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Journal of Neuroscience Methods

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  1. Evaluation of optimal electrode configurations for epidural spinal cord stimulation in cervical spinal cord injured rats

    Journal of Neuroscience Methods (2004)

    • Dorsal funiculi were injured at C4 spinal cord in adult female rats. • Epidural stimulation electrodes were implanted chronically at C6 and C8....
  2. Automated quantification of neuronal networks and single-cell calcium dynamics using calcium imaging.

    Journal of Neuroscience Methods 243:26 (2015) PMID 25629800

    We introduce FluoroSNNAP, Fluorescence Single Neuron and Network Analysis Package. FluoroSNNAP is an open-source, interactive software developed in MATLAB for automated quantification of numerous biologically relevant features of both the calcium dynamics of single-cells and network activity pattern...
  3. Improving the use of principal component analysis to reduce physiological noise and motion artifacts to increase the sensitivity of task-bas...

    Journal of Neuroscience Methods 241:18 (2015) PMID 25481542

    We developed four variants of the CompCor method. The optimized CompCor method applies PCA to time series in a noise mask, but orthogonalizes each component to the BOLD response waveform and uses an algorithm to determine a favorable number of components to use as "nuisance regressors." Whole brain...
  4. Evaluation of different classification methods for the diagnosis of schizophrenia based on functional near-infrared spectroscopy.

    Journal of Neuroscience Methods 241:101 (2015) PMID 25561396

    We evaluated the classification performance of four classification methods (including linear discriminant analysis, k-nearest neighbors, Gaussian process classifier, and support vector machines) on an NIRS-aided schizophrenia diagnosis. We recruited a large sample of 120 schizophrenia patients and 1...
  5. WGA-Alexa transsynaptic labeling in the phrenic motor system of adult rats: Intrapleural injection versus intradiaphragmatic injection.

    Journal of Neuroscience Methods 241:137 (2015) PMID 25555356 PMCID PMC4324159

    Intrapleural injection of CTB-Alexa 488, a retrograde tracer, provides an alternative labeling technique to the surgically invasive laparotomy required for intradiaphragmatic injection. However, CTB-Alexa 488 is incapable of crossing synapses restricting the tracer to the phrenic nuclei and the inte...
  6. New methods for investigation of neuronal migration in embryonic brain explants.

    Journal of Neuroscience Methods 239:80 (2015) PMID 25291524 PMCID PMC4268085

    We developed an immunocytochemistry (ICC) protocol to stain neurons migrating out of the MGE explant embedded in Matrigel. We also established a protocol to efficiently transfect cells in MGE explants, achieving a transduction efficiency of more than 30%. In addition, we developed microfluidic chamb...
  7. Dynamic spatiotemporal brain analyses using high performance electrical neuroimaging: theoretical framework and validation.

    Journal of Neuroscience Methods 238:11 (2014) PMID 25244954

    We provide a theoretical comparison of the two approaches and present a new suite of data-driven analytic tools for the specific identification of the brain microstates in high-density event-related brain potentials (ERPs). This suite includes four different analytic methods. We validated this appro...
  8. Non-causal spike filtering improves decoding of movement intention for intracortical BCIs.

    Journal of Neuroscience Methods 236:58 (2014) PMID 25128256 PMCID PMC4169749

    We show that replacing the causal filter with an equivalent non-causal filter increases the information content extracted from the extracellular spiking signal and improves decoding of intended movement direction. This method can be used for real-time BCI applications by using a 4ms lag between reco...
  9. How to validate similarity in linear transform models of event-related potentials between experimental conditions?

    Journal of Neuroscience Methods 236:76 (2014) PMID 25158317

    We gain the ratio between two coefficients mapping a source in brain to two points along the scalp. Based on such a ratio, we defined a relative mapping coefficient (RMC). If RMCs between two conditions for an ERP are not significantly different in practice, mapping coefficients of this ERP between...
  10. Application of 3-D imaging sensor for tracking minipigs in the open field test.

    Journal of Neuroscience Methods 235:219 (2014) PMID 25066208

    The minipig is a promising model in neurobiology and psychopharmacology. However, automated tracking of minipig behavior is still unresolved problem. The study was carried out on white, agouti and black (or spotted) minipiglets (n=108) bred in the Institute of Cytology and Genetics. New method of au...