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Molecular Immunology

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CSA, Gale, Proquest, Ingenta, Rcgp, and Sciencedirect from 1979

  1. LMIR5 extracellular domain activates myeloid cells through Toll-like receptor 4.

    Molecular Immunology 62(1):169 (2014) PMID 25004110

    LMIR5/CD300b is an activating immunoglobulin-like receptor whose extracellular domain (LMIR5-Fc) is constitutively released from immune cells. The release of LMIR5-Fc is augmented upon stimulation with TLR agonists. LMIR5-Fc is reported to possess inflammatory activity and amplify LPS-induced lethal...
  2. pH dependence of antibody: hapten association.

    Molecular Immunology 36(6):397 (1999) PMID 10444003

    Monoclonal antibody NC6.8 is specific for the superpotent sweetener, N-(p-cyanophenyl)-N'-(diphenylmethyl)-guanidiniumacetic++ + acid. The three-dimensional structure of the complex shows the close proximity of complementary charged residues on the antibody and groups of the hapten. As a result, asso...
  3. The murine p75 TNF receptor promoter region: DNA sequence and characterization of a cis-acting silencer.

    Molecular Immunology 36(2):125 (1999) PMID 10378684

    The promoter region of the murine p75 TNF receptor (TNF-R) was isolated from a mouse genomic DNA cosmid library. The promoter region is devoid of TATA box and has the characteristics of a house keeping gene since it contains multiple SP1 binding sites. Its mRNA has different initiation sites in diff...
  4. Modulation of class I major histocompatibility complex antigen cell-surface stability by transmembrane domain length variation.

    Molecular Immunology 34(11):771 (1997) PMID 9444976

    I proteins is conferred to a large extent by their transmembrane domains (TMs) which exhibit allelic, inter-locus and inter-species variation in both amino acid composition and length. Here, the consequences of TM length variation on trafficking and cell-surface stability were examined using the hum...
  5. Isolation and N-terminal sequence determination of a novel gamma/delta T cell surface antigen.

    Molecular Immunology 34(8-9):583 (1997) PMID 9393961

    We use digestion with the proteolytic enzyme bromelain to selectively release the MAC319 antigen as a soluble fragment, for further characterisation. A cytofluorometric inhibition assay was developed to follow the purification of this fragment, as the conformation sensitivity of the MAC319 epitope p...
  6. Blood clearance in the rat of a recombinant mouse monoclonal antibody lacking the N-linked oligosaccharide side chains of the CH2 domains.

    Molecular Immunology 29(2):213 (1992) PMID 1542298

    The serum half-lives of a wild-type recombinant mouse monoclonal antibody of the IgG2b isotype and a mutant antibody differing from the wild-type antibody by a single amino acid substitution introduced into the CH2 domain, the replacement of Asn 297 by Ala to delete the conserved sit...
  7. A murine monoclonal anti-metallothionein autoantibody recognizes a chemically synthesized amino-terminal heptapeptide common to various anim...

    Molecular Immunology 25(10):1033 (1988) PMID 2464135

    These results demonstrate that the MT 189-14-7 autoantibody recognizes the epitope located within the amino-terminal heptapeptide common to various MTs....
  8. Altered DNA methylation profile in Norwegian patients with Autoimmune Addison's Disease.

    Molecular Immunology 59(2):208 (2014) PMID 24667071

    We identified multiple hypomethylated gene promoter regions in patients with isolated AAD using DNA isolated from CD4+ T cells. The identified differentially methylated regions were distributed evenly across the 10.5-kb-promoter regions covered by the array, and a substantial number localized to pro...
  9. Serum amyloid A induces mitogenic signals in regulatory T cells via monocyte activation.

    Molecular Immunology 59(2):172 (2014) PMID 24632292 PMCID PMC4068397

    We provide evidence that IL-1β and IL-6 are directly involved in the SAA-mediated proliferation of Treg. By engaging its several cognate receptors, SAA induces IL-1β and IL-6 secretion by monocytes and drives them toward an HLA-DR(hi) HVEM(lo) phenotype resembling immature dendritic cells, which hav...
  10. Active demethylation of the IL-2 Promoter in CD4+ T cells is mediated by an inducible DNA glycosylase, Myh.

    Molecular Immunology 58(1):38 (2014) PMID 24291244

    We describe a 5-methylcytosine glycosylase activity for the murine DNA base excision repair enzyme Myh and show that it is critically involved in remodeling the IL-2 Promoter for transcription. The enzyme is not expressed in naïve CD4(+) T cells, but can be transiently induced following T cell activ...