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ApiCOWplexa 2013 - 2nd International Meeting on Apicomplexan Parasites in Farm Animals.
Parasite co-infections show synergistic and antagonistic interactions on growth performance of East African zebu cattle under one year.
We have tested associations of infections and their co-infections with variation in growth rate using a subset of 455 animals of the Infectious Diseases of East Africa Livestock (IDEAL) cohort study surviving to one year. Data on live body weight, infections with helminth parasites and haemoparasite...
A Candide response to Panglossian accusations by Randolph and Dobson: biodiversity buffers disease.
Randolph and Dobson (2012) criticize the dilution effect, which describes the negative relationship between biodiversity and infectious disease risk. Unfortunately, their commentary includes distortions, errors of omission, and errors of commission, which are rebutted herein. Contrary to their claim...
High throughput sequencing of the Angiostrongylus cantonensis genome: a parasite spreading worldwide.
We present data collected from DNA random high-throughput sequencing together with proteomic analyses and a cDNA walking methodology to identify and obtain the nucleotide or amino acid sequences of unknown immunoreactive proteins. 28 080 putative ORFs were obtained, of which 3371 had homology to oth...
Can parasites use predators to spread between primary hosts?
We tested experimentally whether these parasites can use R. hartii as an alternative host. In aquaria, G. bullatarudis was the only species able to transmit from prey to predator. Both parasite species transferred equally well to prey when the predator was experimentally infected. However, in semi-n...
Cloning and molecular analysis of the aspartic protease Sc-ASP110 gene transcript in Steinernema carpocapsae.
We have cloned and analysed the gene transcript of Sc-ASP110 in S. carpocapsae....
Dances with worms: the ecological and evolutionary impacts of deworming on coinfecting pathogens.
I develop a theoretical framework to explore how helminth coinfection with other pathogens affects host mortality and pathogen spread and evolution under different interspecific parasite interactions. In all cases the outcomes of coinfection are highly context-dependent, depending on the mechanism o...
Structural modelling studies and immunoprophylactic potential of Brugia malayi DEAD Box RNA helicase.
We have previously over-expressed and biochemically characterized an immunodominant cDNA clone encoding DEAD box RNA helicase (BmL3-Helicase) isolated by immunoscreening of the larval stage cDNA library of Brugia malayi. In the current study, the 3D structure was determined and the immunoprophylacti...
Evidence for direct transmission of the cat lungworm Troglostrongylus brevior (Strongylida: Crenosomatidae).
We provide, for the first time, observational evidence suggesting the direct transmission of T. brevior from queen cat to suckling kittens. This new knowledge will have a significant impact on current scientific information of this parasite and shed new light into the biology and epidemiology of met...
Unresponsiveness of Mycobacterium w vaccine in managing acute and chronic Leishmania donovani infections in mouse and hamster.
SUMMARY The role of Mycobacterium w (Mw) vaccine as an immunomodulator and immunoprophylactant in the treatment of mycobacterial diseases (leprosy and pulmonary tuberculosis) is well established. The fact that it shares common antigens with leishmanial parasites prompted its assessment as an immunos...