Annals of the New York Academy of Sciences
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Risk for anxiety and implications for treatment: developmental, environmental, and genetic factors governing fear regulation.
Anxiety disorders are the most common psychiatric disorders, affecting as many as 10% of youth, with diagnoses peaking during adolescence. A core component of these disorders is an unremitting fear in the absence of present threat. One of the most commonly used therapies to treat these disorders is...
Barrett's esophagus: cancer and molecular biology.
The following paper on the molecular biology of Barrett's esophagus (BE) includes commentaries on signaling pathways central to the development of BE including Hh, NF-κB, and IL-6/STAT3; surgical approaches for esophagectomy and classification of lesions by appropriate therapy; the debate over the m...
On the relevance of brown adipose tissue in children.
The visualization of brown adipose tissue (BAT) in pediatric patients undergoing positron emission tomography/computed tomography (PET/CT) examinations is dependent on multiple physiologic and technical factors, such as age, sexual maturity, fat accumulation, disease status, medications, plasma gluc...
Systemic control of brown fat thermogenesis: integration of peripheral and central signals.
We summarize recent findings on bone morphogenetic protein signaling as an example of secreted factors in the regulation of brown adipocyte formation and systemic control of energy metabolism. We further highlight endocrine communication routes between the different types of brown adipocytes and oth...
An adipocentric perspective of resveratrol as a calorie restriction mimetic.
Adipose tissue is an active endocrine organ that responds to changes in energy balance and influences whole-body physiology. Adipose tissue dysfunction with obesity is associated with metabolic disease, neurodegeneration, inflammation, and cancer, whereas calorie restriction (CR) decreases both adip...
The pig as a valuable model for testing the effect of resveratrol to prevent cardiovascular disease.
We discuss the advantage of using clinically relevant pig models of diabetes, hypercholesterolemia, and myocardial ischemia to investigate the role of resveratrol in cardiovascular disease prevention. © 2013 New York Academy of Sciences....
Resveratrol, from experimental data to nutritional evidence: the emergence of a new food ingredient.
The polyphenol resveratrol is found notably in grapes and in a variety of medicinal plants. Recently, resveratrol has been suggested to have cardioprotective effects and to improve metabolic health by mimicking the effects of calorie restriction. Numerous animal and in vitro studies suggest that res...
Neuroanatomical asymmetries and handedness in chimpanzees (Pan troglodytes): a case for continuity in the evolution of hemispheric specializ...
I summarize comparative data on neuroanatomical asymmetries in the planum temporale (PT) and inferior frontal gyrus (IFG) of humans and chimpanzees, regions considered the morphological equivalents to Broca's and Wernicke's areas. I also review evidence of population-level handedness in captive and...
Laterality of handgrip strength: age- and physical training-related changes in Lithuanian schoolchildren and conscripts.
Laterality in handgrip strength was assessed by analyzing dynamometric data of the right and left hand in three samples of Lithuanian boys and girls aged 7-20 years. In addition, the influence of general physical training on the laterality of handgrip strength was explored in a sample of conscripts....
Biased semantics for right and left in 50 Indo-European and non-Indo-European languages.
The negative bias accompanying the terms left and left-handers has long interested researchers. This paper examines a large number of languages of Indo-European and non-Indo-European origin for such biasing. One surprising outcome is that, within the Indo-European language family, the terms for righ...