Advances in Experimental Medicine and Biology

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  1. Epigenetic Alterations in Epstein-Barr Virus-Associated Diseases.

    Advances in Experimental Medicine and Biology 879:39 (2016) PMID 26659263

    Latent Epstein-Bar virus genomes undergo epigenetic modifications which are dependent on the respective tissue type and cellular phenotype. These define distinct viral epigenotypes corresponding with latent viral gene expression profiles. Viral Latent Membrane Proteins 1 and 2A can induce cellul...
  2. The Reproductive System.

    Advances in Experimental Medicine and Biology 886:1 (2016) PMID 26659484

    Correct sexual development is arguably the most important trait in an organism's life history since it is directly related to its genetic fitness. The developing gonad houses the germ cells, the only legacy we pass on to subsequent generations. Given the pivotal importance of correct reproductiv...
  3. Lung Cancer Genomics in the Era of Accelerated Targeted Drug Development.

    Advances in Experimental Medicine and Biology 890:1 (2016) PMID 26703796

    Lung cancer is the leading cause of cancer-related deaths in the United States and the 5-year overall survival outlook for a patient has not improved in several decades. Recently, however, molecular and genomic profiling of the lung tumors has revealed recurring somatic mutations. As a result th...
  4. Epigenetic regulatory mechanisms ensure the heritable alterations of cellular states. Introduction.

    Advances in Experimental Medicine and Biology 879:vii (2016) PMID 27088148

  5. Non-coding RNA in Spermatogenesis and Epididymal Maturation.

    Advances in Experimental Medicine and Biology 886:95 (2016) PMID 26659489

    Testicular germ and somatic cells express many classes of small ncRNAs, including Dicer-independent PIWI-interacting RNAs, Dicer-dependent miRNAs, and endogenous small interfering RNA. Several studies have identified ncRNAs that are highly, exclusively, or preferentially expressed in the testis ...
  6. Non-coding RNAs in Prostate Cancer: From Discovery to Clinical Applications.

    Advances in Experimental Medicine and Biology 886:155 (2016) PMID 26659491

    Prostate cancer is a heterogeneous disease for which the molecular mechanisms are still not fully elucidated. Prostate cancer research has traditionally focused on genomic and epigenetic alterations affecting the proteome, but over the last decade non-coding RNAs, especially microRNAs, have been...
  7. Chemotherapy Resistance in Lung Cancer.

    Advances in Experimental Medicine and Biology 893:189 (2016) PMID 26667345

    Despite a growing interest in development of non-cytotoxic targeted agents, systemic chemotherapy is still the mainstay of treatment for both non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). However, chemotherapy resistance limits our ability to effectively treat advanced lu...
  8. Cell Surface Interference with Plasma Membrane and Transport Processes in Yeasts.

    Advances in Experimental Medicine and Biology 892:11 (2016) PMID 26721269

    The wall of the yeast Saccharomyces cerevisiae is a shell of about 120 nm thick, made of two distinct layers, which surrounds the cell. The outer layer is constituted of highly glycosylated proteins and the inner layer is composed of β-glucan and chitin. These two layers are interconnected throu...
  9. Next-Generation Sequencing and Applications to the Diagnosis and Treatment of Lung Cancer.

    Advances in Experimental Medicine and Biology 890:123 (2016) PMID 26703802

    Cancer is a genetic disease characterized by uncontrolled growth of abnormal cells. Over time, somatic mutations accumulate in the cells of an individual due to replication errors, chromosome segregation errors, or DNA damage. When not caught by traditional mechanisms, these somatic mutations ca...
  10. Personalized Therapy of Small Cell Lung Cancer.

    Advances in Experimental Medicine and Biology 890:149 (2016) PMID 26703804

    Small cell lung cancer (SCLC) is an aggressive, poorly differentiated neuroendocrine carcinoma with distinct clinical, pathological and molecular characteristics. Despite robust responses to initial chemotherapy and radiation, the prognosis of patients with SCLC remains poor with an overall 5-ye...
  11. Epithelial Mesenchymal Transition in Aggressive Lung Cancers.

