Journal of Neuroscience Methods
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A method for measuring brain partial pressure of oxygen in unanesthetized unrestrained subjects: the effect of acute and chronic hypoxia on ...
We present a novel fiber optic method to measure brain PtO(2). This method can be used in unanesthetized, unrestrained animals, provides absolute values for PO(2), has a stable calibration, does not consume oxygen and is MRI compatible. Brain PtO(2) was studied during acute hypoxia, as well as befor...
Assessing spatial vision - automated measurement of the contrast-sensitivity function in the hooded rat.
We therefore designed an economical and rapid method to assess the hooded rat's CSF, using a computer monitor to display stimuli and an infrared touch screen to record responses. A six-alternative forced-choice task presented trials in which a sine-wave grating (S+), varying in spatial frequency and...
Independent component analyses for quantifying neuronal ensemble interactions.
We describe applications of principal component analysis (PCA) and independent component analysis (ICA) (Cardoso J-F, Souloumiac A. IEE-Proc F 1993;140:362-70; Hyvarinen A, Oja E. Neural Comput 1997;9:1483-92; Lee TW, Girolami M, Sejnowski TJ. Neural Comp 1999;11:417-41) to neuronal ensemble data. S...
A simple analytical method for determining the steady-state potential in models of geometrically complex neurons.
A method is presented for solving the cable equation for a spiking neuron below firing threshold or a nonspiking neuron of arbitrary geometry under constant stimulation. The neuron structure is considered as a tree composed of a set of cylinder cables of three types (terminal, intermediate and branc...
Development of new optical imaging systems of oxygen metabolism and simultaneous measurement in hemodynamic changes using awake mice.
We developed a simultaneous measurement system of LSI and IOSI, which was verified by LDF. Moreover, to evaluate oxygen metabolism, FAI was performed from the same brain area as LSI and IOSI measurements. The change in CBF according to LSI was correlated with that by LDF. Similarly, the change in CB...
A direct comparison of active and passive amplification electrodes in the same amplifier system.
Active amplification electrodes are becoming more popular for ERP data collection, as they amplify the EEG at the scalp and thereby potentially decrease the influence of ambient electrical noise. However, the performance of active electrodes has not been directly compared with that of passive electr...
Burrowing and nest building behavior as indicators of well-being in mice.
The assessment of pain, distress and suffering, as well as evaluation of the efficacy of stress-reduction strategies, is crucial in animal experimentation but can be challenging in laboratory mice. Nest building and burrowing performance, observed in the home cage, have proved to be valuable and eas...
The effect of swallowing treatments on corticobulbar excitability: a review of transcranial magnetic stimulation induced motor evoked potent...
Transcranial magnetic stimulation (TMS) has been used extensively as a method of investigating the corticomotor physiology of many motor tasks, including healthy and disordered swallowing. Changes in excitability of cortical projections to various swallowing muscles have been documented in response...
A two-compartment organotypic model of mammalian peripheral nerve repair.
Our previous organotypic model accurately modeled nerve repair, but did not allow individual control of motoneuron and growth cone environments. This model isolates treatment effects to growing axons while reproducing the complex three-dimensional structure of peripheral nerve. Additionally, it faci...
Innervation mapping of the hind paw of the rat using Evans Blue extravasation, Optical Surface Mapping and CASAM.
We have used the Evans Blue extravasation technique to chart the skin areas innervated by the sural, peroneal, tibial and/or saphenous nerves, which together innervate the entire hind paw of the rat, and use a new technique to analyze the distribution, overlap and variability of the results. The tec...