Science

Print ISSN
0036-8075
Electronic ISSN
1095-9203
Impact factor
31.377
Publisher
highwire
URL
http://www.sciencemag.org
Usage rank
1
Article count
165826
Free count
1675
Free percentage
0.0101009
PDFs via platforms
Ama, CSA, Endocrine, Rupress, Csh, Aacr, Gale, Highwire, Aaas, Proquest, Jstor, Ovid, and Nephrology

  1. Tracking cancer drugs in living cells by thermal profiling of the proteome.

    Science 346(6205):1255784 (2014) PMID 25278616

    The thermal stability of proteins can be used to assess ligand binding in living cells. We have generalized this concept by determining the thermal profiles of more than 7000 proteins in human cells by means of mass spectrometry. Monitoring the effects of small-molecule ligands on the profiles de...