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Highwire, Nephrology, Rupress, Proquest, CSA, Aaas, Ama, Aacr, Jstor, Csh, Endocrine, Gale, and National Academy of Sciences

  1. Single-molecule level analysis of the subunit composition of the T cell receptor on live T cells.

    PNAS 104(45):17662 (2007) PMID 17971442 PMCID PMC2077052

    The T cell receptor (TCR) expressed on most T cells is a protein complex consisting of TCRalphabeta heterodimers that bind antigen and cluster of differentiation (CD) 3epsilondelta, epsilongamma, and zetazeta dimers that initiate signaling. A long-standing controversy concerns whether there is o...
  2. Ablation of sarcolipin enhances sarcoplasmic reticulum calcium transport and atrial contractility.

    PNAS 104(45):17867 (2007) PMID 17971438 PMCID PMC2077025

    Sarcolipin is a novel regulator of cardiac sarcoplasmic reticulum Ca2+ ATPase 2a (SERCA2a) and is expressed abundantly in atria. In this study we investigated the physiological significance of sarcolipin in the heart by generating a mouse model deficient for sarcolipin. The sarcolipin-null mice ...
  3. Disruption of maternal DNA repair increases sperm-derived chromosomal aberrations.

    PNAS 104(45):17725 (2007) PMID 17978187 PMCID PMC2077046

    Male and female germ cells can transmit genetic defects that lead to pregnancy loss, infant mortality, birth defects, and genetic diseases in offspring; however, the parental origins of transmitted defects are not random, with de novo mutations and chromosomal structural aberrations transmitted ...
  4. Adult spinal cord progenitor cells are repelled by netrin-1 in the embryonic and injured adult spinal cord.

    PNAS 104(45):17837 (2007) PMID 17978191 PMCID PMC2077035

    Adult neural progenitor cells (aNPCs) exhibit limited migration in vivo with the exception of the rostral migratory stream and injury-induced movement. Surprisingly little is known regarding those signals regulating attraction or inhibition of the aNPC. These studies demonstrate that aNPCs respo...
  5. Abl tyrosine kinases regulate cell-cell adhesion through Rho GTPases.

    PNAS 104(45):17686 (2007) PMID 17965237 PMCID PMC2077043

    Adherens junctions are calcium-dependent cell-cell contacts that link neighboring cells through cadherin receptors. Coordinated regulation of the actin cytoskeleton by the Rho GTPases is required for the formation and dissolution of adherens junctions. However, the pathways that link cadherin si...
  6. Gamma-band deficiency and abnormal thalamocortical activity in P/Q-type channel mutant mice.

    PNAS 104(45):17819 (2007) PMID 17968008 PMCID PMC2077027

    Thalamocortical in vivo and in vitro function was studied in mice lacking P/Q-type calcium channels (Cav2.1), in which N-type calcium channels (Cav2.2) supported central synaptic transmission. Unexpectedly, in vitro patch recordings from thalamic neurons demonstrated no gamma-band subthreshold o...
  7. Molecular level stochastic model for competence cycles in Bacillus subtilis.

    PNAS 104(45):17582 (2007) PMID 17962411 PMCID PMC2077070

    The role of stochasticity and noise in controlling genetic circuits is investigated in the context of transitions into and from competence in Bacillus subtilis. Recent experiments have demonstrated that bistability is not necessary for this function, but that the existence of one stable fixed po...
  8. Novelty and collective attention.

    PNAS 104(45):17599 (2007) PMID 17962416 PMCID PMC2077036

    The subject of collective attention is central to an information age where millions of people are inundated with daily messages. It is thus of interest to understand how attention to novel items propagates and eventually fades among large populations. We have analyzed the dynamics of collective ...
  9. Stochastic inhibitor release and binding from single-enzyme molecules.

    PNAS 104(45):17680 (2007) PMID 17965235 PMCID PMC2077050

    Inhibition kinetics of single-beta-galactosidase molecules with the slow-binding inhibitor d-galactal have been characterized by segregating individual enzyme molecules in an array of 50,000 ultra small reaction containers and observing substrate turnover changes with fluorescence microscopy. In...
  10. Genomic analysis of human microRNA transcripts.

