Annals of Biomedical Engineering
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In vitro ceramic scaffold mineralization: comparison between histological and micro-computed tomographical analysis.
The porous structure of beta-tricalcium phosphate (β-TCP) scaffolds was assessed by conventional histomorphometry and micro-computed tomography (micro-CT) to evaluate the substitutability of time-consuming histomorphometry by rapid micro-CT. Extracellular matrix mineralization on human mesenchymal s...
Direct regularized estimation of retinal vascular oxygen tension based on an experimental model.
We provide an improved solution by devising a regularized direct least squares (RDLS) method that exploits available knowledge in studies that provide models of oxygen tension in retinal arteries and veins, unlike the earlier regularized LS approach where knowledge about intermediate variables is li...
Vascular occlusion affects gait variability patterns of healthy younger and older individuals.
Insufficient blood flow is one possible mechanism contributing to altered gait patterns in lower extremity peripheral arterial disease (PAD). Previously, our laboratory found that induced occlusion alters gait variability patterns in healthy young individuals. However the effect of age was not explo...
High wall shear stress and spatial gradients in vascular pathology: a review.
We have begun to elucidate EC responses to high WSS alone and in combination with WSSG. Understanding such responses will provide insight into not only aneurysm formation, but also plaque destabilization and other vascular pathologies and potentially lead to improved strategies for disease managemen...
Sensitivity of the Wolf's and Rosenstein's Algorithms to Evaluate Local Dynamic Stability from Small Gait Data Sets: Response to Commentarie...
Modeling brain injury response for rotational velocities of varying directions and magnitudes.
An estimated 1.7 million people in the United States sustain a traumatic brain injury (TBI) annually. To investigate the effects of rotational motions on TBI risk and location, this study modeled rotational velocities of five magnitudes and 26 directions of rotation using the Simulated Injury Monito...
The development of novel biodegradable bifurcation stents for the sustainable release of anti-proliferative sirolimus.
In this report, a balloon-expandable, biodegradable, drug-eluting bifurcation stent (DEBS) that provides a sustainable release of anti-proliferative sirolimus was developed. Biodegradable bifurcation stents, made of polycaprolactone, were first manufactured by injection molding and hot spot welding...
Algorithm to assess cranial suture fusion with varying and discontinuous mineral density.
One of the most difficult challenges in medical imaging is the accurate segmentation of mineralized tissues. This process is complicated when studying developmental or regenerative processes due to the changes in mineral density that these tissues undergo over time. To address these limitations an a...
Impact performance of modern football helmets.
Linear impact tests were conducted on 17 modern football helmets. The helmets were placed on the Hybrid III head with the neck attached to a sliding table. The head was instrumented with an array of 3-2-2-2 accelerometers to determine translational acceleration, rotational acceleration, and HIC. Twe...
Cervical spine model to predict capsular ligament response in rear impact.
Predicting neck kinematics and tissue level response is essential to evaluate the potential for occupant injury in rear impact. A detailed 50th percentile male finite element model, previously validated for frontal impact, was validated for rear impact scenarios with material properties based on act...