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Journal of Nuclear Medicine

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Csh, Endocrine, Proquest, Ama, Nephrology, Highwire from 1964, Aaas, Rupress, CSA, and Aacr

  1. Dosimetry of Pediatric PET/CT.

    Journal of Nuclear Medicine 50(9):1483 (2009) PMID 19690036

    The use of PET/CT in children has grown substantially in the past few years. There is also an increased interest in keeping the radiation dose to children from CT as low as is clinically practical. This article reviews the physical aspects of both PET and CT separately and how CT is used in the ...
  2. Evaluation of the role of hexokinase type II in cellular proliferation and apoptosis using human hepatocellular carcinoma cell lines.

    Journal of Nuclear Medicine 50(9):1525 (2009) PMID 19690031

    The (18)F-FDG uptake pattern on PET could be an indicator of the prognosis and aggressiveness of various tumors, including hepatocellular carcinoma (HCC). Hexokinase, especially hexokinase type II (HKII), plays a critical role in (18)F-FDG uptake in rapidly growing tumors. We established a stabl...
  3. Directions and magnitudes of misregistration of CT attenuation-corrected myocardial perfusion studies: incidence, impact on image quality, and guidance for reregistration.

    Journal of Nuclear Medicine 50(9):1471 (2009) PMID 19690038

    CT-based attenuation-corrected (AC) myocardial perfusion imaging (MPI) studies may show significant artifacts caused by misregistration between SPECT and CT data. The present study aimed at identifying the directions and magnitudes of misregistration with greatest impact on AC myocardial perfusi...
  4. A 2-helix small protein labeled with 68Ga for PET imaging of HER2 expression.

    Journal of Nuclear Medicine 50(9):1492 (2009) PMID 19690041 PMCID PMC4216181

    Affibody molecules are a class of scaffold proteins being developed into a generalizable approach to targeting tumors. Many 3-helix-based Affibody proteins have shown excellent in vivo properties for tumor imaging and therapy. By truncating one alpha-helix that is not responsible for receptor re...
  5. Whole-body dosimetry for individualized treatment planning of 131I-MIBG radionuclide therapy for neuroblastoma.

    Journal of Nuclear Medicine 50(9):1518 (2009) PMID 19713562

    The aims of this study were to examine the relationship between whole-body absorbed dose and hematologic toxicity and to assess the most accurate method of delivering a prescribed whole-body absorbed dose in (131)I-metaiodobenzylguanidine ((131)I-MIBG) therapy for neuroblastoma. A total of 20 ch...
  6. Automated quality control for segmentation of myocardial perfusion SPECT.

    Journal of Nuclear Medicine 50(9):1418 (2009) PMID 19690019 PMCID PMC2935909

    Left ventricular (LV) segmentation, including accurate assignment of LV contours, is essential for the quantitative assessment of myocardial perfusion SPECT (MPS). Two major types of segmentation failures are observed in clinical practices: incorrect LV shape determination and incorrect valve-pl...
  7. Hypertension increases cerebral 6-18F-fluorodopa-derived radioactivity.

    Journal of Nuclear Medicine 50(9):1479 (2009) PMID 19690020 PMCID PMC4164388

    6-(18)F-fluorodopa PET depicts the striatal dopaminergic lesion characterizing Parkinson disease (PD); however, striatal uptake of 6-(18)F-fluorodopa-derived radioactivity can be normal. Supine hypertension (SH) might increase 6-(18)F-fluorodopa uptake. We measured putamen, caudate, and occipita...
  8. Molecular imaging of cartilage.

    Journal of Nuclear Medicine 50(9):1391 (2009) PMID 19690037

  9. 123I-5-IA-85380 SPECT imaging of nicotinic receptors in Alzheimer disease and mild cognitive impairment.

    Journal of Nuclear Medicine 50(9):1455 (2009) PMID 19690024

    Postmortem binding studies have established that the concentration of alpha(4)beta(2)-nicotinic acetylcholine receptors (alpha(4)beta(2)-nAChR) is reduced in advanced Alzheimer disease (AD). However, the status of this receptor in mild or prodromal AD has remained the subject of controversy. We ...
  10. Relationship of cerebrospinal fluid markers to 11C-PiB and 18F-FDDNP binding.

    Journal of Nuclear Medicine 50(9):1464 (2009) PMID 19690025

    The purpose of this study was to investigate the potential relationships between cerebrospinal fluid (CSF) measurements of beta-amyloid-1-42 (Abeta(1-42)) and total tau to (11)C-Pittsburgh compound B ((11)C-PiB) and 2-(1-{6-[(2-(18)F-fluoroethyl)(methyl)amino]-2-naphthyl}ethylidene) malononitril...