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[Absorption of calcitonin in oral and pulmonary administration with polymer-coated liposomes].
We have developed polymer-coated liposomes for effective and non-invasive delivery of peptide drugs. Polymer-coated liposomes, which are liposomal particles coated with functional polymers, were designed in order to have suitable functions required for drug delivery. So far, we have reported prolong...
Hepatocyte growth factor regulates immune reactions caused by transplantation and autoimmune diseases.
We previously demonstrated that its administration inhibited acute graft-versus-host disease (GVHD) after treatment with hematopoietic stem cell transplantation. We also demonstrated that HGF inhibited lupus nephritis induced by chronic GVHD and dermal sclerosis in systemic sclerosis using model mic...
Development of deuterium labeling method based on the heterogeneous platinum group metal-catalyzed C-h activation.
Deuterium (D) labeled compounds are utilized in various scientific fields such as mechanistic elucidation of reactions, preparation of new functional materials, tracers for microanalysis, deuterium labeled heavy drugs and so on. Although the H-D exchange reaction is a straightforward method to pro...
Migration behavior of breast cancer cells in the environment of high glucose level and the role of zinc and its transporter.
We demonstrated that breast cancer cells, MCF-7, cultured in hyperglycemic level significantly promotes the motile activity in comparison to normal physiological glucose level. Moreover, Zn(2+) uptake activity into cellular cytosol and the mRNA expression of zinc transporters, ZIP6 and ZIP10, in the...
[Dopaminergic neuroprotection via Nrf2-ARE pathway activation: identification of an activator from green perilla leaves].
We review a mechanism in which proteasome inhibition provides dopaminergic neuroprotection from oxidative stress. Treatment with lactacystin, a proteasome inhibitor, significantly suppressed 6-hydroxydopamine (6-OHDA)-induced toxicity and oxidative stress in PC12 cells. In addition, lactacystin enha...
[Study on molecular function of proteins of human immunodeficiency virus].
We found that Vpx enhances genome nuclear import in T lymphocytes, and is critical for reverse transcription of viral RNA in macrophages. This finding on the function in macrophages corrected long-term misleading belief. Furthermore, functional region mapping of Vpx was performed. In 2011, the prote...
[Analysis of the risk factors for severe neutropenia in advanced non-small cell lung cancer after the first course of chemotherapy with thir...
We analyzed 100 patients who received such agents (paclitaxel, docetaxel, gemcitabine, irinotecan, or vinorelbine) for advanced NSCLC. The endpoint of the survey was the occurrence of severe neutropenia (grade 4). Risk factors significantly related to severe neutropenia were identified using logisti...
Use of psychotropics and the risk of falls in hospitalized psychiatric patients.
We attempted to investigate, from the aspect of drug prescription, to what degree the number and doses of psychotropics must be adjusted in order to reduce risk of falls in hospitalized psychiatric patients. The subjects were 526 patients, consisting of a fall group of 313 patients, who had experien...
Recent Progress and Challenges in Investigator-driven Clinical Development of Novel Drugs and Medical Devices at The University of Tokyo Hos...
At the University of Tokyo Hospital, investigator-driven clinical development of novel drugs and medical devices is mainly supported by the Translational Research Center and Clinical Research Support Center. The former supports non-clinical research and the preparation of test materials and the latt...
Enhanced Ca(2+)-sensing Receptor Function in Pulmonary Hypertension.
We recently found that the extracellular Ca(2+)-sensing receptor (CaSR), a G protein-coupled receptor (GPCR), is upregulated in PASMCs from patients with idiopathic pulmonary arterial hypertension (IPAH). In addition, blockage of the CaSR with an antagonist (NPS2143) prevents the development of pulm...