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Journal of Nuclear Medicine

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Csh, Endocrine, Proquest, Ama, Nephrology, Highwire from 1964, Aaas, Rupress, CSA, and Aacr

  1. Dosimetry of Pediatric PET/CT.

    Journal of Nuclear Medicine 50(9):1483 (2009) PMID 19690036

    The use of PET/CT in children has grown substantially in the past few years. There is also an increased interest in keeping the radiation dose to children from CT as low as is clinically practical. This article reviews the physical aspects of both PET and CT separately and how CT is used in the ...
  2. Evaluation of the role of hexokinase type II in cellular proliferation and apoptosis using human hepatocellular carcinoma cell lines.

    Journal of Nuclear Medicine 50(9):1525 (2009) PMID 19690031

    The (18)F-FDG uptake pattern on PET could be an indicator of the prognosis and aggressiveness of various tumors, including hepatocellular carcinoma (HCC). Hexokinase, especially hexokinase type II (HKII), plays a critical role in (18)F-FDG uptake in rapidly growing tumors. We established a stabl...
  3. Directions and magnitudes of misregistration of CT attenuation-corrected myocardial perfusion studies: incidence, impact on image quality, and guidance for reregistration.

    Journal of Nuclear Medicine 50(9):1471 (2009) PMID 19690038

    CT-based attenuation-corrected (AC) myocardial perfusion imaging (MPI) studies may show significant artifacts caused by misregistration between SPECT and CT data. The present study aimed at identifying the directions and magnitudes of misregistration with greatest impact on AC myocardial perfusi...
  4. A 2-helix small protein labeled with 68Ga for PET imaging of HER2 expression.

    Journal of Nuclear Medicine 50(9):1492 (2009) PMID 19690041 PMCID PMC4216181

    Affibody molecules are a class of scaffold proteins being developed into a generalizable approach to targeting tumors. Many 3-helix-based Affibody proteins have shown excellent in vivo properties for tumor imaging and therapy. By truncating one alpha-helix that is not responsible for receptor re...
  5. Whole-body dosimetry for individualized treatment planning of 131I-MIBG radionuclide therapy for neuroblastoma.

    Journal of Nuclear Medicine 50(9):1518 (2009) PMID 19713562

    The aims of this study were to examine the relationship between whole-body absorbed dose and hematologic toxicity and to assess the most accurate method of delivering a prescribed whole-body absorbed dose in (131)I-metaiodobenzylguanidine ((131)I-MIBG) therapy for neuroblastoma. A total of 20 ch...
  6. Automated quality control for segmentation of myocardial perfusion SPECT.

    Journal of Nuclear Medicine 50(9):1418 (2009) PMID 19690019 PMCID PMC2935909

    Left ventricular (LV) segmentation, including accurate assignment of LV contours, is essential for the quantitative assessment of myocardial perfusion SPECT (MPS). Two major types of segmentation failures are observed in clinical practices: incorrect LV shape determination and incorrect valve-pl...
  7. In vivo characterization of a series of 18F-diaryl sulfides (18F-2-(2'-((dimethylamino)methyl)-4'-(fluoroalkoxy)phenylthio)benzenamine) for PET imaging of the serotonin transporter.

    Journal of Nuclear Medicine 50(9):1509 (2009) PMID 19690040

    PET of the serotonin transporter (SERT) in the brain is a useful tool for examining normal physiologic functions as well as disease states involving the serotonergic system. The goal of this study was to further develop and refine a series of 4'-fluoroalkoxy-substituted, (18)F-radiolabeled SERT ...
  8. Combination of converging collimators for high-sensitivity brain SPECT.

    Journal of Nuclear Medicine 50(9):1548 (2009) PMID 19690042

    The objective of this study, which is related to human brain SPECT, was to increase the sensitivity of a triple-camera SPECT system and reduce statistical noise in reconstructed images using a combination of converging collimators. The reason for combining collimators is to ensure both high sens...
  9. Usefulness of 123I-MIBG scintigraphy in the evaluation of patients with known or suspected primary or metastatic pheochromocytoma or paraganglioma: results from a prospective multicenter trial.

    Journal of Nuclear Medicine 50(9):1448 (2009) PMID 19690028

    Although (123)I-MIBG has been in clinical use for the imaging of pheochromocytoma for many years, a large multicenter evaluation of this agent has never been performed. The present study was designed to provide a prospective confirmation of the performance of (123)I-MIBG scintigraphy for the eva...
  10. Molecular imaging of cartilage.

    Journal of Nuclear Medicine 50(9):1391 (2009) PMID 19690037