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- Proquest, CSA, Ovid from 2003, and Cambridge
Dynamics of Besnoitia besnoiti infection in cattle.
Bovine besnoitiosis is caused by the cyst-forming apicomplexan parasite Besnoitia besnoiti. This disease progresses in two sequential phases: a febrile acute phase with oedemas and respiratory disorders, and a chronic phase characterized by the presence of subcutaneous tissue cysts and skin lesions....
In vitro investigation of the efficacy of novel diamidines against Trypanosoma cruzi.
Our results show that although active against the extracellular forms, with some of them like DB2247 being 6-fold more effective than benznidazole and displaying very low toxicity (>96 μm), none presented superior trypanocidal effect against intracellular forms as compared with the reference drug. T...
Disruption of vitellogenesis and spermatogenesis by triclabendazole (TCBZ) in a TCBZ-resistant isolate of Fasciola hepatica following incuba...
A study has been carried out to investigate whether the action of triclabendazole (TCBZ) against Fasciola hepatica is altered by inhibition of P-glycoprotein (Pgp)-linked drug efflux pumps. The Sligo TCBZ-resistant fluke isolate was used for these experiments and the Pgp inhibitor selected was R(+)-...
Epidemiological review of toxoplasmosis in humans and animals in Romania.
We review prevalence, clinical spectrum and epidemiology of T. gondii in humans and animals in Romania. This knowledge should be useful to biologists, public health workers, veterinarians and physicians....
Animal models of efficacy to accelerate drug discovery in malaria.
We intend to analyse how efficacy models are used to discover new antimalarial drugs. Our analysis indicates that testing drug efficacy is often the last assay in each discovery stage and the experimental designs utilized are not optimized to expedite decision-making and inform clinical development....
Emerging paradigms in anti-infective drug design.
We provide an overview of those processes as an introduction to a series of articles from experts in this area that emerged from a meeting entitled "Emerging Paradigms in Anti-Infective Drug Design" held in London on the 17th and 18th September 2012. The symposium was organised jointly by British So...
Identifying permethrin resistance loci in malaria vectors by genetic mapping.
We revisited the use of quantitative trait loci (QTL) mapping to study resistance phenotypes in this vector species. Earlier work, identified two major QTL associated with pyrethroid resistance in A. gambiae s.s. from East Africa using genetic crossing of laboratory-colonized resistant and susceptib...
Does the carotenoid-based colouration of Polymorphus minutus facilitate its trophic transmission to definitive hosts?
We investigated the selective preference of mallard towards two prey types: uninfected gammarids on which we applied a dot of inconspicuous brown paint, and uninfected gammarids on which we applied a dot of bright orange paint to mimic the change in appearance due to P. minutus without changes in ho...
Identification of high-risk regions for schistosomiasis in the Guichi region of China: an adaptive kernel density estimation-based approach.
We conducted the first study to apply the newly developed method of adaptive kernel density estimation (KDE)-based spatial relative risk function (sRRF) to detect the high-risk regions of schistosomiasis in the Guichi region of China and compared it with the fixed KDE-based sRRF. We found that the a...
Characterization of the novel Trypanosoma brucei inosine 5'-monophosphate dehydrogenase.
We characterize recombinant Trypanosoma brucei IMPDH (TbIMPDH) to investigate the enzymatic differences between TbIMPDH and host IMPDH. Size-exclusion chromatography and analytical ultracentrifugation sedimentation velocity experiments reveal that TbIMPDH forms a heptamer, different from type 1 and...