Journal of Neuroscience Methods
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Reproducibility and relevance of future behavioral sciences should benefit from a cross fertilization of past recommendations and today's te...
Journal of Neuroscience Methods 234:2 (2014)We discuss this ‘status quo’ and propose solutions to advance behavioral testing. • Examples are given to illustrate the enlarged discriminability of novel test methods....
Fish in behavior research: Unique tools with a great promise!
Journal of Neuroscience Methods 234:54 (2014)• Comparative behavioral neuroscience answers phenogenetic and phylogenetic questions. • Study of new species increases translational relevance in biomedical research....
Assessing spatial vision - automated measurement of the contrast-sensitivity function in the hooded rat.
We therefore designed an economical and rapid method to assess the hooded rat's CSF, using a computer monitor to display stimuli and an infrared touch screen to record responses. A six-alternative forced-choice task presented trials in which a sine-wave grating (S+), varying in spatial frequency and...
Independent component analyses for quantifying neuronal ensemble interactions.
We describe applications of principal component analysis (PCA) and independent component analysis (ICA) (Cardoso J-F, Souloumiac A. IEE-Proc F 1993;140:362-70; Hyvarinen A, Oja E. Neural Comput 1997;9:1483-92; Lee TW, Girolami M, Sejnowski TJ. Neural Comp 1999;11:417-41) to neuronal ensemble data. S...
A simple analytical method for determining the steady-state potential in models of geometrically complex neurons.
A method is presented for solving the cable equation for a spiking neuron below firing threshold or a nonspiking neuron of arbitrary geometry under constant stimulation. The neuron structure is considered as a tree composed of a set of cylinder cables of three types (terminal, intermediate and branc...
SCOPRISM: A new algorithm for automatic sleep scoring in mice
Journal of Neuroscience Methods 235:277 (2014)We tested a new open-source sleep-scoring algorithm (SCOPRISM) on 92 mice. • We successfully validated SCOPRISM in wild-type mice and mouse models of obesity and narcolepsy. •...
Hybrid voltage sensor imaging of eGFP-F expressing neurons in chicken midbrain slices.
We have adapted a hVoS system for a chicken midbrain slice preparation by combining genetically expressed farnesylated eGFP with dipicrylamine (DPA). Depending on the cellular potential, DPA is shifted in the membrane, resulting in quenching of eGFP fluorescence linearly to the membrane potential by...
Localising and classifying neurons from high density MEA recordings.
We show how the spatial pattern of the extracellular signal is determined by both the electrophysiology and morphology of neurons. Starting from known current source models for the generation of the extracellular potential, we use the spatial pattern observed across a multi-electrode array to locali...
Brain penetration assessment in vivo: a reliable and simple method in anesthetized rats at steady state.
For CNS drugs, brain disposition is of critical importance during drug discovery. In vitro methods are used early followed by more predictive in vivo methods later on in the drug discovery process. Current in vivo methods are costly, have long turnover times or do not measure brain disposition at st...
Constructing fMRI connectivity networks: a whole brain functional parcellation method for node definition.
We introduce a novel method for the intra subject topological characterization of the nodes of fMRI brain networks, based on a whole brain parcellation scheme. The proposed whole brain parcellation algorithm divides the brain into clusters that are homogeneous from the anatomical and functional poin...