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Clinical Therapeutics

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Gale, Ingenta, Rcgp, and Sciencedirect from 1995

  1. Adherence to Guidelines and the Screening Tool of Older Persons’ Potentially Inappropriate Prescriptions Criteria for Colchicine Dosing for Gout Treatment in Beneficiaries of the Nova Scotia Seniors’ Pharmacare Program

    Clinical Therapeutics 37(10):2339 (2015) PMID 26391146

    Purpose Colchicine is commonly used in the management of gout; however, older persons have higher risks of toxicity. Accordingly, the Screening Tool of Older Person’s potentially inappropriate Prescriptions (STOPP) criteria for colchicine consider >3 months of treatment as po...
  2. Role of Gross Tumor Volume in the Prognosis of Non–small Cell Lung Cancer Treated With 3D Conformal Radiotherapy: A Meta-analysis

    Clinical Therapeutics 37(10):2256 (2015) PMID 26293808

    Purpose Three-dimensional conformal radiotherapy (3D-CRT) has become widely applied in patients with non–small cell lung cancer (NSCLC), and gross tumor volume (GTV) is a reliable index for predicting prognosis in patients with NSCLC. This meta-analysis investigated the assoc...
  3. Tablet Splitting of Psychotropic Drugs for Patients With Dementia: A Pharmacoepidemiologic Study in a Brazilian Sample

    Clinical Therapeutics 37(10):2332 (2015) PMID 26383240

    Purpose The objective of this study was to assess the frequency of tablet splitting of psychotropic drugs in a population of older adults with a diagnosis of dementia.
  4. Table of Contents
    Author(s) unavailable

    Clinical Therapeutics 37(10):A4 (2015)

  5. Effects of Paroxetine, a CYP2D6 Inhibitor, on the Pharmacokinetic Properties of Hydrocodone After Coadministration With a Single-entity, Once-daily, Extended-release Hydrocodone Tablet

    Clinical Therapeutics 37(10):2286 (2015) PMID 26350273

    Purpose A single-entity, once-daily, extended-release formulation of hydrocodone bitartrate (HYD) has been developed for the management of moderate to severe chronic pain. Hydrocodone undergoes cytochrome P-450 (CYP)-mediated metabolism involving the CYP3A4 and CYP2D6 isozyme...
  6. Pharmacokinetic Properties and Safety Profile of Histamine Dihydrochloride Injection in Chinese Healthy Volunteers: A Phase I, Single-center, Open-label, Randomized Study

    Clinical Therapeutics 37(10):2352 (2015) PMID 26276501

    Purpose Histamine dihydrochloride (HDC) injection has been approved in Europe for the treatment of adults with acute myeloid leukemia, used in combination therapy with the T-cell−derived cytokine interleukin-2. Despite years of clinical applications of HDC in Europe, no data ...
  7. Should β-Blockers Be Used in Patients With Heart Failure and Atrial Fibrillation?

    Clinical Therapeutics 37(10):2215 (2015) PMID 26391145

    Purpose There is overwhelming evidence that β-blockers reduce cardiovascular hospitalizations and mortality in patients with heart failure and a reduced left ventricular ejection fraction provide they are in sinus rhythm. However, a recent meta-analysis of individual patient ...
  8. Prospective Quality of Life Study of South African Women Undergoing Treatment for Advanced-stage Cervical Cancer

    Clinical Therapeutics 37(10):2324 (2015) PMID 26385584

    Purpose The majority of South African cervical cancer patients present with advanced-stage disease. Chemoradiation therapy, in comparison with radiation therapy, results in marginally improved survival in women with advanced cervical cancer. The impact on the quality of life ...
  9. Corrigendum to ‘Inpatient Resource Utilization and Cost Burden of Deep Vein Thrombosis and Pulmonary Embolism in the United States’ Clin Ther 2015;37:62–70

    Clinical Therapeutics 37(10):2382 (2015)

  10. Nonstatin Therapies for Management of Dyslipidemia: A Review

    Clinical Therapeutics 37(10):2153 (2015) PMID 26412799

    Purpose Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in the United States. Recently published cholesterol treatment guidelines emphasize the use of statins as the preferred treatment strategy for both primary and secondary prevention of CVD. Ho...