New England Journal of Medicine

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  1. New Agents for Hyperkalemia

    New England Journal of Medicine 372(16):1569 (2015) PMID 25875263

    To the Editor: In the study by Weir et al. (Jan. 15 issue),1 the low baseline rate of use of loop diuretics (32% of patients) is noteworthy and might limit the clinical applicability of their finding that patiromer was effective in reducing hyperkalemia in patients with chronic kidney ...
  2. Trends in Opioid Analgesic Abuse and Mortality in the United States

    New England Journal of Medicine 372(16):1572 (2015) PMID 25875268

    To the Editor: Dart et al. (Jan. 15 issue)1 conclude that the United States may be making progress in controlling the abuse of opioid analgesics. However, they understate the increasing problem of opioid-associated deaths, especially those related to heroin. First, the death ...
  3. This Week in the Journal
    Author(s) unavailable

    New England Journal of Medicine 372(16):1488 (2015)

  4. Case 12-2015: A Newborn Boy with Respiratory Distress, Lethargy, and Hypernatremia

    New England Journal of Medicine 372(16):1550 (2015) PMID 25875261

    A newborn boy was admitted to the hospital because of respiratory distress and hypotension. At delivery, meconium was suctioned from the airway. Respiration and blood pressure improved after intervention, but lethargy and myoclonus developed. Presentation of Case Dr...
  5. Loss of Fingerprints

    New England Journal of Medicine 372(16):e22 (2015) PMID 25875278

    A 65-year-old woman with stage IV triple-negative breast cancer (a tumor characterized by the lack of estrogen and progesterone receptors and expression of human epidermal growth factor receptor type 2 [HER2]) presented after being denied authorization to perform a banking transaction ...
  6. Sodium Zirconium Cyclosilicate for Urgent Therapy of Severe Hyperkalemia

    New England Journal of Medicine 372(16):1577 (2015) PMID 25875277

    The authors of this letter report that in patients with severe hyperkalemia at baseline, treatment with a single dose of sodium zirconium cyclosilicate was associated a rapid and significant reduction in potassium as early as 1 hour after administration. To the Editor: Severe...
  7. Lowering LDL Cholesterol Is Good, but How and in Whom?

    New England Journal of Medicine 372(16):1564 (2015) PMID 25773740

    Genetic findings reported approximately 9 years ago in the Journal indicated that rare sequence variants in the gene encoding proprotein convertase subtilisin–kexin type 9 serine protease (PCSK9) were associated with significantly lower long-term plasma levels of low-density lipoprotei...
  8. More on Hidden Formaldehyde in E-Cigarette Aerosols

    New England Journal of Medicine 372(16):1575 (2015) PMID 25875273

    To the Editor: The data presented by Jensen et al. (Jan. 22 issue)1 in their recent letter to the Editor do not support their conclusion that e-cigarette use presents a likely risk of excessive exposure to formaldehyde. The 5-V puff topography used by Jensen et al. appears to have over...
  9. Tuberculosis among the Homeless — Preventing Another Outbreak through Community Action

    New England Journal of Medicine 372(16):1483 (2015) PMID 25875254

    A Seattle clinic offers homeless people with latent tuberculosis infection vouchers for meals at a local bakery as an incentive for adhering to newly available 12-week directly observed therapy — a cost-effective solution that may stem future tuberculosis outbreaks. Over the ...
  10. Social Distancing and the Unvaccinated

    New England Journal of Medicine 372(16):1481 (2015) PMID 25806793

    In January 2015, a federal appeals court ruled that New York State has the authority to bar unvaccinated children from school during outbreaks of vaccine-preventable illnesses, even if doing so overrides a family's religious freedom with regard to vaccination. If a state allo...
  11. Hyphema

    New England Journal of Medicine 372(16):1549 (2015) PMID 25875260

    A 33-year-old pig farmer presented with sudden blurred vision, pain, redness, and photophobia in both eyes and a 10-day history of fever, malaise, and myalgia. Local treatment alleviated the pain and photophobia, but the next morning he had hyphema in his left eye. A 33-year-...
  12. Toward a True Bacteriotherapy for Clostridium difficile Infection

    New England Journal of Medicine 372(16):1566 (2015) PMID 25875262

    The extent to which microbiota influence health is the focus of many research efforts, but most published findings are ones of association. A recent study of bacterial species that confer resistance to Clostridium difficile infection is designed to identify a causal relationship. ...
  13. Clostridium difficile Infection

    New England Journal of Medicine 372(16):1539 (2015) PMID 25875259

    This article reviews the pathogenesis, epidemiology, diagnosis, and treatment of this nosocomial and potentially fatal infectious diarrhea, as well as the associated risk factors. New treatments include fecal microbiota transplantation for disease that is resistant to vancomycin. ...
  14. Origins of Cystic Fibrosis Lung Disease

    New England Journal of Medicine 372(16):1574 (2015) PMID 25875271

    To the Editor: On the basis of their seminal findings in models of disease in large animals, Stoltz and colleagues (Jan. 22 issue)1 report that the origins of cystic fibrosis lung disease result from impaired chloride and bicarbonate epithelial transport, defective mucociliary transpor...