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- CSA, Gale, Proquest, Ingenta, Rcgp, and Sciencedirect from 1979
Damnacanthal inhibits IgE receptor-mediated activation of mast cells.
We considered the possibility that the biological actions of damnacanthal, at least partly, could be due to effects on mast cells. Many of the biological activities of mast cells are mediated by IgE receptor cross-linking, which results in degranulation with release of preformed granule mediators, a...
Adenine suppresses IgE-mediated mast cell activation
We investigated the anti-allergic effect of adenine on IgE-mediated mast cell activation in vitro and passive cutaneous anaphylaxis (PCA) in mice. Intraperitoneal injection of adenine to IgE-sensitized mice attenuated IgE-mediated PCA reaction in a dose dependent manner, resulting in a median effect...
Engineered hypoallergenic variants of osmotin demonstrate hypoallergenicity with in vitro and in vivo methods.
The molecular structure of protein and epitope mapping strategies are required to engineer the epitopes of a protein. In the present study, IgE binding regions of osmotin were identified and mutated to obtain hypoallergenic variant. The three dimensional (3-D) model of osmotin obtained by homology m...
MBL, a potential therapeutic target for type 1 diabetes?
Discerning the kinetics of autoimmune manifestations in a model of Sjögren's syndrome.
Our studies show that by 8 weeks of age, young NOD·H2h4 mice spontaneously develop an abundance of splenic germinal centers, prior to the emergence of lymphocyte infiltration in the salivary gland tissue. Ectopic follicle formation in the salivary gland begins to appear in these mice between 12 and...
Viral regulators of complement activation: structure, function and evolution.
The complement system surveillance in the host is effective in controlling viral propagation. Consequently, to subvert this effector mechanism, viruses have developed a series of adaptations. One among these is encoding mimics of host regulators of complement activation (RCA) which help viruses to a...
Demethylation within the proximal promoter region of human estrogen receptor alpha gene correlates with its enhanced expression: Implication...
We have previously observed that expression of ERα gene and protein in lupus patients is significantly higher than in healthy controls and that estradiol up-regulates calcineurin expression via over-expression of ERα gene in SLE. However, the pathogenesis of over-expression of ERα gene is unknown. H...
Divergent roles of histone deacetylase 6 (HDAC6) and histone deacetylase 11 (HDAC11) on the transcriptional regulation of IL10 in antigen pr...
We report that another HDAC, HDAC6, primarily a cytoplasmic protein, associates with HDAC11 and modulates the expression of IL-10 as a transcriptional activator. To our knowledge, this is the first demonstration of two different HDACs being recruited to the same gene promoter to dictate divergent tr...
Serum amyloid A induces mitogenic signals in regulatory T cells via monocyte activation.
We provide evidence that IL-1β and IL-6 are directly involved in the SAA-mediated proliferation of Treg. By engaging its several cognate receptors, SAA induces IL-1β and IL-6 secretion by monocytes and drives them toward an HLA-DR(hi) HVEM(lo) phenotype resembling immature dendritic cells, which hav...
Circulating immune cell and microRNA in patients with uveal melanoma developing metastatic disease.
The immune response has been implicated in the control of uveal melanoma progression. Epigenetic mechanisms mediated by specific microRNAs (miRs) regulate immune responses. Blood was drawn from six patients with uveal melanoma followed from diagnosis, at which time there was no clinical or radiograp...