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[Current possibilities of correcting subchondral bone resorption as a major pathogenetic factor for progressive osteoarthrosis].
The paper considers the current pathogenesis, by choosing the actual targets of pharmacotherapy with available drugs. It reflects the cytokine mechanisms responsible for lesion of the synovial membranes, cartilage, and subchondral bone. Particular emphasis is laid on the role of chondroitin sulfate,...
[Hormonal aspects of the development of obesity and metabolic syndrome in ethnic groups (by the population of the Chuvash Republic)].
To study the specific features of the hormonal status in the development of obesity and metabolic syndrome (MS) in different ethnic groups. The prevalence of obesity and MS was studied in Russian and Chuvash people, the relationship of MS to body mass index (BMI), the levels of insulin, dehydroepian...
[Knee joint osteoarthrosis: risk factors of rapid progression].
We examined 158 females with primary KJO (by ACR criteria). Each patient's record contained demographic and disease history information, pain score in the knee joints by visual analog scale and joint status. All the patients have undergone standard rhoentgenography of the knee joints in two projecti...
[Survival of gout patients].
To assess survival and lethal outcome risk fahctors in gout patients. The study included 286 gout patients (246 males, 86% and 49 females, 14%) treated for gout in the Research Institute of Rheumatology from 2001 to 2006. From 2010 to May 2011 a telephone survey was m...
[The role of Helicobacter pylori in normal microbiocenosis and dysbacteriosis of mucous microflora of the esophagogastroduodenal zone in its...
To determine a population level and significance of Helicobacter pylori in normal microbiocenosis and dysbiosis of mucosal microflora in the esophagogastroduodenal zone. Qualitative and quantitative composition of mucosal microflora was defined in biopsy specimens from different parts of the esophag...
[New approaches to morphological diagnosis of gluten-sensitive celiac disease].
To characterize cell adhesion molecules (CAM), components of intercellular matrix (ICM) in gluten-sensitive celiac disease (GSCD). A histological examination was made of biopsies of small intestinal mucosa (SIM) obtained from 890 patients with clinical and laboratory symptoms of GSCD. Of them, 124 (...
[Comparative investigation of quality of life and clinical pancreatic index in patients with chronic pancreatitis].
To compare efficacy of using EORTC QLQ-C30 and clinic pancreatic index (CPI) in assessment of severity and treatment efficacy of chronic pancreatitis (CP). The CPI is proposed which is an integrated quantitative index based on formalization of CP symptoms (number of o...
[Apical hypertrophic cardiomyopathy associated with HCV infection].
A case is reported of a female patient with apical hypertrophic cardiomyopathy with negative chest T waves associated with HCV infection.
[Coronary heart disease in Russia: prevalence and treatment (according to clinical-epidemiological data)].
Monitoring of arterial hypertension on representative samples has shown that overall prevelance of coronary heart disease (CHD) in Russia is 13.5 +/- 0.1%, in men--14.3 +/- 0.3%, in women--13.0 +/- 0.2%. This is three times higher than in the United States where this figure in 2004 w...
[The extent of coronary stenosis and the level of antibodies to atherogenic lipoproteins in patients with coronary heart disease].
To study association between the level of antibodies to oxidized low-density lipoproteins (anti-OLDL) and the extent of coronary stenosis (CS) in patients with coronary heart disease (CHD). Sixty CHD patients were examined for titer of anti-OLDL, levels of total chole...