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Ama, CSA, Endocrine, Rupress, Csh, Aacr, Gale, Highwire, Aaas, Proquest, Jstor, Ovid, and Nephrology

  1. Tracking cancer drugs in living cells by thermal profiling of the proteome.

    Science 346(6205):1255784 (2014) PMID 25278616

    The thermal stability of proteins can be used to assess ligand binding in living cells. We have generalized this concept by determining the thermal profiles of more than 7000 proteins in human cells by means of mass spectrometry. Monitoring the effects of small-molecule ligands on the profiles de...
  2. Comment on "Revealing nature's cellulase diversity: the digestion mechanism of Caldicellulosiruptor bescii CelA".

    Science 344(6184):578 (2014) PMID 24812381

    Brunecky et al. (Reports, 20 December 2013, p. 1513) compared the cellulolytic activity of bacterial multimodular cellulase CelA with fungal Cel7A (cellobiohydrolase I from Trichoderma reesei). If more active Cel7A from another fungus were used as a reference enzyme under optimal conditions with ...
  3. Lignin valorization: improving lignin processing in the biorefinery.

    Science 344(6185):1246843 (2014) PMID 24833396

    Research and development activities directed toward commercial production of cellulosic ethanol have created the opportunity to dramatically increase the transformation of lignin to value-added products. Here, we highlight recent advances in this lignin valorization effort. Discovery of genetic v...
  4. Mechanism of activation of protein kinase JAK2 by the growth hormone receptor.

    Science 344(6185):1249783 (2014) PMID 24833397

    Signaling from JAK (Janus kinase) protein kinases to STAT (signal transducers and activators of transcription) transcription factors is key to many aspects of biology and medicine, yet the mechanism by which cytokine receptors initiate signaling is enigmatic. We present a complete mechanistic mod...
  5. A Useful Selective Bactericidal Property of Tergitol-7.

    Science 103(2687):758 (2010) PMID 17836453

    Starch tryptone agar containing 1 : 20,000 Tergitol-7 was successfully sterilized in the Arnold by one 30-minute heating period. Decreasing the concentration to 1 : 30,000 resulted in 4 per cent failures. A concentration of 1 : 20,000 in the cold killed spores of B. mycoides and an unidentified h...
  6. Solar system exploration. Researchers fear merger could muffle their voice.

    Science 295(5552):37 (2002) PMID 11778024

  7. Solar system exploration. Technology is essential, but it's a tough sell.

    Science 295(5552):39 (2002) PMID 11778026

  8. Nuclear science. U.S. breeder reactor runs out of lives.

    Science 295(5552):31 (2002) PMID 11778020

  9. Antibiotic resistance. Livestock feed ban preserves drugs' power.

    Science 295(5552):27 (2002) PMID 11778017

  10. Cosmology. How the cosmic dark age ended.

    Science 295(5552):51 (2002) PMID 11778028

  11. Surface science. Water on a metal surface.

    Science 295(5552):58 (2002) PMID 11778032

  12. Germ cell survival through carbohydrate-mediated interaction with Sertoli cells.

    Science 295(5552):124 (2002) PMID 11778047

    Spermatogenesis is a precisely regulated process in which the germ cells closely interact with Sertoli cells. The molecular basis of this cell-cell adhesion is unknown. Here, we demonstrate that targeted disruption of Man2a2, a gene encoding alpha-mannosidase IIx (MX), an enzyme that forms inter...
  13. Combined functional genomic maps of the C. elegans DNA damage response.

    Science 295(5552):127 (2002) PMID 11778048

    Many human cancers originate from defects in the DNA damage response (DDR). Although much is known about this process, it is likely that additional DDR genes remain to be discovered. To identify such genes, we used a strategy that combines protein-protein interaction mapping and large-scale phen...
  14. A one-step conversion of benzene to phenol with a palladium membrane.

    Science 295(5552):105 (2002) PMID 11778042

    Existing phenol production processes tend to be energy-consuming and produce unwanted by-products. We report an efficient process using a shell-and-tube reactor, in which a gaseous mixture of benzene and oxygen is fed into a porous alumina tube coated with a palladium thin layer and hydrogen is ...
  15. Role of cell-specific SpoIIIE assembly in polarity of DNA transfer.

    Science 295(5552):137 (2002) PMID 11778051 PMCID PMC2885158

    SpoIIIE mediates postseptational chromosome partitioning in Bacillus subtilis, but the mechanism controlling the direction of DNA transfer remains obscure. Here, we demonstrated that SpoIIIE acts as a DNA exporter: When SpoIIIE was synthesized in the larger of the two cells necessary for sporula...
  16. Constraints on melt movement beneath the East Pacific Rise from 230Th-238U disequilibrium.

    Science 295(5552):107 (2002) PMID 11778043

    We report 230Th-238U disequilibrium data on mid-ocean ridge basalts recovered 5 to 40 kilometers off the ridge axis near 9 degrees 30'N of the East Pacific Rise. These data indicate near-symmetrical eruptions of normal mid-ocean ridge basalts (NMORBs) and incompatible element-enriched mid-ocean ...
  17. Plant biology. Prime time for cellulose.

    Science 295(5552):59 (2002) PMID 11778033

  18. The runts of the cosmic litter.

    Science 295(5552):64 (2002) PMID 11778035

  19. Formation of recent martian debris flows by melting of near-surface ground ice at high obliquity.

    Science 295(5552):110 (2002) PMID 11729267

    The observation of small gullies associated with recent surface runoff on Mars has renewed the question of liquid water stability at the surface of Mars. The gullies could be formed by groundwater seepage from underground aquifers; however, observations of gullies originating from isolated peaks...
  20. Aging research. Cancer-stalling system accelerates aging.

    Science 295(5552):28 (2002) PMID 11778018