Journal of Theoretical Biology
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The economics of vaccination
Journal of Theoretical Biology 363:105 (2014)We show that his conditions are not necessary for the welfare theorem to hold but that in general, the market yields inefficiently low vaccination uptake. Equilibrium non-optimality may obtain if (i) agents can recover from infection, (ii) vaccines are imperfect, (iii) individuals are ex ante hetero...
Journal of Theoretical Biology 360:IFC (2014)
A study on stability and medical implications for a complex delay model for CML with cell competition and treatment
Journal of Theoretical Biology 363:30 (2014)We study a mathematical model describing the dynamics of leukemic and normal cell populations (stem-like and differentiated) in chronic myeloid leukemia (CML). This model is a system of four delay differential equations incorporating three types of cell division. The competition between normal and l...
Potential non homologous protein targets of mycobacterium tuberculosis H37Rv identified from protein–protein interaction network
Journal of Theoretical Biology 361:152 (2014)We used centrality measures to identify the most central proteins from protein–protein interaction network of mycobacterium tuberculosis H37Rv which was retrieved from STRING database by hypothesizing these proteins would be important to alter the function of the network. We then refined the result...
Journal of Theoretical Biology 359:IFC (2014)
Journal of Theoretical Biology 354:IFC (2014)
Decoding synchronized oscillations within the brain: phase-delayed inhibition provides a robust mechanism for creating a sharp synchrony fil...
We use a computational and mathematical approach to investigate the efficacy of the phase-delayed inhibition motif in detecting synchronized oscillations. We show that phase-delayed inhibition is capable of creating a synchrony detector with sharp synchrony filtering properties that depend criticall...
Investigating the link between epithelial-mesenchymal transition and the cancer stem cell phenotype: A mathematical approach.
We mathematically investigate the nature of this increase in stem cell activity. A stochastic model is used when small number of cells are under consideration, namely in simulating the mammosphere assay, while a related continuous model is used to probe the dynamics of larger cell populations. Two s...
On the dynamics of the growth plate in primary ossification.
We show that the size of the Proliferative Zone in the growth plate is rather insensitive to variations in the flux coefficients for Ihh and PTHrP at their boundaries. Besides, we also show that the model is also insensitive to large changes in the (comparatively small) critical value of the PTHrP c...
Adhesion induced by mobile cross-bridges: steady state peeling of conjugated cell pairs.
We introduce a specific adhesion model to investigate the complex interaction between rate of peeling, lateral diffusivity and the rate of detachment of bonds. Our analysis show that adhesive energy density increases with the rate of peeling and with lateral diffusivity of the bonds but decreases wi...