    PNAS 104(45):17719 (2007) PMID 17965236 PMCID PMC2077053

    MicroRNAs (miRNAs) are important genetic regulators of development, differentiation, growth, and metabolism. The mammalian genome encodes approximately 500 known miRNA genes. Approximately 50% are expressed from non-protein-coding transcripts, whereas the rest are located mostly in the introns o...
  11. Drosophila TRP channels require a protein with a distinctive motif encoded by the inaF locus.

    PNAS 104(45):17730 (2007) PMID 17968007 PMCID PMC2077074

    In both vertebrates and invertebrates, ion channels of the TRP superfamily are known to be influenced by a variety of accessory factors, but the list of interacting proteins is acknowledged to be incomplete. Although previous work showed that Drosophila TRP function is disrupted by mutations in ...
  12. Programmed death-1 concentration at the immunological synapse is determined by ligand affinity and availability.

    PNAS 104(45):17765 (2007) PMID 17968013 PMCID PMC2077030

    Despite the importance of programmed death-1 (PD-1) for T cell inhibition, little is known about its intracellular trafficking or requirements for localization to the immunological synapse. Here, we show that in activated T cells, PD-1 is present at the plasma membrane, near the Golgi and in the...
  13. A functional genetic screen identifies retinoic acid signaling as a target of histone deacetylase inhibitors.

    PNAS 104(45):17777 (2007) PMID 17968018 PMCID PMC2077016

    Understanding the pathways that are targeted by cancer drugs is instrumental for their rational use in a clinical setting. Inhibitors of histone deacetylases (HDACI) selectively inhibit proliferation of malignant cells and are used for the treatment of cancer, but their cancer selectivity is und...
  14. The ailing invader.

    PNAS 104(45):17561 (2007) PMID 17968006 PMCID PMC2077049

  15. Phylogenetic analyses of behavior support existence of culture among wild chimpanzees.

    PNAS 104(45):17588 (2007) PMID 17968009 PMCID PMC2077048

    Culture has long been considered to be not only unique to humans, but also responsible for making us qualitatively different from all other forms of life. In recent years, however, researchers studying chimpanzees (Pan troglodytes) have challenged this idea. Natural populations of chimpanzees ha...
  16. High-resolution design of a protein loop.

    PNAS 104(45):17668 (2007) PMID 17971437 PMCID PMC2077077

    Despite having irregular structure, protein loops often adopt specific conformations that are critical to protein function. Most studies in de novo protein design have focused on creating proteins with regular elements of secondary structure connected by very short loops or turns. To design long...
  17. Accretion of ferromanganese nodules that form pavement in Second Connecticut Lake, New Hampshire.

    PNAS 104(45):17579 (2007) PMID 17978181 PMCID PMC2077037

    We discovered ferromanganese nodules that measure up to 46 cm in diameter with stromatolitic growth patterns in the western central near-shore portion of Second Connecticut Lake, Pittsburg, New Hampshire. They occur as four distinct morphotypes: irregular laminated convex plates that form concen...
  18. JY-1, an oocyte-specific gene, regulates granulosa cell function and early embryonic development in cattle.

    PNAS 104(45):17602 (2007) PMID 17978182 PMCID PMC2077078

    Oocyte-specific gene products play a key role in regulation of fertility in mammals. Here, we describe the discovery, molecular characterization, and function of JY-1, a bovine oocyte-expressed gene shown to regulate both function of ovarian granulosa cells and early embryogenesis in cattle and ...
  19. In silico and in vitro pharmacogenetic analysis in mice.

    PNAS 104(45):17735 (2007) PMID 17978195 PMCID PMC2077071

    Combining the experimental efficiency of a murine hepatic in vitro drug biotransformation system with in silico genetic analysis produces a model system that can rapidly analyze interindividual differences in drug metabolism. This model system was tested by using two clinically important drugs, ...
  20. Designer enediynes generate DNA breaks, interstrand cross-links, or both, with concomitant changes in the regulation of DNA damage responses.

    PNAS 104(45):17632 (2007) PMID 17978180 PMCID PMC2077023

    The ability of the radiomimetic anticancer enediyne C-1027 to induce ataxia-telangiectasia mutated (ATM) and ATM and Rad3-related (ATR)-independent damage responses was discovered to reside in its unique ability to concurrently generate robust amounts of double-strand breaks (DSBs) and interstra...