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Annals of the New York Academy of Sciences

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  1. Intensive care treatment of ovarian hyperstimulation syndrome (OHSS)

    Annals of the New York Academy of Sciences 1221(1):109 (2011) PMID 21401638

    Ovarian hyperstimulation syndrome (OHSS) is a morbid, iatrogenic, and potentially lethal condition caused by the pharmacological induction of ovulation. In OHSS, the ovaries are the site of significant stromal edema with bilateral cystic ovarian enlargement. It has been suggested tha...
  2. Long-term progestin-only contraception in humans versus animal models

    Annals of the New York Academy of Sciences 1221(1):119 (2011) PMID 21401639

    We describe these models including the guinea pig, an animal model we have previously investigated, to assess the mechanisms involved in abnormal uterine bleeding following long-term progestin-only contraception. © 2011 New York Academy of Sciences....
  3. Epigenetics in lupus

    Annals of the New York Academy of Sciences 1217(1):154 (2011) PMID 21251010

    Accumulating epidemiological, clinical, and experimental evidence supports the conclusion of a critical role of epigenetic factors in immune programming. This understanding provides the basis for elucidating how the intricate interactions of the genome, epigenome, and transcriptome s...
  4. The role played by natural selection on Mendelian traits in humans

    Annals of the New York Academy of Sciences 1214(1):1 (2010) PMID 21175682

    We review several examples of Mendelian mutations-associated with various disease conditions or other traits of anthropological interest-that have increased in frequency in the human population as a result of past positive selection. These examples clearly illustrate the value of a population geneti...

    Annals of the New York Academy of Sciences 1213(1):112 (2010) PMID 21175680

  6. CNS leptin and insulin action in the control of energy homeostasis

    Annals of the New York Academy of Sciences 1212(1):97 (2010) PMID 21070248

    We summarize the recent findings concerning the mechanisms and novel neuronal mediators of both insulin and leptin action in the CNS. © 2010 New York Academy of Sciences....
  7. The crossover of bisphosphonates to cancer therapy

    Annals of the New York Academy of Sciences 1211(1):107 (2010) PMID 21062299

    Bisphosphonates form a class of drugs commonly used to treat disorders of osteoclastic bone resorption, including osteoporosis, Paget's disease of the bone, rheumatoid arthritis, and bone metastases. Although long established as the therapy of choice to treat such disorders, bisphosp...
  8. ELMO1 signaling in apoptotic germ cell clearance and spermatogenesis.

    Annals of the New York Academy of Sciences 1209(1):30 (2010) PMID 20958313

    We are beginning to understand the signaling pathways that control the phagocytic clearance of apoptotic cells, the physiological relevance of these pathways is lacking. During spermatogenesis, over half of the developing germ cells eventually die by apoptosis, yet the signaling pathways that regula...
  9. Fertility drugs and ovarian cancer risk: a critical review of the literature

    Annals of the New York Academy of Sciences 1205(1):214 (2010) PMID 20840275

    We attempt to describe this relationship according to the most recent epidemiologic data and to present the possible mechanisms on the molecular level that could potentially explain this correlation. Currently there is no proven relationship between any type of ovarian cancer and drugs used for infe...
  10. Reproductive aging in tephritid fruit flies

    Annals of the New York Academy of Sciences 1204(1):139 (2010) PMID 20738284

    We summarize the research findings from empirical studies and modeling investigations involving reproduction in the two tephritid species. At the end we identify and discuss four general principles regarding reproductive aging in tephritids including reciprocity of reproductive and aging costs, qual...