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Developmental & Comparative Immunology

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  1. An LRR-only protein representing a new type of pattern recognition receptor in Chlamys farreri

    Developmental & Comparative Immunology 54(1):145 (2016)

    Accumulating evidence has demonstrated that leucine-rich repeat (LRR)-only proteins could mediate protein-ligand and protein–protein interactions and were involved in the immune response. In the present study, an LRR-only protein (designed as CfLRRop-1) was cloned from Zhikong scallop ...
  2. LBP/BPI homologue in Eisenia andrei earthworms

    Developmental & Comparative Immunology 54(1):1 (2016)

    LBP/BPIs are pattern recognition receptors that are often present in vertebrates and in invertebrates, and they play a defense role against pathogens. We have identified 1698 bp cDNA sequence from the Eisenia andrei earthworm with predicted amino acid sequence that shares homology with...
  3. Structurally diverse genes encode Tlr2 in rainbow trout: The conserved receptor cannot be stimulated by classical ligands to activate NF-κB in vitro

    Developmental & Comparative Immunology 54(1):75 (2016)

    The mammalian toll-like receptor 2 (TLR2) is a dominant receptor for the recognition of Gram-positive bacteria. Its structure and functional properties were unknown in salmonid fish. In RT-PCR and RACE experiments, we obtained the full-length cDNA sequence encoding Tlr2 from rainbow tr...
  4. DNA vaccination boosts Bacillus Calmette–Guérin protection against mycobacterial infection in zebrafish

    Developmental & Comparative Immunology 54(1):89 (2016)

    Despite the widespread use of the current Bacillus Calmette–Guérin (BCG) vaccine, tuberculosis is still a major cause of morbidity and mortality worldwide. Vaccination with BCG does not prevent a Mycobacterium tuberculosis infection, nor does it inhibit the reactivation of latent tuber...
  5. L-C1qDC-1, a novel C1q domain-containing protein from Lethenteron camtschaticum that is involved in the immune response

    Developmental & Comparative Immunology 54(1):66 (2016)

    The C1q domain-containing (C1qDC) proteins are a family of proteins characterized by a globular C1q (gC1q) domain at their C-terminus. These proteins are involved in various processes in vertebrates and are assumed to serve as important pattern recognition receptors in innate immunity ...
  6. Nemo like kinase negatively regulates NF-κB activation and coelomocytes apoptosis in Apostichopus japonicus

    Developmental & Comparative Immunology 54(1):109 (2016)

    Nuclear factor kappa B (NF-κB) transcription factors are related to several physiological processes, including innate and acquired immunity. In this study, a novel negative regulator of the Nemo-like kinase (NLK) gene was identified from Apostichopus japonicus through PCR (denoted as A...
  7. Glyceraldehyde-3-phosphate dehydrogenase is a mediator of hemocyte-spreading behavior and molecular target of immunosuppressive factor CrV1

    Developmental & Comparative Immunology 54(1):97 (2016)

    Cellular immunity is accompanied by hemocyte-spreading behavior, which undergoes cytoskeletal rearrangement. Polydnaviral factor CpBV-CrV1 can inhibit the hemocyte-spreading behavior and suppress host immune response of Plutella xylostella. However, host target molecule of CpBV-CrV1 th...
  8. MHC in a monogamous lizard – Characterization of class I MHC genes in the Australian skink Tiliqua rugosa

    Developmental & Comparative Immunology 53(2):320 (2015) PMID 26208969

    The major histocompatibility complex (MHC) is a highly variable region of vertebrate genomes that encodes cellular proteins involved in the immune response. In addition to the benefits of MHC research in understanding the genetic basis of host resistance to disease, the MHC is an ideal...
  9. CgIL17-5, an ancient inflammatory cytokine in Crassostrea gigas exhibiting the heterogeneity functions compared with vertebrate interleukin17 molecules

    Developmental & Comparative Immunology 53(2):339 (2015) PMID 26257382

    Interleukin 17 (IL17) is a proinflammatory cytokine that plays an important role in immune response. Recently, five novel IL17 homologs have been identified by screening and analyzing the genome of pacific oyster Crassostrea gigas. In the present study, the functions of CgIL17-5 were i...
  10. Tracheal and bronchial polymeric immunoglobulin secretory immune system (PISIS) development in a porcine model

    Developmental & Comparative Immunology 53(2):271 (2015) PMID 26188097

    Polymeric immunoglobulins (pIgs) mucosal secretion is mediated by the pIg secretory immune system (PISIS), which is composed of J-chain (JC) and antibody (IgM/IgA) producing cells (JC-AbPC), pIg receptor (pIgR) epithelial cell expression and the efficient release of secretory Igs (SIgs...