Annals of the New York Academy of Sciences

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  1. The Year in Diabetes and Obesity
    Author(s) unavailable

    Annals of the New York Academy of Sciences 1281(1):i (2013) PMCID PMC3712481

  2. Suppression of renal alpha-dicarbonyl compounds generated following ureteral obstruction by kidney-specific alpha-dicarbonyl/L-xylulose reductase.

    Annals of the New York Academy of Sciences 1126:320 (2008) PMID 18079483

    Renal unilateral ureteral obstruction (UUO) causes acute generation of alpha-dicarbonyl stress substances, such as glyoxal, 3-deoxyglucosone, and methylglyoxal, in the kidneys. These alpha-dicarbonyl compounds are prone to form advanced glycation end products (AGEs) via the nonenzymatic Maillard...
  3. Some natural compounds enhance N epsilon-(carboxymethyl)lysine formation.

    Annals of the New York Academy of Sciences 1126:152 (2008) PMID 18079486

    Since pyridoxamine, which traps intermediates in the Maillard reaction and lipid peroxidation reaction, significantly inhibits the development of retinopathy and neuropathy in the streptozotocin-induced diabetic rat, treatment with advanced glycation end product inhibitors and antioxidants may b...
  4. A419C (E111A) polymorphism of the glyoxalase I gene and vascular complications in chronic hemodialysis patients.

    Annals of the New York Academy of Sciences 1126:268 (2008) PMID 18079478

    Advanced glycation end products (AGEs) take part in the pathogenesis of vascular, diabetic, and uremic complications. Their precursors are detoxified by the glyoxalase system. Our aim was to study A419C (E111A) single nucleotide polymorphism (SNP) of the glyoxalase I gene in hemodialysis (HD) pa...
  5. The dicarbonyl proteome: proteins susceptible to dicarbonyl glycation at functional sites in health, aging, and disease.

    Annals of the New York Academy of Sciences 1126:124 (2008) PMID 18448805

    Reactive, physiological, dicarbonyl, glycating agents, glyoxal and methylglyoxal, are arginine-directed glycating agents forming mainly hydroimidazolone residues. Arginine residues have high-frequency occurrence in sites of protein-protein, enzyme substrate and protein-nucleotide binding sites. ...
  6. Methylglyoxal and methylglyoxal-arginine adducts do not directly inhibit endothelial nitric oxide synthase.

    Annals of the New York Academy of Sciences 1126:231 (2008) PMID 18079474

    Increased formation of the reactive dicarbonyl compound methylglyoxal (MGO) and MGO-derived advanced glycation end products (AGEs) seems to be implicated in endothelial dysfunction and the development of diabetic vascular complications. MGO reacts with arginine residues in proteins to generate t...
  7. Maillard reaction versus other nonenzymatic modifications in neurodegenerative processes.

    Annals of the New York Academy of Sciences 1126:315 (2008) PMID 18079479

    Nonenzymatic protein modifications are generated from direct oxidation of amino acid side chains and from reaction of the nucleophilic side chains of specific amino acids with reactive carbonyl species. These reactions give rise to specific markers that have been analyzed in different neurodegen...
  8. Post-schiff base chemistry of the Maillard reaction: mechanism of imine isomerization.

    Annals of the New York Academy of Sciences 1126:30 (2008) PMID 18448793

    Schiff bases play a critical role, not only in initiating the Maillard reaction, but also in its propagation. Little attention has been paid so far to the ability of these imines to undergo isomerization and thus contribute to the diversity of Maillard reaction products. In this study, imine iso...
  9. The sense of smell: reception of flavors.

    Annals of the New York Academy of Sciences 1126:1 (2008) PMID 18079480

    The sensory and hedonic evaluation of most food-related flavors is mainly dependent on olfactory perception. The sense of smell is able to recognize and discriminate myriads of airborne molecules with great accuracy and sensitivity. The primary processes of odor perception are mediated by the ch...
  10. Maillard reaction products in the Escherichia coli-derived therapeutic protein interferon alfacon-1.

    Annals of the New York Academy of Sciences 1126:181 (2008) PMID 18079487

    We have recently shown that recombinant human interferon-gamma is affected by early stages of the Maillard reaction during its production in Escherichia coli. Over time, advanced glycation end products accumulated in the purified protein, accompanied with degradation, cross-linking, and a drop i...
  11. Time-dependent component-specific regulation of gastric acid secretion-related proteins by roasted coffee constituents.

