Annals of the New York Academy of Sciences
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- CSA, Gale, Ebscoatoz, Ebsconet, Ingenta, Wiley from 1879, Proquest, Ovid from 1038, and Rcgp
Intensive care treatment of ovarian hyperstimulation syndrome (OHSS)
Ovarian hyperstimulation syndrome (OHSS) is a morbid, iatrogenic, and potentially lethal condition caused by the pharmacological induction of ovulation. In OHSS, the ovaries are the site of significant stromal edema with bilateral cystic ovarian enlargement. It has been suggested tha...
Long-term progestin-only contraception in humans versus animal models
We describe these models including the guinea pig, an animal model we have previously investigated, to assess the mechanisms involved in abnormal uterine bleeding following long-term progestin-only contraception. © 2011 New York Academy of Sciences....
Epigenetics in lupus
Accumulating epidemiological, clinical, and experimental evidence supports the conclusion of a critical role of epigenetic factors in immune programming. This understanding provides the basis for elucidating how the intricate interactions of the genome, epigenome, and transcriptome s...
The role played by natural selection on Mendelian traits in humans
We review several examples of Mendelian mutations-associated with various disease conditions or other traits of anthropological interest-that have increased in frequency in the human population as a result of past positive selection. These examples clearly illustrate the value of a population geneti...
PRODUCTION OF ANTIBIOTIC SUBSTANCES BY ACTINOMYCETES*
CNS leptin and insulin action in the control of energy homeostasis
We summarize the recent findings concerning the mechanisms and novel neuronal mediators of both insulin and leptin action in the CNS. © 2010 New York Academy of Sciences....
The crossover of bisphosphonates to cancer therapy
Bisphosphonates form a class of drugs commonly used to treat disorders of osteoclastic bone resorption, including osteoporosis, Paget's disease of the bone, rheumatoid arthritis, and bone metastases. Although long established as the therapy of choice to treat such disorders, bisphosp...
ELMO1 signaling in apoptotic germ cell clearance and spermatogenesis.
We are beginning to understand the signaling pathways that control the phagocytic clearance of apoptotic cells, the physiological relevance of these pathways is lacking. During spermatogenesis, over half of the developing germ cells eventually die by apoptosis, yet the signaling pathways that regula...
Reperfusion of chronic tissue ischemia: nitrite and dipyridamole regulation of innate immune responses.
We have found that the beneficial effects of dipyridamole therapy are due to its ability to increase tissue nitric oxide bioavailability that corrects tissue redox imbalance. Importantly, we have also discovered that dipyridamole treatment invoking nitric oxide (NO) production significantly downregu...
Fertility drugs and ovarian cancer risk: a critical review of the literature
We attempt to describe this relationship according to the most recent epidemiologic data and to present the possible mechanisms on the molecular level that could potentially explain this correlation. Currently there is no proven relationship between any type of ovarian cancer and drugs used for infe...