Journal of Experimental Psychology: Animal Behavior Processes
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Correlation between the behavior of magnetic iron oxide particles in the lungs of rabbits and phagocytosis.
Five New Zealand white male rabbits were exposed (30 min; 300 mg/m3) to a submicrometric magnetic iron oxide aerosol (gamma-Fe2O3) produced by burning iron pentacarbonyl in a reducing atmosphere. After aerosol inhalation, an external magnetic field was applied to the rabbits to magnetize and align t...
Development of bronchus-associated lymphoid tissue hyperplasia following lipopolysaccharide-induced lung inflammation in rats.
Gram-negative bacterial endotoxin lipopolysaccharide (LPS) administration has been used as an animal model of sepsis-related acute lung injury and adult respiratory distress syndrome (ALI/ARDS). This paper describes the lung histology following lung injury induced by the intraperitoneal (i.p.) admin...
Migratory behaviors of alveolar macrophages during the alveolar clearance of light to heavy burdens of particles.
We investigated the unstimulated and stimulated migratory activities of lavaged alveolar macrophages (AMs) in vitro over the course of alveolar clearance of three different mass lung burdens of microspheres. Our intent was to uncover potentially important relationships between the migratory behavior...
Mitigation of pulmonary oxygen toxicity in premature lambs with intravenous antioxidants.
We delivered 32 premature lambs, 16 pairs of twins, by cesarean section at 125-141 days of gestation (term 146 days) and stabilized them on ventilators in normocapnic hyperoxia for a period of 8 h. One lamb of each twin pair received an intravenous dose of 7,500-50,000 IU/kg of PEG-SOD and of 37,500...
Altered clearance of inhaled 99mTc-pentetate aerosols following exposure to cadmium chloride aerosols in ferrets.
The rate of clearance of inhaled 99mTc-pentetate aerosols has been used as an indicator of pulmonary epithelial "permeability" in human and animal studies. In order to evaluate this technique further, groups of eight male ferrets (Mustela putorius furo) were given acute exposures to aerosols of CdCl...
Distribution of nonciliated bronchiolar epithelial (Clara) cells in intra- and extrapulmonary airways of the rabbit.
We correlated airway size, generation of branching, and airway wall components with Clara cell morphology and abundance. Lungs of 6 male rabbits (8-15 weeks old) free of respiratory disease were fixed by airway infusion of glutaraldehyde/paraformaldehyde at 30 cm pressure. The trachea, primary bronc...
Comparison of nonciliated tracheal epithelial cells in six mammalian species: ultrastructure and population densities.
We characterized the ultrastructure and population densities of tracheal epithelial cells in six species: hamster (H), rat (Rt), rabbit (Rb), cat (C), Bonnet monkey (M. radiata) (B), and sheep (S). Following fixation by airway infusion with glutaraldehyde/paraformaldehyde, tracheal tissue was proces...
Establishment and characterization of a novel in vitro angiogenesis model using a microvascular endothelial cell line, F-2C, cultured in che...
We adapted a murine microvascular endothelial cell line, F-2, to a chemically defined medium, Cos Medium 001, and successfully established a subline of F-2, designated F-2C, which revealed a unique growth pattern. In Cos Medium 001, F-2C proliferates in a cobblestone pattern at an early growth stage...
The H9C2 cell line and primary neonatal cardiomyocyte cells show similar hypertrophic responses in vitro.
We have directly compared the hypertrophic responses of H9C2 cells with those of primary rat neonatal cardiomyocytes following stimulation with hypertrophic factors. Primary rat neonatal cardiomyocytes and H9C2 cells were cultured in vitro and treated with angiotensin II and endothelin-1 to promote...
Effect of enalapril treatment on the heart of normal rats.
Previous experiments showed that enalapril (EN) treatment as well as enalaprilic acid, when added to the perfusion bath, diminish the inotropic response of the papillary muscles to isoproterenol (ISO). The main objective of this study was to evaluate, in normal rats, the effect of EN on basal contra...