Human immunodeficiency virus-1 (HIV-1) employs accessory proteins to evade innate immune responses by neutralizing the anti-viral activity of host restriction factors. Apolipoprotein B mRNA-editing enzyme 3G (APOBEC3G, A3G) and bone marrow stromal cell antigen 2 (BST2) are host resista...
  8. An elaboration of theory about preventing outbreaks in homogeneous populations to include heterogeneity or preferential mixing

    Journal of Theoretical Biology 386:177 (2015) PMID 26375548

    The goal of many vaccination programs is to attain the population immunity above which pathogens introduced by infectious people (e.g., travelers from endemic areas) will not cause outbreaks. Using a simple meta-population model, we demonstrate that, if sub-populations either differ in...
  9. The phenotypic equilibrium of cancer cells: From average-level stability to path-wise convergence

    Journal of Theoretical Biology 386:7 (2015) PMID 26365152

    The phenotypic equilibrium, i.e. heterogeneous population of cancer cells tending to a fixed equilibrium of phenotypic proportions, has received much attention in cancer biology very recently. In the previous literature, some theoretical models were used to predict the experimental phe...
  10. Dinucleotide circular codes and bijective transformations

    Journal of Theoretical Biology 386:159 (2015) PMID 26423358

    The presence of circular codes in mRNA coding sequences is postulated to be involved in informational mechanisms aimed at detecting and maintaining the normal reading frame during protein synthesis. Most of the recent research is focused on trinucleotide circular codes. However, also d...