    Annals of the New York Academy of Sciences 1126:310 (2008) PMID 18448837

    Consumption of coffee beverages has been reported to cause gastric irritation in some consumers as a result of increased gastric acid secretion. In the complex mechanisms of gastric acid secretion, the activity and expression of the H+,K+-ATPase is regulated by transmitters, such as histamine, a...
  12. Isolation and partial characterization of four fluorophores formed by nonenzymatic browning of methylglyoxal and glutamine-derived ammonia.

    Annals of the New York Academy of Sciences 1126:158 (2008) PMID 18448810

    An aqueous solution of L-glutamine (50 mmol/L) and methylglyoxal (100 mmol/L) was incubated at 120 degrees C for 3 h in a 200 mmol/L phosphate buffer (pH 7.4). Four major fluorophores were revealed on the HPLC chromatogram. The same four fluorophores were obtained from the heating of a mixture o...
  13. Analysis of amadori peptides enriched by boronic acid affinity chromatography.

    Annals of the New York Academy of Sciences 1126:253 (2008) PMID 18448825

    Glycation of peptides and proteins by D-glucose is a universal, nonenzymatic reaction with important implications for the pathogenesis and diagnosis of many diseases, including diabetes mellitus. Whereas some modification sites have been identified in serum albumin and hemoglobin, a general appr...
  14. Aging, diabetes, and renal failure catalyze the oxidation of lysyl residues to 2-aminoadipic acid in human skin collagen: evidence for metal-catalyzed oxidation mediated by alpha-dicarbonyls.

    Annals of the New York Academy of Sciences 1126:205 (2008) PMID 18448817

    The epsilon-amino group of lysyl residues oxidatively deaminates in the presence of alpha-dicarbonyl sugars and redox-active metals forming alpha-aminoadipic acid-delta-semialdehyde (allysine; Suyama's hypothesis), which can further oxidize into 2-aminoadipic acid. Here we show that 2-aminoadipi...
  15. Science, precaution, and the politics of technological risk: converging implications in evolutionary and social scientific perspectives.

    Annals of the New York Academy of Sciences 1128:95 (2008) PMID 18469218

    This paper examines apparent tensions between "science-based," "precautionary," and "participatory" approaches to decision making on risk. Partly by reference to insights currently emerging in evolutionary studies, the present paper looks for ways to reconcile some of the contradictions. First, ...
  16. Risk communication and risky choice in context: ambiguity and ambivalence hypothesis.

    Annals of the New York Academy of Sciences 1128:78 (2008) PMID 18469216

    This chapter takes a synthetic approach to six related lines of research on decision making at risk and views risky choice as a function of cue use with priorities in the context of risk communication. An evolutionary analysis of risk and risk communication is presented in which risk is defined ...
  17. Numeracy and the perception and communication of risk.

    Annals of the New York Academy of Sciences 1128:1 (2008) PMID 18469208

    In the present paper, I focus on a small but important piece of the risk communication/perception puzzle, namely how individuals who differ in number ability comprehend and use numeric information about risks differently. Highly numerate individuals appear to pay more attention to numbers, bette...
  18. Endometriosis and infertility: epidemiology and evidence-based treatments.

    Annals of the New York Academy of Sciences 1127:92 (2008) PMID 18443335

    Endometriosis is an estrogen-dependent disorder defined as the presence of endometrial tissue outside of the uterine cavity. A leading cause of infertility, endometriosis has a prevalence of 0.5-5% in fertile and 25-40% in infertile women. The optimal choice of management for endometriosis-assoc...
  19. Bioinformatics and transcriptomics studies of early implantation.

    Annals of the New York Academy of Sciences 1127:116 (2008) PMID 18443338

    Little is known of the genes that mediate cell interactions at implantation. A combined transcriptomics/bioinformatics protocol is described that identifies cell surface glycoproteins in endometrium with potential involvement in implantation. This is linked to an in vitro model in which function...
  20. Inhibition of advanced glycation end products: an implicit goal in clinical medicine for the treatment of diabetic nephropathy?

    Annals of the New York Academy of Sciences 1126:141 (2008) PMID 18448808

    Several factors have been incriminated in the genesis of diabetic nephropathy. To elucidate their interplay, we have used a hypertensive, obese, diabetic rat model with nephropathy (SHR/NDmcr-cp) that mimics human type 2 diabetes. This model is characterized by hypertension, obesity with the met...