    Advances in Experimental Medicine and Biology 890:37 (2016) PMID 26703798

    The progression of a cancer cell into a metastatic entity contributes to more than 90 % of cancer related deaths. Therefore, the prevention and treatment of metastasis is an unmet clinical need. Epithelial to mesenchymal transition (EMT) is an evolutionary conserved developmental program, which ...
  12. Advances in the Treatment of Neuropathic Pain.

    Advances in Experimental Medicine and Biology 904:117 (2016) PMID 26900067

    Neuropathic pain is pain that arises as a direct consequence of a lesion or diseases affecting the somatosensory system. Treatments for neuropathic pain include pharmacological, nonpharmacological, and interventional therapies. Currently recommended first-line pharmacological treatments include ...
  13. Stimulation of Bone Repair with Ultrasound.

    Advances in Experimental Medicine and Biology 880:385 (2016) PMID 26486349

    This chapter reviews the different options available for the use of ultrasound in the enhancement of fracture healing or in the reactivation of a failed healing process: LIPUS, shock waves and ultrasound-mediated delivery of bioactive molecules, such as growth factors or plasmids. The main empha...
  14. HIFU Tissue Ablation: Concept and Devices.

    Advances in Experimental Medicine and Biology 880:3 (2016) PMID 26486329

    High intensity focused ultrasound (HIFU) is rapidly gaining clinical acceptance as a technique capable of providing non-invasive heating and ablation for a wide range of applications. Usually requiring only a single session, treatments are often conducted as day case procedures, with the patient...
  15. Sonodynamic Therapy: Concept, Mechanism and Application to Cancer Treatment.

    Advances in Experimental Medicine and Biology 880:429 (2016) PMID 26486350

    Sonodynamic therapy (SDT) represents an emerging approach that offers the possibility of non-invasively eradicating solid tumors in a site-directed manner. It involves the sensitization of target tissues with a non-toxic sensitizing chemical agent and subsequent exposure of the sensitized tissue...
  16. Mas-Related G Protein-Coupled Receptors Offer Potential New Targets for Pain Therapy.

    Advances in Experimental Medicine and Biology 904:87 (2016) PMID 26900065

    The founding member of the Mas-related G-protein-coupled receptor (Mrgpr) family was discovered in 1986. Since then, many more members of this receptor family have been identified in multiple species, and their physiologic functions have been investigated widely. Because they are expressed exclu...
  17. Gene Structure of the 10q26 Locus: A Clue to Cracking the ARMS2/HTRA1 Riddle?

    Advances in Experimental Medicine and Biology 854:23 (2016) PMID 26427389

    Age-related macular degeneration (AMD) is a sight-threatening disorder of the central retina. Being the leading cause of visual impairment in senior citizens, it represents a major public health issue in developed countries. Genetic studies of AMD identified two major susceptibility loci on chro...
  18. Geranylgeranylacetone Suppresses N-Methyl-N-nitrosourea-Induced Photoreceptor Cell Loss in Mice.

    Advances in Experimental Medicine and Biology 854:237 (2016) PMID 26427417

    Retinitis pigmentosa is a disease characterized by the loss of photoreceptor cells. The N-methyl-N-nitrosourea (MNU)-induced retinal degeneration model is widely used to study the mechanism of these retinal degenerative disorders because of its selective photoreceptor cell death. As for the cell...
  19. Malattia Leventinese/Doyne Honeycomb Retinal Dystrophy: Similarities to Age-Related Macular Degeneration and Potential Therapies.

    Advances in Experimental Medicine and Biology 854:153 (2016) PMID 26427406

    Fibulin-3 (F3) is a secreted, disulfide-rich glycoprotein which is expressed in a variety of tissues within the body, including the retina. An Arg345Trp (R345W) mutation in F3 was identified as the cause of a rare retinal dystrophy, Malattia Leventinese/Doyne Honeycomb Retinal Dystrophy (ML/DHRD...
  20. VEGF-A and the NLRP3 Inflammasome in Age-Related Macular Degeneration.

    Advances in Experimental Medicine and Biology 854:79 (2016) PMID 26427397

    The pathomechanisms that lead to age-related macular degeneration (AMD) are only partially understood. The NLRP3 inflammasome has been shown to be activated in the retinal pigment epithelium (RPE) in eyes with AMD. However, it is not known whether inflammasome activation is a cause or consequenc...