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  1. Evidence that primary infection of Charollais sheep with Toxoplasma gondii may not prevent foetal infection and abortion in subsequent lambings.

    Parasitology 135(2):169 (2008) PMID 17922930

    A study carried out on a sheep farm examined whether Toxoplasma gondii foetal infection and associated abortion occur in successive lambings. We identified 29 ewes that gave birth to lambs on at least 2 successive years over our study period, 2000-2003. Tissue samples from the progeny of these e...
  2. Transgenesis of schistosomes: approaches employing mobile genetic elements.

    Parasitology 135(2):141 (2008) PMID 17991304

    Draft genome sequences for Schistosoma mansoni and Schistosoma japonicum are now available. However, the identity and importance of most schistosome genes have yet to be determined. Recently, progress has been made towards the genetic manipulation and transgenesis of schistosomes. Both loss-of-f...
  3. Anti-Trypanosoma cruzi effects of cyclosporin A derivatives: possible role of a P-glycoprotein and parasite cyclophilins.

    Parasitology 135(2):217 (2008) PMID 17922928

    Cyclophilins are target molecules for cyclosporin A (CsA), an immunosuppressive antimicrobial drug. We have previously reported the in vitro anti-Trypanosoma cruzi activity of H-7-94 and F-7-62 non-immunosuppressive CsA analogues. In this work, we continue the study of the parasiticidal effect o...
  4. Searching for general patterns in parasite ecology: host identity versus environmental influence on gamasid mite assemblages in small mammals.

    Parasitology 135(2):229 (2008) PMID 17908362

    The abundance and diversity of parasites vary among different populations of host species. In some host-parasite associations, much of the variation seems to depend on the identity of the host species, whereas in other cases it is better explained by local environmental conditions. The few paras...
  5. Quantitative analysis of parasite DNA in the blood of immunized and naïve mice after infection with Neospora caninum.

    Parasitology 135(2):175 (2008) PMID 17922929

    Real-time PCR was used to study the duration and level of parasitaemia in mice immunized with immune-stimulating complexes (iscoms) containing recombinant NcSRS2, one of the immunodominant surface antigens of Neospora caninum. After challenge infection, blood was collected daily for 9 days. Duri...
  6. Gene expression profiling of Leishmania (Leishmania) donovani: overcoming technical variation and exploiting biological variation.

    Parasitology 135(2):183 (2008) PMID 17931458

    Gene expression profiling is increasingly used in the field of infectious diseases for characterization of host, pathogen and the nature of their interaction. The purpose of this study was to develop a robust, standardized method for comparative expression profiling and molecular characterizatio...
  7. Expression of Plasmodium falciparum 3D7 STEVOR proteins for evaluation of antibody responses following malaria infections in naïve infants.

    Parasitology 135(2):155 (2008) PMID 17931459

    Clinical immunity to Plasmodium falciparum malaria develops after repeated exposure to the parasite. At least 2 P. falciparum variant antigens encoded by multicopy gene families (var and rif) are targets of this adaptive antibody-mediated immunity. A third multigene family of variant antigens co...
  8. The influence of temperature on the development, hatching and survival of Nematodirus battus larvae.

    Parasitology 135(2):269 (2008) PMID 17991303

    Although Nematodirus battus (Nematoda: Trichostrongyloidea) is an economically important and highly pathogenic parasite of sheep in the temperate regions, very little is known about the population dynamics of its free-living stages and their relationship with ambient temperature. Here we describ...
  9. Identification and localization of a putative ATP-binding cassette transporter in sea lice (Lepeophtheirus salmonis) and host Atlantic salmon (Salmo salar).

    Parasitology 135(2):243 (2008) PMID 17961285

    Some members of the ABC-transporter superfamily, such as P-glycoprotein and the multidrug resistance associated protein, may confer resistance to the avermectin subclass of macrocyclic lactones. The aim of this study was to examine the presence of ABC transporters in both sea lice (Lepeophtheiru...
  10. Halfway up the trophic chain: development of parasite communities in the sparid fish Boops boops.

    Parasitology 135(2):257 (2008) PMID 17908363

    We examined the patterns of composition and structure of parasite communities in the Mediterranean sparid fish Boops boops along a gradient of fish sizes, using a large sample from a single population. We tested the hypothesis that species forming the core of the bogue parasite fauna (i.e. speci...