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Journal of Theoretical Biology

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  1. Systematic modeling for the insulin signaling network mediated byIRS1andIRS2

    Journal of Theoretical Biology 355:40 (2014)

    We construct systematic models for the insulin signaling network mediated by IRS1 and IRS2, through the integration of current knowledge in the literature into mathematical models of insulin signaling pathways. We hypothesize that the specificity of the IRS signaling mechanisms emerges from the wiri...
  2. Decoding synchronized oscillations within the brain: phase-delayed inhibition provides a robust mechanism for creating a sharp synchrony fil...

    Journal of Theoretical Biology 334:13 (2013) PMID 23747525

    We use a computational and mathematical approach to investigate the efficacy of the phase-delayed inhibition motif in detecting synchronized oscillations. We show that phase-delayed inhibition is capable of creating a synchrony detector with sharp synchrony filtering properties that depend criticall...
  3. Investigating the link between epithelial-mesenchymal transition and the cancer stem cell phenotype: A mathematical approach.

    Journal of Theoretical Biology 265(3):329 (2010) PMID 20648969

    We mathematically investigate the nature of this increase in stem cell activity. A stochastic model is used when small number of cells are under consideration, namely in simulating the mammosphere assay, while a related continuous model is used to probe the dynamics of larger cell populations. Two s...
  4. On the dynamics of the growth plate in primary ossification.

    Journal of Theoretical Biology 265(4):543 (2010) PMID 20665967

    We show that the size of the Proliferative Zone in the growth plate is rather insensitive to variations in the flux coefficients for Ihh and PTHrP at their boundaries. Besides, we also show that the model is also insensitive to large changes in the (comparatively small) critical value of the PTHrP c...
  5. Adhesion induced by mobile cross-bridges: steady state peeling of conjugated cell pairs.

    Journal of Theoretical Biology 140(1):1 (1989) PMID 2615387

    We introduce a specific adhesion model to investigate the complex interaction between rate of peeling, lateral diffusivity and the rate of detachment of bonds. Our analysis show that adhesive energy density increases with the rate of peeling and with lateral diffusivity of the bonds but decreases wi...
  6. The cost of departure from optimal radii in microvascular networks.

    Journal of Theoretical Biology 136(3):245 (1989) PMID 2811392

    We have previously had no expressions for evaluating the apparent energy cost for departures from the optimal junction exponent of 3. Such expressions are derived here. They show that junction exponents, from about 1.5 to large positive values, are within 5% of the energy minimum. With the new equat...
  7. Evolutionarily stable strategies for a finite population and a variable contest size.

    Journal of Theoretical Biology 132(4):469 (1988) PMID 3226137

    This paper presents a generalization of Maynard Smith's concept of an evolutionarily stable strategy (ESS) to cover the cases of a finite population and a variable contest size. Both equilibrium and stability conditions are analysed. The standard Maynard Smith ESS with an infinite po...
  8. Algebraic expressions for the waveforms of sea urchin sperm flagella.

    Journal of Theoretical Biology 116(1):127 (1985) PMID 3840220

    The waveforms of live sea urchin sperm flagella were digitized with video-digitizing apparatus. The flagellar waveforms were expressed by the coordinates of 20 points spaced 2 micron apart along the flagella. The waveforms were condensed into simple algebraic expression with four parameters. Each of...
  9. The relationship between ecology and the optimal helping strategy in cooperative breeders

    Journal of Theoretical Biology 354:25 (2014)

    We construct an explicit population model of cooperative breeding when help is under either maternal and auxiliary control, and obtain an ecologically-specific optimal strategy. Our optimal strategy reveals that there is a critical point at which helpers are no longer ‘making the best of a bad situa...
  10. Residue interaction network analysis of Dronpa and a DNA clamp

    Journal of Theoretical Biology 348:55 (2014) PMID 24486230

    Topology is an essential aspect of protein structure. The network paradigm is increasingly used to describe the topology and dynamics of proteins. In this paper, the effect of topology on residue interaction network was investigated for two different proteins: Dronpa and a DNA clamp, which...