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The Journal of Urology

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  1. Moniliformediquinone Induces In Vitro and In Vivo Antitumor Activity through Glutathione Involved DNA Damage Response and Mitochondrial Stre...

    The Journal of Urology 191(5):1429 (2014) PMID 24316097

    Our data suggest that moniliformediquinone is a potential anticancer agent for hormone refractory metastatic prostate cancer by decreasing cellular glutathione, leading to a DNA damage response and cell cycle arrest at the S-phase. Mitochondrial stress also occurs due to moniliformediquinone action...
  2. Outcomes after urethroplasty for radiotherapy induced bulbomembranous urethral stricture disease.

    The Journal of Urology 191(5):1307 (2014) PMID 24333513

    We recently demonstrated that radiotherapy induced urethral strictures can be successfully managed with urethroplasty. We increased size and followup in our multi-institutional cohort, and evaluated excision and primary anastomosis as treatment for radiotherapy induced urethral strictures. A retrosp...
  3. Re: High Submuscular Placement of Urologic Prosthetic Balloons and Reservoirs via Transscrotal Approach.

    The Journal of Urology 191(5):1354 (2014) PMID 24745520

  4. Re: paternal aging and associated intraindividual alterations of global sperm 5-methylcytosine and 5-hydroxymethylcytosine levels.

    The Journal of Urology 191(5):1356 (2014) PMID 24745524

  5. Pilot randomized, placebo controlled trial to investigate the effect of antibiotic prophylaxis on the rate of urinary tract infection in inf...

    The Journal of Urology 191(5 Suppl):1501 (2014) PMID 24679865

    We determined the feasibility of a clinical trial of continuous antibiotic prophylaxis to prevent urinary tract infections in children with prenatal hydronephrosis. We piloted a blinded, randomized, placebo controlled study of the urinary tract infection rate in infants with grades III-IV prenatal h...
  6. F2-isoprostanes as a biomarker of oxidative stress in the mouse bladder.

    The Journal of Urology 191(5 Suppl):1597 (2014) PMID 24679873

    We theorized that progressive bladder dysfunction due to clinical diagnoses such as outlet obstruction occurs as a result of cyclical oxidative stress events. We hypothesized that measurement of F2-isoprostane, a marker of lipid peroxidation, could serve as a biomarker of oxidative stress in the mur...
  7. Prospective comparison of molecular signatures in urothelial cancer of the bladder and the upper urinary tract-is there evidence for discord...

    The Journal of Urology 191(4):926 (2014) PMID 24060642

    We prospectively evaluate molecular profiles of upper tract urothelial carcinoma and bladder cancer using a cell cycle biomarker panel. Immunohistochemical staining for p21, p27, p53, cyclin E and Ki-67 was prospectively performed for 96 patients with upper tract urothelial carcinoma and 159 patient...
  8. Prostate cancer biomarker profiles in urinary sediments and exosomes.

    The Journal of Urology 191(4):1132 (2014) PMID 24211598

    We evaluated 2 urinary fractions that contain nucleic acids, ie cell pellets and exosomes. The influence of digital rectal examination before urine collection was also studied and the prostate cancer specific biomarkers PCA3 and TMPRSS2-ERG were assayed. Urine samples were prospectively obtained bef...
  9. A phase 2, randomized, double-blind, efficacy and safety study of oxybutynin vaginal ring for alleviation of overactive bladder symptoms in ...

    The Journal of Urology 191(4):1014 (2014) PMID 24231837

    We evaluated the efficacy and safety of a once monthly oxybutynin vaginal ring in women with overactive bladder. This randomized, multicenter, double-blind, 12-week phase 2 study compared oxybutynin vaginal ring (4 or 6 mg daily) to a placebo vaginal ring in women with well-defined overactive bladde...
  10. The Relationship between Characteristics of Inguinal Lymph Nodes and Pelvic Lymph Node Involvement in Penile Squamous Cell Carcinoma: A Sing...

    The Journal of Urology 191(4):977 (2014) PMID 24262497

    We determined predictors of pelvic lymph node metastases in patients with penile cancer. We retrieved a total of 188 node positive inguinal groins from 142 patients treated for penile cancer. Logistic regression models were fitted to test for predictors of pelvic lymph node metastases. The minimum p...