PNAS

Print ISSN
0027-8424
Electronic ISSN
1091-6490
Impact factor
9.771
Publisher
highwire
URL
http://www.pnas.org
Usage rank
2
Article count
110575
Free count
100897
Free percentage
0.912476
PDFs via platforms
Highwire, Nephrology, Rupress, Proquest, CSA, Aaas, Ama, Aacr, Jstor, Csh, Endocrine, Gale, and National Academy of Sciences

  1. Single-molecule level analysis of the subunit composition of the T cell receptor on live T cells.

    PNAS 104(45):17662 (2007) PMID 17971442 PMCID PMC2077052

    The T cell receptor (TCR) expressed on most T cells is a protein complex consisting of TCRalphabeta heterodimers that bind antigen and cluster of differentiation (CD) 3epsilondelta, epsilongamma, and zetazeta dimers that initiate signaling. A long-standing controversy concerns whether there is o...
  2. Ablation of sarcolipin enhances sarcoplasmic reticulum calcium transport and atrial contractility.

    PNAS 104(45):17867 (2007) PMID 17971438 PMCID PMC2077025

    Sarcolipin is a novel regulator of cardiac sarcoplasmic reticulum Ca2+ ATPase 2a (SERCA2a) and is expressed abundantly in atria. In this study we investigated the physiological significance of sarcolipin in the heart by generating a mouse model deficient for sarcolipin. The sarcolipin-null mice ...
  3. Disruption of maternal DNA repair increases sperm-derived chromosomal aberrations.

    PNAS 104(45):17725 (2007) PMID 17978187 PMCID PMC2077046

    Male and female germ cells can transmit genetic defects that lead to pregnancy loss, infant mortality, birth defects, and genetic diseases in offspring; however, the parental origins of transmitted defects are not random, with de novo mutations and chromosomal structural aberrations transmitted ...
  4. Adult spinal cord progenitor cells are repelled by netrin-1 in the embryonic and injured adult spinal cord.

    PNAS 104(45):17837 (2007) PMID 17978191 PMCID PMC2077035

    Adult neural progenitor cells (aNPCs) exhibit limited migration in vivo with the exception of the rostral migratory stream and injury-induced movement. Surprisingly little is known regarding those signals regulating attraction or inhibition of the aNPC. These studies demonstrate that aNPCs respo...
  5. Abl tyrosine kinases regulate cell-cell adhesion through Rho GTPases.

    PNAS 104(45):17686 (2007) PMID 17965237 PMCID PMC2077043

    Adherens junctions are calcium-dependent cell-cell contacts that link neighboring cells through cadherin receptors. Coordinated regulation of the actin cytoskeleton by the Rho GTPases is required for the formation and dissolution of adherens junctions. However, the pathways that link cadherin si...
  6. Gamma-band deficiency and abnormal thalamocortical activity in P/Q-type channel mutant mice.

    PNAS 104(45):17819 (2007) PMID 17968008 PMCID PMC2077027

    Thalamocortical in vivo and in vitro function was studied in mice lacking P/Q-type calcium channels (Cav2.1), in which N-type calcium channels (Cav2.2) supported central synaptic transmission. Unexpectedly, in vitro patch recordings from thalamic neurons demonstrated no gamma-band subthreshold o...
  7. Molecular level stochastic model for competence cycles in Bacillus subtilis.

    PNAS 104(45):17582 (2007) PMID 17962411 PMCID PMC2077070

    The role of stochasticity and noise in controlling genetic circuits is investigated in the context of transitions into and from competence in Bacillus subtilis. Recent experiments have demonstrated that bistability is not necessary for this function, but that the existence of one stable fixed po...
  8. Novelty and collective attention.

    PNAS 104(45):17599 (2007) PMID 17962416 PMCID PMC2077036

    The subject of collective attention is central to an information age where millions of people are inundated with daily messages. It is thus of interest to understand how attention to novel items propagates and eventually fades among large populations. We have analyzed the dynamics of collective ...
  9. Stochastic inhibitor release and binding from single-enzyme molecules.

    PNAS 104(45):17680 (2007) PMID 17965235 PMCID PMC2077050

    Inhibition kinetics of single-beta-galactosidase molecules with the slow-binding inhibitor d-galactal have been characterized by segregating individual enzyme molecules in an array of 50,000 ultra small reaction containers and observing substrate turnover changes with fluorescence microscopy. In...
  10. Genomic analysis of human microRNA transcripts.

