Annals of Biomedical Engineering
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In vitro ceramic scaffold mineralization: comparison between histological and micro-computed tomographical analysis.
The porous structure of beta-tricalcium phosphate (β-TCP) scaffolds was assessed by conventional histomorphometry and micro-computed tomography (micro-CT) to evaluate the substitutability of time-consuming histomorphometry by rapid micro-CT. Extracellular matrix mineralization on human mesenchymal s...
Direct regularized estimation of retinal vascular oxygen tension based on an experimental model.
We provide an improved solution by devising a regularized direct least squares (RDLS) method that exploits available knowledge in studies that provide models of oxygen tension in retinal arteries and veins, unlike the earlier regularized LS approach where knowledge about intermediate variables is li...
Vascular occlusion affects gait variability patterns of healthy younger and older individuals.
Insufficient blood flow is one possible mechanism contributing to altered gait patterns in lower extremity peripheral arterial disease (PAD). Previously, our laboratory found that induced occlusion alters gait variability patterns in healthy young individuals. However the effect of age was not explo...
High wall shear stress and spatial gradients in vascular pathology: a review.
We have begun to elucidate EC responses to high WSS alone and in combination with WSSG. Understanding such responses will provide insight into not only aneurysm formation, but also plaque destabilization and other vascular pathologies and potentially lead to improved strategies for disease managemen...
Algorithm to assess cranial suture fusion with varying and discontinuous mineral density.
One of the most difficult challenges in medical imaging is the accurate segmentation of mineralized tissues. This process is complicated when studying developmental or regenerative processes due to the changes in mineral density that these tissues undergo over time. To address these limitations an a...
Impact performance of modern football helmets.
Linear impact tests were conducted on 17 modern football helmets. The helmets were placed on the Hybrid III head with the neck attached to a sliding table. The head was instrumented with an array of 3-2-2-2 accelerometers to determine translational acceleration, rotational acceleration, and HIC. Twe...
Cervical spine model to predict capsular ligament response in rear impact.
Predicting neck kinematics and tissue level response is essential to evaluate the potential for occupant injury in rear impact. A detailed 50th percentile male finite element model, previously validated for frontal impact, was validated for rear impact scenarios with material properties based on act...
Measurement of synchronous activity by microelectrode arrays uncovers differential effects of sublethal and lethal glutamate concentrations ...
We grew cultures of rat cortical cells on microelectrode arrays to investigate the effects of glutamate-mediated neurotoxicity as a model of traumatic brain injury. Treatment with two different concentrations of glutamate, 175 and 250 μM, led to different outcomes. Cultures treated with 250 μM gluta...
Significance of extensional stresses to red blood cell lysis in a shearing flow.
We sought to re-examine flow features related to hemolysis in a shearing flow by computationally modeling a set of classic experiments performed in a capillary tube. Simulating 21 different flows of varying entrance contraction ratio, flowrate and viscosity, we identified hemolysis threshold streaml...
Experimental friction coefficients for bovine cartilage measured with a pin-on-disk tribometer: testing configuration and lubricant effects.
We provide evidence according to which a commercial pin-on-disk tribometer allows us to assess different lubrication mechanisms active in cartilage. Specifically, we find that the measured friction coefficient strongly depends on the testing configuration. Our results show that the friction coeffici...