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Clinical Therapeutics

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Gale, Ingenta, Rcgp, and Sciencedirect from 1995

  1. Table of Contents
    Author(s) unavailable

    Clinical Therapeutics 37(3):A4 (2015)

  2. Tolerability and Pharmacokinetics of Two Formulations of Megestrol Acetate under Fed Conditions in Healthy Volunteers

    Clinical Therapeutics 37(2):439 (2015) PMID 25450470

    Purpose Megestrol acetate oral suspension is an appetite stimulant indicated for cachexia. It is available in a conventional formulation and as a nanocrystal dispersion. The aim of this study was to compare the tolerability and pharmacokinetics of these formulations under fed...
  3. Table of Contents
    Author(s) unavailable

    Clinical Therapeutics 37(2):A4 (2015)

  4. Single- and Multiple-dose Pharmacokinetics of a Hydrocodone Bitartrate Extended-release Tablet Formulated With Abuse-deterrence Technology in Healthy, Naltrexone-blocked Volunteers

    Clinical Therapeutics 37(2):390 (2015) PMID 25542074

    Purpose A hydrocodone extended-release (ER) formulation was developed to provide sustained pain relief with twice-daily dosing. Developed using the CIMA abuse-deterrence technology platform (CIMA Labs Inc, Brooklyn Park, Minnesota), this formulation also provides resistance a...
  5. Reimbursement of Targeted Cancer Therapies Within 3 Different European Health Care Systems

    Clinical Therapeutics 37(2):474 (2015)

    Purpose Targeted cancer therapies (TCTs) are drugs that specifically act on molecular targets within the cancer cell, causing its regression and/or destruction. Although TCTs offer clinically important gains in survival in one of the most challenging therapeutic areas, these ...
  6. The Shortened Infusion Time of Intravenous Ibuprofen, Part 2: A Multicenter, Open-label, Surgical Surveillance Trial to Evaluate Safety

    Clinical Therapeutics 37(2):368 (2015) PMID 25592331

    Purpose The literature and clinical data support the use of intravenous (IV) infusions of ibuprofen to control pain and reduce the opioid requirements associated with surgical pain. According to current guidelines, IV ibuprofen can be administered via a slow IV infusion perfo...
  7. Editorial Board
    Author(s) unavailable

    Clinical Therapeutics 37(2):A2 (2015)

  8. Cervical Cancer 2015 and Beyond: A Focus on Innovative Treatments and Attention to Survivorship

    Clinical Therapeutics 37(1):6 (2015) PMID 25592087

  9. Table of Contents
    Author(s) unavailable

    Clinical Therapeutics 37(1):A4 (2015)

  10. Pharmacokinetic Properties of Single- and Repeated-dose Sufentanil Sublingual Tablets in Healthy Volunteers

    Clinical Therapeutics 37(1):145 (2015) PMID 25544247

    Purpose Sufentanil is a μ-opioid agonist with a high therapeutic index in preclinical studies and no active metabolites, and it is highly lipophilic, thereby enabling a transmucosal route of administration. Rapid distribution from the plasma after IV sufentanil administration...