    PNAS 104(45):17719 (2007) PMID 17965236 PMCID PMC2077053

    MicroRNAs (miRNAs) are important genetic regulators of development, differentiation, growth, and metabolism. The mammalian genome encodes approximately 500 known miRNA genes. Approximately 50% are expressed from non-protein-coding transcripts, whereas the rest are located mostly in the introns o...
  11. Drosophila TRP channels require a protein with a distinctive motif encoded by the inaF locus.

    PNAS 104(45):17730 (2007) PMID 17968007 PMCID PMC2077074

    In both vertebrates and invertebrates, ion channels of the TRP superfamily are known to be influenced by a variety of accessory factors, but the list of interacting proteins is acknowledged to be incomplete. Although previous work showed that Drosophila TRP function is disrupted by mutations in ...
  12. Programmed death-1 concentration at the immunological synapse is determined by ligand affinity and availability.

    PNAS 104(45):17765 (2007) PMID 17968013 PMCID PMC2077030

    Despite the importance of programmed death-1 (PD-1) for T cell inhibition, little is known about its intracellular trafficking or requirements for localization to the immunological synapse. Here, we show that in activated T cells, PD-1 is present at the plasma membrane, near the Golgi and in the...
  13. A functional genetic screen identifies retinoic acid signaling as a target of histone deacetylase inhibitors.

    PNAS 104(45):17777 (2007) PMID 17968018 PMCID PMC2077016

    Understanding the pathways that are targeted by cancer drugs is instrumental for their rational use in a clinical setting. Inhibitors of histone deacetylases (HDACI) selectively inhibit proliferation of malignant cells and are used for the treatment of cancer, but their cancer selectivity is und...
  14. Programmed death-1 concentration at the immunological synapse is determined by ligand affinity and availability.

    PNAS 104(45):17765 (2007) PMID 17968013 PMCID PMC2077030

    Despite the importance of programmed death-1 (PD-1) for T cell inhibition, little is known about its intracellular trafficking or requirements for localization to the immunological synapse. Here, we show that in activated T cells, PD-1 is present at the plasma membrane, near the Golgi and in the...
  15. Quantum dots provide an optical signal specific to full collapse fusion of synaptic vesicles.

    PNAS 104(45):17843 (2007) PMID 17968015 PMCID PMC2077028

    Synaptic vesicles are responsible for releasing neurotransmitters and are thus essential to brain function. The classical mode of vesicle recycling includes full collapse of the vesicle into the plasma membrane and clathrin-mediated regeneration of a new vesicle. In contrast, a nonclassical mode...
  16. Cooperative DNA binding by CI repressor is dispensable in a phage lambda variant.

    PNAS 104(45):17741 (2007) PMID 17962420 PMCID PMC2077068

    Complex gene regulatory circuits contain many interacting components. In principle, all of these components and interactions may be essential to the function of the circuit. Alternatively, some of them may be refinements to a simpler version of the circuit that improve its fitness. In this work,...
  17. Visual- and saccade-related signals in the primate inferior colliculus.

    PNAS 104(45):17855 (2007) PMID 17978183 PMCID PMC2077072

    The inferior colliculus (IC) is normally thought of as a predominantly auditory structure because of its early position in the ascending auditory pathway just before the auditory thalamus. Here, we show that a majority of IC neurons (64% of 180 neurons) in awake monkeys carry visual- and/or sacc...
  18. Telomere uncapping in progenitor cells with critical telomere shortening is coupled to S-phase progression in vivo.

    PNAS 104(45):17747 (2007) PMID 17965232 PMCID PMC2077026

    Telomeres protect chromosome ends and serve as a substrate for telomerase, a reverse transcriptase that adds DNA repeats to the telomere terminus. In the absence of telomerase, telomeres progressively shorten, ultimately leading to telomere uncapping, a structural change at the telomere that act...
  19. Abl tyrosine kinases regulate cell-cell adhesion through Rho GTPases.

    PNAS 104(45):17686 (2007) PMID 17965237 PMCID PMC2077043

    Adherens junctions are calcium-dependent cell-cell contacts that link neighboring cells through cadherin receptors. Coordinated regulation of the actin cytoskeleton by the Rho GTPases is required for the formation and dissolution of adherens junctions. However, the pathways that link cadherin si...
  20. Dendritic cell preactivation impairs MHC class II presentation of vaccines and endogenous viral antigens.

    PNAS 104(45):17753 (2007) PMID 17978177 PMCID PMC2077019

    When dendritic cells (DCs) encounter signals associated with infection or inflammation, they become activated and undergo maturation. Mature DCs are very efficient at presenting antigens captured in association with their activating signal but fail to present subsequently encountered antigens, a...