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Developmental & Comparative Immunology

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  1. First evidence of comparative responses of Toll-like receptor 22 (TLR22) to relatively resistant and susceptible Indian farmed carps to Argu...

    Developmental & Comparative Immunology 47(1):25 (2014) PMID 24998226

    We have cloned and characterized TLR22 genes of L. rohita (rTLR22) and C. catla (cTLR22). The full-length cDNAs of rTLR22 and cTLR22 contained an open reading frame of 2838 and 2841 nucleotides, respectively; bearing the typical structural features. Phylogenetically rTLR22/cTLR22 was most closely re...
  2. Functional characterization of mannose-binding lectin in zebrafish: Implication for a lectin-dependent complement system in early embryos.

    Developmental & Comparative Immunology 46(2):314 (2014) PMID 24858663

    We demonstrate that the transcript of MBL gene is present in the early embryo of zebrafish, and MBL protein is also present in the embryo. In addition, we show that recombinant zebrafish MBL was able to bind the Gram-negative bacterium Escherichia coli and the Gram-positive bacterium Staphylococcus...
  3. Tissue-specific molecular immune response to lipopolysaccharide challenge in emaciated anadromous Arctic charr.

    Developmental & Comparative Immunology 45(1):133 (2014) PMID 24594135

    We tested the hypothesis that extended fasting will compromise the ability of this species to evoke an immune response. Charr were either fed or fasted for 85 days and challenged with lipopolysaccharide (LPS), and the molecular immune response in the liver and spleen assessed at 8 and 96 h post-inje...
  4. Immunity to betanodavirus infections of marine fish.

    Developmental & Comparative Immunology 43(2):174 (2014) PMID 23916690

    Betanodaviruses cause viral nervous necrosis in numerous fish species, but some species are resistant to infection by these viruses. It is essential to fully characterize the immune responses that underlie this protective response. Complete characterization of the immune responses against nodaviruse...
  5. f57f4.4p::gfp as a fluorescent reporter for analysis of the C. elegans response to bacterial infection.

    Developmental & Comparative Immunology 42(2):132 (2014) PMID 24012871

    We use Caenorhabditis elegans as a model host and introduce a new pathogen-inducible fluorescent reporter involving the promoter of f57f4.4, a gene encoding a putative component of the glycocalyx. We show that this reporter construct does not respond to heavy metal or hypertonic environments, but is...
  6. Activation of an innate immune response in the schistosome-transmitting snail Biomphalaria glabrata by specific bacterial PAMPs.

    Developmental & Comparative Immunology 42(2):256 (2014) PMID 24113288 PMCID PMC3855869

    We tested the effects of the following injected substances on the snail APO: crude LPS, ultrapurified LPS (lacking lipoprotein contamination), two forms of lipid A, (diphosphoryl lipid A and Kdo2-lipid A), O-polysaccharide, Gram negative PGN, both crude and ultrapurified (with and without endotoxin...
  7. Peptidoglycan recognition proteins in Drosophila immunity.

    Developmental & Comparative Immunology 42(1):36 (2014) PMID 23796791 PMCID PMC3808481

    Innate immunity is the front line of self-defense against infectious non-self in vertebrates and invertebrates. The innate immune system is mediated by germ-line encoding pattern recognition molecules (pathogen sensors) that recognize conserved molecular patterns present in the pathogens but absent...
  8. RNA-Seq analysis reveals genes associated with resistance to Taura syndrome virus (TSV) in the Pacific white shrimp Litopenaeus vannamei.

    Developmental & Comparative Immunology 41(4):523 (2013) PMID 23921257

    We conducted the first transcriptomic profiling of host responses in hemolymph and hemocytes in order to identify the differentially expressed genes associated with resistance to TSV in L. vannamei. High-throughput RNA-Seq was employed, obtaining 193.6 and 171.2 million high-quality Illumina reads f...
  9. Expressions of transcription factors in goldfish (Carassius auratus L.) macrophages and their progenitors.

    Developmental & Comparative Immunology 41(2):230 (2013) PMID 23748037

    We report on the mRNA levels of transcription factors (cebpa, cjun, cmyb, egr1, gata1, gata2, gata3, lmo2, mafb, pax5, pu.1 and runx1) in sorted goldfish progenitor cells, monocytes, and macrophages from primary kidney macrophage cultures. The mRNA levels of runx1 and pu.1 were significantly higher,...
  10. B cell memory following infection and challenge of channel catfish with Ichthyophthirius multifiliis.

    Developmental & Comparative Immunology 39(3):302 (2013) PMID 23041614

    B cell responses in channel catfish to infection with the parasitic ciliate Ichthyophthirius multifiliis were followed for 3years. High titers of serum IgM antibodies recognizing I. multifiliis immobilization antigens were present 5weeks after immunizing infection, but by 1year titers were at low or...