Acta Neurobiologiae Experimentalis
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Bone marrow stromal cell transplantation enhances recovery of motor function after lacunar stroke in rats.
This study was aimed to clarify if the bone marrow stromal cells (BMSCs) significantly improve functional outcome after lacunar stroke when stereotactically transplanted into the brain. Ouabain, a Na/K ATPase pump inhibitor, was stereotactically injected into the right striatum of Wistar rats. One w...
Region-related modular nerve-dependent motor activity in anorectum--cholinergic and nitrergic contribution to rat model.
Our results suggest that cholinergic and nitrergic systems are not equally involved in modular nerve networks of various regions of anorectum. Cholinergic transmission is more expressed in distal rectum, underlying its contractile potency, while nitric oxide-dependent transmission(s) control the rel...
Cholinergic modulation of synaptic properties of cortical layer VI input to posteromedial thalamic nucleus of the rat investigated in vitro.
We used patch-clamp recording in thalamocortical slices from the rat's brain. Excitatory postsynaptic potentials (EPSPs) were evoked in PoM cells by trains of 5 electrical pulses at 20 Hz frequency applied to corticothalamic fibers. After carbachol was applied to mimic activation of the cholinergic...
Opioid peptides in peripheral pain control.
Opioids have a long history of therapeutic use as a remedy for various pain states ranging from mild acute nociceptive pain to unbearable chronic advanced or end-stage disease pain. Analgesia produced by classical opioids is mediated extensively by binding to opioid receptors located in the brain or...
Cold pressor stimulation diminishes P50 amplitude in normal subjects.
We measured the P50 auditory evoked response potential in two groups of subjects who immersed their foot in either cold (0-2°C) or room temperature (22-24°C) water for 50 seconds. The P50, which was recorded before and after stimulation, is sleep-state dependent and sensitive to states of arousal in...
No association between cytokine gene polymorphism and risk of Alzheimer's disease in Slovaks.
Clinical and immunopathological evidence support a potential role of inflammatory cytokines in Alzheimer's disease (AD). However, studies examining the association between cytokine gene polymorphisms and risk of developing AD yielded conflicting results. The objective of our study was to evaluate th...
Effects of phosphodiesterase 10 inhibition on striatal cyclic AMP and peripheral physiology in rats.
Phosphodiesterases (PDEs) form a family of enzymes involved in the hydrolysis of cyclic adenosine and guanosine monophosphate (cAMP and cGMP). PDE10A is a member of this family that is almost exclusively expressed in the striatum. Increasing cAMP/cGMP levels via inhibition of PDE10A is under conside...
The relationship between pain sensitivity and conditioned fear response in rats.
We investigated the relationship between pain sensitivity in two pain tests (the 'tail-flick' and 'flinch-jump' tests) and a conditioned, fear-evoked, freezing response in rats. The results show that there was no correlation between: (1) the conditioned (associative) and the novelty-evoked (non-spec...
Molecular mechanisms of dendritic spine development and maintenance.
The large majority of excitatory synapses are located on dendritic spines which are discrete membrane protrusions present on neuronal dendrites. Interestingly the highly heterogeneous morphology of dendritic spines is thought to be the morphological basis for synaptic plasticity associated to learni...
Emotionally negative stimuli are resistant to repetition priming.
The study was aimed at testing whether the repetition priming was influenced by affective valence of visual stimuli. Neutral and emotionally negative words and images were shown in the right or in the left visual field. Each of the stimuli was repeated twice, with 2 to 4 other stimuli presented betw...