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- Proquest, CSA, Ovid from 2003, and Cambridge
Levels of circulating anti-muscarinic and anti-adrenergic antibodies and their effect on cardiac arrhythmias and dysautonomia in murine mode...
We describe that Trypanosoma cruzi-infected C3H/He mice show increased P and QRS wave duration, and PR and QTc intervals, while the most significant ECG alterations in C57BL/6 are prolonged P wave and PR interval. Echocardiogram analyses show right ventricle dilation in infected animals of both mous...
Species limits in avian malaria parasites (Haemosporida): how to move forward in the molecular era.
We highlight some of the issues, both historical and contemporary, that have hindered the development of objective criteria to diagnose, delimit and define species of haemosporidians. Defining species is not the focal interest of most researchers, most of whom merely wish to determine whether lineag...
Molecular identification of Sarcocystis spp. helped to define the origin of green pythons (Morelia viridis) confiscated in Germany.
Our research shows that information on the infection of snakes with Sarcocystis spp. may be used to assess compliance with regulations on the trade with wildlife species....
Target-based drug discovery for human African trypanosomiasis: selection of molecular target and chemical matter.
Target-based approaches for human African trypanosomiasis (HAT) and related parasites can be a valuable route for drug discovery for these diseases. However, care needs to be taken in selection of both the actual drug target and the chemical matter that is developed. In this article, potential crite...
Parasitism and phenotypic change in colonial hosts.
We characterized changes in host phenotype in a colonial host–endoparasite system that lacks trophic transmission (the freshwater bryozoan Fredericella sultana and myxozoan parasite Tetracapsuloides bryosalmonae). We show that parasitism exerts opposing phenotypic effects at the colony and module le...
Diversity and distribution of Blastocystis sp. subtypes in non-human primates.
Blastocystis SSU-rDNA sequence data from 317 captive and free-living non-human primates (NHPs) representing 30 genera of apes, Old and New World (OW and NW) monkeys and prosimians were analysed to investigate subtype (ST) and allele distribution among hosts. Excluding 20 mixed ST infections, 27% of...
The role of surface glycoconjugates in Leishmania midgut attachment examined by competitive binding assays and experimental development in s...
We examined midgut attachment of Leishmania lines mutated in GPI-anchored molecules and compared results from 2 different techniques: in vivo development in sand flies and in vitro competitive binding assays using fluorescently labelled parasites. In combination with previous studies, our data provi...
Structural modelling studies and immunoprophylactic potential of Brugia malayi DEAD Box RNA helicase.
We have previously over-expressed and biochemically characterized an immunodominant cDNA clone encoding DEAD box RNA helicase (BmL3-Helicase) isolated by immunoscreening of the larval stage cDNA library of Brugia malayi. In the current study, the 3D structure was determined and the immunoprophylacti...
Reproductive consequences of host age in a desert flea.
We tested for the effect of age of a rodent host (Meriones crassus) on reproductive performance of fleas in terms of number and quality of offspring and predicted that fleas would perform better on juvenile and old than on subadult and adult hosts. The number of flea offspring was evaluated via egg...
Viability of Ascaris suum eggs in stored raw and separated liquid slurry.
Separation of pig slurry into solid and liquid fractions is gaining importance as a way to manage increasing volumes of slurry. In contrast to solid manure and slurry, little is known about pathogen survival in separated liquid slurry. The viability of Ascaris suum eggs, a conservative indicator of...