Progress in Lipid Research
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- Sciencedirect from 1978, Ingenta, Rcgp, and Gale
Lipid synthesis in protozoan parasites: A comparison between kinetoplastids and apicomplexans.
We discuss the tremendous recent advances that have been made in the understanding of the synthesis and uptake pathways for fatty acids and phospholipids in apicomplexan and kinetoplastid parasites, including Plasmodium, Toxoplasma, Cryptosporidium, Trypanosoma and Leishmania. Lipid synthesis differ...
Bacterial lipids: metabolism and membrane homeostasis.
Membrane lipid homeostasis is a vital facet of bacterial cell physiology. For decades, research in bacterial lipid synthesis was largely confined to the Escherichia coli model system. This basic research provided a blueprint for the biochemistry of lipid metabolism that has largely defined the indiv...
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Regulation of HMG-CoA reductase in mammals and yeast.
We discuss regulation of mammalian, Saccharomyces cerevisiae and Schizosaccharomyces pombe HMGR and highlight recent advances in the field. We find that the general features of HMGR regulation, including a requirement for the HMGR-binding protein Insig, are remarkably conserved between mammals and a...
Alpha-synuclein, lipids and Parkinson's disease
We review the evidence linking alpha-synuclein, lipid metabolism, fatty acid oxidation, mitochondrial damage and Parkinson's disease. We propose that association of alpha-synuclein with oxidized lipid metabolites can lead to mitochondrial dysfunction in turn leading to dopaminergic neuron death and...
Structuring food emulsions in the gastrointestinal tract to modify lipid digestion
We discuss the formation and properties of oil-in-water (O/W) emulsions, especially how these emulsions are modified as they traverse through the gastrointestinal tract. Among other factors, the changes in the nature of the droplet adsorbed layer and the droplet size play a major role in controlling...
Fish oils and aggression or hostility
We have been working on the effects of fish oils on aggressive behavior and hostility. Unfortunately this area of research is not mature yet. The number of related papers is rather limited, so we will take aggression and/or hostility in a broader sense including oppositional behavior, violence etc....
Biosynthesis and function of polyacetylenes and allied natural products.
Polyacetylenic natural products are a substantial class of often unstable compounds containing a unique carbon-carbon triple bond functionality, that are intriguing for their wide variety of biochemical and ecological functions, economic potential, and surprising mode of biosynthesis. Isotopic trace...
Probing phospholipid dynamics by electrospray ionisation mass spectrometry.
Recent advances in electrospray ionisation mass spectrometry (ESI-MS) have greatly facilitated the analysis of phospholipid molecular species in a growing diversity of biological and clinical settings. The combination of ESI-MS and metabolic labelling employing substrates labelled with stable isotop...