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Annals of the New York Academy of Sciences

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  1. Understanding ?-globin gene regulation and implications for the treatment of ?-thalassemia.

    Annals of the New York Academy of Sciences (2015) PMID 26695885

    Over the past three decades, a vast amount of new information has been uncovered describing how the globin genes are regulated. This knowledge has provided significant insights into the general understanding of the regulation of human genes. It is now known that molecular defects within and aroun...
  2. The Year in Diabetes and Obesity
    Author(s) unavailable

    Annals of the New York Academy of Sciences 1281(1):i (2013) PMCID PMC3712481

  3. Methylglyoxal and methylglyoxal-arginine adducts do not directly inhibit endothelial nitric oxide synthase.

    Annals of the New York Academy of Sciences 1126:231 (2008) PMID 18079474

    Increased formation of the reactive dicarbonyl compound methylglyoxal (MGO) and MGO-derived advanced glycation end products (AGEs) seems to be implicated in endothelial dysfunction and the development of diabetic vascular complications. MGO reacts with arginine residues in proteins to generate t...
  4. Time-dependent component-specific regulation of gastric acid secretion-related proteins by roasted coffee constituents.

    Annals of the New York Academy of Sciences 1126:310 (2008) PMID 18448837

    Consumption of coffee beverages has been reported to cause gastric irritation in some consumers as a result of increased gastric acid secretion. In the complex mechanisms of gastric acid secretion, the activity and expression of the H+,K+-ATPase is regulated by transmitters, such as histamine, a...
  5. Analysis of amadori peptides enriched by boronic acid affinity chromatography.

    Annals of the New York Academy of Sciences 1126:253 (2008) PMID 18448825

    Glycation of peptides and proteins by D-glucose is a universal, nonenzymatic reaction with important implications for the pathogenesis and diagnosis of many diseases, including diabetes mellitus. Whereas some modification sites have been identified in serum albumin and hemoglobin, a general appr...
  6. Aging, diabetes, and renal failure catalyze the oxidation of lysyl residues to 2-aminoadipic acid in human skin collagen: evidence for metal-catalyzed oxidation mediated by alpha-dicarbonyls.

    Annals of the New York Academy of Sciences 1126:205 (2008) PMID 18448817

    The epsilon-amino group of lysyl residues oxidatively deaminates in the presence of alpha-dicarbonyl sugars and redox-active metals forming alpha-aminoadipic acid-delta-semialdehyde (allysine; Suyama's hypothesis), which can further oxidize into 2-aminoadipic acid. Here we show that 2-aminoadipi...
  7. Suppression of renal alpha-dicarbonyl compounds generated following ureteral obstruction by kidney-specific alpha-dicarbonyl/L-xylulose reductase.

    Annals of the New York Academy of Sciences 1126:320 (2008) PMID 18079483

    Renal unilateral ureteral obstruction (UUO) causes acute generation of alpha-dicarbonyl stress substances, such as glyoxal, 3-deoxyglucosone, and methylglyoxal, in the kidneys. These alpha-dicarbonyl compounds are prone to form advanced glycation end products (AGEs) via the nonenzymatic Maillard...
  8. Some natural compounds enhance N epsilon-(carboxymethyl)lysine formation.

    Annals of the New York Academy of Sciences 1126:152 (2008) PMID 18079486

    Since pyridoxamine, which traps intermediates in the Maillard reaction and lipid peroxidation reaction, significantly inhibits the development of retinopathy and neuropathy in the streptozotocin-induced diabetic rat, treatment with advanced glycation end product inhibitors and antioxidants may b...
  9. A419C (E111A) polymorphism of the glyoxalase I gene and vascular complications in chronic hemodialysis patients.

    Annals of the New York Academy of Sciences 1126:268 (2008) PMID 18079478

    Advanced glycation end products (AGEs) take part in the pathogenesis of vascular, diabetic, and uremic complications. Their precursors are detoxified by the glyoxalase system. Our aim was to study A419C (E111A) single nucleotide polymorphism (SNP) of the glyoxalase I gene in hemodialysis (HD) pa...
  10. Isolation and partial characterization of four fluorophores formed by nonenzymatic browning of methylglyoxal and glutamine-derived ammonia.

    Annals of the New York Academy of Sciences 1126:158 (2008) PMID 18448810

    An aqueous solution of L-glutamine (50 mmol/L) and methylglyoxal (100 mmol/L) was incubated at 120 degrees C for 3 h in a 200 mmol/L phosphate buffer (pH 7.4). Four major fluorophores were revealed on the HPLC chromatogram. The same four fluorophores were obtained from the heating of a mixture o...