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Human Pathology

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  1. Transformation of Merkel cell carcinoma to ganglioneuroblastoma in intracranial metastasis.

    Human Pathology 45(9):1978 (2014) PMID 24996688

    We describe a case of Merkel cell carcinoma displaying unique patterns of differentiation in the primary focus and brain metastasis. The skin primary was almost uniformly small cell carcinoma positive for epithelial and neuroendocrine markers, with a few glial fibrillary acidic protein- and cytokera...
  2. MicroRNA expression patterns in adrenocortical carcinoma variants and clinical pathologic correlations.

    Human Pathology 45(8):1555 (2014) PMID 24890943

    Our aim was to assess the expression of 5 selected miRNAs (IGF2 gene-related miR-483-3p and 5p and hypoxia-induced miR-210, miR-195, and miR-1974) in a series of 51 ACCs (35 classical, 6 myxoid, and 10 oncocytic) as compared with clinical and pathologic features and immunohistochemical expression of...
  3. Frequent hepatocyte growth factor overexpression and low frequency of c-Met gene amplification in human papillomavirus-negative tonsillar sq...

    Human Pathology 45(7):1327 (2014) PMID 24810547

    We therefore investigated the prognostic values of HGF and c-Met expression in TSCC according to HPV status. Immunohistochemical analyses of HGF and c-Met protein expression and silver in situ hybridization of c-Met gene copy number were performed in 79 formalin-fixed, paraffin-embedded specimens. I...
  4. Targeted gene analysis: increased B-cell lymphoma 6 in preeclamptic placentas.

    Human Pathology 45(6):1234 (2014) PMID 24767250

    We designed our own gene array containing genes involved in various signaling transduction pathways and analyzed placental samples from patients with preeclampsia and controls. We verify that genes associated with angiogenesis and migration pathways are mostly altered in preeclamptic placentas. Inte...
  5. Activation of the Akt/mammalian target of rapamycin pathway in myxofibrosarcomas.

    Human Pathology 45(5):984 (2014) PMID 24746202

    We conducted a large-scale examination of the clinicopathological and activation statuses of the Akt/mTOR pathways in myxofibrosarcoma. The phosphorylation status of Akt, mTOR, S6 ribosomal protein, and the eukaryotic translation initiation factor 4E-binding protein, and mitogen-activated protein ki...
  6. Intratumoral heterogeneous amplification of ERBB2 and subclonal genetic diversity in gastric cancers revealed by multiple ligation-dependent...

    Human Pathology 45(4):725 (2014) PMID 24491355

    A humanized monoclonal antibody against ERBB2 is used in neoadjuvant therapy for patients with gastric cancer. A critical factor in determining patient eligibility and predicting outcomes of this therapy is the intratumoral heterogeneity of ERBB2 amplification in gastric adenocarcinomas. The aims of...
  7. Composite lymphoid neoplasm of B-cell and T-cell origins: a pathologic study of 14 cases.

    Human Pathology 45(4):768 (2014) PMID 24565206

    We retrospectively analyzed 14 composite lymphoma/lymphoid neoplasms (CL) of B-cell/T-cell origins. These consisted of a spectrum of T-cell neoplasms in combination with different B-cell lymphomas/leukemias, with peripheral T-cell lymphoma and diffuse large B-cell lymphoma encountered most frequentl...
  8. African Americans with oropharyngeal carcinoma have significantly poorer outcomes despite similar rates of human papillomavirus-mediated car...

    Human Pathology 45(2):310 (2014) PMID 24355195

    We examined racial disparities among 102 oropharyngeal carcinoma (OPC) patients (30 African Americans and 72 whites) comparing rates of transcriptionally active human papillomavirus (HPV)16/18 and p16(INK4a) overexpression, with times to disease progression and disease-specific survival (DSS). Expre...
  9. TP53 mutations of intestinal metaplasia--reply.

    Human Pathology 45(2):431 (2014) PMID 24439231

  10. High-stage urachal adenocarcinoma can be associated with microsatellite instability and KRAS mutations.

    Human Pathology 45(2):327 (2014) PMID 24355196

    Our UAC series showed mutual exclusivity of MSI and KRAS mutations. Furthermore, our UAC cases with KRAS mutations showed markedly better overall survival (mean, 101.7 versus 6.5 months; P = .035). Thus, our study justifies ancillary testing for MSI and KRAS in UAC, particularly when there is high-s...