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An altered neural response to reward may contribute to alcohol problems among late adolescents with an evening chronotype.
We explored the neural mechanisms underlying these chronotype differences by comparing the neural response to reward in morning- and evening-types. Using a monetary reward fMRI paradigm, we compared the neural response to reward in 13 morning-types and 21 evening-types (all 20 y/o males). Region-of-...
AMPA receptors in post-mortem brains of Cloninger type 1 and 2 alcoholics: A whole-hemisphere autoradiography study.
Dysfunction of the brain glutamate system has been associated with alcoholism. Ionotropic glutamatergic alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors (AMPARs) play an important role in both neurotransmission and post-synaptic plasticity. Alterations in AMPAR densities may also p...
Normal brain activation in schizophrenia patients during associative emotional learning.
We investigated whether schizophrenia patients demonstrated impaired function of limbic and prefrontal areas during associative emotional learning. Patients and controls filled out an alexithymia questionnaire and performed an associative emotional learning task with positive, negative and neutral p...
Comorbidity of schizotypy and psychopathy: Skin conductance to affective pictures.
Prior research indicates a relationship between psychopathy and schizophrenia, elucidating a specific trajectory toward violence. Recent research has suggested that this relationship exists at the nonclinical trait level of schizotypy; however, this finding has not been examined objectively. To expl...
Associations between therapy skills and patient experiences of change processes in cognitive behavioral therapy for psychosis.
We randomly selected one tape-recorded therapy session from each of the cases. General and technical therapy skills were assessed by the Cognitive Therapy Scale for Psychosis. The Bern Post Session Report for Patients was applied to measure patient experiences of general change processes in the sens...
The association between self-reported change in vote for the presidential election of 2012 and posttraumatic stress disorder symptoms follow...
The relationship between vote change for the presidential election in 2012 and posttraumatic stress disorder (PTSD) symptoms has not been previously explored. An online sample of 1000 people mainly from New York Metropolitan Area was surveyed during the fourth week of November 2012 after Hurricane S...
Prevalence of self-reported childhood abuse in psychosis: a meta-analysis of retrospective studies.
We conducted, a systematic literature search to identify retrospective studies addressing self-reported childhood abuse in patients with DSM/ICD psychosis. Demographic, clinical, and methodological variables were extracted from each publication, or obtained directly from its authors. Quantitative me...
Psychoeducation for major depressive disorders: a randomised controlled trial.
We tested the efficacy of adding psychoeducation focussed on how to deal with the family's expressed emotion to treatment as usual (TAU) to prevent relapse among patients with remitted major depression. A total of 34 patients with major depressive disorders in full or partial remission were randomis...
Validity of the patient health questionnaire-9 for depression screening and diagnosis in East Africa.
We conducted this study to evaluate the reliability and validity of the Patient Health Questionnaire-9 (PHQ-9) as a screen for diagnosing major depressive disorder among adults in Ethiopia, the second most populous country in sub-Saharan Africa. A total of 926 adults attending outpatient departments...
Theory of mind deficits in patients with mild symptoms of major depressive disorder.
The aim of this study was to investigate theory of mind (ToM) in a sample of depressed patients with mild symptom severity using a measure with varied cognitive processing demands. Patients demonstrated impaired performance on second-order, cognitively demanding ToM scenarios. Reduced ToM ability wa...